{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:38:53Z","timestamp":1772138333430,"version":"3.50.1"},"reference-count":42,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2021,7,7]],"date-time":"2021-07-07T00:00:00Z","timestamp":1625616000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Instituto Mexicano del Seguro Social","award":["FIS\/IMSS\/PROT\/PRIO\/19\/104"],"award-info":[{"award-number":["FIS\/IMSS\/PROT\/PRIO\/19\/104"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Nowadays, the HIV pandemic is far from controlled. HIV+\/AIDS patients show a serious risk of developing resistance to HIV antiretroviral drugs and to be orally colonized by albicans and non-albicans Candida strains resistant to antifungals. As a consequence, new drugs that possess anti-candidal and anti-HIV effects would represent an alternative in the comprehensive treatment of HIV+\/AIDS patients. The present study evaluates the possible anti-HIV and anti-Candida effects of a methanolic extract from Heteropterys brachiata (Hb MeOH), an American tropical plant. The anti-HIV effect of Hb MeOH was tested using a non-radioactive colorimetric method (Lenti RT\u00ae Activity Assay; Cavidi Tech) that uses reverse transcriptase of HIV-1 enzyme as enzymatic target. The anti-candidal effect of HbMeOH extract was evaluated by following a standardized test protocol of microdilution for yeast using the Candida albicans strain ATCC\u00ae 90028. The Hb MeOH at 1 mg\/mL concentration shows 38.5% RT-HIV inhibition, while Hb MeOH at 10 mg\/mL concentration produced 98% C. albicans growth inhibition. Our findings show that the Hb MeOH possesses a strong anti-candidal activity and moderate anti-HIV effect and suggests that the plant extract could be considered as a potential candidate for HIV\/AIDS treatment.<\/jats:p>","DOI":"10.3390\/ijerph18147270","type":"journal-article","created":{"date-parts":[[2021,7,7]],"date-time":"2021-07-07T12:31:25Z","timestamp":1625661085000},"page":"7270","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Anti-HIV and Anti-Candidal Effects of Methanolic Extract from Heteropterys brachiata"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1133-5044","authenticated-orcid":false,"given":"Maira","family":"Huerta-Reyes","sequence":"first","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Enfermedades Nefrol\u00f3gicas, Hospital de Especialidades \u201cDr. Bernardo Sep\u00falveda Guti\u00e9rrez\u201d, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de M\u00e9xico 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis O.","family":"S\u00e1nchez-Vargas","sequence":"additional","affiliation":[{"name":"Laboratorio de Bioqu\u00edmica y Microbiolog\u00eda Oral, Facultad de Estomatolog\u00eda, Universidad Aut\u00f3noma de San Luis Potos\u00ed, San Luis Potos\u00ed 78290, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Getseman\u00ed S.","family":"Villanueva-Amador","sequence":"additional","affiliation":[{"name":"Departamento de Medicina y Patolog\u00eda Oral y Maxilofacial, Divisi\u00f3n de Estudios de Postgrado e Investigaci\u00f3n, Facultad de Odontolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Circuito Institutos s\/n, Ciudad Universitaria, Coyoac\u00e1n, Ciudad de M\u00e9xico 04510, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4777-6829","authenticated-orcid":false,"given":"Luis A.","family":"Gait\u00e1n-Cepeda","sequence":"additional","affiliation":[{"name":"Departamento de Medicina y Patolog\u00eda Oral y Maxilofacial, Divisi\u00f3n de Estudios de Postgrado e Investigaci\u00f3n, Facultad de Odontolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Circuito Institutos s\/n, Ciudad Universitaria, Coyoac\u00e1n, Ciudad de M\u00e9xico 04510, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1056\/NEJMp1916753","article-title":"Four Decades of HIV\/AIDS Much Accomplished, Much to Do","volume":"383","author":"Fauci","year":"2020","journal-title":"N. 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