{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T11:06:51Z","timestamp":1768561611043,"version":"3.49.0"},"reference-count":68,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T00:00:00Z","timestamp":1625702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["16-16-10073"],"award-info":[{"award-number":["16-16-10073"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Functional foods promote health benefits in human metabolism, with bioactive compounds acting as therapeutic agents. The aim was to investigate the biological effects of a p\u00e2t\u00e9 made of pork hearts and aortas, minced, sterilised and packed in tins. Adults (61\u201366 years old) with a body mass index of 26.4\u201360.7 kg\/m2 (n = 36) were randomly divided into two groups: one group consumed a low-calorie diet (LCD), while the other consumed an LCD with the developed meat product (MP) for 28\u201330 days. Serum biochemical parameters, anthropometry and blood pressure were measured. Consumption of an LCD + MP by experimental group participants helped to maintain reduced cholesterol levels. The difference in total cholesterol was significantly different (p = 0.018) from that of the control group, mainly due to the difference in low-density lipoprotein cholesterol (p = 0.005). Six peptides with potential cholesterol-binding properties and four peptides with potential antioxidant activity were identified in the MP, while elevation of the content of two peptides with potential angiotensin-converting enzyme-inhibitory activity was detected in patients\u2019 plasma. Intervention with the MP can be considered as a supportive therapy to the main treatment for medical cardiovascular diseases due to a positive effect on serum cholesterol.<\/jats:p>","DOI":"10.3390\/ijerph18147330","type":"journal-article","created":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T10:42:17Z","timestamp":1625740937000},"page":"7330","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Bioactive Compounds of Porcine Hearts and Aortas May Improve Cardiovascular Disorders in Humans"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4298-0927","authenticated-orcid":false,"given":"Irina","family":"Chernukha","sequence":"first","affiliation":[{"name":"V. M. Gorbatov Federal Research Center for Food Systems of RAS, Experimental Clinic and Research Laboratory for Bioactive Substances of Animal Origin, Talalikhina St. 26, Moscow 109316, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1864-8115","authenticated-orcid":false,"given":"Elena","family":"Kotenkova","sequence":"additional","affiliation":[{"name":"V. M. Gorbatov Federal Research Center for Food Systems of RAS, Experimental Clinic and Research Laboratory for Bioactive Substances of Animal Origin, Talalikhina St. 26, Moscow 109316, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1876-1230","authenticated-orcid":false,"given":"Svetlana","family":"Derbeneva","sequence":"additional","affiliation":[{"name":"Federal Research Center of Nutrition, Biotechnology and Food Safety, Department of Cardiovascular Pathology, Kashirskoe Sh. 21, Moscow 115446, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3445-4559","authenticated-orcid":false,"given":"Daniil","family":"Khvostov","sequence":"additional","affiliation":[{"name":"V. M. Gorbatov Federal Research Centre for Food Systems of RAS, Laboratory of Molecular Biology and Bioinformatics, Talalikhina St. 26, Moscow 109316, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2929","DOI":"10.2174\/0929867323666160615105746","article-title":"Functional Foods and Health Effects: A Nutritional Biochemistry Perspective","volume":"23","year":"2016","journal-title":"Curr. Med. Chem."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"499S","DOI":"10.1080\/07315724.2000.10718972","article-title":"The Changing Face of Functional Foods","volume":"19","author":"Hasler","year":"2000","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.meatsci.2006.04.028","article-title":"Strategies for designing novel functional meat products","volume":"74","author":"Arihara","year":"2006","journal-title":"Meat Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.tifs.2016.10.026","article-title":"Prospects of microalgae proteins in producing peptide-based functional foods for promoting cardiovascular health","volume":"59","author":"Ejike","year":"2017","journal-title":"Trends Food Sci. Technol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.foodchem.2010.05.104","article-title":"Design and development of meat-based functional foods with walnut: Technological, nutritional and health impact","volume":"123","year":"2010","journal-title":"Food Chem."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.meatsci.2013.03.030","article-title":"Development and assessment of healthy properties of meat and meat products designed as functional foods","volume":"95","year":"2013","journal-title":"Meat Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"127293","DOI":"10.1016\/j.foodchem.2020.127293","article-title":"Wild rice (Zizania spp.): A review of its nutritional constituents, phytochemicals, antioxidant activities, and health-promoting effects","volume":"331","author":"Yu","year":"2020","journal-title":"Food Chem."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Tur, J., and Bibiloni, M. (2016). Functional Foods. Encyclopedia of Food and Health, Elsevier.","DOI":"10.1016\/B978-0-12-384947-2.00340-8"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Sanchez-Sabate, R., and Sabat\u00e9, J. (2019). Consumer Attitudes Towards Environmental Concerns of Meat Consumption: A Systematic Review. Int. J. Environ. Res. Public Health, 16.","DOI":"10.3390\/ijerph16071220"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Modlinska, K., and Pisula, W. (2018). Selected Psychological Aspects of Meat Consumption\u2014A Short Review. Nutrients, 10.","DOI":"10.3390\/nu10091301"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/B978-0-12-814774-0.00007-4","article-title":"Bioactive Compounds as Ingredients of Functional Foods","volume":"7","author":"Fernandes","year":"2019","journal-title":"Bioact. Compd."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Hui, Y.H. (2012). Handbook of Meat and Meat Processing, CRC Press. [2nd ed.].","DOI":"10.1201\/b11479"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.meatsci.2010.05.008","article-title":"Advances in ingredient and processing systems for meat and meat products","volume":"86","author":"Weiss","year":"2010","journal-title":"Meat Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"5377","DOI":"10.1007\/s13197-015-1731-5","article-title":"Bioactive peptides of animal origin: A review","volume":"52","author":"Bhat","year":"2015","journal-title":"J. Food Sci. Technol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.meatsci.2014.05.036","article-title":"Bioactive peptides from meat muscle and by-products: Generation, functionality and application as functional ingredients","volume":"98","author":"Lafarga","year":"2014","journal-title":"Meat Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"765","DOI":"10.3390\/nu3090765","article-title":"Bioactive Peptides from Muscle Sources: Meat and Fish","volume":"3","author":"Ryan","year":"2011","journal-title":"Nutrients"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.foodres.2012.10.002","article-title":"Meat proteome as source of functional biopeptides","volume":"54","author":"Udenigwe","year":"2013","journal-title":"Food Res. Int."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Aguiar, L.M., Geraldi, M.V., Cazarin, C.B.B., and Junior, M.R.M. (2019). Functional Food Consumption and Its Physiological Effects. Bioactive Compounds, Elsevier.","DOI":"10.1016\/B978-0-12-814774-0.00011-6"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.meatsci.2010.04.032","article-title":"A review of meat protein hydrolysates and hypertension","volume":"86","author":"Ahhmed","year":"2010","journal-title":"Meat Sci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1111\/bph.13608","article-title":"Potential role of bioactive peptides in prevention and treatment of chronic diseases: A narrative review","volume":"174","author":"Cicero","year":"2016","journal-title":"Br. J. Pharmacol."},{"key":"ref_21","unstructured":"Terrien, C. (2017). Meat Analogs. Challenges and Perspectives, Elsevier."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.meatsci.2017.04.243","article-title":"Alternative uses for co-products: Harnessing the potential of valuable compounds from meat processing chains","volume":"132","author":"Mullen","year":"2017","journal-title":"Meat Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.meatsci.2012.04.004","article-title":"Innovations in value-addition of edible meat by-products","volume":"92","author":"Aristoy","year":"2012","journal-title":"Meat Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.meatsci.2016.04.021","article-title":"New insights into meat by-product utilization","volume":"120","author":"Mora","year":"2016","journal-title":"Meat Sci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1111\/asj.12986","article-title":"Hypolipidemic and anti-inflammatory effects of aorta and heart tissues of cattle and pigs in the atherosclerosis rat model","volume":"89","author":"Chernukha","year":"2018","journal-title":"Anim. Sci. J."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"331","DOI":"10.5219\/1119","article-title":"Influence of technological processing on lipid-lowering activity of substances containing in porcine hearts and aortas","volume":"13","author":"Kotenkova","year":"2019","journal-title":"Potravinarstvo Slovak J. Food Sci."},{"key":"ref_27","first-page":"38","article-title":"Influence of heat treatment on tissue specific proteins in the Sus scrofa cardiac muscle and aorta","volume":"8","author":"Chernukha","year":"2016","journal-title":"Russ. J. Biopharm."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1134\/S1061934816110046","article-title":"Determination of unsaturated fatty acids with a migrating double bond in complex biological matrices by gas chromatography with flame ionization and mass spectrometry detection","volume":"71","author":"Ivankin","year":"2016","journal-title":"J. Anal. Chem."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Chen, J., and Liu, H. (2020). Nutritional Indices for Assessing Fatty Acids: A Mini-Review. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21165695"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1021\/pr4008078","article-title":"DeNovoGUI: An Open Source Graphical User Interface for de Novo Sequencing of Tandem Mass Spectra","volume":"13","author":"Muth","year":"2014","journal-title":"J. Proteome Res."},{"key":"ref_31","unstructured":"(2020, June 19). Quick Search on the Home Page. Available online: http:\/\/pepbank.mgh.harvard.edu\/."},{"key":"ref_32","unstructured":"Databases (2020, June 22). Search in Bioactive peptides. Available online: http:\/\/www.uwm.edu.pl\/biochemia\/index.php\/en\/biopep\/."},{"key":"ref_33","unstructured":"Download Datasets (2020, June 22). Small Peptides (2\u20135 residues). Available online: https:\/\/webs.iiitd.edu.in\/raghava\/ahtpdb\/."},{"key":"ref_34","unstructured":"(2021, April 26). UniProt. Available online: https:\/\/www.uniprot.org\/."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.3945\/jn.115.213595","article-title":"Higher Total Protein Intake and Change in Total Protein Intake Affect Body Composition but Not Metabolic Syndrome Indexes in Middle-Aged Overweight and Obese Adults Who Perform Resistance and Aerobic Exercise for 36 Weeks","volume":"145","author":"Campbell","year":"2015","journal-title":"J. Nutr."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1093\/nutrit\/nuv065","article-title":"Effects of dietary protein intake on body composition changes after weight loss in older adults: A systematic review and meta-analysis","volume":"74","author":"Kim","year":"2016","journal-title":"Nutr. Rev."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"46","DOI":"10.5114\/aoms.2017.64713","article-title":"Blood pressure, dyslipidemia and inflammatory factors are related to body mass index in scholar adolescents","volume":"1","author":"Bouchouicha","year":"2017","journal-title":"Arch. Med Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/j.jacc.2014.12.039","article-title":"Dietary Sodium and Health","volume":"65","author":"Farquhar","year":"2015","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"430","DOI":"10.5713\/ajas.18.0455","article-title":"Isolation and identification of angiotensin I-converting enzyme inhibitory peptides derived from thermolysin-injected beef M. longissimus","volume":"32","author":"Choe","year":"2019","journal-title":"Asian Australas. J. Anim. Sci."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Mora, L., Gallego, M., and Toldr\u00e1, F. (2018). ACEI-Inhibitory Peptides Naturally Generated in Meat and Meat Products and Their Health Relevance. Nutrients, 10.","DOI":"10.3390\/nu10091259"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.3390\/jcm4121956","article-title":"Pork as a Source of Omega-3 (n-3) Fatty Acids","volume":"4","author":"Dugan","year":"2015","journal-title":"J. Clin. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"583","DOI":"10.2527\/jas.2006-239","article-title":"Effects of breed, sex, and halothane genotype on fatty acid composition of pork longissimus muscle","volume":"85","author":"Zhang","year":"2007","journal-title":"J. Anim. Sci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"279","DOI":"10.17221\/6826-CJAS","article-title":"Effect of dietary linseed supplementation on the performance, meat quality, and fatty acid profile of pigs","volume":"58","author":"Stupka","year":"2013","journal-title":"Czech J. Anim. Sci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"379","DOI":"10.5194\/aab-58-379-2015","article-title":"Fatty acid profile of pork from a local and a commercial breed","volume":"58","author":"Kasprzyk","year":"2015","journal-title":"Arch. Anim. Breed."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e037","DOI":"10.3989\/gya.0234141","article-title":"Effect of genotype on fatty acid composition of intramuscular and subcutaneous fat of Celta pig breed","volume":"65","author":"Lorenzo","year":"2014","journal-title":"Grasas y Aceites"},{"key":"ref_46","first-page":"77","article-title":"Comparison of fatty acid composition in different pig tissues","volume":"58","year":"2012","journal-title":"Vet. Med. Zoot."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jff.2017.09.012","article-title":"Effects of dry-cured ham rich in bioactive peptides on cardiovascular health: A randomized controlled trial","volume":"38","author":"Haro","year":"2017","journal-title":"J. Funct. Foods"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Rodgers, J.L., Jones, J., Bolleddu, S.I., Vanthenapalli, S., Rodgers, L.E., Shah, K., Karia, K., and Panguluri, S.K. (2019). Cardiovascular Risks Associated with Gender and Aging. J. Cardiovasc. Dev. Dis., 6.","DOI":"10.3390\/jcdd6020019"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13098-019-0468-0","article-title":"Cardiovascular risk and obesity","volume":"11","author":"Cercato","year":"2019","journal-title":"Diabetol. Metab. Syndr."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1136\/heartjnl-2015-308769","article-title":"Sex differences in cardiovascular ageing","volume":"102","author":"Merz","year":"2016","journal-title":"Heart"},{"key":"ref_51","first-page":"CD001918","article-title":"Dietary treatment for familial hypercholesterolaemia","volume":"1","author":"Shafiq","year":"2010","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_52","first-page":"CD001918","article-title":"Dietary treatment for familial hypercholesterolaemia","volume":"2","author":"Poustie","year":"2001","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e000299","DOI":"10.3945\/cdn.116.000299","article-title":"Animal-Protein Intake Is Associated with Insulin Resistance in Adventist Health Study 2 (AHS-2) Calibration Substudy Participants: A Cross-Sectional Analysis","volume":"1","author":"Azemati","year":"2017","journal-title":"Curr. Dev. Nutr."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Moreno-Fern\u00e1ndez, S., Garc\u00e9s-Rim\u00f3n, M., Vera, G., Astier, J., Landrier, J.F., and Miguel, M. (2018). High Fat\/High Glucose Diet Induces Metabolic Syndrome in an Experimental Rat Model. Nutrients, 10.","DOI":"10.3390\/nu10101502"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1093\/advances\/nmy026","article-title":"A Systematic Review of Renal Health in Healthy Individuals Associated with Protein Intake above the US Recommended Daily Allowance in Randomized Controlled Trials and Observational Studies","volume":"9","author":"Weatherford","year":"2018","journal-title":"Adv. Nutr."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5402\/2013\/126929","article-title":"Adverse Effects Associated with Protein Intake above the Recommended Dietary Allowance for Adults","volume":"2013","author":"Delimaris","year":"2013","journal-title":"ISRN Nutr."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Alao, B.O., Falowo, A.B., Chulayo, A., and Muchenje, V. (2017). The Potential of Animal By-Products in Food Systems: Production, Prospects and Challenges. Sustainability, 9.","DOI":"10.3390\/su9071089"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1007\/s13197-011-0290-7","article-title":"Utilization of byproducts and waste materials from meat, poultry and fish processing industries: A review","volume":"49","author":"Jayathilakan","year":"2011","journal-title":"J. Food Sci. Technol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"189","DOI":"10.22358\/jafs\/65548\/2016","article-title":"Animal by-products for feed: Characteristics, European regulatory framework, and potential impacts on human and animal health and the environment","volume":"25","author":"Levic","year":"2016","journal-title":"J. Anim. Feed. Sci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1074\/mcp.M113.035600","article-title":"Analysis of the Human Tissue-specific Expression by Genome-wide Integration of Transcriptomics and Antibody-based Proteomics","volume":"13","author":"Fagerberg","year":"2014","journal-title":"Mol. Cell. Proteom."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"4991","DOI":"10.1210\/endo.139.12.6390","article-title":"Peripheral-Type Benzodiazepine Receptor Function in Cholesterol Transport. Identification of a Putative Cholesterol Recognition\/Interaction Amino Acid Sequence and Consensus Pattern","volume":"139","author":"Li","year":"1998","journal-title":"Endocrinology"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/j.foodchem.2006.07.002","article-title":"Isolation and identification of antioxidative peptides from porcine collagen hydrolysate by consecutive chromatography and electrospray ionization\u2013mass spectrometry","volume":"102","author":"Li","year":"2007","journal-title":"Food Chem."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.foodchem.2014.03.117","article-title":"Stability of ACE inhibitory ham peptides against heat treatment and in vitro digestion","volume":"161","author":"Escudero","year":"2014","journal-title":"Food Chem."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Iwaniak, A., Mogut, D., Minkiewicz, P., \u017bulewska, J., and Darewicz, M. (2021). Gouda Cheese with Modified Content of \u03b2-Casein as a Source of Peptides with ACE- and DPP-IV-Inhibiting Bioactivity: A Study Based on In Silico and In Vitro Protocol. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22062949"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Ganzorig, K., Urashima, T., and Fukuda, K. (2020). Exploring Potential Bioactive Peptides in Fermented Bactrian Camel\u2019s Milk and Mare\u2019s Milk Made by Mongolian Nomads. Foods, 9.","DOI":"10.3390\/foods9121817"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1080\/10942912.2013.787626","article-title":"In SilicoEvaluation of Potential DPP-III Inhibitor Precursors from Dietary Proteins","volume":"18","author":"Khaket","year":"2014","journal-title":"Int. J. Food Prop."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Daliri, E.B.-M., Oh, D.H., and Lee, B.H. (2017). Bioactive Peptides. Foods, 6.","DOI":"10.3390\/foods6050032"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1166\/jbn.2020.3001","article-title":"A Review of Bioactive Peptides: Chemical Modification, Structural Characterization and Therapeutic Applications","volume":"16","author":"Hou","year":"2020","journal-title":"J. Biomed. Nanotechnol."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/18\/14\/7330\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:27:56Z","timestamp":1760164076000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/18\/14\/7330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,8]]},"references-count":68,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2021,7]]}},"alternative-id":["ijerph18147330"],"URL":"https:\/\/doi.org\/10.3390\/ijerph18147330","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,8]]}}}