{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:10:52Z","timestamp":1788739852946,"version":"build-2803163510"},"reference-count":56,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2021,7,23]],"date-time":"2021-07-23T00:00:00Z","timestamp":1626998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>The aim of this study was to analyze selected indicators of oxidative stress. The study subjects consisted of 42 women with Hashimoto\u2019s disease and a control group of 30 healthy women. The concentration of zinc (Zn) and copper (Cu) in the serum was determined by Atomic Absorption Spectrometry (AAS) and the total antioxidative potential by the Ferric Reducing Ability of Plasma (FRAP) method. In addition, an assessment of concentrations of thiobarbituric acid reactive substances (TBARS) and total phenolics was carried out. Our research showed a significant difference in TBARS concentration (p &lt; 0.0001 (ES: 0.92)) without significant differences in Zn, Cu, FRAP and total phenolics concentrations. Analysis of the correlation of the obtained results of biochemical tests for both groups showed a highly significant dependence of FRAP and total phenolics concentration in the blood of the examined women (r = 0.5283, p = 0.0003). The obtained results indicate no differences in Cu, Zn, and FRAP concentrations in the blood between two analyzed groups and a significantly higher concentration of TBARS in Hashimoto\u2019s thyroiditis women. The concentration of total phenolics significantly influences the value of the FRAP.<\/jats:p>","DOI":"10.3390\/ijerph18157805","type":"journal-article","created":{"date-parts":[[2021,7,23]],"date-time":"2021-07-23T04:29:14Z","timestamp":1627014554000},"page":"7805","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The Level of Zinc, Copper and Antioxidant Status in the Blood Serum of Women with Hashimoto\u2019s Thyroiditis"],"prefix":"10.3390","volume":"18","author":[{"given":"Joanna","family":"Szczepanik","sequence":"first","affiliation":[{"name":"Faculty of Health Sciences, School of Socio-Economics in Sroda Wielkopolska, 63-000 Sroda Wielkopolska, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0745-4606","authenticated-orcid":false,"given":"Tomasz","family":"Podg\u00f3rski","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biochemistry, Poznan University of Physical Education, 61-871 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8117-1714","authenticated-orcid":false,"given":"Katarzyna","family":"Domaszewska","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, Calisia University, 62-800 Kalisz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"38891","DOI":"10.1074\/jbc.M007319200","article-title":"A redox signaling mechanism for density dependent inhibition of cell growth","volume":"275","author":"Pani","year":"2000","journal-title":"JBC"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.intimp.2012.08.010","article-title":"Oxidative stress parameters in serum and low density lipoproteins of Hashimoto\u2019s thyroiditis patients with subclinical and overt hypothyroidism","volume":"14","author":"Vural","year":"2012","journal-title":"Int. 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