{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T23:22:34Z","timestamp":1783120954230,"version":"3.54.6"},"reference-count":31,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T00:00:00Z","timestamp":1627430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100015309","name":"Tobacco Settlement Endowment Trust","doi-asserted-by":"publisher","award":["092-016-0002"],"award-info":[{"award-number":["092-016-0002"]}],"id":[{"id":"10.13039\/100015309","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30CA225520"],"award-info":[{"award-number":["P30CA225520"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P20CA221697"],"award-info":[{"award-number":["P20CA221697"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P20CA221696"],"award-info":[{"award-number":["P20CA221696"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006545","name":"National Institute on Minority Health and Health Disparities","doi-asserted-by":"publisher","award":["U54MD015946"],"award-info":[{"award-number":["U54MD015946"]}],"id":[{"id":"10.13039\/100006545","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Psychiatric medication nonadherence continues to be a leading cause of poor health outcomes for individuals experiencing homelessness. Identifying the sociodemographic factors that contribute to medication nonadherence may help guide strategies to care for and support this group. This study examined 200 adults with depression diagnoses and active anti-depressant prescriptions (Mage = 43.98 \u00b1 12.08, 59.4% Caucasian, 58.5% male, 70% uninsured, 89.5% unemployed) and 181 adults with anxiety diagnoses and active anti-anxiety prescriptions (Mage = 43.45 \u00b1 11.02, 54.4% Caucasian, 57.5% male, 66.3% uninsured, 88.9% unemployed) recruited from six homeless-serving agencies in Oklahoma City. Self-reported sociodemographic variables included: age, sex, race\/ethnicity, education, monthly income, employment status, and health insurance status. Adjusted logistic regression analyses revealed that employed (OR = 4.022, CI0.95: 1.244\u201313.004) and insured (OR = 2.923, CI0.95: 1.225\u20136.973) participants had greater odds of depression medication nonadherence. For anxiety, being employed (OR = 3.573, CI0.95: 1.160\u201311.010) was associated with greater odds of anxiety medication nonadherence, whereas having depression and anxiety diagnostic comorbidity (OR = 0.333, CI0.95: 0.137\u20130.810) was associated with lower odds of anxiety medication nonadherence. Interventions aimed at facilitating accessible prescription acquisition or otherwise reducing barriers to prescription medications for employed adults, including those with health insurance, may benefit adherence, but more research is needed. Future studies would benefit from using a qualitative approach to better delineate nuanced barriers to psychiatric medication adherence.<\/jats:p>","DOI":"10.3390\/ijerph18157958","type":"journal-article","created":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T05:23:48Z","timestamp":1627449828000},"page":"7958","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Sociodemographic Determinants of Nonadherence to Depression and Anxiety Medication among Individuals Experiencing Homelessness"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9436-1848","authenticated-orcid":false,"given":"Sahar S.","family":"Eshtehardi","sequence":"first","affiliation":[{"name":"Department of Psychological, Health, & Learning Sciences, The University of Houston, 3657 Cullen Blvd Stephen Power Farish Hall, Houston, TX 77204, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley A.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Psychological, Health, & Learning Sciences, The University of Houston, 3657 Cullen Blvd Stephen Power Farish Hall, Houston, TX 77204, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzuan A.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Psychological, Health, & Learning Sciences, The University of Houston, 3657 Cullen Blvd Stephen Power Farish Hall, Houston, TX 77204, USA"},{"name":"HEALTH Research Institute, The University of Houston, 4849 Calhoun Rd., Houston, TX 77204, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel A.","family":"de Dios","sequence":"additional","affiliation":[{"name":"Department of Psychological, Health, & Learning Sciences, The University of Houston, 3657 Cullen Blvd Stephen Power Farish Hall, Houston, TX 77204, USA"},{"name":"HEALTH Research Institute, The University of Houston, 4849 Calhoun Rd., Houston, TX 77204, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virmarie","family":"Correa-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Psychological, Health, & Learning Sciences, The University of Houston, 3657 Cullen Blvd Stephen Power Farish Hall, Houston, TX 77204, USA"},{"name":"HEALTH Research Institute, The University of Houston, 4849 Calhoun Rd., Houston, TX 77204, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7273-1916","authenticated-orcid":false,"given":"Darla E.","family":"Kendzor","sequence":"additional","affiliation":[{"name":"TSET Health Promotion Research Center, The University of Oklahoma Health Sciences Center, 655 Research Parkway, Suite 400, Oklahoma, OK 73104, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9038-2238","authenticated-orcid":false,"given":"Michael S.","family":"Businelle","sequence":"additional","affiliation":[{"name":"TSET Health Promotion Research Center, The University of Oklahoma Health Sciences Center, 655 Research Parkway, Suite 400, Oklahoma, OK 73104, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7165-5720","authenticated-orcid":false,"given":"Lorraine R.","family":"Reitzel","sequence":"additional","affiliation":[{"name":"Department of Psychological, Health, & Learning Sciences, The University of Houston, 3657 Cullen Blvd Stephen Power Farish Hall, Houston, TX 77204, USA"},{"name":"HEALTH Research Institute, The University of Houston, 4849 Calhoun Rd., Houston, TX 77204, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1177\/2150131914560610","article-title":"Barriers to prescription medication adherence among homeless and vulnerably housed adults in three Canadian cities","volume":"6","author":"Hunter","year":"2015","journal-title":"J. Prim. Care Community Health"},{"key":"ref_2","unstructured":"World Health Organization (2003). Adherence to Long-Term Therapies: Evidence for Action, World Health Organization Publishing."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"304","DOI":"10.4065\/mcp.2010.0575","article-title":"Medication adherence: WHO cares?","volume":"86","author":"Brown","year":"2011","journal-title":"Mayo Clin. Proc."},{"key":"ref_4","first-page":"189","article-title":"The challenge of patient adherence","volume":"1","author":"Martin","year":"2005","journal-title":"Ther. Clin. Risk Manag."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/s11606-017-4198-4","article-title":"Advancing the science and practice of medication adherence","volume":"33","author":"Stirratt","year":"2018","journal-title":"J. Gen. Intern. Med."},{"key":"ref_6","first-page":"728","article-title":"Comparing adherence and persistence across 6 chronic medication classes","volume":"15","author":"Yeaw","year":"2009","journal-title":"J. Manag. Care Pharm."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1056\/NEJMra050100","article-title":"Adherence to Medication","volume":"353","author":"Osterberg","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e110","DOI":"10.1016\/j.sapharm.2012.11.004","article-title":"Medication adherence challenges among patients experiencing homelessness in a behavioral health clinic","volume":"11","author":"Coe","year":"2015","journal-title":"Res. Soc. Adm. Pharm."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/s11524-011-9562-9","article-title":"Homelessness and adherence to antiretroviral therapy among a cohort of HIV-infected injection drug users","volume":"88","author":"Palepu","year":"2011","journal-title":"J. Urban Health"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1080\/09540120802270250","article-title":"Factors associated with adherence to highly active antiretroviral therapy in homeless or unstably housed adults living with HIV","volume":"21","author":"Royal","year":"2009","journal-title":"AIDS Care"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.2105\/AJPH.2006.090209","article-title":"Health status, health care use, medication use, and medication adherence among homeless and housed people living with HIV\/AIDS","volume":"97","author":"Kidder","year":"2007","journal-title":"Am. J. Public Health"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1086\/424008","article-title":"Adherence to highly active antiretroviral therapy in the homeless population in San Francisco: A prospective study","volume":"39","author":"Moss","year":"2004","journal-title":"Clin. Infect. Dis."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1007\/s00127-016-1259-7","article-title":"Adherence to antipsychotic medication among homeless adults in Vancouver, Canada: A 15-year retrospective cohort study","volume":"51","author":"Rezansoff","year":"2016","journal-title":"Soc. Psychiatry Psychiatr. Epidemiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1007\/s00127-017-1411-z","article-title":"Homeless women with schizophrenia reported lower adherence to their medication than men: Results from the French housing first experience","volume":"52","author":"Tinland","year":"2017","journal-title":"Soc. Psychiatry Psychiatr. Epidemiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.psychres.2009.05.004","article-title":"Predictors and clinical consequences of non-adherence with antipsychotic medication in the outpatient treatment of schizophrenia","volume":"176","author":"Novick","year":"2010","journal-title":"Psychiatry Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.comppsych.2010.07.002","article-title":"Illness experience and reasons for nonadherence among individuals with bipolar disorder who are poorly adherent with medication","volume":"52","author":"Sajatovic","year":"2011","journal-title":"Compr. Psychiatry"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1001\/jamainternmed.2013.1604","article-title":"Mortality among homeless adults in Boston: Shifts in causes of death over a 15-year period","volume":"173","author":"Baggett","year":"2013","journal-title":"JAMA Intern. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1111\/j.1745-7599.2012.00756.x","article-title":"Medication adherence among homeless patients: A pilot study of cell phone effectiveness","volume":"24","author":"Burda","year":"2012","journal-title":"J. Am. Acad. Nurse Pract."},{"key":"ref_19","unstructured":"Henry, M., Morrill, T., Robinson, A., Shivji, A., Watt, R., and Abt Associates (2018). The 2018 Annual Homeless Assessment Report (AHAR) to Congress. Part 1: Point-In-Time Estimates of Homelessness."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.psychres.2011.04.016","article-title":"Clinical and economic consequences of medication non-adherence in the treatment of patients with a manic\/mixed episode of bipolar disorder: Results from the European Mania in Bipolar Longitudinal Evaluation of Medication (EMBLEM) study","volume":"190","author":"Hong","year":"2011","journal-title":"Psychiatry Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1447-0349.2006.00420.x","article-title":"Self-management of medication for mental health problems by homeless young people","volume":"15","author":"Fereday","year":"2006","journal-title":"Int. J. Ment. Health Nurs."},{"key":"ref_22","first-page":"CD000011","article-title":"Interventions for enhancing medication adherence","volume":"2","author":"Haynes","year":"2008","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_23","first-page":"151","article-title":"Sociodemographic and clinical predictors of compliance with antidepressants for depressive disorders: Systematic review of observational studies","volume":"7","year":"2013","journal-title":"Patient Prefer. Adherence"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s00127-009-0041-5","article-title":"Non-adherence with psychotropic medications in the general population","volume":"45","author":"Bulloch","year":"2010","journal-title":"Soc. Psychiatry Psychiatr. Epidemiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1097\/MLR.0b013e3180616c1b","article-title":"Development and validation of a short-form, rapid estimate of adult literacy in medicine","volume":"45","author":"Arozullah","year":"2007","journal-title":"Med. Care"},{"key":"ref_26","unstructured":"SAS Institute (2014). SAS 9.4 ODS Graphics Procedures Guide, SAS Institute Inc.. [3rd ed.]."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1353\/hpu.2017.0036","article-title":"Financial strain is associated with medication nonadherence and worse self-rated health among cardiovascular patients","volume":"28","author":"Osborn","year":"2017","journal-title":"J. Health Care Poor Underserved"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"805","DOI":"10.2147\/PPA.S50055","article-title":"The influence of symptoms of anxiety and depression on medication nonadherence and its causes: A population based survey of prescription drug users in Sweden","volume":"7","author":"Sundbom","year":"2013","journal-title":"Patient Prefer. Adherence"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/j.1467-9280.2006.01695.x","article-title":"Stigma as ego depletion: How being the target of prejudice affects self-control","volume":"17","author":"Inzlicht","year":"2006","journal-title":"Psychol. Sci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s11096-013-9865-x","article-title":"Assessing medication adherence: Options to consider","volume":"36","author":"Lehmann","year":"2014","journal-title":"Int. J. Clin. Pharm."},{"key":"ref_31","unstructured":"Oklahoma City Planning Department-Housing & Community Development Division (2016). 2016 Point-In-Time A Snapshot of Homelessness in Oklahoma City."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/18\/15\/7958\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:35:58Z","timestamp":1760164558000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/18\/15\/7958"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,28]]},"references-count":31,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2021,8]]}},"alternative-id":["ijerph18157958"],"URL":"https:\/\/doi.org\/10.3390\/ijerph18157958","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,28]]}}}