{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:39:34Z","timestamp":1790674774454,"version":"4.1.0"},"reference-count":49,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T00:00:00Z","timestamp":1627430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Background: To the authors\u2019 knowledge, there have been no studies comparing the acute responses to \u201call out\u201d efforts in concentric (isoinertial) vs. eccentric (isovelocity) cycling. Methods: After two familiarization sessions, 12 physically active men underwent the experimental protocols consisting of a 2-min warm-up and 8 maximal efforts of 5 s, separated by 55 s of active recovery at 80 rpm, in concentric vs. eccentric cycling. Comparisons between protocols were conducted during, immediately after, and 24-h post-sessions. Results: Mechanical (Work: 82,824 \u00b1 6350 vs. 60,602 \u00b1 8904 J) and cardiometabolic responses (mean HR: 68.8 \u00b1 6.6 vs. 51.3 \u00b1 5.7% HRmax, lactate: 4.9 \u00b1 2.1 vs. 1.8 \u00b1 0.6 mmol\/L) were larger in concentric cycling (p &lt; 0.001). The perceptual responses to both protocols were similarly low. Immediately after concentric cycling, vertical jump was potentiated (p = 0.028). Muscle soreness (VAS; p = 0.016) and thigh circumference (p = 0.045) were slightly increased only 24-h after eccentric cycling. Serum concentrations of CK, BAG3, and MMP-13 did not change significantly post-exercise. Conclusions: These results suggest the appropriateness of the eccentric cycling protocol used as a time-efficient (i.e., ~60 kJ in 10 min) and safe (i.e., without exercise-induced muscle damage) alternative to be used with different populations in future longitudinal interventions.<\/jats:p>","DOI":"10.3390\/ijerph18157968","type":"journal-article","created":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T05:23:48Z","timestamp":1627449828000},"page":"7968","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Acute and Delayed Effects of Time-Matched Very Short \u201cAll Out\u201d Efforts in Concentric vs. Eccentric Cycling"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8477-127X","authenticated-orcid":false,"given":"Daniel","family":"Boullosa","sequence":"first","affiliation":[{"name":"Integrated Institute of Health, Federal University of Mato Grosso do Sul, 79070-900 Campo Grande, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Dragutinovic","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Research and Sports Medicine, Department of Molecular and Cellular Sports Medicine, German Sport University, 50933 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5293-7001","authenticated-orcid":false,"given":"Jan-Philip","family":"Deutsch","sequence":"additional","affiliation":[{"name":"Intervention Research in Exercise Training, German Sports University, 50933 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Held","sequence":"additional","affiliation":[{"name":"Intervention Research in Exercise Training, German Sports University, 50933 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Donath","sequence":"additional","affiliation":[{"name":"Intervention Research in Exercise Training, German Sports University, 50933 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilhelm","family":"Bloch","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Research and Sports Medicine, Department of Molecular and Cellular Sports Medicine, German Sport University, 50933 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9605-3489","authenticated-orcid":false,"given":"Moritz","family":"Schumann","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Research and Sports Medicine, Department of Molecular and Cellular Sports Medicine, German Sport University, 50933 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2915","DOI":"10.1113\/JP273196","article-title":"Physiological adaptations to interval training and the role of exercise intensity","volume":"595","author":"MacInnis","year":"2017","journal-title":"J. Physiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1152\/japplphysiol.01095.2004","article-title":"Six sessions of sprint interval training increases muscle oxidative potential and cycle endurance capacity in humans","volume":"98","author":"Burgomaster","year":"2005","journal-title":"J. Appl. Physiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1249\/MSS.0000000000001204","article-title":"Effect of number of sprints in an SIT session on change in VO2max: A meta-analysis","volume":"49","author":"Vollaard","year":"2017","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12966-015-0254-9","article-title":"High-intensity interval exercise training for public health: A big HIT or shall we HIT it on the head?","volume":"12","author":"Biddle","year":"2015","journal-title":"Int. J. Behav. Nutr. Phys. Act."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2604","DOI":"10.1249\/MSS.0000000000000721","article-title":"Affective Responses to Repeated Sessions of High-Intensity Interval Training","volume":"47","author":"Saanijoki","year":"2015","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1007\/s40279-017-0727-x","article-title":"Research into the Health Benefits of Sprint Interval Training Should Focus on Protocols with Fewer and Shorter Sprints","volume":"47","author":"Vollaard","year":"2017","journal-title":"Sport. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1139\/apnm-2017-0595","article-title":"Modified sprint interval training protocols: Physiological and psychological responses to 4 weeks of training","volume":"43","author":"McKie","year":"2018","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1152\/japplphysiol.00536.2016","article-title":"Factors contributing to lower metabolic demand of eccentric compared with concentric cycling","volume":"123","author":"Blazevich","year":"2017","journal-title":"J. Appl. Physiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1055\/a-0783-2581","article-title":"Cardiorespiratory and Autonomic Nervous System Responses to Prolonged Eccentric Cycling","volume":"40","author":"Ritter","year":"2019","journal-title":"Int. J. Sports Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1519\/JSC.0b013e31824f2055","article-title":"Reliability of Power Output During Eccentric Sprint Cycling","volume":"27","author":"Brughelli","year":"2013","journal-title":"J. Strength Cond. Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1080\/17461391.2018.1498131","article-title":"Oxygen consumption, rate of perceived exertion and enjoyment in high-intensity interval eccentric cycling","volume":"18","author":"Lipski","year":"2018","journal-title":"Eur. J. Sport Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1007\/s00421-020-04341-5","article-title":"Comparison between high- and low-intensity eccentric cycling of equal mechanical work for muscle damage and the repeated bout effect","volume":"120","author":"Mavropalias","year":"2020","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s00421-020-04548-6","article-title":"Moving forward with backward pedaling: a review on eccentric cycling","volume":"121","author":"Barreto","year":"2021","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"536","DOI":"10.3389\/fphys.2019.00536","article-title":"Eccentric muscle contractions: Risks and benefits","volume":"10","author":"Hody","year":"2019","journal-title":"Front. Physiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s00421-020-04528-w","article-title":"Eccentric exercise per se does not affect muscle damage biomarkers: Early and late phase adaptations","volume":"121","author":"Margaritelis","year":"2020","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1002\/mus.21679","article-title":"Quadriceps low-frequency fatigue and muscle pain are contraction-type-dependent","volume":"42","author":"Iguchi","year":"2010","journal-title":"Muscle Nerve"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1007\/s00421-019-04220-8","article-title":"Eccentric and concentric blood flow restriction resistance training on indices of delayed onset muscle soreness in untrained women","volume":"119","author":"Hill","year":"2019","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1080\/02701367.2019.1699234","article-title":"Metabolic Demand and Indirect Markers of Muscle Damage after Eccentric Cycling with Blood Flow Restriction","volume":"91","author":"Penailillo","year":"2020","journal-title":"Res. Q. Exerc. Sport"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s00421-019-04272-w","article-title":"Comparison among three different intensities of eccentric contractions of the elbow flexors resulting in the same strength loss at one day post-exercise for changes in indirect muscle damage markers","volume":"120","author":"Chen","year":"2020","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.jshs.2018.06.002","article-title":"Basic science and clinical use of eccentric contractions: History and uncertainties","volume":"7","author":"Nishikawa","year":"2018","journal-title":"J. Sport Health Sci."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Sonkodi, B., Berkes, I., and Koltai, E. (2020). Have We Looked in the Wrong Direction for More Than 100 Years? Delayed Onset Muscle Soreness Is, in Fact, Neural Microdamage Rather Than Muscle Damage. Antioxidants, 9.","DOI":"10.3390\/antiox9030212"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2697","DOI":"10.1519\/JSC.0000000000002867","article-title":"Sex-Related Differences After a Single Bout of Maximal Eccentric Exercise in Response to Acute Effects: A Systematic Review and Meta-analysis","volume":"34","author":"Morawetz","year":"2020","journal-title":"J. Strength Cond. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"C529","DOI":"10.1152\/ajpcell.00051.2013","article-title":"Matrix metalloproteinase 13 is a new contributor to skeletal muscle regeneration and critical for myoblast migration","volume":"305","author":"Lei","year":"2013","journal-title":"Am. J. Physiol. Physiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"129628","DOI":"10.1016\/j.bbagen.2020.129628","article-title":"The multiple activities of BAG3 protein: Mechanisms","volume":"1864","author":"Marzullo","year":"2020","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1080\/15548627.2015.1017186","article-title":"Induction and adaptation of chaperone-assisted selective autophagy CASA in response to resistance exercise in human skeletal muscle","volume":"11","author":"Ulbricht","year":"2015","journal-title":"Autophagy"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jelekin.2018.03.005","article-title":"Torque, power and muscle activation of eccentric and concentric isokinetic cycling","volume":"40","author":"Green","year":"2018","journal-title":"J. Electromyogr. Kinesiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0735-1097(00)01054-8","article-title":"Age-predicted maximal heart rate revisited","volume":"37","author":"Tanaka","year":"2001","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"137","DOI":"10.26582\/k.50.2.13","article-title":"Shorter sprints elicit greater cardiorespiratory and mechanical responses with less fatigue during time-matched sprint interval training (SIT) sessions","volume":"50","author":"Rosa","year":"2018","journal-title":"Kinesiology"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s00421-012-2421-x","article-title":"Associations between Borg\u2019s rating of perceived exertion and physiological measures of exercise intensity","volume":"113","author":"Scherr","year":"2013","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1123\/jsep.11.3.304","article-title":"Not What, but How One Feels: The Measurement of Affect during Exercise","volume":"11","author":"Hardy","year":"1989","journal-title":"J. Sport Exerc. Psychol."},{"key":"ref_31","first-page":"109","article-title":"A New Approach to Monitoring Exercise Training","volume":"15","author":"Foster","year":"2001","journal-title":"J. Strength Cond. Res."},{"key":"ref_32","first-page":"90","article-title":"The influence of training background on different rate of force calculations during countermovement jump","volume":"50","author":"Boullosa","year":"2018","journal-title":"Kinesiology"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"3187","DOI":"10.1519\/JSC.0000000000002149","article-title":"A brief review of handgrip strength and sport performance","volume":"31","author":"Cronin","year":"2017","journal-title":"J. Strength Cond. Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3758\/BF03334122","article-title":"The lateral preference inventory for measurement of handedness, footedness, eyedness, and earedness: Norms for young adults","volume":"31","author":"Coren","year":"1993","journal-title":"Bull. Psychon. Soc."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"320","DOI":"10.3109\/10582452.2013.848967","article-title":"Visual analog scale and pressure pain threshold for delayed onset muscle soreness assessment","volume":"21","author":"Lau","year":"2013","journal-title":"J. Musculoskelet. Pain"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1007\/s00421-019-04125-6","article-title":"Combined effects of very short \u201call out\u201d efforts during sprint and resistance training on physical and physiological adaptations after 2 weeks of training","volume":"119","author":"Medeiros","year":"2019","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1123\/jab.2013-0246","article-title":"Joint-Specific Power-Pedaling Rate Relationships During Maximal Cycling","volume":"30","author":"McDaniel","year":"2014","journal-title":"J. Appl. Biomech."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1055\/a-0989-2387","article-title":"Isovelocity vs. Isoinertial Sprint Cycling Tests for Power- and Torque-cadence Relationships","volume":"40","author":"Kordi","year":"2019","journal-title":"Int. J. Sports Med."},{"key":"ref_39","first-page":"16","article-title":"Evaluation of the Cyclus ergometer and the Stages power meter against the SRM crankset for measurement of power output in cycling","volume":"5","author":"Rodger","year":"2016","journal-title":"J. Sci. Cycl."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1123\/ijspp.2020-0599","article-title":"25 Years of Session Rating of Perceived Exertion: Historical Perspective and Development","volume":"16","author":"Foster","year":"2021","journal-title":"Int. J. Sports Physiol. Perform."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/sms.12241","article-title":"Rate of force development as a measure of muscle damage","volume":"25","author":"Blazevich","year":"2015","journal-title":"Scand. J. Med. Sci. Sports"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1080\/17461391.2018.1438519","article-title":"Post-activation potentiation (PAP) in endurance sports: A review","volume":"18","author":"Boullosa","year":"2018","journal-title":"Eur. J. Sport Sci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1123\/ijspp.6.1.82","article-title":"Concurrent fatigue and potentiation in endurance athletes","volume":"6","author":"Boullosa","year":"2011","journal-title":"Int. J. Sports Physiol. Perform."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1249\/JES.0000000000000095","article-title":"Mechanisms and Mediators of the Skeletal Muscle Repeated Bout Effect","volume":"45","author":"Hyldahl","year":"2017","journal-title":"Exerc. Sport Sci. Rev."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1007\/s00421-019-04213-7","article-title":"Changes in oxidative stress, inflammation and muscle damage markers following eccentric versus concentric cycling in older adults","volume":"119","author":"Mackay","year":"2019","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"333","DOI":"10.33594\/000000223","article-title":"Matrix metalloproteinase 13 from satellite cells is required for efficient muscle growth and regeneration","volume":"54","author":"Smith","year":"2020","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1139\/h05-028","article-title":"Comparison between old and young men for changes in makers of muscle damage following voluntary eccentric exercise of the elbow flexors","volume":"31","author":"Lavender","year":"2006","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s00421-006-0224-7","article-title":"Responses of old men to repeated bouts of eccentric exercise of the elbow flexors in comparison with young men","volume":"97","author":"Lavender","year":"2006","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/BF00839156","article-title":"The effects of eccentric exercise on motor performance in young and older women","volume":"60","author":"Dedrick","year":"1990","journal-title":"Eur. J. Appl. Physiol. Occup. Physiol."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/18\/15\/7968\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:36:02Z","timestamp":1760164562000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/18\/15\/7968"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,28]]},"references-count":49,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2021,8]]}},"alternative-id":["ijerph18157968"],"URL":"https:\/\/doi.org\/10.3390\/ijerph18157968","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,28]]}}}