{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T22:10:57Z","timestamp":1784153457834,"version":"3.55.0"},"reference-count":120,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T00:00:00Z","timestamp":1628121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["268555672 \u2013 SFB 1213, Project A06, A07, B04, B08, B09"],"award-info":[{"award-number":["268555672 \u2013 SFB 1213, Project A06, A07, B04, B08, B09"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Right ventricular (RV) function is the main determinant of the outcome of patients with pulmonary hypertension (PH). RV dysfunction develops gradually and worsens progressively over the course of PH, resulting in RV failure and premature death. Currently, approved therapies for the treatment of left ventricular failure are not established for the RV. Furthermore, the direct effects of specific vasoactive drugs for treatment of pulmonary arterial hypertension (PAH, Group 1 of PH) on RV are not fully investigated. Pulmonary artery banding (PAB) allows to study the pathogenesis of RV failure solely, thereby testing potential therapies independently of pulmonary vascular changes. This review aims to discuss recent studies of the mechanisms of RV remodeling and RV-directed therapies based on the PAB model.<\/jats:p>","DOI":"10.3390\/ijerph18168297","type":"journal-article","created":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T09:35:32Z","timestamp":1628156132000},"page":"8297","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Novel Therapeutic Targets for the Treatment of Right Ventricular Remodeling: Insights from the Pulmonary Artery Banding Model"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2140-4819","authenticated-orcid":false,"given":"Argen","family":"Mamazhakypov","sequence":"first","affiliation":[{"name":"Excellence Cluster Cardio-Pulmonary Institute (CPI), Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University, 35392 Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natascha","family":"Sommer","sequence":"additional","affiliation":[{"name":"Excellence Cluster Cardio-Pulmonary Institute (CPI), Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University, 35392 Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Assmus","sequence":"additional","affiliation":[{"name":"Excellence Cluster Cardio-Pulmonary Institute (CPI), Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University, 35392 Giessen, Germany"},{"name":"Department of Cardiology, Justus-Liebig University, 35390 Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khodr","family":"Tello","sequence":"additional","affiliation":[{"name":"Excellence Cluster Cardio-Pulmonary Institute (CPI), Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University, 35392 Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph Theo","family":"Schermuly","sequence":"additional","affiliation":[{"name":"Excellence Cluster Cardio-Pulmonary Institute (CPI), Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University, 35392 Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Djuro","family":"Kosanovic","sequence":"additional","affiliation":[{"name":"Excellence Cluster Cardio-Pulmonary Institute (CPI), Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University, 35392 Giessen, Germany"},{"name":"Department of Pulmonology, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119992 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akpay Sh.","family":"Sarybaev","sequence":"additional","affiliation":[{"name":"Department of Mountain and Sleep Medicine and Pulmonary Hypertension, National Center of Cardiology and Internal Medicine, Bishkek 720040, Kyrgyzstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2675-3871","authenticated-orcid":false,"given":"Norbert","family":"Weissmann","sequence":"additional","affiliation":[{"name":"Excellence Cluster Cardio-Pulmonary Institute (CPI), Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University, 35392 Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleg","family":"Pak","sequence":"additional","affiliation":[{"name":"Excellence Cluster Cardio-Pulmonary Institute (CPI), Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University, 35392 Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"D22","DOI":"10.1016\/j.jacc.2013.10.027","article-title":"Right heart adaptation to pulmonary arterial hypertension: Physiology and pathobiology","volume":"62","author":"Haddad","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/bph.15016","article-title":"Current and future treatments of pulmonary arterial hypertension","volume":"178","author":"Sommer","year":"2021","journal-title":"Br. J. Pharm."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1801913","DOI":"10.1183\/13993003.01913-2018","article-title":"Haemodynamic definitions and updated clinical classification of pulmonary hypertension","volume":"53","author":"Simonneau","year":"2019","journal-title":"Eur. Respir. J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"101S","DOI":"10.1378\/chest.114.1_Supplement.101S","article-title":"The pressure-overloaded right ventricle in pulmonary hypertension","volume":"114","author":"Bristow","year":"1998","journal-title":"Chest"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1161\/CIRCULATIONAHA.106.632208","article-title":"Right ventricular function and failure: Report of a National Heart, Lung, and Blood Institute working group on cellular and molecular mechanisms of right heart failure","volume":"114","author":"Voelkel","year":"2006","journal-title":"Circulation"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/0735-1097(93)90433-2","article-title":"Echocardiographic characterization of the improvement in right ventricular function in patients with severe pulmonary hypertension after single-lung transplantation","volume":"22","author":"Ritchie","year":"1993","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/j.hlc.2018.04.299","article-title":"Left Ventricular Assist Devices in Pulmonary Hypertension Group 2 With Significantly Elevated Pulmonary Vascular Resistance: A Bridge to Cure","volume":"28","author":"Selim","year":"2019","journal-title":"Heart Lung Circ."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1016\/S0003-4975(03)00828-2","article-title":"Pulmonary endarterectomy: Experience and lessons learned in 1500 cases","volume":"76","author":"Jamieson","year":"2003","journal-title":"Ann. Thorac. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/j.jcmg.2014.07.012","article-title":"Prognostic value of RV function before and after lung transplantation","volume":"7","author":"Kusunose","year":"2014","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e010999","DOI":"10.1136\/heartasia-2018-010999","article-title":"Renin\u2013angiotensin\u2013aldosterone inhibition improves right ventricular function: A meta-analysis","volume":"10","author":"Cao","year":"2018","journal-title":"Heart Asia"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1086\/675984","article-title":"The role of the renin-angiotensin-aldosterone system in the pathobiology of pulmonary arterial hypertension (2013 Grover Conference series)","volume":"4","author":"Maron","year":"2014","journal-title":"Pulm. Circ."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e003703","DOI":"10.1161\/CIRCHEARTFAILURE.116.003703","article-title":"Use of beta-Blockers in Pulmonary Hypertension","volume":"10","author":"Perros","year":"2017","journal-title":"Circ. Heart Fail."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1093\/eurheartj\/ehp022","article-title":"A meta-analysis of randomized controlled trials in pulmonary arterial hypertension","volume":"30","author":"Galie","year":"2009","journal-title":"Eur. Heart J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1183\/09059180.00007109","article-title":"Perspectives on novel therapeutic strategies for right heart failure in pulmonary arterial hypertension: Lessons from the left heart","volume":"19","author":"Handoko","year":"2010","journal-title":"Eur. Respir. Rev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1056\/NEJMoa1413687","article-title":"Initial use of ambrisentan plus tadalafil in pulmonary arterial hypertension","volume":"373","author":"Frost","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1183\/09031936.00116313","article-title":"Upfront triple combination therapy in pulmonary arterial hypertension: A pilot study","volume":"43","author":"Sitbon","year":"2014","journal-title":"Eur. Respir. J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.chest.2019.09.009","article-title":"Risk reduction and right heart reverse remodeling by upfront triple combination therapy in pulmonary arterial hypertension","volume":"157","author":"Badagliacca","year":"2020","journal-title":"Chest"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.chest.2019.10.022","article-title":"Restoring the Right Ventricle","volume":"157","author":"Noordegraaf","year":"2020","journal-title":"Chest"},{"key":"ref_19","first-page":"e58050","article-title":"A Pulmonary Trunk Banding Model of Pressure Overload Induced Right Ventricular Hypertrophy and Failure","volume":"141","author":"Andersen","year":"2018","journal-title":"J. Vis. Exp. JoVE"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Axelsen, J.B., Andersen, S., Sun, X.-Q., Ringgaard, S., Hyldebrandt, J.A., Kurakula, K., Goumans, M.-J., de Man, F.S., Nielsen-Kudsk, J.E., and Bogaard, H.-J. (2019). Effects of 6-mercaptopurine in pressure overload induced right heart failure. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0225122"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1161\/CIRCRESAHA.111.300448","article-title":"Endothelin axis is upregulated in human and rat right ventricular hypertrophy","volume":"112","author":"Nagendran","year":"2013","journal-title":"Circ. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1161\/CIRCULATIONAHA.109.883843","article-title":"Chronic pulmonary artery pressure elevation is insufficient to explain right heart failure","volume":"120","author":"Bogaard","year":"2009","journal-title":"Circulation"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1152\/japplphysiol.00148.2020","article-title":"Pulmonary artery banding is a relevant model to study the right ventricular remodeling and dysfunction that occurs in pulmonary arterial hypertension","volume":"129","author":"Akazawa","year":"2020","journal-title":"J. Appl. Physiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.matbio.2018.01.010","article-title":"Right ventricular fibrosis and dysfunction: Actual concepts and common misconceptions","volume":"68","author":"Egemnazarov","year":"2018","journal-title":"Matrix Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"609","DOI":"10.3389\/fphys.2018.00609","article-title":"Inflammatory Mediators Drive Adverse Right Ventricular Remodeling and Dysfunction and Serve as Potential Biomarkers","volume":"9","author":"Sydykov","year":"2018","journal-title":"Front. Physiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"L443","DOI":"10.1152\/ajplung.00374.2017","article-title":"Emerging role of angiogenesis in adaptive and maladaptive right ventricular remodeling in pulmonary hypertension","volume":"314","author":"Frump","year":"2018","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3389\/fcvm.2018.00179","article-title":"The Role of G Protein-Coupled Receptors in the Right Ventricle in Pulmonary Hypertension","volume":"5","author":"Viswanathan","year":"2018","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1161\/CIRCULATIONAHA.114.006979","article-title":"Emerging concepts in the molecular basis of pulmonary arterial hypertension: Part I: Metabolic plasticity and mitochondrial dynamics in the pulmonary circulation and right ventricle in pulmonary arterial hypertension","volume":"131","author":"Ryan","year":"2015","journal-title":"Circulation"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1007\/s00109-010-0679-1","article-title":"Mitochondrial metabolic adaptation in right ventricular hypertrophy and failure","volume":"88","author":"Piao","year":"2010","journal-title":"J. Mol. Med."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Shults, N.V., Melnyk, O., Suzuki, D.I., and Suzuki, Y.J. (2018). Redox Biology of Right-Sided Heart Failure. Antioxidants, 7.","DOI":"10.3390\/antiox7080106"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Turner, N.A., and Blythe, N.M. (2019). Cardiac Fibroblast p38 MAPK: A Critical Regulator of Myocardial Remodeling. J. Cardiovasc. Dev. Dis., 6.","DOI":"10.3390\/jcdd6030027"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3389\/fimmu.2019.00085","article-title":"Cell Type-Specific Roles of NF-kappaB Linking Inflammation and Thrombosis","volume":"10","author":"Mussbacher","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1701024","DOI":"10.1183\/13993003.01024-2017","article-title":"Impact of the mitochondria-targeted antioxidant MitoQ on hypoxia-induced pulmonary hypertension","volume":"51","author":"Pak","year":"2018","journal-title":"Eur. Respir. J."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1146\/annurev-physiol-031620-123956","article-title":"Metabolism in Pulmonary Hypertension","volume":"83","author":"Xu","year":"2021","journal-title":"Annu. Rev. Physiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/bph.14932","article-title":"Targeting histone acetylation in pulmonary hypertension and right ventricular hypertrophy","volume":"178","author":"Chelladurai","year":"2021","journal-title":"Br. J. Pharmacol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1161\/CIRCULATIONAHA.118.035326","article-title":"Right ventricular fibrosis: A pathophysiological factor in pulmonary hypertension?","volume":"139","author":"Andersen","year":"2019","journal-title":"Circulation"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1093\/cvr\/cvaa324","article-title":"Cardiac fibrosis","volume":"117","author":"Frangogiannis","year":"2021","journal-title":"Cardiovasc. Res."},{"key":"ref_38","first-page":"173","article-title":"Role of mitogen-activated protein kinase in cardiac hypertrophy and heart failure","volume":"8","author":"Zhang","year":"2003","journal-title":"Exp. Clin. Cardiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.tcm.2003.11.002","article-title":"Stress-activated MAP kinases in cardiac remodeling and heart failure: New insights from transgenic studies","volume":"14","author":"Petrich","year":"2004","journal-title":"Trends Cardiovasc. Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1164\/rccm.201703-0502OC","article-title":"ASK1 inhibition halts disease progression in preclinical models of pulmonary arterial hypertension","volume":"197","author":"Budas","year":"2018","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1165\/rcmb.2016-0374OC","article-title":"p38 MAPK inhibition improves heart function in pressure-loaded right ventricular hypertrophy","volume":"57","author":"Kojonazarov","year":"2017","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_42","first-page":"OA1983","article-title":"The ARROW study: A phase 2, prospective, randomized, double-blind, placebo-controlled study of selonsertib in subjects with pulmonary arterial hypertension","volume":"50","author":"Rosenkranz","year":"2017","journal-title":"Eur. Respir. J."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"101","DOI":"10.7150\/ijms.1.101","article-title":"Tyrosine kinase\u2014Role and significance in Cancer","volume":"1","author":"Paul","year":"2004","journal-title":"Int. J. Med. Sci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/bph.14919","article-title":"Kinases as potential targets for treatment of pulmonary hypertension and right ventricular dysfunction","volume":"178","author":"Weiss","year":"2021","journal-title":"Br. J. Pharmacol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1161\/CIRCULATIONAHA.108.776831","article-title":"Mechanisms of cardiac dysfunction associated with tyrosine kinase inhibitor cancer therapeutics","volume":"118","author":"Chen","year":"2008","journal-title":"Circulation"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2630","DOI":"10.1016\/j.ijcard.2012.06.129","article-title":"Effects of multikinase inhibitors on pressure overload-induced right ventricular remodeling","volume":"167","author":"Kojonazarov","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"H604","DOI":"10.1152\/ajpheart.00656.2015","article-title":"Tyrosine kinase inhibitor BIBF1000 does not hamper right ventricular pressure adaptation in rats","volume":"311","author":"Herrmann","year":"2016","journal-title":"Am. J. Physiol. Circ. Physiol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1093\/cvr\/cvw065","article-title":"miR-223\u2013IGF-IR signalling in hypoxia-and load-induced right-ventricular failure: A novel therapeutic approach","volume":"111","author":"Shi","year":"2016","journal-title":"Cardiovasc. Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"H512","DOI":"10.1152\/ajpheart.00137.2015","article-title":"Pirfenidone exhibits cardioprotective effects by regulating myocardial fibrosis and vascular permeability in pressure-overloaded hearts","volume":"309","author":"Yamagami","year":"2015","journal-title":"Am. J. Physiol. Circ. Physiol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1164\/rccm.201809-1737OC","article-title":"Disconnect between fibrotic response and right ventricular dysfunction","volume":"199","author":"Crnkovic","year":"2019","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2045894019848659","DOI":"10.1177\/2045894019848659","article-title":"Pressure overload induced right ventricular remodeling is not attenuated by the anti-fibrotic agent pirfenidone","volume":"9","author":"Andersen","year":"2019","journal-title":"Pulm. Circ."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1165\/rcmb.2016-0364OC","article-title":"Pharmacological Inhibition of mTOR Kinase Reverses Right Ventricle Remodeling and Improves Right Ventricle Structure and Function in Rats","volume":"57","author":"Pena","year":"2017","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"L369","DOI":"10.1152\/ajplung.00015.2019","article-title":"Interdependence of hypoxia and beta-adrenergic receptor signaling in pulmonary arterial hypertension","volume":"317","author":"Stephens","year":"2019","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1093\/cvr\/cvn301","article-title":"Energy metabolism in heart failure and remodelling","volume":"81","author":"Ingwall","year":"2009","journal-title":"Cardiovasc. Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1111\/bph.12475","article-title":"Mitochondrial fatty acid oxidation alterations in heart failure, ischaemic heart disease and diabetic cardiomyopathy","volume":"171","author":"Fillmore","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1161\/CIRCRESAHA.120.316443","article-title":"Epigenetic metabolic reprogramming of right ventricular fibroblasts in pulmonary arterial hypertension: A pyruvate dehydrogenase kinase-dependent shift in mitochondrial metabolism promotes right ventricular fibrosis","volume":"126","author":"Tian","year":"2020","journal-title":"Circ. Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"11635","DOI":"10.1038\/ncomms11635","article-title":"HIF-1\u03b1-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity","volume":"7","author":"Semba","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1513\/AnnalsATS.201206-029OC","article-title":"Fasting 2-deoxy-2-[18F] fluoro-D-glucose positron emission tomography to detect metabolic changes in pulmonary arterial hypertension hearts over 1 year","volume":"10","author":"Lundgrin","year":"2013","journal-title":"Ann. Am. Thorac. Soc."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s00109-011-0804-9","article-title":"Therapeutic inhibition of fatty acid oxidation in right ventricular hypertrophy: Exploiting Randle\u2019s cycle","volume":"90","author":"Fang","year":"2012","journal-title":"J. Mol. Med."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s00109-009-0524-6","article-title":"The inhibition of pyruvate dehydrogenase kinase improves impaired cardiac function and electrical remodeling in two models of right ventricular hypertrophy: Resuscitating the hibernating right ventricle","volume":"88","author":"Piao","year":"2010","journal-title":"J. Mol. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"236","DOI":"10.4103\/2231-4040.90879","article-title":"The peroxisome proliferator-activated receptor: A family of nuclear receptors role in various diseases","volume":"2","author":"Tyagi","year":"2011","journal-title":"J. Adv. Pharm. Technol. Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1161\/01.RES.0000060700.55247.7C","article-title":"Peroxisome proliferator-activated receptor (PPAR) \u03b1 and PPAR\u03b2\/\u03b4, but not PPAR\u03b3, modulate the expression of genes involved in cardiac lipid metabolism","volume":"92","author":"Gilde","year":"2003","journal-title":"Circ. Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1038\/nm1116","article-title":"Cardiomyocyte-restricted peroxisome proliferator-activated receptor-\u03b4 deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy","volume":"10","author":"Cheng","year":"2004","journal-title":"Nat. Med."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1161\/HYPERTENSIONAHA.110.164590","article-title":"Peroxisome proliferator-activated receptor \u03b2\/\u03b4 activation in adult hearts facilitates mitochondrial function and cardiac performance under pressure-overload condition","volume":"57","author":"Liu","year":"2011","journal-title":"Hypertension"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Harrington, L.S., Moreno, L., Reed, A., Wort, S.J., Desvergne, B., Garland, C., Zhao, L., and Mitchell, J.A. (2010). The PPAR\u03b2\/\u03b4agonist GW0742 relaxes pulmonary vessels and limits right heart hypertrophy in rats with hypoxia-induced pulmonary hypertension. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0009526"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1086\/674755","article-title":"The peroxisome proliferator\u2013activated receptor \u03b2\/\u03b4 agonist GW0742 has direct protective effects on right heart hypertrophy","volume":"3","author":"Kojonazarov","year":"2013","journal-title":"Pulm. Circ."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"e33","DOI":"10.1161\/01.RES.0000086964.07404.A5","article-title":"Beneficial effects of trimetazidine in ex vivo working ischemic hearts are due to a stimulation of glucose oxidation secondary to inhibition of long-chain 3-ketoacyl coenzyme a thiolase","volume":"93","author":"Lopaschuk","year":"2003","journal-title":"Circ. Res."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1161\/01.RES.86.5.580","article-title":"The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase","volume":"86","author":"Kantor","year":"2000","journal-title":"Circ. Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1161\/CIRCULATIONAHA.108.778019","article-title":"Trimetazidine, a metabolic modulator, has cardiac and extracardiac benefits in idiopathic dilated cardiomyopathy","volume":"118","author":"Tuunanen","year":"2008","journal-title":"Circulation"},{"key":"ref_70","first-page":"CD003614","article-title":"Trimetazidine for stable angina","volume":"4","author":"Ciapponi","year":"2005","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1097\/00019501-200304000-00010","article-title":"Efficacy and tolerability of trimetazidine in stable angina: A meta-analysis of randomized, double-blind, controlled trials","volume":"14","author":"Marzilli","year":"2003","journal-title":"Coron. Artery Dis."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1124\/jpet.106.115519","article-title":"A comparison between ranolazine and CVT-4325, a novel inhibitor of fatty acid oxidation, on cardiac metabolism and left ventricular function in rat isolated perfused heart during ischemia and reperfusion","volume":"321","author":"Wang","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"e26","DOI":"10.1161\/01.RES.0000086943.72932.71","article-title":"The antianginal agent trimetazidine does not exert its functional benefit via inhibition of mitochondrial long-chain 3-ketoacyl coenzyme A thiolase","volume":"93","author":"MacInnes","year":"2003","journal-title":"Circ. Res."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S0140-6736(20)31824-9","article-title":"SGLT2 inhibitors in patients with heart failure with reduced ejection fraction: A meta-analysis of the EMPEROR-Reduced and DAPA-HF trials","volume":"396","author":"Zannad","year":"2020","journal-title":"Lancet"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Szekeres, Z., Toth, K., and Szabados, E. (2021). The Effects of SGLT2 Inhibitors on Lipid Metabolism. Metabolites, 11.","DOI":"10.3390\/metabo11020087"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.bbrc.2020.01.015","article-title":"The SGLT2 inhibitor empagliflozin reduces mortality and prevents progression in experimental pulmonary hypertension","volume":"524","author":"Chowdhury","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s10741-016-9526-y","article-title":"The right ventricle and pulmonary hypertension","volume":"21","author":"Bogaard","year":"2016","journal-title":"Heart Fail. Rev."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"eaao4583","DOI":"10.1126\/scitranslmed.aao4583","article-title":"Inhibition of pyruvate dehydrogenase kinase improves pulmonary arterial hypertension in genetically susceptible patients","volume":"9","author":"Michelakis","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"3898","DOI":"10.1111\/bph.13818","article-title":"Targeting inflammation to reduce cardiovascular disease risk: A realistic clinical prospect?","volume":"174","author":"Welsh","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41569-019-0315-x","article-title":"Reappraising the role of inflammation in heart failure","volume":"17","author":"Adamo","year":"2020","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1161\/CIRCULATIONAHA.114.008788","article-title":"Immune cell and other noncardiomyocyte regulation of cardiac hypertrophy and remodeling","volume":"131","author":"Frieler","year":"2015","journal-title":"Circulation"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/bph.14826","article-title":"The role of chemokines and chemokine receptors in pulmonary arterial hypertension","volume":"178","author":"Mamazhakypov","year":"2021","journal-title":"Br. J. Pharmacol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"e13146","DOI":"10.14814\/phy2.13146","article-title":"Pressure overload leads to an increased accumulation and activity of mast cells in the right ventricle","volume":"5","author":"Luitel","year":"2017","journal-title":"Physiol. Rep."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Sydykov, A., Luitel, H., Mamazhakypov, A., Wygrecka, M., Pradhan, K., Pak, O., Petrovic, A., Kojonazarov, B., Weissmann, N., and Seeger, W. (2020). Genetic Deficiency and Pharmacological Stabilization of Mast Cells Ameliorate Pressure Overload-Induced Maladaptive Right Ventricular Remodeling in Mice. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21239099"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1093\/cvr\/cvy209","article-title":"Inhibition of TLR9-NF-\u03baB-mediated sterile inflammation improves pressure overload-induced right ventricular dysfunction in rats","volume":"115","author":"Yoshida","year":"2019","journal-title":"Cardiovasc. Res."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"H1696","DOI":"10.1152\/ajpheart.00545.2010","article-title":"Rapamycin treatment augments both protein ubiquitination and Akt activation in pressure-overloaded rat myocardium","volume":"300","author":"Harston","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1089\/ars.2012.5149","article-title":"Reactive oxygen species in inflammation and tissue injury","volume":"20","author":"Mittal","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1161\/CIRCRESAHA.117.311349","article-title":"Mitochondrial cardiomyopathy caused by elevated reactive oxygen species and impaired cardiomyocyte proliferation","volume":"122","author":"Zhang","year":"2018","journal-title":"Circ. Res."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.cardiores.2007.05.012","article-title":"Right-ventricular failure is associated with increased mitochondrial complex II activity and production of reactive oxygen species","volume":"75","author":"Redout","year":"2007","journal-title":"Cardiovasc. Res."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.jash.2017.03.008","article-title":"Galectin-3 mediates the pulmonary arterial hypertension\u2013induced right ventricular remodeling through interacting with NADPH oxidase 4","volume":"11","author":"He","year":"2017","journal-title":"J. Am. Soc. Hypertens."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.3389\/fphys.2018.01799","article-title":"Review on chamber-specific differences in right and left heart reactive oxygen species handling","volume":"9","author":"Kutsche","year":"2018","journal-title":"Front. Physiol."},{"key":"ref_92","unstructured":"Lei, H., Hu, J., Sun, K., and Xu, D. (2020). The role and molecular mechanism of epigenetics in cardiac hypertrophy. Heart Fail. Rev., 1\u201310. Online ahead of print."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1161\/CIRCRESAHA.116.303630","article-title":"Readers, writers, and erasers: Chromatin as the whiteboard of heart disease","volume":"116","author":"Gillette","year":"2015","journal-title":"Circ. Res."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1016\/j.bbamcr.2016.03.005","article-title":"Epigenetic and lncRNA regulation of cardiac pathophysiology","volume":"1863","author":"Chang","year":"2016","journal-title":"Biochim. Biophys. Acta (BBA) Mol. Cell Res."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"11638","DOI":"10.1111\/jcmm.15819","article-title":"LncRNAs in cardiac hypertrophy: From basic science to clinical application","volume":"24","author":"Liu","year":"2020","journal-title":"Cell. Mol. Med."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1161\/CIRCULATIONAHA.120.047626","article-title":"Identification of Long Noncoding RNA H19 as a New Biomarker and Therapeutic Target in Right Ventricular Failure in Pulmonary Arterial Hypertension","volume":"142","author":"Omura","year":"2020","journal-title":"Circulation"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1161\/01.RES.0000197782.21444.8f","article-title":"Control of cardiac growth by histone acetylation\/deacetylation","volume":"98","author":"Backs","year":"2006","journal-title":"Circ. Res."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1161\/CIRCULATIONAHA.106.625467","article-title":"Suppression of class I and II histone deacetylases blunts pressure-overload cardiac hypertrophy","volume":"113","author":"Kong","year":"2006","journal-title":"Circulation"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/nm1552","article-title":"Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3\u03b2 activity","volume":"13","author":"Trivedi","year":"2007","journal-title":"Nat. Med."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1164\/rccm.201007-1106OC","article-title":"Suppression of histone deacetylases worsens right ventricular dysfunction after pulmonary artery banding in rats","volume":"183","author":"Bogaard","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1253\/circj.CJ-09-0580","article-title":"Sodium valproate, a histone deacetylase inhibitor, but not captopril, prevents right ventricular hypertrophy in rats","volume":"74","author":"Cho","year":"2010","journal-title":"Circ. J."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1161\/CIRCRESAHA.120.315929","article-title":"BET epigenetic reader proteins in cardiovascular transcriptional programs","volume":"126","author":"Borck","year":"2020","journal-title":"Circ. Res."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"13141","DOI":"10.1074\/jbc.R700001200","article-title":"The double bromodomain-containing chromatin adaptor Brd4 and transcriptional regulation","volume":"282","author":"Wu","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.yjmcc.2013.07.017","article-title":"BET acetyl-lysine binding proteins control pathological cardiac hypertrophy","volume":"63","author":"Spiltoir","year":"2013","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1161\/ATVBAHA.117.309156","article-title":"Implication of inflammation and epigenetic readers in coronary artery remodeling in patients with pulmonary arterial hypertension","volume":"37","author":"Meloche","year":"2017","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1164\/rccm.201812-2275OC","article-title":"Multicenter preclinical validation of BET inhibition for the treatment of pulmonary arterial hypertension","volume":"200","author":"Kurakula","year":"2019","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1161\/CIRCRESAHA.117.312486","article-title":"Preclinical studies of stem cell therapy for heart disease","volume":"122","author":"Tompkins","year":"2018","journal-title":"Circ. Res."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1161\/CIRCRESAHA.113.300219","article-title":"Cell therapy for heart failure: A comprehensive overview of experimental and clinical studies, current challenges, and future directions","volume":"113","author":"Sanganalmath","year":"2013","journal-title":"Circ. Res."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/s41586-019-1802-2","article-title":"An acute immune response underlies the benefit of cardiac stem cell therapy","volume":"577","author":"Vagnozzi","year":"2020","journal-title":"Nature"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature13309","article-title":"c-kit+ cells minimally contribute cardiomyocytes to the heart","volume":"509","author":"Kanisicak","year":"2014","journal-title":"Nature"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/CRD.0000000000000173","article-title":"Cardiosphere-derived cells and ischemic heart failure","volume":"26","author":"Ashur","year":"2018","journal-title":"Cardiol. Rev."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/emmm.201201737","article-title":"Cardiomyocyte proliferation and progenitor cell recruitment underlie therapeutic regeneration after myocardial infarction in the adult mouse heart","volume":"5","author":"Malliaras","year":"2013","journal-title":"EMBO Mol. Med."},{"key":"ref_113","first-page":"201","article-title":"Exosomes secreted by cardiosphere-derived cells reduce scarring, attenuate adverse remodelling, and improve function in acute and chronic porcine myocardial infarction","volume":"38","author":"Gallet","year":"2017","journal-title":"Eur. Heart J."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1161\/CIRCRESAHA.118.311217","article-title":"Clinical studies of cell therapy in cardiovascular medicine: Recent developments and future directions","volume":"123","author":"Banerjee","year":"2018","journal-title":"Circ. Res."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1186\/s13287-020-02022-w","article-title":"The role of regenerative therapy in the treatment of right ventricular failure: A literature review","volume":"11","author":"Haller","year":"2020","journal-title":"Stem Cell Res. Ther."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"H1816","DOI":"10.1152\/ajpheart.00955.2015","article-title":"Mesenchymal stem cells preserve neonatal right ventricular function in a porcine model of pressure overload","volume":"310","author":"Wehman","year":"2016","journal-title":"Am. J. Physiol. Circ. Physiol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-015-0044-y","article-title":"Human umbilical cord blood-derived mononuclear cells improve murine ventricular function upon intramyocardial delivery in right ventricular chronic pressure overload","volume":"6","author":"Oommen","year":"2015","journal-title":"Stem Cell Res. Ther."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.athoracsur.2009.10.035","article-title":"Human cord blood stem cells enhance neonatal right ventricular function in an ovine model of right ventricular training","volume":"89","author":"Davies","year":"2010","journal-title":"Ann. Thorac. Surg."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1016\/j.athoracsur.2017.04.058","article-title":"Cardiac progenitor cells enhance neonatal right ventricular function after pulmonary artery banding","volume":"104","author":"Wehman","year":"2017","journal-title":"Ann. Thorac. Surg."},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Bittle, G.J., Morales, D., Pietris, N., Parchment, N., Parsell, D., Peck, K., Deatrick, K.B., Rodriguez-Borlado, L., Smith, R.R., and Marb\u00e1n, L. (2020). Exosomes isolated from human cardiosphere\u2013derived cells attenuate pressure overload\u2013induced right ventricular dysfunction. J. Thorac. Cardiovasc. Surg., Online ahead of print.","DOI":"10.1016\/j.jtcvs.2020.06.154"}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/18\/16\/8297\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:41:03Z","timestamp":1760164863000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/18\/16\/8297"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,5]]},"references-count":120,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2021,8]]}},"alternative-id":["ijerph18168297"],"URL":"https:\/\/doi.org\/10.3390\/ijerph18168297","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,5]]}}}