{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T05:54:27Z","timestamp":1793858067870,"version":"4.6.1"},"reference-count":33,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T00:00:00Z","timestamp":1628208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008368","name":"Gigtforeningen","doi-asserted-by":"publisher","award":["R151-A4644"],"award-info":[{"award-number":["R151-A4644"]}],"id":[{"id":"10.13039\/100008368","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008218","name":"Gangstedfonden","doi-asserted-by":"publisher","award":["A31661"],"award-info":[{"award-number":["A31661"]}],"id":[{"id":"10.13039\/501100008218","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007403","name":"Dagmar Marshalls Fond","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/100007403","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008267","name":"Kong Christian den Tiendes Fond","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/501100008267","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001275","name":"Oak Foundation","doi-asserted-by":"publisher","award":["OCAY-13-309"],"award-info":[{"award-number":["OCAY-13-309"]}],"id":[{"id":"10.13039\/100001275","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>This study reports age- and sex-specific incidence rates of juvenile idiopathic arthritis (JIA) in complete Danish birth cohorts from 1992 through 2002. Data were obtained from the Danish registries. All persons born in Denmark, from 1992\u20132002, were followed from birth and until either the date of first diagnosis recording, death, emigration, 16th birthday or administrative censoring (17 May 2017), whichever came first. The number of incident JIA cases and its incidence rate (per 100,000 person-years) were calculated within sex and age group for each of the birth cohorts. A multiplicative Poisson regression model was used to analyze the variation in the incidence rates by age and year of birth for boys and girls separately. The overall incidence of JIA was 24.1 (23.6\u201324.5) per 100,000 person-years. The rate per 100,000 person-years was higher among girls (29.9 (29.2\u201330.7)) than among boys (18.5 (18.0\u201319.1)). There were no evident peaks for any age group at diagnosis for boys but for girls two small peaks appeared at ages 0\u20135 years and 12\u201315 years. This study showed that the incidence rates of JIA in Denmark were higher for girls than for boys and remained stable over the observed period for both sexes.<\/jats:p>","DOI":"10.3390\/ijerph18168331","type":"journal-article","created":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T08:01:42Z","timestamp":1628236902000},"page":"8331","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Age and Sex Specific Trends in Incidence of Juvenile Idiopathic Arthritis in Danish Birth Cohorts from 1992 to 2002: A Nationwide Register Linkage Study"],"prefix":"10.3390","volume":"18","author":[{"given":"Isabel","family":"Cardoso","sequence":"first","affiliation":[{"name":"The Parker Institute, Bispebjerg and Frederiksberg Hospital, 2000 Frederiksberg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peder","family":"Frederiksen","sequence":"additional","affiliation":[{"name":"The Parker Institute, Bispebjerg and Frederiksberg Hospital, 2000 Frederiksberg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ina Olmer","family":"Specht","sequence":"additional","affiliation":[{"name":"The Parker Institute, Bispebjerg and Frederiksberg Hospital, 2000 Frederiksberg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8256-8756","authenticated-orcid":false,"given":"Mina Nicole","family":"H\u00e4ndel","sequence":"additional","affiliation":[{"name":"The Parker Institute, Bispebjerg and Frederiksberg Hospital, 2000 Frederiksberg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3070-782X","authenticated-orcid":false,"given":"Fanney","family":"Thorsteinsdottir","sequence":"additional","affiliation":[{"name":"The Parker Institute, Bispebjerg and Frederiksberg Hospital, 2000 Frederiksberg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6809-4504","authenticated-orcid":false,"given":"Berit Lilienthal","family":"Heitmann","sequence":"additional","affiliation":[{"name":"The Parker Institute, Bispebjerg and Frederiksberg Hospital, 2000 Frederiksberg, Denmark"},{"name":"The Boden Institute of Obesity, Nutrition, Exercise & Eating Disorders, University of Sydney, Sydney, NSW 2006, Australia"},{"name":"The Department of Public Health, Section for General Medicine, University of Copenhagen, 1014 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars Erik","family":"Kristensen","sequence":"additional","affiliation":[{"name":"The Parker Institute, Bispebjerg and Frederiksberg Hospital, 2000 Frederiksberg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1016\/S0140-6736(11)60244-4","article-title":"Juvenile idiopathic arthritis","volume":"377","author":"Prakken","year":"2011","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jbspin.2013.09.003","article-title":"Prevalence and incidence of juvenile idiopathic arthritis: A systematic review","volume":"81","author":"Thierry","year":"2014","journal-title":"Jt. Bone Spine"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/s10067-012-2159-1","article-title":"What do we know about juvenile idiopathic arthritis and vitamin D? A systematic literature review and meta-analysis of current evidence","volume":"32","author":"Nisar","year":"2013","journal-title":"Clin. Rheumatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.pcl.2012.03.014","article-title":"Juvenile Idiopathic Arthritis","volume":"59","author":"Gowdie","year":"2012","journal-title":"Pediatr. Clin. N. Am."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1546-0096-10-37","article-title":"CLARITY\u2013ChiLdhood Arthritis Risk factor Identification sTudY","volume":"10","author":"Ellis","year":"2012","journal-title":"Pediatr. Rheumatol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"c6434","DOI":"10.1136\/bmj.c6434","article-title":"Diagnosis and management of juvenile idiopathic arthritis","volume":"341","author":"Prince","year":"2010","journal-title":"BMJ"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1136\/annrheumdis-2014-205265","article-title":"Early predictors of prognosis in juvenile idiopathic arthritis: A systematic literature review","volume":"74","author":"Wulffraat","year":"2015","journal-title":"Ann. Rheum. Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/S0140-6736(07)60363-8","article-title":"Juvenile idiopathic arthritis","volume":"369","author":"Ravelli","year":"2007","journal-title":"Lancet"},{"key":"ref_9","first-page":"2275","article-title":"Incidence of juvenile idiopathic arthritis in the Nordic countries. A population based study with special reference to the validity of the ILAR and EULAR criteria","volume":"30","author":"Berntson","year":"2003","journal-title":"J. Rheumatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1177\/1403494810387965","article-title":"The Danish Civil Registration System","volume":"39","author":"Pedersen","year":"2011","journal-title":"Scand. J. Public Health"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s10654-014-9930-3","article-title":"The Danish Civil Registration System as a tool in epidemiology","volume":"29","author":"Schmidt","year":"2014","journal-title":"Eur. J. Epidemiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1177\/1403494811401482","article-title":"The Danish National Patient Register","volume":"39","author":"Lynge","year":"2011","journal-title":"Scand. J. Public Health"},{"key":"ref_13","unstructured":"R Core Team (2018). R: A Language and Environment for Statistical Computing, R Foundation for Statistical Computing."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1136\/bmj.39335.541782.AD","article-title":"Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: Guidelines for reporting observational studies","volume":"335","author":"Altman","year":"2007","journal-title":"BMJ"},{"key":"ref_15","first-page":"342","article-title":"The incidence and types of juvenile rheumatoid arthritis in the County of North Jutland during the periods 1970\u201377 and 1978\u20131986","volume":"150","author":"Ostergard","year":"1988","journal-title":"Ugeskr L\u00e6ger."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1002\/art.1780261006","article-title":"The epidemiology of juvenile arthritis in Rochester, Minnesota 1960\u20131979","volume":"26","author":"Towner","year":"1983","journal-title":"Arthritis Rheum."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"472","DOI":"10.3109\/03009741003742722","article-title":"Incidence and prevalence of juvenile idiopathic arthritis in Catalonia (Spain)","volume":"39","author":"Modesto","year":"2010","journal-title":"Scand. J. Rheumatol."},{"key":"ref_18","first-page":"217","article-title":"Epidemiologic survey of juvenile chronic arthritis in France. Comparison of data obtained from two different regions","volume":"5","author":"Prieur","year":"1987","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_19","first-page":"2460","article-title":"Total incidence and distribution of inflammatory joint diseases in a defined population: Results from the Kuopio 2000 arthritis survey","volume":"30","author":"Savolainen","year":"2003","journal-title":"J. Rheumatol."},{"key":"ref_20","first-page":"99","article-title":"Epidemiology of juvenile chronic arthritis in northern Norway: A ten-year retrospective study","volume":"16","author":"Moe","year":"1998","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1093\/rheumatology\/40.8.928","article-title":"Changes in the incidence of juvenile rheumatoid arthritis in Finland","volume":"40","author":"Savolainen","year":"2001","journal-title":"Rheumatology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1136\/ard.46.4.277","article-title":"Incidence and prevalence of juvenile chronic arthritis: A population survey","volume":"46","author":"Gare","year":"1987","journal-title":"Ann. Rheum. Dis."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1542\/peds.90.6.950","article-title":"Epidemiology of juvenile chronic arthritis in southwestern Sweden: A 5-year prospective population study","volume":"90","author":"Fasth","year":"1992","journal-title":"Pediatrics"},{"key":"ref_24","first-page":"1377","article-title":"Epidemiology of juvenile idiopathic arthritis in Alsace, France","volume":"33","author":"Danner","year":"2006","journal-title":"J. Rheumatol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1136\/ard.60.10.940","article-title":"Incidence and prevalence of juvenile arthritis in an urban population of southern Germany: A prospective study","volume":"60","author":"Truckenbrodt","year":"2001","journal-title":"Ann. Rheum. Dis."},{"key":"ref_26","first-page":"1837","article-title":"Incidence and prevalence of juvenile chronic arthritis in East Berlin 1980-88","volume":"25","author":"Kiessling","year":"1998","journal-title":"J. Rheumatol."},{"key":"ref_27","first-page":"24","article-title":"Epidemiological study of juvenile idiopathic arthtitis in the last sixteen years in Asturias (Spain)","volume":"66","year":"2007","journal-title":"An. Pediatr."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/art.1780180309","article-title":"Pathogenic implications of age of onset in juvenile rheumatoid arthritis","volume":"18","author":"Sullivan","year":"1975","journal-title":"Arthritis Rheum."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1002\/art.1780390817","article-title":"Juvenile rheumatoid arthritis in rochester, minnesota 1960\u20131993. Is the epidemiology changing?","volume":"39","author":"Peterson","year":"1996","journal-title":"Arthritis Rheum."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/art.39323","article-title":"Juvenile Idiopathic Arthritis in Olmsted County, Minnesota, 1960\u20132013","volume":"68","author":"Krause","year":"2015","journal-title":"Arthritis Rheumatol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"449","DOI":"10.2147\/CLEP.S91125","article-title":"The Danish National Patient Registry: A review of content, data quality, and research potential","volume":"7","author":"Schmidt","year":"2015","journal-title":"Clin. Epidemiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S0049-0172(96)80009-6","article-title":"Epidemiology of chronic arthritis in childhood","volume":"26","author":"Oen","year":"1996","journal-title":"Semin. Arthritis Rheum."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/ar2669","article-title":"Epidemiological studies in incidence, prevalence, mortality, and comorbidity of the rheumatic diseases","volume":"11","author":"Gabriel","year":"2009","journal-title":"Arthritis Res. Ther."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/18\/16\/8331\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:41:43Z","timestamp":1760164903000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/18\/16\/8331"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,6]]},"references-count":33,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2021,8]]}},"alternative-id":["ijerph18168331"],"URL":"https:\/\/doi.org\/10.3390\/ijerph18168331","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,6]]}}}