{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T17:13:02Z","timestamp":1784826782305,"version":"3.55.0"},"reference-count":37,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2021,8,7]],"date-time":"2021-08-07T00:00:00Z","timestamp":1628294400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>We evaluated the short- and longer-term effects of exercise therapy in hip osteoarthritis patients (OA) at baseline, three, six, and 12 months in a randomized setting, followed by a non-randomized setting. The primary randomized intervention (E = exercise, P = placebo\u2013ultrasound, C = control) was followed by a voluntary three-month exercise therapy for P and C (renamed P-E, C-E). Participants randomized to E were not offered treatment again (E-C). Effect sizes (ES; 95% CI) were calculated for within-group effects across time for bodily pain (SF-36) and WOMAC pain, function, and stiffness. ANCOVAs of post-treatment scores were used for group comparison after the group-specific exercise intervention phase. Exercise adherence was assessed and related to post-treatment scores of clinical outcomes. Data of 115 participants of the RCT eligible for follow-up and completing exercise therapy were included into our analyses. Small to medium beneficial long-term effects of cumulative interventional effects, including exercise training, persisted in all groups. Group E-C (n = 49) showed significant 12 months vs. baseline within-group ES in all outcomes (ES 0.39\u20130.59) except stiffness. Findings were less prominent for exercise therapy in a non-randomized setting (C-E, P-E, both n = 33). Differences are partially explained by adherence rates, highlighting the relevance of therapy compliance strategies. Short-term between-group differences (ANCOVAs) only showed statistically significant differences for WOMAC function between P-E and E-C in favor of E-C (6.4 (95% CI 1.6\u201311.2; score range 0\u2013100)).<\/jats:p>","DOI":"10.3390\/ijerph18168366","type":"journal-article","created":{"date-parts":[[2021,8,8]],"date-time":"2021-08-08T21:49:41Z","timestamp":1628459381000},"page":"8366","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Secondary Analysis of a Study on Exercise Therapy in Hip Osteoarthritis: Follow-Up Data on Pain and Physical Functioning"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4373-5539","authenticated-orcid":false,"given":"Inka","family":"Roesel","sequence":"first","affiliation":[{"name":"Institute for Clinical Epidemiology and Applied Biometry, Medical Faculty, University Hospital Tuebingen, 72076 Tubingen, Germany"},{"name":"Department of Sports Medicine, Medical Clinic, University Hospital Tuebingen, 72076 Tubingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Steinhilber","sequence":"additional","affiliation":[{"name":"Institute of Occupational and Social Medicine and Health Services Research, Medical Faculty, University Hospital Tuebingen, 72076 Tubingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Martus","sequence":"additional","affiliation":[{"name":"Institute for Clinical Epidemiology and Applied Biometry, Medical Faculty, University Hospital Tuebingen, 72076 Tubingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia","family":"Janssen","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine, Medical Clinic, University Hospital Tuebingen, 72076 Tubingen, Germany"},{"name":"Interfaculty Research Institute for Sports and Physical Activity, Tuebingen, 72076 Tubingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inga","family":"Krauss","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine, Medical Clinic, University Hospital Tuebingen, 72076 Tubingen, Germany"},{"name":"Interfaculty Research Institute for Sports and Physical Activity, Tuebingen, 72076 Tubingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,7]]},"reference":[{"key":"ref_1","unstructured":"WHO (2021, May 03). Chronic Rheumatic Conditions. Available online: https:\/\/www.who.int\/chp\/topics\/rheumatic\/en\/."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1136\/annrheumdis-2012-202745","article-title":"EULAR recommendations for the non-pharmacological core management of hip and knee osteoarthritis","volume":"72","author":"Fernandes","year":"2013","journal-title":"Ann. Rheum. Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.joca.2014.01.003","article-title":"OARSI guidelines for the non-surgical management of knee osteoarthritis","volume":"22","author":"McAlindon","year":"2014","journal-title":"Osteoarthr. Cartil."},{"key":"ref_4","first-page":"276","article-title":"Sport- und Bewegungstherapie bei Gon- und Coxarthrose","volume":"67","year":"2016","journal-title":"Deutsche Zeitschrift f\u00fcr Sportmedizin"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1016\/j.joca.2019.06.011","article-title":"OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis","volume":"27","author":"Bannuru","year":"2019","journal-title":"Osteoarthr. Cartil."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.berh.2014.01.009","article-title":"Exercise in osteoarthritis: Moving from prescription to adherence","volume":"28","author":"Bennell","year":"2014","journal-title":"Best. Pract. Res. Clin. Rheumatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1097\/BOR.0000000000000478","article-title":"Exercise in the management of knee and hip osteoarthritis","volume":"30","author":"Wellsandt","year":"2018","journal-title":"Curr. Opin. Rheumatol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1001\/jama.1997.03540250033028","article-title":"A randomized trial comparing aerobic exercise and resistance exercise with a health education program in older adults with knee osteoarthritis. The Fitness Arthritis and Seniors Trial (FAST)","volume":"277","author":"Ettinger","year":"1997","journal-title":"JAMA"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1016\/j.pec.2015.05.020","article-title":"What do measures of patient satisfaction with the doctor tell us?","volume":"98","author":"Boquiren","year":"2015","journal-title":"Patient Educ. Couns."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1177\/0269215515606198","article-title":"Ottawa Panel evidence-based clinical practice guidelines for therapeutic exercise in the management of hip osteoarthritis","volume":"30","author":"Brosseau","year":"2016","journal-title":"Clin. Rehabil."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.joca.2010.01.013","article-title":"OARSI recommendations for the management of hip and knee osteoarthritis Part III: Changes in evidence following systematic cumulative update of research published through January 2009","volume":"18","author":"Zhang","year":"2010","journal-title":"Osteoarthr. Cartil."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1177\/0269215515622670","article-title":"The effects of manual therapy or exercise therapy or both in people with hip osteoarthritis: A systematic review and meta-analysis","volume":"30","author":"Sampath","year":"2016","journal-title":"Clin. Rehabil."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1016\/j.joca.2017.06.004","article-title":"The importance of dose in land-based supervised exercise for people with hip osteoarthritis. A systematic review and meta-analysis","volume":"25","author":"Moseng","year":"2017","journal-title":"Osteoarthr. Cartil."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.joca.2015.07.023","article-title":"Effectiveness of exercise therapy added to general practitioner care in patients with hip osteoarthritis: A pragmatic randomized controlled trial","volume":"24","author":"Teirlinck","year":"2016","journal-title":"Osteoarthr. Cartil."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1080\/14397595.2016.1213940","article-title":"Exercise therapy in patients with hip osteoarthritis: Effect on hip muscle strength and safety aspects of exercise-results of a randomized controlled trial","volume":"27","author":"Steinhilber","year":"2017","journal-title":"Mod. Rheumatol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Krauss, I., Steinhilber, B., Haupt, G., Miller, R., Grau, S., and Janssen, P. (2011). Efficacy of conservative treatment regimes for hip osteoarthritis\u2014Evaluation of the therapeutic exercise regime \u201cHip School\u201d: A protocol for a randomised, controlled trial. BMC Musculoskelet. Disord., 12.","DOI":"10.1186\/1471-2474-12-270"},{"key":"ref_17","first-page":"592","article-title":"Exercise therapy in hip osteoarthritis\u2014A randomized controlled trial","volume":"111","author":"Krauss","year":"2014","journal-title":"Dtsch. Arztebl. Int."},{"key":"ref_18","first-page":"2","article-title":"Application of the TIDieR checklist to improve understanding and replicability of studies in Physical and Rehabilitation Medicine","volume":"51","author":"Negrini","year":"2015","journal-title":"Eur. J. Phys. Rehabil. Med."},{"key":"ref_19","unstructured":"Haupt, G., Jan\u00dfen, P., Krau\u00df, I., and Steinhilber, B. (2014). Das T\u00fcbinger H\u00fcftkonzept, Verlag hellblau."},{"key":"ref_20","unstructured":"Bullinger, B., and Kirchberger, I. (1998). SF-36 Fragebogen zum Gesundheitszustand, Handanweisung, Hogrefe, Verlag f\u00fcr Psychologie."},{"key":"ref_21","first-page":"834","article-title":"Responsiveness of the WOMAC osteoarthritis index as compared with the SF-36 in patients with osteoarthritis of the legs undergoing a comprehensive rehabilitation intervention","volume":"60","author":"Angst","year":"2001","journal-title":"Ann. Rheum. Dis."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s10067-010-1398-2","article-title":"Validity, reliability, and comparison of the WOMAC osteoarthritis index and Lequesne algofunctional index in Turkish patients with hip or knee osteoarthritis","volume":"29","author":"Basaran","year":"2010","journal-title":"Clin. Rheumatol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.jclinepi.2008.11.011","article-title":"The Lower Extremity Functional Scale could be an alternative to the Western Ontario and McMaster Universities Osteoarthritis Index physical function scale","volume":"62","author":"Pua","year":"2009","journal-title":"J. Clin. Epidemiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"863","DOI":"10.3389\/fpsyg.2013.00863","article-title":"Calculating and reporting effect sizes to facilitate cumulative science: A practical primer for t-tests and ANOVAs","volume":"4","author":"Lakens","year":"2013","journal-title":"Front. Psychol."},{"key":"ref_25","unstructured":"Cohen, J. (1988). Statistical Power Analysis for the Behavioural Sciences, Lawrence Erlbaum Associates."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"555","DOI":"10.4097\/kjae.2016.69.6.555","article-title":"Alternatives to P value: Confidence interval and effect size","volume":"69","author":"Lee","year":"2016","journal-title":"Korean J. Anesthesiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/j.joca.2010.05.015","article-title":"Efficacy of patient education and supervised exercise vs patient education alone in patients with hip osteoarthritis: A single blind randomized clinical trial","volume":"18","author":"Fernandes","year":"2010","journal-title":"Osteoarthr. Cartil."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1177\/0269215510388313","article-title":"A pragmatic randomized controlled study of the effectiveness and cost consequences of exercise therapy in hip osteoarthritis","volume":"25","author":"Juhakoski","year":"2011","journal-title":"Clin. Rehabil."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.apmr.2012.09.030","article-title":"Exercise and manual physiotherapy arthritis research trial (EMPART) for osteoarthritis of the hip: A multicenter randomized controlled trial","volume":"94","author":"French","year":"2013","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_30","first-page":"1106","article-title":"The effects of an exercise program for older adults with osteoarthritis of the hip","volume":"32","author":"Tak","year":"2005","journal-title":"J. Rheumatol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.joca.2012.12.014","article-title":"Manual therapy, exercise therapy, or both, in addition to usual care, for osteoarthritis of the hip or knee: A randomized controlled trial. 1: Clinical effectiveness","volume":"21","author":"Abbott","year":"2013","journal-title":"Osteoarthr. Cartil."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1056\/NEJMra1510059","article-title":"Pragmatic Trials","volume":"375","author":"Ford","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/S0196-0644(95)70009-9","article-title":"Hawthorne effect: Implications for prehospital research","volume":"26","author":"Campbell","year":"1995","journal-title":"Ann. Emerg. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.jbspin.2008.02.016","article-title":"Adherence to, and results of, physical therapy programs in patients with hip or knee osteoarthritis. Development of French clinical practice guidelines","volume":"75","author":"Mazieres","year":"2008","journal-title":"Jt. Bone Spine"},{"key":"ref_35","unstructured":"Bildungsberichterstattung, A. (2018). Bildung in Deutschland 2018, wbv Media."},{"key":"ref_36","unstructured":"Hrsg, R.K.-I. (2014). Daten und Fakten: Ergebnisse der Studie \u201cGesundheit in Deutschland aktuell 2012\u201d, Robert Koch Institut."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Krauss, I., Mueller, G., Haupt, G., Steinhilber, S., Janssen, P., Jentner, N., and Martus, P. (2016). Efficacy and efficiency of an 11-week exercise intervention for patients with hip or knee osteoarthritis: A protocol for a controlled study in the context of health service research. 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