{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:40:49Z","timestamp":1792194049256,"version":"4.4.0"},"reference-count":46,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T00:00:00Z","timestamp":1628726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Adolescent pregnancy remains a health issue worldwide also in developed countries, since it has been associated with adverse maternal and neonatal outcomes. Some data suggest that very young adolescents have higher risk, likely due to immaturity. Therefore, we aimed to assess the influence of maternal age on complications during gestation and labor in pregnant women between 13 and 19 years of age. In particular, we evaluated the possible association between maternal age and obstetric, fetal and labor complications. This is a retrospective, observational and exploratory study conducted at Hospital Universitario La Paz (HULP, Madrid, Spain). The clinical history of 279 women who delivered between 2013 and 2018 was analyzed. Maternal age and the presence of maternal, fetal and labor complications, as well as risk of postpartum depression and breastfeeding intention, were recorded. General regression models were used to analyze the contribution of maternal age on each complication. The percentage of adolescent pregnancies at HULP between 2013 and 2018 was 0.9%. The risk of all the maternal complications analyzed decreased significantly with every year of age of the mother (hyperemesis, lower back pain, anemia, gestational diabetes mellitus, and threat of premature labor and premature rupture of membranes). Every year of maternal age decreased 0.8-fold [0.8; 0.9] the prevalence of fetal complications and also reduced the risk of C-section, postpartum hemorrhage and obstetrical hysterectomy. Furthermore, higher maternal age increased 1.1-fold [1.0; 1.2] the breastfeeding intention. In conclusion, young adolescents are at higher risk of complications during pregnancy and labor.<\/jats:p>","DOI":"10.3390\/ijerph18168514","type":"journal-article","created":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T10:54:41Z","timestamp":1628765681000},"page":"8514","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Younger Age in Adolescent Pregnancies Is Associated with Higher Risk of Adverse Outcomes"],"prefix":"10.3390","volume":"18","author":[{"given":"Maria","family":"de la Calle","sequence":"first","affiliation":[{"name":"Obstetrics and Gynecology Service, Hospital Universitario La Paz, Paseo de la Castellana 261, 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose L.","family":"Bartha","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Service, Hospital Universitario La Paz, Paseo de la Castellana 261, 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina M.","family":"Lopez","sequence":"additional","affiliation":[{"name":"Pediatrics Service, Hospital Universitario La Paz, Paseo de la Castellana 261, 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Turiel","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Service, Hospital Universitario La Paz, Paseo de la Castellana 261, 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Martinez","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Service, Hospital Universitario La Paz, Paseo de la Castellana 261, 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia M.","family":"Arribas","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Universidad Aut\u00f3noma de Madrid, C\/Arzobispo Morcillo 2, 28049 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7442-1586","authenticated-orcid":false,"given":"David","family":"Ramiro-Cortijo","sequence":"additional","affiliation":[{"name":"Department of Medicine, Beth Israel Deaconess Medical Center-Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,12]]},"reference":[{"key":"ref_1","unstructured":"UNFPA (2021, June 30). Motherhood in Childhood: Facing the Challenge of Adolescent Pregnancy. Available online: https:\/\/www.unfpa.org\/publications\/state-world-population-2013-0."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/S0031-3955(03)00069-5","article-title":"Adolescent pregnancy","volume":"50","author":"Elfenbein","year":"2003","journal-title":"Pediatr. Clin. N. Am."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1590\/S1679-45082015RW3127","article-title":"Complications in adolescent pregnancy: Systematic review of the literature","volume":"13","author":"Azevedo","year":"2015","journal-title":"Einstein"},{"key":"ref_4","first-page":"42","article-title":"Embarazo adolescente","volume":"5","author":"Minassian","year":"2008","journal-title":"Rev. Ped. Elec."},{"key":"ref_5","first-page":"333","article-title":"Pregnancy and its complications in adolescent mothers","volume":"38","year":"2012","journal-title":"Rev. Cubana. Obstet. Ginecol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"4408","DOI":"10.18203\/2394-6040.ijcmph20183984","article-title":"Adolescent pregnancy and its outcomes: A cross-sectional study","volume":"5","author":"Paladugu","year":"2018","journal-title":"Int. J. Community Med. Public Health"},{"key":"ref_7","first-page":"76","article-title":"Pregnancy in adolescence: What it is like in today\u2019s society","volume":"29","year":"2015","journal-title":"Perinatol. Reprod. Hum."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/s13690-021-00642-z","article-title":"Pregnancy complications, substance abuse, and prenatal care predict birthweight in adolescent mothers","volume":"79","author":"Hacker","year":"2021","journal-title":"Arch. Public Health"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s00404-007-0557-4","article-title":"Young maternal age and risk of intrapartum stillbirth","volume":"278","author":"Wilson","year":"2008","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1056\/NEJM199504273321701","article-title":"Association of young maternal age with adverse reproductive outcomes","volume":"332","author":"Fraser","year":"1995","journal-title":"N. Engl. J. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.pcl.2016.11.007","article-title":"Adolescent pregnancy","volume":"64","author":"Leftwich","year":"2017","journal-title":"Pediatr. Clin. N. Am."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Gila-Diaz, A., Carrillo, G.H., Lopez de Pablo, A.L., Arribas, S.M., and Ramiro-Cortijo, D. (2020). Association between maternal postpartum depression, stress, optimism, and breastfeeding pattern in the first six months. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17197153"},{"key":"ref_13","first-page":"205","article-title":"Factors of risk and consequences of pregnancy in adolescence","volume":"97","year":"2018","journal-title":"Rev. Inf. Cient."},{"key":"ref_14","first-page":"123","article-title":"Pregnancy in adolescents","volume":"23","author":"Black","year":"2012","journal-title":"Adolesc. Med. State Art Rev."},{"key":"ref_15","first-page":"79","article-title":"Embarazo en la adolescencia. Educaci\u00f3n sexual y anticoncepci\u00f3n previa","volume":"11","author":"Diaz","year":"2004","journal-title":"Rev. SOGIA"},{"key":"ref_16","unstructured":"World-Bank (2021, June 30). Adolescent Fertility Rate (Births per 1,000 Women Ages 15\u201319). Available online: https:\/\/data.worldbank.org\/indicator\/SP.ADO.TFRT?name_desc=false&view=map."},{"key":"ref_17","first-page":"395","article-title":"Sociodemographic and clinical data predicting unplanned pregnancy in young 13 to 24 years, Spain","volume":"88","year":"2014","journal-title":"Rev. Esp. Salud Publica"},{"key":"ref_18","first-page":"13","article-title":"Riesgos en el embarazo adolescente","volume":"153","author":"Ulanowicz","year":"2006","journal-title":"Rev. Post. Catedra Med."},{"key":"ref_19","first-page":"1","article-title":"Impacto de la menarqu\u00eda en los resultados maternos perinatales en la adolescencia","volume":"31","year":"2005","journal-title":"Rev. Cubana Obstet. Ginecol."},{"key":"ref_20","first-page":"2","article-title":"Caracterizaci\u00f3n del reci\u00e9n nacido en una muestra de gestantes adolescentes","volume":"30","author":"Fernandez","year":"2004","journal-title":"Rev. Cubana Obstet. Ginecol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1530\/EJE-08-0594","article-title":"Is there a further acceleration in the age at onset of menarche? A cross-sectional study in 1840 school children focusing on age and bodyweight at the onset of menarche","volume":"160","author":"Bau","year":"2009","journal-title":"Eur. J. Endocrinol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1067\/mob.2003.305","article-title":"Screening for fetal well-being in a high-risk pregnant population comparing the nonstress test with umbilical artery Doppler velocimetry: A randomized controlled clinical trial","volume":"188","author":"Williams","year":"2003","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.jad.2018.12.075","article-title":"Validation of the Edinburgh postnatal depression scale as a screening tool for depression in Spanish pregnant women","volume":"246","author":"Vazquez","year":"2019","journal-title":"J. Affect. Disord."},{"key":"ref_24","unstructured":"Dadelszen, P.V. (2009). Pregnancy in Adolescence. The Global Library of Women\u2019s Medicine\u2019s, Kings College."},{"key":"ref_25","unstructured":"United-Nations (2021, June 30). World Population Prospects. Available online: https:\/\/population.un.org\/wpp\/."},{"key":"ref_26","unstructured":"INE (2021, June 30). Tasas de Fecundidad por Comunidad Aut\u00f3noma, Seg\u00fan Orden del Nacimiento y Nacionalidad (Espa\u00f1ola\/Extranjera) y Edad de la Madre. Available online: https:\/\/www.ine.es\/jaxiT3\/Tabla.htm?t=1440&L=0."},{"key":"ref_27","first-page":"121","article-title":"Pregnancy in adolescents in the last 11 years. Reasons for consulting and risk factors","volume":"89","author":"Canedo","year":"2018","journal-title":"Ann. Pediatr."},{"key":"ref_28","first-page":"135","article-title":"Teen pregnancy and educational gaps: Analysis of a national survey in Mexico","volume":"57","author":"Campero","year":"2015","journal-title":"Salud Publica Mex."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1177\/0963662513509764","article-title":"\u201cPregnancy and labour cause more deaths than oral contraceptives\u201d: The debate on the pill in the Spanish press in the 1960s and 1970s","volume":"24","author":"Ignaciuk","year":"2015","journal-title":"Public Underst. Sci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1055\/s-0028-1085620","article-title":"Advanced maternal age. Part I: Obstetric complications","volume":"25","author":"Usta","year":"2008","journal-title":"Am. J. Perinatol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1093\/humrep\/del522","article-title":"Elevated risks of pregnancy complications and adverse outcomes with increasing maternal age","volume":"22","author":"Luke","year":"2007","journal-title":"Hum. Reprod."},{"key":"ref_32","first-page":"78","article-title":"El reci\u00e9n nacido de bajo peso","volume":"9","year":"2008","journal-title":"Protoc. Diagn\u00f3stico Ter. AEP Neonatol."},{"key":"ref_33","unstructured":"Junta-de, A. (2017). Diabetes Mellitus Gestacional: Documento de Apoyo, Consejer\u00eda de Salud."},{"key":"ref_34","unstructured":"Ugarte Libano, R. (2005, January 13\u201315). Retraso de crecimiento intrauterino (RCIU): Retos para el pediatra de atenci\u00f3n primaria. Proceedings of the Curso de Actualizaci\u00f3n Pediatr\u00eda, Madrid, Spain."},{"key":"ref_35","first-page":"172","article-title":"Recomendaciones para el manejo de la rotura prematura de membranas","volume":"25","author":"Andina","year":"2006","journal-title":"Rev. Hosp. Mat. Inf. Ramon Sarda"},{"key":"ref_36","first-page":"13","article-title":"Factores de riesgo asociados a parto pret\u00e9rmino en adolescentes","volume":"23","year":"2017","journal-title":"Salud en Tabasco"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"416","DOI":"10.6018\/eglobal.15.4.236961","article-title":"Risk factors related to premature labor in pregnant adolescents: An integrative literature review","volume":"15","author":"Thomazini","year":"2016","journal-title":"Enferm. Glob."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1093\/geronb\/gbq006","article-title":"Still happy after all these years: Research frontiers on subjective well-being in later life","volume":"65B","author":"George","year":"2010","journal-title":"J. Gerontol. B Psychol. Sci. Soc. Sci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"110665","DOI":"10.1016\/j.nut.2019.110665","article-title":"Diet as a counteracting agent of the effect of some well-known risk factors for small for gestational age","volume":"72","year":"2020","journal-title":"Nutrition"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1159\/000077089","article-title":"Teenage pregnancy","volume":"7","author":"Uzan","year":"2004","journal-title":"Endocr. Dev."},{"key":"ref_41","first-page":"562","article-title":"Pregnancy in girls and adolescents","volume":"108","author":"Repetto","year":"2010","journal-title":"Arch. Argent. Pediatr."},{"key":"ref_42","first-page":"261","article-title":"Adolescent pregnancy prevention","volume":"15","year":"2013","journal-title":"Rev. Pediatr. Aten. Primaria"},{"key":"ref_43","first-page":"141","article-title":"Parto pretermino en adolescentes","volume":"68","author":"Manrique","year":"2008","journal-title":"Rev. Obstet. Ginecol. Venez"},{"key":"ref_44","first-page":"712","article-title":"Teenage mothers","volume":"45","author":"Marino","year":"2016","journal-title":"Aust. Fam. Physician"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jad.2020.05.112","article-title":"Emerging issues and questions on peripartum depression prevention, diagnosis and treatment: A consensus report from the cost action riseup-PPD","volume":"274","author":"Fonseca","year":"2020","journal-title":"J. Affect. Disord."},{"key":"ref_46","first-page":"694","article-title":"Embarazo en adolescentes y sus repercusiones materno perinatales","volume":"80","author":"Panduro","year":"2012","journal-title":"Ginecol. Obstet. Mex."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/18\/16\/8514\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:44:38Z","timestamp":1760165078000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/18\/16\/8514"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,12]]},"references-count":46,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2021,8]]}},"alternative-id":["ijerph18168514"],"URL":"https:\/\/doi.org\/10.3390\/ijerph18168514","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,12]]}}}