{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T19:05:52Z","timestamp":1775243152910,"version":"3.50.1"},"reference-count":39,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2021,8,23]],"date-time":"2021-08-23T00:00:00Z","timestamp":1629676800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>The present study aimed to analyze sleep quality and quality of Life (QoL) in patients undergoing Transcatheter Aortic Valve Implantation (TAVI). It was conducted at the Interventional Cardiology Unit of the Department of Cardiac, Thoracic, Vascular Sciences and Public Health of the University of Padova on 27 adult patients who underwent TAVI via the transfemoral approach. Patients completed two validated instruments, i.e., the Pittsburgh Sleep Quality Index (PSQI) and the EuroQoL (EQ-5D-5L), on the day of discharge and one month after the hospital discharge. Twenty-seven patients were enrolled with a severe aortic stenosis diagnosis, treated with transfemoral TAVI procedure. The study population included seventeen poor sleepers and ten good sleepers with a median age of 81.92 years overall. The global PSQI evaluation revealed a small significant improvement at follow-up (p-value 0.007). Small positive changes were detected in the Self-care and Usual activity domains of the EQ-5D-5L and the EQ-VAS. No correlation was detected between EQ-5D-5L and sleep quality. The present study confirms the importance of sleep quality monitoring in patients who undergo TAVI procedure for aortic stenosis treatment.<\/jats:p>","DOI":"10.3390\/ijerph18168889","type":"journal-article","created":{"date-parts":[[2021,8,23]],"date-time":"2021-08-23T10:24:17Z","timestamp":1629714257000},"page":"8889","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Sleep Quality in Patients Undergoing Transcatheter Aortic Valve Implantation (TAVI)"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1771-4686","authenticated-orcid":false,"given":"Giulia","family":"Lorenzoni","sequence":"first","affiliation":[{"name":"Unit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, 35131 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danila","family":"Azzolina","sequence":"additional","affiliation":[{"name":"Unit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, 35131 Padova, Italy"},{"name":"Department of Medical Sciences, University of Ferrara, 44121 Ferrara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Fraccaro","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, 35128 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caterina","family":"Zoccarato","sequence":"additional","affiliation":[{"name":"Unit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, 35131 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clara","family":"Minto","sequence":"additional","affiliation":[{"name":"Unit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, 35131 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabino","family":"Iliceto","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, 35128 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7906-0580","authenticated-orcid":false,"given":"Dario","family":"Gregori","sequence":"additional","affiliation":[{"name":"Unit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, 35131 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Tarantini","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, 35128 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"238","DOI":"10.2174\/157015909789152182","article-title":"Adenosine and Sleep","volume":"7","author":"Bjorness","year":"2009","journal-title":"Curr. Neuropharmacol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.acap.2018.08.002","article-title":"Sleep, Physical Activity, and General Health Status: US Pediatricians and the General US Adult Population","volume":"19","author":"Gottschlich","year":"2018","journal-title":"Acad. Pediatr."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"151","DOI":"10.2147\/NSS.S134864","article-title":"Short-and Long-Term Health Consequences of Sleep Disruption","volume":"9","author":"Medic","year":"2017","journal-title":"Nat. Sci. Sleep"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1093\/eurheartj\/ehz849","article-title":"Sleep Patterns, Genetic Susceptibility, and Incident Cardiovascular Disease: A Prospective Study of 385 292 UK Biobank Participants","volume":"41","author":"Fan","year":"2020","journal-title":"Eur. Heart J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1093\/eurheartj\/ehab151","article-title":"Sleep Arousal Burden Is Associated with Long-Term All-Cause and Cardiovascular Mortality in 8001 Community-Dwelling Older Men and Women","volume":"42","author":"Shahrbabaki","year":"2021","journal-title":"Eur. Heart J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nrcardio.2016.71","article-title":"Heart Failure and Sleep Disorders","volume":"13","author":"Parati","year":"2016","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.ijcard.2018.05.132","article-title":"Time Trends in First Hospitalization for Heart Failure in a Community-Based Population","volume":"271","author":"Lorenzoni","year":"2018","journal-title":"Int. J. Cardiol."},{"key":"ref_8","first-page":"10","article-title":"Epidemiology of Aortic Valve Stenosis (AS) and of Aortic Valve Incompetence (AI): Is the Prevalence of AS\/AI Similar in Different Parts of the World","volume":"18","author":"Ancona","year":"2020","journal-title":"Eur. Soc. Cardiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ijcard.2019.09.003","article-title":"Transcatheter Aortic Valve Replacement for Bicuspid Aortic Valve Stenosis with First- and New-Generation Bioprostheses: A Systematic Review and Meta-Analysis","volume":"298","author":"Ueshima","year":"2019","journal-title":"Int. J. Cardiol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Linhart, M., Sinning, J.-M., Ghanem, A., Kozhuppakalam, F.J., Fist\u00e9ra, R., Hammerstingl, C., Pizarro, C., Grube, E., Werner, N., and Nickenig, G. (2015). Prevalence and Impact of Sleep Disordered Breathing in Patients with Severe Aortic Stenosis. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0133176"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1177\/1474515115620992","article-title":"Sleep in Octogenarians during the Postoperative Phase after Transcatheter or Surgical Aortic Valve Replacement","volume":"15","author":"Amofah","year":"2016","journal-title":"Eur. J. Cardiovasc. Nurs."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"204","DOI":"10.4037\/NCI.0b013e31822052cb","article-title":"Sleep Disturbances and Fatigue in Critically Ill Patients","volume":"22","author":"Matthews","year":"2011","journal-title":"AACN Adv. Crit. Care"},{"key":"ref_13","first-page":"323","article-title":"Sleep after Critical Illness: Study of Survivors of Acute Respiratory Distress Syndrome and Systematic Review of Literature","volume":"20","author":"Dhooria","year":"2016","journal-title":"Indian J. Crit. Care Med. Peer-Rev. Off. Pub. Indian Soc. Crit. Care Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1046\/j.1365-2648.1999.01006.x","article-title":"Sleep and Quality of Life Assessment in Patients Undergoing Coronary Artery Bypass Grafting","volume":"29","author":"Hetta","year":"1999","journal-title":"J. Adv. Nurs."},{"key":"ref_15","first-page":"137","article-title":"Anxiety, Depression and Sleep in Male Patients Undergoing Coronary Artery Bypass Surgery","volume":"13","author":"Hetta","year":"1999","journal-title":"Scand. J. Care Sci."},{"key":"ref_16","first-page":"342","article-title":"Sleep Patterns and Stress in Patients Having Coronary Bypass","volume":"21","author":"Yarcheski","year":"1992","journal-title":"Heart Lung J. Crit. Care"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Redeker, N.S. (2008). Sleep and quality of Life in cardiac surgery. Sleep and Quality of Life in Clinical Medicine, Springer.","DOI":"10.1007\/978-1-60327-343-5_38"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1037\/0003-066X.56.12.1099","article-title":"APA\u2019s Guidelines for Test User Qualifications: An Executive Summary","volume":"56","author":"Turner","year":"2001","journal-title":"Am. Psychol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"103208","DOI":"10.1016\/j.jbi.2019.103208","article-title":"The REDCap Consortium: Building an International Community of Software Platform Partners","volume":"95","author":"Harris","year":"2019","journal-title":"J. Biomed. Inf."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0165-1781(89)90047-4","article-title":"The Pittsburgh Sleep Quality Index: A New Instrument for Psychiatric Practice and Research","volume":"28","author":"Buysse","year":"1989","journal-title":"Psychiatry Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s10072-012-1085-y","article-title":"Validity of the Italian Version of the Pittsburgh Sleep Quality Index (PSQI)","volume":"34","author":"Curcio","year":"2013","journal-title":"Neurol. Sci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1007\/s11136-011-9903-x","article-title":"Development and Preliminary Testing of the New Five-Level Version of EQ-5D (EQ-5D-5L)","volume":"20","author":"Herdman","year":"2011","journal-title":"Qual. Life Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. R. Stat. Soc. Ser. B"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1002\/(SICI)1097-0258(19981015)17:19<2179::AID-SIM921>3.0.CO;2-L","article-title":"Regression Models for Multiple Outcomes in Large Epidemiologic Studies","volume":"17","author":"Bull","year":"1998","journal-title":"Stat. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/j.1467-9876.2011.01005.x","article-title":"A Versatile Method for Confirmatory Evaluation of the Effects of a Covariate in Multiple Models: Evaluation of Effects of a Covariate in Multiple Models","volume":"61","author":"Pipper","year":"2012","journal-title":"J. R. Stat. Soc. Ser. C"},{"key":"ref_26","unstructured":"R Core Team (2015). R: A Language and Environment for Statistical Computing, R Foundation for Statistical Computing."},{"key":"ref_27","unstructured":"Ristl, R. (2021, August 12). Mmmgee: Simultaneous Inference for Multiple Linear Contrasts in GEE Models. Available online: http:\/\/cran.nexr.com\/web\/packages\/mmmgee\/index.html."},{"key":"ref_28","unstructured":"Carey, V.J., Lumley, T., and Ripley, B.D. (2021, August 12). Gee: Generalized Estimation Equation Solver. R Package Version 4.13-18. Available online: http:\/\/CRAN.R-project.org\/package=gee."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1002\/bimj.200810425","article-title":"Simultaneous Inference in General Parametric Models","volume":"50","author":"Hothorn","year":"2008","journal-title":"Biometr. J."},{"key":"ref_30","unstructured":"Harrell, F.E.J. (2021, August 12). Rms: Regression Modeling Strategies. R Package Version 4.1-3. Available online: https:\/\/rdocumentation.org\/packages\/rms\/versions\/4.1-3."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1038\/nature04285","article-title":"Clues to the Functions of Mammalian Sleep","volume":"437","author":"Siegel","year":"2005","journal-title":"Nature"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1093\/eurheartj\/ehr007","article-title":"Sleep Duration Predicts Cardiovascular Outcomes: A Systematic Review and Meta-Analysis of Prospective Studies","volume":"32","author":"Cappuccio","year":"2011","journal-title":"Eur. Heart J."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.ijcard.2016.01.044","article-title":"Self-Reported Sleep Duration and Coronary Heart Disease Mortality: A Large Cohort Study of 400,000 Taiwanese Adults","volume":"207","author":"Strand","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.mcna.2014.11.013","article-title":"Sleep Problems in the Elderly","volume":"99","author":"Rodriguez","year":"2015","journal-title":"Med. Clin. N. Am."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1159\/000236900","article-title":"Sleep Disorders in the Older Adult\u2014A Mini-Review","volume":"56","author":"Neikrug","year":"2010","journal-title":"Gerontology"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s002280050604","article-title":"Influence of Beta-Blockers on Melatonin Release","volume":"55","author":"Stoschitzky","year":"1999","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"ref_37","unstructured":"Fender, A. (2021, August 12). CV Drugs That Negatively Affect Sleep Quality. Available online: https:\/\/www.acc.org\/latest-in-cardiology\/articles\/2014\/07\/18\/15\/46\/cv-drugs-that-negatively-affect-sleep-quality."},{"key":"ref_38","first-page":"915","article-title":"Sleep Changes Following Statin Therapy: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Polysomnographic Trials","volume":"11","author":"Broncel","year":"2015","journal-title":"Arch. Med. Sci."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Ocagli, H., Lorenzoni, G., Lanera, C., Schiavo, A., D\u2019Angelo, L., Liberti, A.D., Besola, L., Cibin, G., Martinato, M., and Azzolina, D. (2021). Monitoring Patients Reported Outcomes after Valve Replacement Using Wearable Devices: Insights on Feasibility and Capability Study: Feasibility Results. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph18137171"}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/18\/16\/8889\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:49:56Z","timestamp":1760165396000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/18\/16\/8889"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,23]]},"references-count":39,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2021,8]]}},"alternative-id":["ijerph18168889"],"URL":"https:\/\/doi.org\/10.3390\/ijerph18168889","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,23]]}}}