{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:28:43Z","timestamp":1792153723670,"version":"4.4.0"},"reference-count":28,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2021,8,26]],"date-time":"2021-08-26T00:00:00Z","timestamp":1629936000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>The aim of this long-term longitudinal study in Taiwan was to estimate and compare the prevalence of cerebral palsy (CP) and to identify the age of CP diagnosis of term-born and preterm children with different birthweights. Records of 1494 extremely low birth weight (ELBW, &lt;1000 g), 3961 very low birth weight (VLBW, 1000\u20131499 g), 19,612 low birth weight (LBW, 1500\u20132499 g) preterm, and 100,268 matched term-born children were retrieved from Taiwan\u2032s National Health Insurance Research Database. According to a 12-year retrospective data review, the results showed the highest prevalence of CP in preterm ELBW children (147.3 cases per 1000 neonatal survivors), followed by preterm VLBW (97.2 cases), preterm LBW (27.7 cases), with the lowest prevalence in term-born children (2.5 cases). Regardless of the birthweight group, 90% of preterm children with CP were diagnosed by 4 years of age, but it was 7 years before 90% of term-born children with CP were diagnosed. After removing the children whose CP was caused by brain infections, injuries, or cerebrovascular accidents after 4 months of age, there were similar mean ages at the initial CP diagnosis (1.58\u20131.64 years of age) across birthweight groups born prematurely, but initial diagnosis occurred at an older age (2.41 years of age) in term-born children. The results indicate that birthweight is reversely correlated with the prevalence of CP in preterm children. Although the three preterm birthweight groups received different types of developmental follow-up programs after birth, it did not influence their age at the initial diagnosis of CP. Furthermore, we suggest that follow-up for at least 4 years after birth for preterm children, and 7 years for term-born children, is optimal for estimating CP prevalence. In order to identify and provide early intervention for term-born children with CP earlier, it is suggested that parents routinely fill out a self-reported motor developmental screening questionnaire and pediatricians conduct a motor developmental examination on term-born children at each time of scheduled vaccination injections.<\/jats:p>","DOI":"10.3390\/ijerph18178984","type":"journal-article","created":{"date-parts":[[2021,8,26]],"date-time":"2021-08-26T09:27:57Z","timestamp":1629970077000},"page":"8984","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Prevalence and Initial Diagnosis of Cerebral Palsy in Preterm and Term-Born Children in Taiwan: A Nationwide, Population-Based Cohort Study"],"prefix":"10.3390","volume":"18","author":[{"given":"Hsin-Hua","family":"Wang","sequence":"first","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Chi Mei Medical Center, Tainan 71004, Taiwan"},{"name":"Department of Pediatrics, Chi Mei Medical Center, Liouying, Tainan 73657, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yea-Shwu","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Occupational Therapy, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5925-8477","authenticated-orcid":false,"given":"Chung-Han","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Medical Research, Chi Mei Medical Center, Tainan 71004, Taiwan"},{"name":"Department of Information Management, Southern Taiwan University of Science and Technology, Tainan 71005, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Chi","family":"Lai","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurology, Department of Pediatrics, Chi Mei Medical Center, Tainan 71004, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Chin","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Chi Mei Medical Center, Tainan 71004, Taiwan"},{"name":"Department of Pediatrics, Chi Mei Medical Center, ChiaLi, Tainan 72263, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Hui","family":"Tsai","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Chi Mei Medical Center, Tainan 71004, Taiwan"},{"name":"Graduate Institute of Medical Sciences, College of Health Sciences, Chang Jung Christian University, Tainan 71101, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,26]]},"reference":[{"key":"ref_1","first-page":"8","article-title":"A report: The definition and classification of cerebral palsy April 2006","volume":"109","author":"Rosenbaum","year":"2007","journal-title":"Dev. Med. Child. Neurol. Suppl."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1002\/ddrr.1106","article-title":"Cerebral palsy\u2014Don\u2032t delay","volume":"17","author":"McIntyre","year":"2011","journal-title":"Dev. Disabil. Res. Rev."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1001\/jama.296.13.1602","article-title":"Clinical and MRI correlates of cerebral palsy: The European Cerebral Palsy Study","volume":"296","author":"Bax","year":"2006","journal-title":"JAMA"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1097\/GRF.0b013e318187087c","article-title":"Causative factors in cerebral palsy","volume":"51","author":"Nelson","year":"2008","journal-title":"Clin. Obstet. Gynecol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.ejpn.2018.05.001","article-title":"Decreasing prevalence and severity of cerebral palsy in Norway among children born 1999 to 2010 concomitant with improvements in perinatal health","volume":"22","author":"Hollung","year":"2018","journal-title":"Eur. J. Paediatr. Neurol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1136\/adc.2008.144014","article-title":"Dyskinetic cerebral palsy in Europe: Trends in prevalence and severity","volume":"94","author":"Himmelmann","year":"2009","journal-title":"Arch. Dis. Child."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1111\/j.1469-8749.2011.04039.x","article-title":"Rates of cerebral palsy in Victoria, Australia, 1970 to 2004: Has there been a change?","volume":"53","author":"Reid","year":"2011","journal-title":"Dev. Med. Child. Neurol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1111\/dmcn.12080","article-title":"An update on the prevalence of cerebral palsy: A systematic review and meta-analysis","volume":"55","author":"Oskoui","year":"2013","journal-title":"Dev. Med. Child. Neurol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.braindev.2016.03.007","article-title":"Trends in the prevalence of cerebral palsy in children born between 1988 and 2007 in Okinawa, Japan","volume":"38","author":"Touyama","year":"2016","journal-title":"Brain Dev."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"781","DOI":"10.3349\/ymj.2018.59.6.781","article-title":"Incidence of cerebral palsy in Korea and the effect of socioeconomic status: A population-based nationwide study","volume":"59","author":"Kim","year":"2018","journal-title":"Yonsei Med. J."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1111\/dmcn.13675","article-title":"Neurodevelopmental outcome in very preterm and very-low-birthweight infants born over the past decade: A meta-analytic review","volume":"60","author":"Pascal","year":"2018","journal-title":"Dev. Med. Child. Neurol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1111\/j.1651-2227.2001.tb00287.x","article-title":"Neurological development up to the age of four years of extremely low birthweight infants born in Southern Finland in 1991\u20131994","volume":"90","author":"Salokorpi","year":"2001","journal-title":"Acta Paediatr."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"F29","DOI":"10.1136\/fn.88.1.F29","article-title":"A national two year follow up study of extremely low birthweight infants born in 1996\u20131997","volume":"88","author":"Tommiska","year":"2003","journal-title":"Arch. Dis. Child. Fetal Neonatal Ed."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.earlhumdev.2010.07.009","article-title":"Predicting neurosensory disabilities at two years of age in a national cohort of extremely premature infants","volume":"86","author":"Leversen","year":"2010","journal-title":"Early Hum. Dev."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Surveillance of Cerepraly Palsy in Europe (SCPE) (2002). Prevalence and characteristics of children with cerebral palsy in Europe. Dev. Med. Child. Neurol., 44, 633\u2013640.","DOI":"10.1111\/j.1469-8749.2002.tb00848.x"},{"key":"ref_16","unstructured":"Australian Cerebral Palsy Register (ACPR) (2021, April 27). Australian Cerebral Palsy Register Report. Available online: https:\/\/cpregister.com\/wp-content\/uploads\/2019\/02\/Report-of-the-Australian-Cerebral-Palsy-Register-Birth-Years-1995-2012.pdf."},{"key":"ref_17","unstructured":"(2021, March 18). Premature Baby Foundation of Taiwan. Available online: https:\/\/www.pbf.org.tw\/service_02_04."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1377\/hlthaff.22.3.77","article-title":"Does universal health insurance make health care unaffordable? Lessons from Taiwan","volume":"22","author":"Lu","year":"2003","journal-title":"Health Aff."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1377\/hlthaff.22.3.61","article-title":"Taiwan\u2032s new national health insurance program: Genesis and experience so far","volume":"22","author":"Cheng","year":"2003","journal-title":"Health Aff."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/hep.23641","article-title":"Risk of malignant neoplasms of liver and biliary tract in diabetic patients with different age and sex stratifications","volume":"52","author":"Chen","year":"2010","journal-title":"Hepatology"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.2337\/dc11-1511","article-title":"Risk of Parkinson disease onset in patients with diabetes: A 9-year population-based cohort study with age and sex stratifications","volume":"35","author":"Sun","year":"2012","journal-title":"Diabetes Care"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/0021-9681(58)90126-7","article-title":"Maximum utilization of the life table method in analyzing survival","volume":"8","author":"Cutler","year":"1958","journal-title":"J. Chronic Dis."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1111\/dmcn.13341","article-title":"Completeness and correctness of cerebral palsy diagnoses in two health registers: Implications for estimating prevalence","volume":"59","author":"Hollung","year":"2017","journal-title":"Dev. Med. Child. Neurol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.ridd.2014.10.001","article-title":"Estimating the prevalence of cerebral palsy in Taiwan: A comparison of difference case definitions","volume":"36","author":"Chang","year":"2015","journal-title":"Res. Dev. Disabil."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jpeds.2019.09.035","article-title":"Current referral practices for diagnosis and intervention for children with cerebral palsy: A national environment scan","volume":"216","author":"Boychuck","year":"2020","journal-title":"J. Pediatr."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e1584","DOI":"10.1542\/peds.2014-0945","article-title":"Cerebral palsy among children born moderately and late preterm","volume":"134","author":"Hirvonen","year":"2014","journal-title":"Pediatrics"},{"key":"ref_27","unstructured":"(2021, March 18). Health Promotion Administration, Ministry of Health and Welfare in Taiwan, Available online: https:\/\/www.hpa.gov.tw\/Pages\/EBook.aspx?nodeid=1139."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1001\/jamapediatrics.2017.1689","article-title":"Early, accurate diagnosis and early intervention in cerebral palsy: Advances in diagnosis and treatment","volume":"171","author":"Novak","year":"2017","journal-title":"JAMA Pediatr."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/18\/17\/8984\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:52:25Z","timestamp":1760165545000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/18\/17\/8984"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,26]]},"references-count":28,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2021,9]]}},"alternative-id":["ijerph18178984"],"URL":"https:\/\/doi.org\/10.3390\/ijerph18178984","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,26]]}}}