{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T03:16:46Z","timestamp":1781061406060,"version":"3.54.1"},"reference-count":26,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2021,8,26]],"date-time":"2021-08-26T00:00:00Z","timestamp":1629936000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Background: Breast cancer is the most prevalent cancer affecting women and it represents an important economic burden. The aim of this study was to estimate the socio-economic burden of breast cancer (BC) in Italy both from the National Health Service (NHS) and the government perspectives (costs borne by the social security system). Methods: The economic analysis was based on the costs incurred by the NHS from 2008 to 2016 (direct costs related to hospitalizations) and by the National Social Security Institute (INPS) from 2009 to 2015 (costs of social security benefits) for patients with breast cancer. The analysis was based on the Hospital Information System (HIS) and Disability Insurance Awards databases. For both databases, patients affected by a malignant neoplasm of the female breast, carcinoma in situ, or secondary malignant neoplasm of the breast were considered. Results: Results show that more than 75,000 women were hospitalized for breast cancer every year, with an overall cost for hospitalization of about \u20ac300 million per year. From the Social Security analysis, a number of 29,000 beneficiaries each year was estimated. Considering per patient social costs, breast cancer at the primary stage cost \u20ac8828 per year, while secondary neoplasms cost \u20ac9780, with an average total economic burden of \u20ac257 million per year. Conclusions: This analysis focused on the economic impact of breast cancer in Italy, showing that an advanced stage of the disease was associated with a higher cost.<\/jats:p>","DOI":"10.3390\/ijerph18179005","type":"journal-article","created":{"date-parts":[[2021,8,26]],"date-time":"2021-08-26T09:27:57Z","timestamp":1629970077000},"page":"9005","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["An Analysis of the Social and Economic Costs of Breast Cancer in Italy"],"prefix":"10.3390","volume":"18","author":[{"given":"Francesco Saverio","family":"Mennini","sequence":"first","affiliation":[{"name":"EEHTA-CEIS, DEF Department, Faculty of Economics, University of Rome \u201cTor Vergata\u201d, 00133 Rome, Italy"},{"name":"Institute for Leadership and Management in Health, Kingston University, London KT1 2EE, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2327-1455","authenticated-orcid":false,"given":"Marco","family":"Trabucco Aurilio","sequence":"additional","affiliation":[{"name":"Department of Medicine and Health Sciences \u201cV. Tiberio\u201d, University of Molise, 86100 Campobasso, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Gazzillo","sequence":"additional","affiliation":[{"name":"EEHTA-CEIS, DEF Department, Faculty of Economics, University of Rome \u201cTor Vergata\u201d, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Nardone","sequence":"additional","affiliation":[{"name":"EEHTA-CEIS, DEF Department, Faculty of Economics, University of Rome \u201cTor Vergata\u201d, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Sciattella","sequence":"additional","affiliation":[{"name":"EEHTA-CEIS, DEF Department, Faculty of Economics, University of Rome \u201cTor Vergata\u201d, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Marcellusi","sequence":"additional","affiliation":[{"name":"EEHTA-CEIS, DEF Department, Faculty of Economics, University of Rome \u201cTor Vergata\u201d, 00133 Rome, Italy"},{"name":"Institute for Leadership and Management in Health, Kingston University, London KT1 2EE, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Migliorini","sequence":"additional","affiliation":[{"name":"Office of Medical Forensic Coordination, Italian National Social Security Institute (INPS), 0144 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerio","family":"Sciannamea","sequence":"additional","affiliation":[{"name":"Office of Medical Forensic Coordination, Italian National Social Security Institute (INPS), 0144 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5703-8737","authenticated-orcid":false,"given":"Andrea","family":"Piccioni","sequence":"additional","affiliation":[{"name":"Emergency Medicine, Gemelli, IRCCS (Scientific Institute for Hospitalization and Treatment), 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8784-8463","authenticated-orcid":false,"given":"Matteo","family":"Bolcato","sequence":"additional","affiliation":[{"name":"Legal Medicine, University of Padua, Via G. Falloppio 50, 35121 Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandro","family":"Barni","sequence":"additional","affiliation":[{"name":"Local Health Unit\u2014ASST Bergamo Ovest, 24047 Treviglio, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,26]]},"reference":[{"key":"ref_1","unstructured":"Istituto Superiore di Sanit\u00e0 (2021, April 02). The Figures of Cancer in Italy 2019. 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