{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T09:32:14Z","timestamp":1760866334192,"version":"build-2065373602"},"reference-count":30,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T00:00:00Z","timestamp":1630022400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>The objective of this study was to assess whether the standard therapy of ready-to-use therapeutic food in the treatment of uncomplicated severe acute malnutrition (SAM) is effective in improving developmental potential and weight gain in children aged under five years. A multicenter pretest-posttest study was conducted among 91 children aged under five with uncomplicated SAM in Pakistan. Study participants completed their eight weeks\u2019 therapy of ready-to-use therapeutic food according to the World Health Organization\u2019s (WHO) standard guidelines. The study outcome was the proportion of children with improved developmental potential in all domains in comparison with the pretreatment status and children gaining &gt;15% of their baseline weight; mean weight-for-height\/length z-score after completing eight weeks\u2019 therapy of ready-to-use therapeutic food. The Denver Development Screening Tool II was used for developmental screening. Significant changes (p &lt; 0.05) were observed for developmental status milestones in terms of gross motor, fine motor, and personal\/social milestones, as well as language and global development milestones. There was a strong positive correlation (r = 0.961) between initial weight and weight at the last visit (p &lt; 0.001). Ready-to-use therapeutic food is effective in improving development potential as well as promoting weight gain in children aged under five with uncomplicated SAM if provided according to WHO guidelines.<\/jats:p>","DOI":"10.3390\/ijerph18179060","type":"journal-article","created":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T09:53:23Z","timestamp":1630058003000},"page":"9060","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effectiveness of Ready-to-Use Therapeutic Food in Improving the Developmental Potential and Weight of Children Aged under Five with Severe Acute Malnourishment in Pakistan: A Pretest-Posttest Study"],"prefix":"10.3390","volume":"18","author":[{"given":"Javeria","family":"Saleem","sequence":"first","affiliation":[{"name":"Department of Public Health, University of the Punjab, Lahore 54590, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9546-3742","authenticated-orcid":false,"given":"Rubeena","family":"Zakar","sequence":"additional","affiliation":[{"name":"Department of Public Health, University of the Punjab, Lahore 54590, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gul Mehar Javaid","family":"Bukhari","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, Federal Medical and Dental College, Islamabad 44000, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahwish","family":"Naz","sequence":"additional","affiliation":[{"name":"Department of Primary and Secondary Health, Government of Punjab, Lahore 54000, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5896-4433","authenticated-orcid":false,"given":"Faisal","family":"Mushtaq","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Institute of Public Health, Lahore 54000, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4388-1245","authenticated-orcid":false,"given":"Florian","family":"Fischer","sequence":"additional","affiliation":[{"name":"Institute of Public Health, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, 10117 Berlin, Germany"},{"name":"Institute of Gerontological Health Services and Nursing Research, Ravensburg-Weingarten University of Applied Sciences, 88250 Weingarten, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,27]]},"reference":[{"key":"ref_1","unstructured":"UNICEF (2021). 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