{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:56:22Z","timestamp":1790193382086,"version":"4.1.0"},"reference-count":37,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T00:00:00Z","timestamp":1630022400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Center of Excellence on Hazardous Substance Management (HSM) and Faculty of Engineering, Chiang Mai University","award":["No Grant Number"],"award-info":[{"award-number":["No Grant Number"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>The formation of trihalomethanes (THMs) in natural and treated water from water supply systems is an urgent research area due to the carcinogenic risk they pose. Seasonal effects and pH have captured interest as potential factors affecting THM formation in the water supply and distribution systems. We investigated THM occurrence in the water supply chain, including raw and treated water from water treatment plants (coagulation, sedimentation, sand filtration, ClO2-disinfection processes, and distribution pipelines) in the Chiang Mai municipality, particularly the educational institute area. The effects of two seasons, rainy (September\u2013November 2019) and dry (December 2019\u2013February 2020), acted as surrogates for the water quality profile and THM occurrence. The results showed that humic acid was the main aromatic and organic compound in all the water samples. In the raw water sample, we found a correlation between surrogate organic compounds, including SUVA and dissolved organic carbon (DOC) (R2 = 0.9878). Four species of THMs were detected, including chloroform, bromodichloromethane, dibromochloromethane, and bromoform. Chloroform was the dominant species among the THMs. The highest concentration of total THMs was 189.52 \u03bcg\/L. The concentration of THMs tended to increase after chlorination when chlorine dioxide and organic compounds reacted in water. The effect of pH on the formation of TTHMs was also indicated during the study. TTHM concentrations trended lower with a pH \u2264 7 than with a pH \u2265 8 during the sampling periods. Finally, in terms of health concerns, the concentration of TTHMs was considered safe for consumption because it was below the standard (&lt;1.0) of WHO\u2019s Guideline Values (GVs).<\/jats:p>","DOI":"10.3390\/ijerph18179066","type":"journal-article","created":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T09:53:23Z","timestamp":1630058003000},"page":"9066","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Trihalomethanes in Water Supply System and Water Distribution Networks"],"prefix":"10.3390","volume":"18","author":[{"given":"Sornsiri","family":"Sriboonnak","sequence":"first","affiliation":[{"name":"Ph.D.\u2019s Degree Program in Environmental Engineering, Faculty of Engineering, Chiang Mai University, Chiang Mai 50200, Thailand"},{"name":"Graduate School, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phacharapol","family":"Induvesa","sequence":"additional","affiliation":[{"name":"Bodhivijjalaya College, Srinakharinwirot University, Nakhon Nayok 26120, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suraphong","family":"Wattanachira","sequence":"additional","affiliation":[{"name":"Department of Environmental Engineering, Faculty of Engineering, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pharkphum","family":"Rakruam","sequence":"additional","affiliation":[{"name":"Department of Environmental Engineering, Faculty of Engineering, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adisak","family":"Siyasukh","sequence":"additional","affiliation":[{"name":"Department of Industrial Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1866-3641","authenticated-orcid":false,"given":"Chayakorn","family":"Pumas","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand"},{"name":"Research Center in Bioresources for Agriculture, Industry and Medicine, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9180-3949","authenticated-orcid":false,"given":"Aunnop","family":"Wongrueng","sequence":"additional","affiliation":[{"name":"Department of Environmental Engineering, Faculty of Engineering, Chiang Mai University, Chiang Mai 50200, Thailand"},{"name":"Research Center in Bioresources for Agriculture, Industry and Medicine, Chiang Mai University, Chiang Mai 50200, Thailand"},{"name":"Research Program in Control of Hazardous Contaminants in Raw Water Resources for Water Scarcity Resilience, Center of Excellence on Hazardous Substance Management, Bangkok 10330, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6729-2170","authenticated-orcid":false,"given":"Eakalak","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Civil and Environmental Engineering and Construction, University of Nevada, Las Vegas, NV 89154, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,27]]},"reference":[{"key":"ref_1","unstructured":"(2021, August 12). The Population in Thailand. Available online: https:\/\/stat.bora.dopa.go.th."},{"key":"ref_2","unstructured":"(2021, August 12). The Quantity of Production Water in Thailand. Available online: https:\/\/www.mwa.co.th."},{"key":"ref_3","unstructured":"James, E., and American Water Works Association (2011). Water Quality & Treatment: A Handbook on Drinking Water, McGraw Hill Education. [6th ed.]."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"18A","DOI":"10.1021\/es032333c","article-title":"Peer Reviewed: Characterizing Aquatic Dissolved Organic Matter","volume":"37","author":"Leenheer","year":"2003","journal-title":"Environ. Sci. Technol."},{"key":"ref_5","unstructured":"World Health Organization (2011). Guidelines for Drinking-Water Quality, World Health Organization. [4th ed.]."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1080\/15287397809529712","article-title":"Residue organic mixtures from drinking water show in vitro mutagenic and transforming activity","volume":"4","author":"Loper","year":"1978","journal-title":"J. Toxicol. Environ. Health"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.mrgentox.2011.11.004","article-title":"Comparison of DNA damage in human-derived he-patoma line (HepG2) exposed to the fifteen drinking water disinfection byproducts using the single cell gel electrophoresis assay","volume":"741","author":"Zhang","year":"2011","journal-title":"Mutat. Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.mrrev.2007.09.001","article-title":"Occurrence, genotoxicity, and carcinogenicity of regulated and emerging disinfection by-products in drinking water: A review and roadmap for research","volume":"636","author":"Richardson","year":"2007","journal-title":"Mutat. Res. Mutat. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1021\/es071754h","article-title":"Occurrence, Synthesis, and Mammalian Cell Cytotoxicity and Genotoxicity of Haloacetamides: An Emerging Class of Nitrogenous Drinking Water Disinfection Byproducts","volume":"42","author":"Plewa","year":"2007","journal-title":"Environ. Sci. Technol."},{"key":"ref_10","unstructured":"(2020, March 08). Six Year Review 3 Technical Support Document for Disinfectants\/Disinfection Byproducts Rules, Available online: https:\/\/www.epa.gov\/sites\/production\/files\/2016-12\/documents\/810r16012.pdf."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1186\/1471-2407-14-445","article-title":"Colon and rectal cancer incidence and water trihalomethane concentrations in New South Wales, Australia","volume":"14","author":"Rahman","year":"2014","journal-title":"BMC Cancer"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"125999","DOI":"10.1016\/j.chemosphere.2020.125999","article-title":"Radial basis function artificial neural network able to accurately predict disinfection by-product levels in tap water: Taking haloacetic acids as a case study","volume":"248","author":"Lin","year":"2020","journal-title":"Chemosphere"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"067010","DOI":"10.1289\/EHP89","article-title":"Bladder cancer and water disinfection by-product exposures through multiple routes: A popu-lation-based case-control study (New England, USA)","volume":"125","author":"Cantor","year":"2017","journal-title":"Environ. Health Persp."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1093\/aje\/kwj364","article-title":"Bladder Cancer and Exposure to Water Disinfection By-Products through Ingestion, Bathing, Showering, and Swimming in Pools","volume":"165","author":"Villanueva","year":"2006","journal-title":"Am. J. Epidemiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.jes.2019.10.007","article-title":"Disinfection byproducts and halogen-specific total organic halogen speciation in chlorinated source waters\u2014The impact of iopamidol and bromide","volume":"89","author":"Ackerson","year":"2019","journal-title":"J. Environ. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.watres.2017.11.055","article-title":"The influence of precursors and treatment process on the formation of Iodo-THMs in Canadian drinking water","volume":"130","author":"Tugulea","year":"2018","journal-title":"Water Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.scitotenv.2017.03.032","article-title":"Bromine incorporation into five DBP classes upon chlorination of water with extremely low SUVA values","volume":"590\u2013591","author":"Hong","year":"2017","journal-title":"Sci. Total. Environ."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.jhazmat.2013.06.044","article-title":"Formation and speciation of nine haloacetamides, an emerging class of nitrogenous DBPs, during chlorination or chloramination","volume":"260","author":"Chu","year":"2013","journal-title":"J. Hazard. Mater."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1016\/j.chemosphere.2012.12.014","article-title":"Formation of disinfection byproducts upon chlorine dioxide preoxidation followed by chlo-rination or chloramination of natural organic matter","volume":"91","author":"Yang","year":"2013","journal-title":"Chemosphere"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.scitotenv.2013.09.106","article-title":"Examining the Interrelationship between DOC, Bromide and Chlorine Dose on DBP Formation in Drinking Water\u2014A Case Study","volume":"470\u2013471","author":"Bond","year":"2014","journal-title":"Sci. Total. Environ."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"10868","DOI":"10.1021\/es401841t","article-title":"Comparative Developmental Toxicity of New Aromatic Halogenated DBPs in a Chlorinated Saline Sewage Effluent to the Marine PolychaetePlatynereis dumerilii","volume":"47","author":"Yang","year":"2013","journal-title":"Environ. Sci. Technol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1023\/A:1005265509813","article-title":"Identification of New Drinking Water Disinfection by\u2014Products from Ozone, Chlorine Dioxide, Chloramine, and Chlorine","volume":"123","author":"Richardson","year":"2000","journal-title":"Water Air Soil Pollut."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/S0043-1354(01)00194-4","article-title":"Development of chlorine dioxide-related by-product models for drinking water treatment","volume":"36","author":"Korn","year":"2002","journal-title":"Water Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/aheh.200200515","article-title":"Using Chlorine Dioxide for Drinking Water Disinfection by the Application of the Chlorite\/Chlorine Process","volume":"32","author":"Schmidt","year":"2004","journal-title":"Acta Hydrochim. Hydrobiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.2166\/ws.2019.049","article-title":"Occurrence of trihalomethanes and haloacetonitriles in water distribution networks of Khon Kaen Municipality, Thailand","volume":"19","author":"Ratpukdi","year":"2019","journal-title":"Water Supply"},{"key":"ref_26","unstructured":"(2020, March 08). Chiang Mai University Map. Available online: https:\/\/moovitapp.com."},{"key":"ref_27","unstructured":"APHA, AWWA, and WPCF (2012). Standard Methods for the Examination of Water and Wastewater, American Water Works Association. [22nd ed.]."},{"key":"ref_28","unstructured":"(1995). USEPA Method 551.1, Determination of Chlorination Disinfection Byproducts, Chlorinated Solvents and Halogenated Pesticides\/Herbicides in Drinking Water by Liquid-Liquid Extraction and Gas Chromotography with Electron Capture Detection, Revision 1.0."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.2166\/ws.2017.235","article-title":"Investigation of humic acids concentration in different seasons in a raw water canal, Bangkok, Thailand","volume":"18","author":"Tungsudjawong","year":"2017","journal-title":"Water Supply"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"3361","DOI":"10.1016\/j.watres.2008.04.017","article-title":"Mechanism of natural organic matter removal by polyaluminum chloride: Effect of coagulant particle size and hydrolysis kinetics","volume":"42","author":"Yan","year":"2008","journal-title":"Water Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.seppur.2009.05.021","article-title":"Natural organic matter (NOM) removal in a typical North-China water plant by enhanced coagulation: Targets and techniques","volume":"68","author":"Yan","year":"2009","journal-title":"Sep. Purif. Technol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"S1951","DOI":"10.1016\/j.arabjc.2015.08.031","article-title":"Evaluating the removal of organic fraction of commingled chemical industrial wastewater by activated sludge process augmented with powdered activated carbon","volume":"9","author":"Wang","year":"2016","journal-title":"Arab. J. Chem."},{"key":"ref_33","unstructured":"American Water Works Association (1993). Characterization of Natural Organic Matter and Its Relationship to Treatability, AWWARF and AWWA. [1st ed.]."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1002\/j.1551-8833.1995.tb06320.x","article-title":"Measuring UV-absorbing organics: A standard method","volume":"87","author":"Eaton","year":"1995","journal-title":"J. Am. Water Work. Assoc."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"5701","DOI":"10.1021\/es034354c","article-title":"Fluorescence Excitation\u2212Emission Matrix Regional Integration to Quantify Spectra for Dissolved Organic Matter","volume":"37","author":"Chen","year":"2003","journal-title":"Environ. Sci. Technol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.ecoenv.2018.12.106","article-title":"Factors influencing DBPs occurrence in tap water of Jinhua Region in Zhejiang Province, China","volume":"171","author":"Zhou","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2914","DOI":"10.1016\/S2095-3119(17)61798-2","article-title":"pH effect on the formation of THM and HAA disinfection byproducts and potential control strategies for food processing","volume":"16","author":"Hung","year":"2017","journal-title":"J. Integr. Agric."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/18\/17\/9066\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:53:52Z","timestamp":1760165632000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/18\/17\/9066"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,27]]},"references-count":37,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2021,9]]}},"alternative-id":["ijerph18179066"],"URL":"https:\/\/doi.org\/10.3390\/ijerph18179066","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,27]]}}}