{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:52:47Z","timestamp":1790646767949,"version":"4.1.0"},"reference-count":79,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T00:00:00Z","timestamp":1630540800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Human breast milk is the most complete foodstuff for infants but can also be a potential source of exposure to toxic chemicals. The aim of this study was to assess the levels of metal pollution in the breast milk of women living in agricultural and industrial\/mining areas of the Region of Murcia (Spain) that are well known for their cases of environmental pollution. Human milk samples were collected from 50 mothers and inorganic contaminants were analyzed using inductively coupled plasma mass spectrometry (ICP-MS). The mean or maximum concentrations of the different inorganic elements analyzed in breast milk, with the exception of manganese, exceeded the maximum limits established by the WHO and could constitute a high risk for pregnant mothers and their children. The breast milk of women living in the industrial\/mining zone presented the highest levels of aluminum, zinc, arsenic, lead, mercury and nickel. On the contrary, the highest concentrations of manganese, chromium and iron were determined in the milk of women living in the agricultural zone. These results suggested and confirmed different profiles of environmental contamination of these areas.<\/jats:p>","DOI":"10.3390\/ijerph18179289","type":"journal-article","created":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T21:13:36Z","timestamp":1630617216000},"page":"9289","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":79,"title":["Heavy Metals and Trace Elements in Human Breast Milk from Industrial\/Mining and Agricultural Zones of Southeastern Spain"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2229-7779","authenticated-orcid":false,"given":"Miguel","family":"Motas","sequence":"first","affiliation":[{"name":"Department of Toxicology, Regional Campus of International Excellence \u201cCampus Mare Nostrum\u201d, Faculty of Veterinary, Campus of Espinardo, University of Murcia, 30100 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Department of Toxicology, Regional Campus of International Excellence \u201cCampus Mare Nostrum\u201d, Faculty of Veterinary, Campus of Espinardo, University of Murcia, 30100 Murcia, Spain"},{"name":"Department of Legal and Forensic Medicine, Biomedical Research Institute (IMIB), Regional Campus of International Excellence \u201cCampus Mare Nostrum\u201d, Faculty of Medicine, University of Murcia, 30100 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Oliva","sequence":"additional","affiliation":[{"name":"Department of Agricultural Chemistry, Regional Campus of International Excellence \u201cCampus Mare Nostrum\u201d, Faculty of Chemistry, Campus of Espinardo, University of Murcia, 30100 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel \u00c1ngel","family":"C\u00e1mara","sequence":"additional","affiliation":[{"name":"Department of Agricultural Chemistry, Regional Campus of International Excellence \u201cCampus Mare Nostrum\u201d, Faculty of Chemistry, Campus of Espinardo, University of Murcia, 30100 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1879-2969","authenticated-orcid":false,"given":"Mar\u00eda Dolores","family":"P\u00e9rez-C\u00e1rceles","sequence":"additional","affiliation":[{"name":"Department of Legal and Forensic Medicine, Biomedical Research Institute (IMIB), Regional Campus of International Excellence \u201cCampus Mare Nostrum\u201d, Faculty of Medicine, University of Murcia, 30100 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,2]]},"reference":[{"key":"ref_1","unstructured":"WHO (2021, March 29). Guideline: Counselling of Women to Improve Breastfeeding Practices, Available online: https:\/\/www.who.int\/publications\/i\/item\/9789241550468."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1542\/peds.111.5.e580","article-title":"Breastfeeding, exposure to organochlorine compounds, and neurodevelopment in infants","volume":"111","author":"Cardo","year":"2003","journal-title":"Pediatrics"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1017\/S0012162204000647","article-title":"Prenatal exposure to polychlorinated biphenyls and breastfeeding: Opposing effects on auditory P300 latencies in 9-year-old Dutch children","volume":"46","author":"Vreugdenhil","year":"2004","journal-title":"Dev. Med. Child. Neurol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1289\/ehp.116-a426","article-title":"Contaminants in human milk: Weighing the risks against the benefits of breastfeeding","volume":"116","author":"Mead","year":"2008","journal-title":"Environ. Health Perspect."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1289\/ehp.021100317","article-title":"Analytic considerations for measuring environmental chemicals in breast milk","volume":"110","author":"Needham","year":"2002","journal-title":"Environ. Health Perspect."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1289\/ehp.021100339","article-title":"Chemical Contaminants in Breast Milk: Time Trends and Regional Variability","volume":"110","author":"Solomon","year":"2002","journal-title":"Environ. Health Perspect."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.ijheh.2007.01.005","article-title":"Human biomonitoring system in the Czech Republic","volume":"210","author":"Cerna","year":"2007","journal-title":"Int. Environ. Health"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"7405","DOI":"10.1007\/s11356-019-04141-1","article-title":"The impact of environmental pollution on the quality of mother\u2019s milk","volume":"26","year":"2019","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Obeng-Gyasi, E. (2018). Lead exposure and oxidative stress\u2014A life course approach in US adults. Toxics, 6.","DOI":"10.3390\/toxics6030042"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1136\/jech.57.10.778","article-title":"Life course epidemiology","volume":"57","author":"Kuh","year":"2003","journal-title":"J. Epidemiol. Community Health"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1080\/00039890109604466","article-title":"Cancer risk associated with residential proximity to industrial sites: A review","volume":"56","author":"Benedetti","year":"2001","journal-title":"Arch. Environ. Health"},{"key":"ref_12","first-page":"199","article-title":"Assessment of damage to ecosystems: A major issue in ecotoxicological research","volume":"5","author":"Ramade","year":"1997","journal-title":"Qual. Assur."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.chemosphere.2005.08.017","article-title":"Lead, cadmium and arsenic bioavailability in the abandoned mine site of Cabezo Rajao (Murcia, SE Spain)","volume":"63","author":"Navarro","year":"2006","journal-title":"Chemosphere"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1093\/clinchem\/34.3.474","article-title":"Trace elements in human clinical specimens: Evaluation of literature data to identify reference values","volume":"34","author":"Iyengar","year":"1988","journal-title":"Clin. Chem."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Casey, C., Smith, A., Zhang, P., and Jensen, R. (1995). Microminerals in human and animal milks. Handbook of Milk Composition, Academic Press.","DOI":"10.1016\/B978-012384430-9\/50027-5"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1289\/ehp.6615","article-title":"Levels of lead in breast milk and their relation to maternal blood and bone lead levels at one month postpartum","volume":"112","author":"Ettinger","year":"2004","journal-title":"Environ. Health Perspect."},{"key":"ref_17","unstructured":"WHO (2007). Fourth WHO-Coordinated Survey of Human Milk for Persistent Organic Pollutants in Cooperation with UNEP; Guidelines for Developing a National Protocol, World Health Organization."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.chemosphere.2009.10.062","article-title":"Accumulation and tissue distribution of heavy metals and essential elements in loggerhead turtles (Caretta caretta) from Spanish Mediterranean coastline of Murcia","volume":"78","author":"Jerez","year":"2010","journal-title":"Chemosphere"},{"key":"ref_19","unstructured":"WHO (1989). Minor and Trace Elements in Breast Milk: Report of a Joint W.H.O., World Health Organization."},{"key":"ref_20","unstructured":"WHO Infant (2021, March 29). Standards: WHO Child Growth Standards\/Weight-for-Age; WHO. Available online: https:\/\/www.who.int\/tools\/child-growth-standards\/standards\/weight-for-age."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1055\/s-0034-1370343","article-title":"Maternal-child transfer of essential and toxic elements through breast milk in a mine-waste polluted area","volume":"31","author":"Castro","year":"2014","journal-title":"Am. J. Perinatol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.chemosphere.2005.01.084","article-title":"Toxic and essential trace elements in human milk from Greek lactating women: Association with dietary habits and other factors","volume":"61","author":"Leotsinidis","year":"2005","journal-title":"Chemosphere"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1080\/02652030500135201","article-title":"Cadmium, lead and mercury in human milk from Slovakia","volume":"22","author":"Ursinyova","year":"2005","journal-title":"Food Addit. Contam."},{"key":"ref_24","first-page":"92","article-title":"Metals and trace element concentrations in breast milk of first time healthy mothers: A biological monitoring study","volume":"11","author":"Vahter","year":"2012","journal-title":"Environ. Health Glob. Access Sci. Source"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1007\/s002170050395","article-title":"Concentrations of cadmium and lead in different types of milk","volume":"208","author":"Delgado","year":"1999","journal-title":"Unters"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.jtemb.2008.03.007","article-title":"Trace elements in human milk: Correlation with blood levels, inter-element correlations and changes in concentration during the first month of lactation","volume":"22","author":"Almeida","year":"2008","journal-title":"J. Trace Elem. Med. Biol. Organ. Soc. Miner. Trace Elem. (GMS)"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.chemosphere.2007.12.036","article-title":"Persistent environmental contaminants in human milk: Concentrations and time trends in Italy","volume":"73","author":"Abballe","year":"2008","journal-title":"Chemosphere"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1289\/ehp.1307187","article-title":"Maternal blood, plasma, and breast milk lead: Lactational transfer and contribution to infant exposure","volume":"122","author":"Ettinger","year":"2014","journal-title":"Environ. Health Perspect."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"EFSA (2010). Panel on Contaminants in the Food Chain (CONTAM); Scientific Opinion on Lead in Food. EFSA J., 8, 151.","DOI":"10.2903\/j.efsa.2010.1570"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s12011-013-9870-x","article-title":"Cadmium, lead, copper and zinc in breast milk in Poland","volume":"157","year":"2014","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.chemosphere.2017.10.111","article-title":"Lead, cadmium and arsenic in human milk and their socio-demographic and lifestyle determinants in Lebanon","volume":"191","author":"Bassil","year":"2018","journal-title":"Chemosphere"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"109733","DOI":"10.1016\/j.envres.2020.109733","article-title":"Essential and toxic elements in human milk concentrate with human milk lyophilizate: A preclinical study","volume":"188","author":"Oliveira","year":"2020","journal-title":"Environ. Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/0-306-46830-1_40","article-title":"Human milk mercury (Hg) and lead (Pb) levels in Vienna","volume":"478","author":"Gundacker","year":"2000","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1542\/peds.110.5.873","article-title":"Lead and mercury in breast milk","volume":"110","author":"Gundacker","year":"2002","journal-title":"Pediatrics"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/BF02785388","article-title":"Mercury from maternal \u00absilver\u00bb tooth fillings in sheep and human breast milk. A source of neonatal exposure","volume":"56","author":"Vimy","year":"1997","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/BF02990130","article-title":"Selenium, cadmium, lead, and mercury concentrations in human breast milk, in placenta, maternal blood, and the blood of the newborn","volume":"15","author":"Schramel","year":"1988","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1006\/enrs.1997.3813","article-title":"The mercury concentration in breast milk resulting from amalgam fillings and dietary habits","volume":"77","author":"Drexler","year":"1998","journal-title":"Environ. Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1080\/00039896.1996.9936021","article-title":"Total and inorganic mercury in breast milk in relation to fish consumption and amalgam in lactating women","volume":"51","author":"Oskarsson","year":"1996","journal-title":"Arch. Environ. Health"},{"key":"ref_39","unstructured":"Uhn\u00e1k, J., Ursinyova, M., Veningerova, M., Prachar, V., Rosival, L., and Hladikova, V. (1994). Evaluation of Impact of Chemical Substances on Health of Children, Final Report of the Research Project, Institute of Preventive and Clinical Medicine Bratislava."},{"key":"ref_40","first-page":"1","article-title":"Maternal and environmental determinants of breast-milk mercury concentrations","volume":"52","year":"2010","journal-title":"Turk. J. Pediatr."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s12011-016-0750-z","article-title":"Assessment of Aflatoxin M1 and Heavy Metal Levels in Mothers Breast Milk in Famagusta, Cyprus","volume":"175","author":"Kunter","year":"2017","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1385\/BTER:79:3:221","article-title":"Selenium, zinc, and copper concentrations in the blood and milk of lactating women","volume":"79","author":"Wasowicz","year":"2001","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1385\/BTER:96:1-3:21","article-title":"Heavy metal concentrations in the breast milk of Saudi women","volume":"96","author":"Shinwari","year":"2003","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"249","DOI":"10.3923\/pjn.2011.249.253","article-title":"Concentrations of some biochemical parameters in breast milk of a population of Nigerian nursing mothers using hormonal contraceptives","volume":"10","author":"Adesiyan","year":"2011","journal-title":"Pak. J. Nutr."},{"key":"ref_45","first-page":"1784073","article-title":"Analyses of Essential Elements and Heavy Metals by Using ICP-MS in Maternal Breast Milk from \u015eanl\u0131urfa, Turkey","volume":"2018","author":"Paksoy","year":"2018","journal-title":"Int. J. Anal. Chem."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"3075","DOI":"10.1016\/j.scitotenv.2018.10.059","article-title":"Exposure to heavy metals released to the environment through breastfeeding: A probabilistic risk estimation","volume":"650 (Pt. 2)","author":"Samiee","year":"2019","journal-title":"Sci. Total Environ."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/BF03032674","article-title":"Minor and trace elements in human milk from Guatemala, Hungary, Nigeria, Philippines, Sweden, and Zaire. Results from a WHO\/IAEA joint project","volume":"29","author":"Parr","year":"1991","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1385\/BTER:76:3:217","article-title":"A study of factors that may influence the determination of copper, iron, and zinc in human milk during sampling and in sample individuals","volume":"76","author":"Silvestre","year":"2000","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_49","first-page":"90","article-title":"Calcium, magnesium, iron, zinc and copper, compositions of human milk from populations with cereal and \u00abenset\u00bb based diets","volume":"23","author":"Maru","year":"2013","journal-title":"Ethiop. J. Health Sci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"338","DOI":"10.3177\/jnsv.55.338","article-title":"Nutritional status of lactating mothers and their breast milk concentration of iron, zinc and copper in rural Vietnam","volume":"55","author":"Nakamori","year":"2009","journal-title":"J. Nutr. Sci. Vitaminol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1093\/ajcn\/45.5.921","article-title":"Studies in human lactation 3: Molybdenum and nickel in human milk during the first month of lactation","volume":"45","author":"Casey","year":"1987","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"234","DOI":"10.17305\/bjbms.2011.2556","article-title":"In which regions is breast-feeding safer from the impact of toxic elements from the environment?","volume":"11","author":"Cinar","year":"2011","journal-title":"Bosn. J. Basic Med. Sci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1093\/ajcn\/49.5.773","article-title":"Studies in human lactation: Secretion of zinc, copper, and manganese in human milk","volume":"49","author":"Casey","year":"1989","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/BF02784593","article-title":"Chromium content in human milk, cow\u2019s milk, and infant formulas","volume":"32","author":"Cocho","year":"1992","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1093\/ajcn\/57.4.519","article-title":"Breast milk chromium and its association with chromium intake, chromium excretion, and serum chromium","volume":"57","author":"Anderson","year":"1993","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1271\/bbb.80283","article-title":"Molybdenum and chromium concentrations in breast milk from Japanese women","volume":"72","author":"Yoshida","year":"2008","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_57","first-page":"504","article-title":"Determination of 24 minerals in human milk by inductively coupled plasma mass spectrometry with microwave digestion","volume":"42","author":"Sun","year":"2013","journal-title":"Wei Sheng Yan Jiu J. Hyg. Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/BF02788964","article-title":"Daily dietary intake of copper, zinc, and selenium of exclusively breast-fed infants of middle-class women in Burundi, Africa","volume":"49","author":"Robberecht","year":"1995","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0946-672X(98)80005-9","article-title":"Changes in the concentrations of trace elements in human milk during lactation","volume":"12","author":"Krachler","year":"1998","journal-title":"J. Trace Elem. Med. Biol. Organ. Soc. Miner. Trace Elem. (GMS)"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0048-9697(99)00044-3","article-title":"Selenium contents of human milk and infant formulas in Spain","volume":"228","author":"Torres","year":"1999","journal-title":"Sci. Total Environ."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/BF02784398","article-title":"Selenium content of milk and milk products of Turkey. II","volume":"68","author":"Yanadarg","year":"1999","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_62","first-page":"599","article-title":"Longitudinal profile of human milk selenium from birth to 1 year","volume":"15","author":"Dylewski","year":"2001","journal-title":"FASEB"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1385\/BTER:107:1:011","article-title":"Copper, selenium, and zinc concentrations in human milk during the first three weeks of lactation","volume":"107","author":"Hannan","year":"2005","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1079\/BJN19890143","article-title":"Longitudinal manganese and copper balances in young infants and preterm infants fed on breast milk and adapted cow\u2019s milk formulas","volume":"61","author":"Dziadzka","year":"1989","journal-title":"Br. J. Nutr."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0048-9697(94)04314-D","article-title":"Copper, iron, manganese and zinc contents in human colostrum and transitory milk of French women","volume":"159","author":"Arnaud","year":"1995","journal-title":"Sci. Total Environ."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1016\/j.ecoenv.2008.12.001","article-title":"Integrative ecotoxicological assessment of sediment in Portm\u00e1n Bay (southeast Spain)","volume":"72","author":"Cesar","year":"2009","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2248","DOI":"10.1007\/s11368-017-1756-7","article-title":"Assessment of potentially toxic element contamination in soils from Portman Bay (SE, Spain)","volume":"18","year":"2018","journal-title":"J. Soils Sediments"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0048-9697(95)04702-4","article-title":"Aluminum levels in human milk","volume":"170","author":"Seruga","year":"1995","journal-title":"Sci. Total Environ."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1136\/oem.59.6.394","article-title":"Effects of maternal exposure to cadmium on pregnancy outcome and breast milk","volume":"59","author":"Nishijo","year":"2002","journal-title":"Occup. Environ. Med."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.chemosphere.2011.05.029","article-title":"Mercury, lead and cadmium in human milk in relation to diet, lifestyle habits and sociodemographic variables in Madrid (Spain)","volume":"85","author":"Gil","year":"2011","journal-title":"Chemosphere"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s10653-012-9480-0","article-title":"Correlation between lead levels in drinking water and mothers\u2019 breast milk: Dakahlia, Egypt","volume":"35","author":"Mandour","year":"2013","journal-title":"Environ. Geochem. Health"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.toxlet.2003.09.015","article-title":"Influence of body iron store status and cigarette smoking on cadmium body burden of healthy Thai women and men","volume":"148","author":"Satarug","year":"2004","journal-title":"Toxicol. Lett."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/sj.jes.7500518","article-title":"Smoking, cereal consumption, and supplementation affect cadmium content in breast milk","volume":"17","author":"Gundacker","year":"2007","journal-title":"J. Expo. Sci. Environ. Epidemiol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1016\/j.scitotenv.2011.02.035","article-title":"Breast milk lead and cadmium levels from suburban areas of Ankara","volume":"409","author":"Aykut","year":"2011","journal-title":"Sci. Total Environ."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.pedneo.2013.08.005","article-title":"Arsenic, cadmium, lead, and aluminium concentrations in human milk at early stages of lactation","volume":"55","author":"Chao","year":"2014","journal-title":"Pediatr. Neonatol."},{"key":"ref_76","first-page":"51","article-title":"Toxicolog\u00eda del cadmio. Conceptos actuales para evaluar exposici\u00f3n ambiental u ocupacional con indicadores biol\u00f3gicos","volume":"63","year":"2002","journal-title":"An. Fac. Med."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.5740\/jaoacint.12-450","article-title":"Arsenic content in smokeless tobacco products consumed by the population of Pakistan: Related health risk","volume":"97","author":"Arain","year":"2014","journal-title":"J. AOAC Int."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1093\/tropej\/47.2.81","article-title":"Determination of heavy metal contents in human colostrum samples by electrothermal atomic absorption spectrophotometry","volume":"47","author":"Turan","year":"2001","journal-title":"J. Trop Pediatr."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1289\/ehp.1003378","article-title":"Pre- and postnatal arsenic exposure and body size to 2 years of age: A cohort study in rural Bangladesh","volume":"120","author":"Saha","year":"2012","journal-title":"Environ. Health Perspect."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/18\/17\/9289\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:55:22Z","timestamp":1760165722000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/18\/17\/9289"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,2]]},"references-count":79,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2021,9]]}},"alternative-id":["ijerph18179289"],"URL":"https:\/\/doi.org\/10.3390\/ijerph18179289","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,2]]}}}