{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T21:57:31Z","timestamp":1779400651332,"version":"3.53.1"},"reference-count":50,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T00:00:00Z","timestamp":1630886400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Background: oral lichen planus (OLP) is a mucocutaneous disease that affects about 4% of the global population. Hepatitis C virus (HCV) was linked to lichen planus. The current study aimed to assess the impact of OLP associated or not with HCV infection on the oral health-related quality of life (OHRQoL). Methods: The study included patients diagnosed with OLP who filled in the Romanian version of OHIP-14 questionnaire at their first appointment and 6 months later, after the OLP treatment. A control group of OLP-free subjects similar as age and sex was also included in the study. Results: 68 patients with OLP and 46 controls were included in the study. The OHIP scores are significantly higher on OLP group than controls (p-value &lt; 0.0001) and significantly reduced at 6-month follow-up (p-values: &lt; 0.0001 pre- vs. post-treatment in OLP group). Patients with and without HCV associated with OLP demonstrated a similar oral quality of life (p-values &gt; 0.05). Conclusions: the OHRQoL for patients suffering from OLP is compromised but is improved after treatment. The HCV associated with OLP did not influence the overall OHRQoL, but the patients who associate HCV reported more frequently aching in the mouth and discomfort eating food at six-month follow-up.<\/jats:p>","DOI":"10.3390\/ijerph18179382","type":"journal-article","created":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T21:47:38Z","timestamp":1630964858000},"page":"9382","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Influence of Hepatitis C Virus Infection on ORAL Health-Related Quality of Life in Patients with Oral Lichen Planus"],"prefix":"10.3390","volume":"18","author":[{"given":"Doina Iulia","family":"Rotaru","sequence":"first","affiliation":[{"name":"Department of Odontology, Endodontics and Oral Pathology, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400001 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radu Marcel","family":"Chisnoiu","sequence":"additional","affiliation":[{"name":"Department of Odontology, Endodontics and Oral Pathology, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400001 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0774-8121","authenticated-orcid":false,"given":"Andreea Iuliana","family":"Kui","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2342-4311","authenticated-orcid":false,"given":"Sorana D.","family":"Bolboac\u0103","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics and Biostatistics, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3356-9178","authenticated-orcid":false,"given":"Andrea Maria","family":"Chisnoiu","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1111\/j.1601-0825.2005.01142.x","article-title":"Number V Oral lichen planus: Clinical features and management","volume":"11","author":"Eisen","year":"2005","journal-title":"Oral Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1054\/ijom.2002.0377","article-title":"Patient-centred outcome measures for oral mucosal disease are sensitive to treatment","volume":"32","author":"McGrath","year":"2003","journal-title":"Int. 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