{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:57:21Z","timestamp":1789016241393,"version":"build-2803163510"},"reference-count":61,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T00:00:00Z","timestamp":1631145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>This study investigated a model to assess the role of climate fluctuations on dengue (DENV) dynamics from 2010 to 2019 in four Brazilian municipalities. The proposed transmission model was based on a preexisting SEI-SIR model, but also incorporates the vector vertical transmission and the vector\u2019s egg compartment, thus allowing rainfall to be introduced to modulate egg-hatching. Temperature and rainfall satellite data throughout the decade were used as climatic model inputs. A sensitivity analysis was performed to understand the role of each parameter. The model-simulated scenario was compared to the observed dengue incidence and the findings indicate that the model was able to capture the observed seasonal dengue incidence pattern with good accuracy until 2016, although higher deviations were observed from 2016 to 2019. The results further demonstrate that vertical transmission fluctuations can affect attack transmission rates and patterns, suggesting the need to investigate the contribution of vertical transmission to dengue transmission dynamics in future assessments. The improved understanding of the relationship between different environment variables and dengue transmission achieved by the proposed model can contribute to public health policies regarding mosquito-borne diseases.<\/jats:p>","DOI":"10.3390\/ijerph18189493","type":"journal-article","created":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T12:20:37Z","timestamp":1631190037000},"page":"9493","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["A Framework for Weather-Driven Dengue Virus Transmission Dynamics in Different Brazilian Regions"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7836-0135","authenticated-orcid":false,"given":"Leon Diniz","family":"Alves","sequence":"first","affiliation":[{"name":"Centro Federal Celso Suckow da Fonseca, Rio de Janeiro 20271-110, Brazil"},{"name":"Computational Biology and Systems, Oswaldo Cruz Foundation, Rio de Janeiro 21040-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7573-1364","authenticated-orcid":false,"given":"Raquel Martins","family":"Lana","sequence":"additional","affiliation":[{"name":"Scientific Computing Program, Oswaldo Cruz Foundation, Rio de Janeiro 21040-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3868-4391","authenticated-orcid":false,"given":"Fl\u00e1vio Code\u00e7o","family":"Coelho","sequence":"additional","affiliation":[{"name":"School of Applied Mathematics, Getulio Vargas Foundation, Rio de Janeiro 22250-900, Brazil"},{"name":"Institute of Global Health, University of Geneva, 1205 Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.2149\/tmh.2011-S05","article-title":"Dengue, urbanization and globalization: The unholy trinity of the 21st century","volume":"39","author":"Gubler","year":"2011","journal-title":"Trop. Med. Health"},{"key":"ref_2","first-page":"424","article-title":"Aedes albopictus and arboviruses: A concise review of the literature","volume":"2","author":"DA","year":"1986","journal-title":"J. Am. Mosq. Control Assoc."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1093\/jmedent\/30.6.1018","article-title":"Dynamic life table model for Aedes aegypti (Diptera: Culicidae): Simulation results and validation","volume":"30","author":"Focks","year":"1993","journal-title":"J. Med. Entomol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1007\/s11538-006-9067-y","article-title":"A stochastic population dynamics model for Aedes aegypti: Formulation and application to a city with temperate climate","volume":"68","author":"Otero","year":"2006","journal-title":"Bull. Math. Biol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Lima, T., Carneiro, T., Silva, L., Lana, R., Code\u00e7o, C., Reis, I., Maretto, R., Santos, L., Monteiro, A.M., and Medeiros, L. (2014, January 7\u201310). A framework for modeling and simulating Aedes aegypti and dengue fever dynamics. Proceedings of the Winter Simulation Conference 2014, Savannah, GA, USA.","DOI":"10.1109\/WSC.2014.7020001"},{"key":"ref_6","first-page":"96","article-title":"A SIR model for spread of dengue fever disease (simulation for South Sulawesi, Indonesia and Selangor, Malaysia)","volume":"9","author":"Side","year":"2013","journal-title":"World J. Model. Simul."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Huber, J.H., Childs, M.L., Caldwell, J.M., and Mordecai, E.A. (2018). Seasonal temperature variation influences climate suitability for dengue, chikungunya, and Zika transmission. PLoS Negl. Trop. Dis., 12.","DOI":"10.1371\/journal.pntd.0006451"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"9861572","DOI":"10.1155\/2018\/9861572","article-title":"SIR model for dengue disease with effect of dengue vaccination","volume":"2018","author":"Chanprasopchai","year":"2018","journal-title":"Comput. Math. Methods Med."},{"key":"ref_9","first-page":"205","article-title":"Bioecologia do Aedes aegypti","volume":"64","author":"Natal","year":"2002","journal-title":"Biol\u00f3gico"},{"key":"ref_10","unstructured":"Nelson, M.J. (2021, June 25). Aedes Aegypti: Biology and Ecology. Available online: https:\/\/iris.paho.org\/handle\/10665.2\/28514."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Andraud, M., Hens, N., Marais, C., and Beutels, P. (2012). Dynamic epidemiological models for dengue transmission: A systematic review of structural approaches. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0049085"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"12","DOI":"10.5614\/cbms.2019.2.1.2","article-title":"Biological and mechanical transmission models of dengue fever","volume":"2","author":"Laura","year":"2019","journal-title":"Commun. Biomath. Sci."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1093\/jmedent\/27.5.892","article-title":"Temperature-dependent development and survival rates of Culex quinquefasciatus and Aedes aegypti (Diptera: Culicidae)","volume":"27","author":"Rueda","year":"1990","journal-title":"J. Med. Entomol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1046\/j.1365-2915.2000.00207.x","article-title":"Effects of temperature and larval diet on development rates and survival of the dengue vector Aedes aegypti in north Queensland, Australia","volume":"14","author":"Burkot","year":"2000","journal-title":"Med. Vet. Entomol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"143","DOI":"10.4269\/ajtmh.1987.36.143","article-title":"Effect of temperature on the vector efficiency of Aedes aegypti for dengue 2 virus","volume":"36","author":"Watts","year":"1987","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1186\/1475-2875-12-416","article-title":"Relative importance of climatic, geographic and socio-economic determinants of malaria in Malawi","volume":"12","author":"Lowe","year":"2013","journal-title":"Malar. J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1038\/s41564-019-0376-y","article-title":"Past and future spread of the arbovirus vectors Aedes aegypti and Aedes albopictus","volume":"4","author":"Kraemer","year":"2019","journal-title":"Nat. Microbiol."},{"key":"ref_18","first-page":"433","article-title":"Dry season survival of Aedes aegypti eggs in various breeding sites in the Dar es Salaam area, Tanzania","volume":"47","year":"1972","journal-title":"Bull. World Health Organ."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Hii, Y.L., Zhu, H., Ng, N., Ng, L.C., and Rockl\u00f6v, J. (2012). Forecast of dengue incidence using temperature and rainfall. PLoS Negl. Trop. Dis., 6.","DOI":"10.1371\/journal.pntd.0001908"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1603\/ME13047","article-title":"Vertical transmission of Key West dengue-1 virus by Aedes aegypti and Aedes albopictus (Diptera: Culicidae) mosquitoes from Florida","volume":"50","author":"Buckner","year":"2013","journal-title":"J. Med. Entomol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.epidem.2010.01.001","article-title":"How important is vertical transmission in mosquitoes for the persistence of dengue? Insights from a mathematical model","volume":"2","author":"Adams","year":"2010","journal-title":"Epidemics"},{"key":"ref_22","unstructured":"Pan American Health Organization (2020). Epidemiological Update: Dengue and other Arboviruses\u201410 June 2020. World Health Organ. Reg. Off. Am., 1, 15."},{"key":"ref_23","unstructured":"Pan American Health Organization (2019). Epidemiological Update Dengue, 11 November 2019. World Health Organ. Reg. Off. Am., 1, 15."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1550027","DOI":"10.1142\/S0218339015500278","article-title":"Assessing the effects of temperature and dengue virus load on dengue transmission","volume":"23","author":"Esteva","year":"2015","journal-title":"J. Biol. Syst."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"3981","DOI":"10.1590\/1413-812320172212.03522016","article-title":"Pendulum migration and healthcare in border area","volume":"22","author":"Zaslavsky","year":"2017","journal-title":"Ci\u00eancia Sa\u00fade Coletiva"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Magori, K., Legros, M., Puente, M.E., Focks, D.A., Scott, T.W., Lloyd, A.L., and Gould, F. (2009). Skeeter Buster: A stochastic, spatially explicit modeling tool for studying Aedes aegypti population replacement and population suppression strategies. PLoS Negl. Trop. Dis., 3.","DOI":"10.1371\/journal.pntd.0000508"},{"key":"ref_27","unstructured":"Do Estado do Rio de Janeiro, G. (2021, June 25). Informa\u00e7\u00f5es de Sa\u00fade, Available online: http:\/\/sistemas.saude.rj.gov.br\/tabnetbd\/dhx.exe?taxas\/sim_taxas_mortalidade_valores.def."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1093\/jmedent\/29.6.985","article-title":"Variation in the efficiency of vertical transmission of dengue-1 virus by strains of Aedes albopictus (Diptera: Culicidae)","volume":"29","author":"Bosio","year":"1992","journal-title":"J. Med. Entomol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"158","DOI":"10.4269\/ajtmh.2002.67.158","article-title":"Persistence of dengue-3 virus through transovarial transmission passage in successive generations of Aedes aegypti mosquitoes","volume":"67","author":"Joshi","year":"2002","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Lequime, S., Paul, R.E., and Lambrechts, L. (2016). Determinants of arbovirus vertical transmission in mosquitoes. PLoS Pathog., 12.","DOI":"10.1371\/journal.ppat.1005548"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1590\/0074-0276140136","article-title":"Estimation of Aedes aegypti (Diptera: Culicidae) population size and adult male survival in an urban area in Panama","volume":"109","author":"Neira","year":"2014","journal-title":"Mem\u00f3rias Inst. Oswaldo Cruz"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"11","DOI":"10.4269\/ajtmh.2000.62.11","article-title":"Transmission thresholds for dengue in terms of Aedes aegypti pupae per person with discussion of their utility in source reduction efforts","volume":"62","author":"Focks","year":"2000","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_33","unstructured":"Pan American Health Organization (2009). Dengue Guidelines for Diagnosis, Treatment, Prevention and Control: New Edition, World Health Organization."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Mordecai, E.A., Cohen, J.M., Evans, M.V., Gudapati, P., Johnson, L.R., Lippi, C.A., Miazgowicz, K., Murdock, C.C., Rohr, J.R., and Ryan, S.J. (2017). Detecting the impact of temperature on transmission of Zika, dengue, and chikungunya using mechanistic models. PLoS Negl. Trop. Dis., 11.","DOI":"10.1371\/journal.pntd.0005568"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1093\/ee\/28.1.22","article-title":"A novel rate model of temperature-dependent development for arthropods","volume":"28","author":"Briere","year":"1999","journal-title":"Environ. Entomol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1603\/0022-2585-38.5.646","article-title":"Precipitation and temperature effects on populations of Aedes albopictus (Diptera: Culicidae): Implications for range expansion","volume":"38","author":"Alto","year":"2001","journal-title":"J. Med. Entomol."},{"key":"ref_37","unstructured":"Brasil (2021, June 25). Base de Dados, Available online: http:\/\/basededados.turismo.gov.br\/."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"S386","DOI":"10.1016\/j.respe.2018.05.408","article-title":"Infodengue: A nowcasting system for the surveillance of arboviruses in Brazil","volume":"66","author":"Codeco","year":"2018","journal-title":"Revue d\u2019\u00c9pid\u00e9miologie Sant\u00e9 Publique"},{"key":"ref_39","unstructured":"Brasil (2021, June 25). Censo Demogr\u00e1fico, Available online: https:\/\/www.ibge.gov.br\/."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1093\/trstmh\/tru187","article-title":"Entomological impact and social participation in dengue control: A cluster randomized trial in Fortaleza, Brazil","volume":"109","author":"Caprara","year":"2015","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"ref_41","unstructured":"Wan, Z., Hook, S., and Hulley, G. (2015). MOD11A2 MODIS\/Terra Land Surface Temperature\/Emissivity 8-Day L3 Global 1km SIN Grid V006. NASA EOSDIS Land Processes DAAC."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"150066","DOI":"10.1038\/sdata.2015.66","article-title":"The climate hazards infrared precipitation with stations\u2014A new environmental record for monitoring extremes","volume":"2","author":"Funk","year":"2015","journal-title":"Sci. Data"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1590\/S0037-86822009000200008","article-title":"Clima e epidemias de dengue no Estado do Rio de Janeiro","volume":"42","author":"Gomes","year":"2009","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"ref_44","first-page":"126","article-title":"Com\u00e9rcio e deslocamento pendular: Posicionamentos sobre a rede urbana de Foz do Igua\u00e7u","volume":"3","author":"Conte","year":"2013","journal-title":"Rev. Geoaraguaia"},{"key":"ref_45","first-page":"79","article-title":"Um estudo sobre o eixo Cascavel\u2013Foz do Igua\u00e7u na regi\u00e3o oeste do Paran\u00e1","volume":"104","author":"Peris","year":"2011","journal-title":"Rev. Parana. Desenvolv."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"3","DOI":"10.22456\/1807-9806.21245","article-title":"Rela\u00e7\u00f5es entre temperatura do ar e vari\u00e1veis do ambiente urbano de Porto Alegre, RS","volume":"21","author":"Hasenack","year":"1994","journal-title":"Pesqui. Geoci\u00eancias"},{"key":"ref_47","unstructured":"Google Maps (2021, June 25). South America Map. Available online: https:\/\/www.google.com\/maps\/place\/Goi%C3%A1s\/@-19.6461803,-67.8237896,4.5z."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Martinez-Romero, N., Osorio-Peralta, O., and Santamaria-Vite, I. (2002, January 10). Natural gas network optimization and sensibility analysis. Proceedings of the SPE International Petroleum Conference and Exhibition in Mexico, Villahermosa, Mexico.","DOI":"10.2118\/74384-MS"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"97","DOI":"10.21105\/joss.00097","article-title":"SALib: An open-source Python library for sensitivity analysis","volume":"2","author":"Herman","year":"2017","journal-title":"J. Open Source Softw."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.mbs.2017.04.005","article-title":"An SIR-Dengue transmission model with seasonal effects and impulsive control","volume":"289","author":"Siegmund","year":"2017","journal-title":"Math. Biosci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ecocom.2016.12.010","article-title":"Modeling dengue data from Semarang, Indonesia","volume":"30","author":"Altmeier","year":"2017","journal-title":"Ecol. Complex."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"4314","DOI":"10.3934\/mbe.2019215","article-title":"On the role of vector modeling in a minimalistic epidemic model","volume":"16","author":"Rashkov","year":"2019","journal-title":"Math. Biosci. Eng."},{"key":"ref_53","first-page":"6953","article-title":"A simulation model for the chikungunya with vectorial capacity","volume":"9","author":"Osorio","year":"2015","journal-title":"Appl. Math. Sci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"85","DOI":"10.11121\/ijocta.01.2020.00862","article-title":"Modeling the impact of temperature on fractional order dengue model with vertical transmission","volume":"10","author":"Defterli","year":"2020","journal-title":"Int. J. Optim. Control Theor. Appl."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1747134","DOI":"10.1155\/2017\/1747134","article-title":"Modeling impact of temperature and human movement on the persistence of dengue disease","volume":"2017","author":"Phaijoo","year":"2017","journal-title":"Comput. Math. Methods Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.hgmx.2016.09.011","article-title":"Clinical and differential diagnosis: Dengue, chikungunya and Zika","volume":"81","year":"2018","journal-title":"Rev. M\u00e9d. Hosp. Gen. M\u00e9xico"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"33130","DOI":"10.1038\/srep33130","article-title":"Record-breaking warming and extreme drought in the Amazon rainforest during the course of El Ni\u00f1o 2015\u20132016","volume":"6","author":"Mattar","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3354\/cr019035","article-title":"Dengue epidemics and the El Ni\u00f1o southern oscillation","volume":"19","author":"Gagnon","year":"2001","journal-title":"Clim. Res."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Tipayamongkholgul, M., Fang, C.T., Klinchan, S., Liu, C.M., and King, C.C. (2009). Effects of the El Ni\u00f1o-Southern Oscillation on dengue epidemics in Thailand, 1996\u20132005. BMC Public Health, 9.","DOI":"10.1186\/1471-2458-9-422"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"3813","DOI":"10.1002\/joc.6744","article-title":"The 2018\u20132019 weak El Ni\u00f1o: Predicting the risk of a dengue outbreak in Machala, Ecuador","volume":"41","author":"Petrova","year":"2020","journal-title":"Int. J. Climatol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s00484-011-0402-0","article-title":"The effects of simulated rainfall on immature population dynamics of Aedes albopictus and female oviposition","volume":"56","author":"Dieng","year":"2012","journal-title":"Int. J. Biometeorol."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/18\/18\/9493\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:59:11Z","timestamp":1760165951000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/18\/18\/9493"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,9]]},"references-count":61,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2021,9]]}},"alternative-id":["ijerph18189493"],"URL":"https:\/\/doi.org\/10.3390\/ijerph18189493","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,9]]}}}