{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T04:56:27Z","timestamp":1783659387297,"version":"3.55.0"},"reference-count":80,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2021,9,10]],"date-time":"2021-09-10T00:00:00Z","timestamp":1631232000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Background: Myofascial pain is an important cause of disability among the whole population, and it is a common symptom of temporomandibular joint disorders (TMDs). Its management techniques vary widely; however, in recent years, there has been a growing interest especially in needling therapies within masticatory muscles, due to their simplicity and effectiveness in pain reduction. Methods: The construction of the following study is based on PICOS and PRISMA protocols. A systematic literature search was conducted based on the PubMed and BASE search engines. Searching the abovementioned databases yielded a total of 367 articles. The screening procedure and analysis of full texts resulted in the inclusion of 28 articles for detailed analysis. Results: According to analyzed data, clinicians manage myofascial pain either with wet or dry needling therapies. The most thoroughly studied approach that prevails significantly within the clinical trials is injecting the botulinum toxin into the masseter and temporalis. Other common methods are the application of local anesthetics or dry needling; however, we notice the introduction of entirely new substances, such as platelet-rich plasma or collagen. In the analyzed articles, the target muscles for the needling therapies are most commonly localized by manual palpation although there are a variety of navigational support systems described: EMG, MRI or EIP electrotherapy equipment, which often aid the access to located deeper lateral and medial pterygoid muscle. Conclusions: Needling therapies within masticatory muscles provide satisfactory effects while being simple, safe and accessible procedures although there still is a need for high quality clinical trials investigating especially injections of non-Botox substances and needling within lateral and medial pterygoid muscles.<\/jats:p>","DOI":"10.3390\/ijerph18189552","type":"journal-article","created":{"date-parts":[[2021,9,10]],"date-time":"2021-09-10T10:31:34Z","timestamp":1631269894000},"page":"9552","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Intramuscular Injections and Dry Needling within Masticatory Muscles in Management of Myofascial Pain. Systematic Review of Clinical Trials"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1826-7275","authenticated-orcid":false,"given":"Zuzanna","family":"Nowak","sequence":"first","affiliation":[{"name":"Department of Temporomandibular Disorders, Medical University of Silesia in Katowice, Traugutta sq. 2, 41-800 Zabrze, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6199-4753","authenticated-orcid":false,"given":"Maciej","family":"Ch\u0119ci\u0144ski","sequence":"additional","affiliation":[{"name":"Preventive Medicine Center, Komorowskiego 12, 30-106 Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0322-2130","authenticated-orcid":false,"given":"Aleksandra","family":"Nitecka-Buchta","sequence":"additional","affiliation":[{"name":"Department of Temporomandibular Disorders, Medical University of Silesia in Katowice, Traugutta sq. 2, 41-800 Zabrze, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylwia","family":"Bulanda","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, Medical University of Silesia in Katowice, Traugutta sq. 2, 41-800 Zabrze, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danuta","family":"Ilczuk-Rypu\u0142a","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, Medical University of Silesia in Katowice, Traugutta sq. 2, 41-800 Zabrze, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia","family":"Postek-Stefa\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, Medical University of Silesia in Katowice, Traugutta sq. 2, 41-800 Zabrze, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Baron","sequence":"additional","affiliation":[{"name":"Department of Temporomandibular Disorders, Medical University of Silesia in Katowice, Traugutta sq. 2, 41-800 Zabrze, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1055\/s-0038-1673674","article-title":"Myofascial Pain","volume":"38","author":"Weller","year":"2018","journal-title":"Semin. Neurol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/08869634.2017.1361052","article-title":"Frequency of temporomandibular disorders diagnoses based on RDC\/TMD in a Polish patient population","volume":"36","author":"Osiewicz","year":"2017","journal-title":"CRANIO\u00ae"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"32","DOI":"10.5606\/tftrd.2021.6615","article-title":"Are occlusal splints effective in reducing myofascial pain in patients with muscle-related temporomandibular disorders? A randomized-controlled trial","volume":"67","author":"Deregibus","year":"2021","journal-title":"Turk. J. Phys. Med. Rehabil."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"109","DOI":"10.4103\/0975-5950.154810","article-title":"Trends in management of myofacial pain","volume":"5","author":"Pal","year":"2014","journal-title":"Natl. J. Maxillofac. Surg."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"6","DOI":"10.11607\/jop.1151","article-title":"Diagnostic Criteria for Temporomandibular Disorders (DC\/TMD) for Clinical and Research Applications: Recommendations of the International RDC\/TMD Consortium Network* and Orofacial Pain Special Interest Group\u2020","volume":"28","author":"Schiffman","year":"2014","journal-title":"J. Oral Facial Pain Headache"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"(2020). International Classification of Orofacial Pain, 1st edition (ICOP). Cephalalgia, 40, 129\u2013221. Available online: https:\/\/journals.sagepub.com\/doi\/10.1177\/0333102419893823?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed.","DOI":"10.1177\/0333102419893823"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"299","DOI":"10.11607\/ofph.1885","article-title":"Interaction Between Awake and Sleep Bruxism Is Associated with Increased Presence of Painful Temporomandibular Disorder","volume":"31","author":"Reissmann","year":"2017","journal-title":"J. Oral Facial Pain Headache"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"656","DOI":"10.3389\/fpsyg.2017.00646","article-title":"Mental Status as a Common Factor for Masticatory Muscle Pain: A Systematic Review","volume":"8","author":"Wieckiewicz","year":"2017","journal-title":"Front. Psychol."},{"key":"ref_9","first-page":"8261090","article-title":"Comparison between Collagen and Lidocaine Intramuscular Injections in Terms of Their Efficiency in Decreasing Myofascial Pain within Masseter Muscles: A Randomized, Single-Blind Controlled Trial","volume":"2018","author":"Wieckiewicz","year":"2018","journal-title":"Pain Res. Manag."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.2147\/JPR.S154728","article-title":"Trigger point dry needling for the treatment of myofascial pain syndrome: Current perspectives within a pain neuroscience paradigm","volume":"12","author":"Nijs","year":"2019","journal-title":"J. Pain Res."},{"key":"ref_11","unstructured":"Simons, D.G., Travell, J.G., and Simons, L. (2019). Myofascial Pain and Dysfunction. The Trigger Point Manual, Wolters Kluwer. [3rd ed.]."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1016\/j.jpain.2011.09.005","article-title":"Latent Myofascial Trigger Points are Associated With an Increased Antagonistic Muscle Activity During Agonist Muscle Contraction","volume":"12","author":"Ibarra","year":"2011","journal-title":"J. Pain"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.jormas.2019.02.015","article-title":"The use of botulinum toxin-a in the treatment of muscular temporomandibular joint disorders","volume":"120","author":"Colakoglu","year":"2019","journal-title":"J. Stomatol. Oral Maxillofac. Surg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s40902-016-0051-7","article-title":"A clinical evaluation of botulinum toxin-A injections in the temporomandibular disorder treatment","volume":"38","author":"Kim","year":"2016","journal-title":"Maxillofac. Plast. Reconstr. Surg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1111\/joor.12960","article-title":"Needling therapies in the management of myofascial pain of the masticatory muscles: A network meta-analysis of randomised clinical trials","volume":"47","author":"Alradom","year":"2020","journal-title":"J. Oral Rehabil."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1136\/emermed-2020-209567","article-title":"Population, Intervention, Comparison, Outcomes and Study (PICOS) design as a framework to formulate eligibility criteria in systematic reviews","volume":"37","author":"Janati","year":"2020","journal-title":"Emerg. Med. J."},{"key":"ref_17","unstructured":"(2021, April 18). PubMed Overview, Available online: https:\/\/pubmed.ncbi.nlm.nih.gov\/about\/."},{"key":"ref_18","unstructured":"(2021, April 18). BASE: Content Providers. Available online: https:\/\/www.base-search.net\/about\/en\/about_sources_date.php."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: An updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"ref_20","unstructured":"(2021, April 18). Rayyan QCRI. Available online: https:\/\/www.rayyan.ai\/about.html."},{"key":"ref_21","first-page":"e112","article-title":"Treatment of chronic pain associated with nocturnal bruxism with botulinum toxin. A prospective and randomized clinical study","volume":"9","year":"2016","journal-title":"J. Clin. Exp. Dent."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.oooo.2019.09.014","article-title":"The effect of the twin block compared with trigger point injections in patients with masticatory myofascial pain: A pilot study","volume":"129","author":"Ananthan","year":"2020","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"37","DOI":"10.2334\/josnusd.20-0090","article-title":"Incobotulinum toxin type A for treatment of chronic myofascial pain","volume":"63","author":"Chaurand","year":"2021","journal-title":"J. Oral Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"351","DOI":"10.2334\/josnusd.16-0614","article-title":"Efficacy of botulinum toxin therapy in treatment of myofascial pain","volume":"59","author":"Chaurand","year":"2017","journal-title":"J. Oral Sci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1016\/j.pain.2011.03.036","article-title":"Efficacy of botulinum toxin type A for treatment of persistent myofascial TMD pain: A randomized, controlled, double-blind multicenter study","volume":"152","author":"Ernberg","year":"2011","journal-title":"Pain"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"128","DOI":"10.15171\/joddd.2019.020","article-title":"Effect of injection of botulinum toxin on decreasing the symptoms and signs of masticatory muscles in patients with temporomandibular dysfunction","volume":"13","author":"Ghavimi","year":"2019","journal-title":"J. Dent. Res. Dent. Clin. Dent. Prospect."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1179\/crn.2012.014","article-title":"Myofascial Pain of the Jaw Muscles: Comparison of Short-Term Effectiveness of Botulinum Toxin Injections and Fascial Manipulation Technique","volume":"30","author":"Stecco","year":"2012","journal-title":"CRANIO\u00ae"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"335","DOI":"10.5125\/jkaoms.2020.46.5.335","article-title":"Efficacy of botulinum toxin in the management of temporomandibular myofascial pain and sleep bruxism","volume":"46","author":"Hosgor","year":"2020","journal-title":"J. Korean Assoc. Oral Maxillofac. Surg."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e99","DOI":"10.1016\/j.oooo.2016.05.008","article-title":"Intramuscular botulinum toxin injection additional to arthrocentesis in the management of temporomandibular joint pain","volume":"122","author":"Ivask","year":"2016","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1111\/odi.12919","article-title":"Effects of intramuscular morphine in men and women with temporomandibular disorder with myofascial pain","volume":"24","author":"Kang","year":"2018","journal-title":"Oral Dis."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1080\/08869634.2018.1562660","article-title":"Evaluation of patient satisfaction after botulinum toxin A injection for the management of masticatory myofascial pain and dysfunction\u2014A pilot study","volume":"39","author":"Meral","year":"2019","journal-title":"CRANIO\u00ae"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"250","DOI":"10.3389\/fneur.2019.00250","article-title":"Platelet-Rich Plasma Intramuscular Injections\u2014Antinociceptive Therapy in Myofascial Pain Within Masseter Muscles in Temporomandibular Disorders Patients: A Pilot Study","volume":"10","author":"Kempa","year":"2019","journal-title":"Front. Neurol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1080\/08869634.2018.1526848","article-title":"Efficacy of dry needling in patients with myofascial temporomandibular disorders related to the masseter muscle","volume":"38","author":"Ozden","year":"2020","journal-title":"CRANIO\u00ae"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1177\/0003489417693013","article-title":"IncobotulinumtoxinA Injection for Temporomandibular Joint Disorder","volume":"126","author":"Patel","year":"2017","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s10194-016-0621-1","article-title":"The efficiency of botulinum toxin type A for the treatment of masseter muscle pain in patients with temporomandibular joint dysfunction and tension-type headache","volume":"17","author":"Pihut","year":"2016","journal-title":"J. Headache Pain"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.jormas.2018.11.002","article-title":"MR-guided navigation for botulinum toxin injection in the lateral pterygoid muscle. First results in the treatment of temporomandibular joint disorders","volume":"120","author":"Pons","year":"2018","journal-title":"J. Stomatol. Oral Maxillofac. Surg."},{"key":"ref_37","first-page":"1","article-title":"The effectiveness of the masseteric nerve block compared with trigger point injections and dry needling in myofascial pain","volume":"16","author":"Cezairli","year":"2020","journal-title":"CRANIO\u00ae"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1080\/08869634.2019.1588518","article-title":"Effectiveness of dry needling on the local pressure pain threshold in patients with masticatory myofascial pain. Systematic review and preliminary clinical trial","volume":"39","author":"Tesch","year":"2019","journal-title":"CRANIO\u00ae"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"175","DOI":"10.2334\/josnusd.55.175","article-title":"Laser therapy and needling in myofascial trigger point deactivation","volume":"55","author":"Uemoto","year":"2013","journal-title":"J. Oral Sci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.jormas.2018.10.007","article-title":"Improvement in quality of life after botulinum toxin injection for temporomandibular disorder","volume":"120","author":"Villa","year":"2018","journal-title":"J. Stomatol. Oral Maxillofac. Surg."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"88.e1","DOI":"10.1016\/j.joms.2020.09.013","article-title":"Comparison of the Efficacy of Botulinum Toxin, Local Anesthesia, and Platelet-Rich Plasma Injections in Patients With Myofascial Trigger Points in the Masseter Muscle","volume":"79","author":"Yilmaz","year":"2020","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1016\/j.joms.2019.06.005","article-title":"Which Treatment Is Effective for Bruxism: Occlusal Splints or Botulinum Toxin?","volume":"77","author":"Yurttutan","year":"2019","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_43","first-page":"e326","article-title":"Deep dry needling of trigger points located in the lateral pterygoid muscle: Efficacy and safety of treatment for management of myofascial pain and temporomandibular dysfunction","volume":"20","author":"Martos","year":"2015","journal-title":"Med. Oral Patol. Oral Cirug\u00eda Bucal"},{"key":"ref_44","first-page":"e454","article-title":"Randomized, double-blind study comparing percutaneous electrolysis and dry needling for the management of temporomandibular myofascial pain","volume":"23","author":"Martos","year":"2018","journal-title":"Patol. Oral Cir. Bucal."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"102197","DOI":"10.1016\/j.msksp.2020.102197","article-title":"Cadaveric and in vivo validation of needle placement in the medial pterygoid muscle","volume":"49","author":"Koppenhaver","year":"2020","journal-title":"Musculoskelet. Sci. Pr."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1007\/s40279-018-0860-1","article-title":"Is Platelet-Rich Plasma (PRP) Effective in the Treatment of Acute Muscle Injuries? A Systematic Review and Meta-Analysis","volume":"48","author":"Grassi","year":"2018","journal-title":"Sports Med."},{"key":"ref_47","first-page":"475","article-title":"Platelet rich fibrin matrix effects on skeletal muscle lesions: An experimental study","volume":"26","author":"Gigante","year":"2012","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1177\/0363546518771076","article-title":"Platelet-rich plasma releasate promotes regeneration and decreases inflammation and apoptosis of injured skeletal muscle","volume":"46","author":"Tsai","year":"2018","journal-title":"Am. J. Sports Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1177\/0363546517702864","article-title":"Postinjury Exercise and Platelet-Rich Plasma Therapies Improve Skeletal Muscle Healing in Rats but Are Not Synergistic When Combined","volume":"45","author":"Torrella","year":"2017","journal-title":"Am. J. Sports Med."},{"key":"ref_50","first-page":"3","article-title":"A new and refined injectable treatment for musculoskeletal disorders-bioscaffold properties of collagen and its clinical use","volume":"1","author":"Milani","year":"2010","journal-title":"Physiol. Regul. Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1111\/joor.12180","article-title":"Osteopenic consequences of botulinum toxin injections in the masticatory muscles: A pilot study","volume":"41","author":"Raphael","year":"2014","journal-title":"J. Oral Rehabil."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"De la Torre Canales, G., Alvarez-Pinzon, N., Mu\u00f1oz-Lora, V.R.M., Vieira Peroni, L., Farias Gomes, A., S\u00e1nchez-Ayala, A., Haiter-Neto, F., Manfredini, D., and Rizzatti-Barbosa, C.M. (2020). Efficacy and Safety of Botulinum Toxin Type A on Persistent Myofascial Pain: A Randomized Clinical Trial. Toxins, 12.","DOI":"10.3390\/toxins12060395"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1111\/joor.13087","article-title":"Effect of multiple injections of botulinum toxin into painful masticatory muscles on bone density in the temporomandibular complex","volume":"47","author":"Raphael","year":"2020","journal-title":"J. Oral Rehabil."},{"key":"ref_54","unstructured":"Autralian Society of Acupuncture Physiotherapists (ASAP) (2014). Guidelines for Safe Acupuncture and Dry Needling Practice, Autralian Society of Acupuncture Physiotherapists (ASAP)."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1097\/00002060-199407000-00006","article-title":"Lidocaine injection versus dry needling to myofascial trigger point","volume":"73","author":"Hong","year":"1994","journal-title":"Am. J. Phys. Med. Rehabil."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"717","DOI":"10.3233\/BMR-181286","article-title":"The effect of dry needling on the active trigger point of upper trapezius muscle: Eliciting local twitch response on long-term clinical outcomes","volume":"32","author":"Hakim","year":"2019","journal-title":"J. Back Musculoskelet. Rehabil."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.jbmt.2017.03.008","article-title":"The local twitch response during trigger point dry needling: Is it necessary for successful outcomes?","volume":"21","author":"Perreault","year":"2017","journal-title":"J. Bodyw. Mov. Ther."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1002\/hed.2880120504","article-title":"Botulinum a toxin for the treatment of spasmodic torticollis: Dysphagia and regional toxin spread","volume":"12","author":"Borodic","year":"1990","journal-title":"Head Neck"},{"key":"ref_59","unstructured":"Dantec Clavis Handheld Device (2021, July 19). Natus. Available online: https:\/\/neuro.natus.com\/products-services\/dantec-clavis-handheld-emg."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/eye.2017.276","article-title":"Botulinum toxin as an initial therapy for management of sixth nerve palsies caused by nasopharyngeal carcinomas","volume":"32","author":"Wong","year":"2018","journal-title":"Eye"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Datta Gupta, A., Tucker, G., Koblar, S., Visvanathan, R., and Cameron, I.D. (2018). Spatiotemporal Gait Analysis and Lower Limb Functioning in Foot Dystonia Treated with Botulinum Toxin. Toxins, 10.","DOI":"10.3390\/toxins10120532"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Datta Gupta, A., Visvanathan, R., Cameron, I., Koblar, S.A., Howell, S., and Wilson, D. (2019). Efficacy of botulinum toxin in modifying spasticity to improve walking and quality of life in post-stroke lower limb spasticity\u2014A randomized double-blind placebo controlled study. BMC Neurol., 19.","DOI":"10.1186\/s12883-019-1325-3"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"e011751","DOI":"10.1136\/bmjopen-2016-011751","article-title":"Efficacy of two injection-site localisation techniques for botulinum toxin injections: A single-blind, crossover, randomised trial protocol among adults with hemiplegia due to stroke","volume":"6","author":"Morel","year":"2016","journal-title":"BMJ Open"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"4173218","DOI":"10.1155\/2020\/4173218","article-title":"Percutaneous Application of Galvanic Current in Rodents Reverses Signs of Myofascial Trigger Points","volume":"2020","author":"Margalef","year":"2020","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"432635","DOI":"10.1155\/2014\/432635","article-title":"A Novel Method for Intraoral Access to the Superior Head of the Human Lateral Pterygoid Muscle","volume":"2014","author":"Oliveira","year":"2014","journal-title":"BioMed Res. Int."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"e13","DOI":"10.11607\/ofph.1955","article-title":"Computer-Aided Design\/Computer-Assisted Manufacture\u2013Derived Needle Guide for Injection of Botulinum Toxin into the Lateral Pterygoid Muscle in Patients with Oromandibular Dystonia","volume":"32","author":"Yoshida","year":"2018","journal-title":"J. Oral Facial Pain Headache"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1016\/j.ultrasmedbio.2020.06.022","article-title":"Ultrasound Imaging of Injections in Masseter Muscle without Contrast Agent Using Strain Elastography and a Novel B-Mode Spatiotemporal Filter","volume":"46","author":"Sanabria","year":"2020","journal-title":"Ultrasound Med. Biol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"20200024","DOI":"10.1259\/dmfr.20200024","article-title":"Great potential of ultrasound elastography for the assessment of the masseter muscle in patients with temporomandibular disorders. A systematic review","volume":"49","author":"Olchowy","year":"2020","journal-title":"Dentomaxillofacial Radiol."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Kang, J.J., Kim, J., Park, S., Paek, S., Kim, T.H., and Kim, D.K. (2019). Feasibility of Ultrasound-Guided Trigger Point Injection in Patients with Myofascial Pain Syndrome. Healthcare, 7.","DOI":"10.3390\/healthcare7040118"},{"key":"ref_70","first-page":"157","article-title":"The Role of Botulinum Toxin A in Treatment of Temporomandibular Joint Disorders: A Review","volume":"18","author":"Ataran","year":"2017","journal-title":"J. Dent."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"20160229","DOI":"10.1259\/dmfr.20160229","article-title":"Correlation between the lateral pterygoid muscle attachment type and temporomandibular joint disc position in magnetic resonance imaging","volume":"45","author":"Litko","year":"2016","journal-title":"Dentomaxillofacial Radiol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1097\/SCS.0000000000005658","article-title":"Extraoral Versus Intraoral Botulinum Toxin Type A Injection for Management of Temporomandibular Joint Disc Displacement With Reduction","volume":"30","author":"Altaweel","year":"2019","journal-title":"J. Craniofacial Surg."},{"key":"ref_73","first-page":"133","article-title":"Point-of-care testing for hepatitis C virus infection at an Italian dental clinic: Portrait of the pilot study population","volume":"42","author":"Tecco","year":"2019","journal-title":"N Microbiol."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Sikora, M., Ch\u0119ci\u0144ski, M., Nowak, Z., Ch\u0119ci\u0144ska, K., Olszowski, T., and Chlubek, D. (2021). The Use of Titanium 3D Mini-Plates in the Surgical Treatment of Fractures of the Mandibular Condyle: A Systematic Review and Meta-Analysis of Clinical Trials. J. Clin. Med., 10.","DOI":"10.3390\/jcm10163604"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Sikora, M., Czerwi\u0144ska-Niezabitowska, B., Ch\u0119ci\u0144ski, M.A., Sielski, M., and Chlubek, D. (2020). Short-Term Effects of Intra-Articular Hyaluronic Acid Administration in Patients with Temporomandibular Joint Disorders. J. Clin. Med., 9.","DOI":"10.3390\/jcm9061749"},{"key":"ref_76","first-page":"1144","article-title":"Sinus floor elevation by osteotome: Hand mallet versus electric mallet. A prospective clinical study","volume":"27","author":"Crespi","year":"2012","journal-title":"Int. J. Oral Maxillofac. Implants"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Sikora, M., Ch\u0119ci\u0144ski, M., Nowak, Z., and Chlubek, D. (2021). Variants and Modifications of the Retroauricular Approach Using in Temporomandibular Joint Surgery: A Systematic Review. J. Clin. Med., 10.","DOI":"10.3390\/jcm10102049"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Sikora, M., Ch\u0119ci\u0144ski, M., and Chlubek, D. (2021). Retro-Auricular Approach to the Fractures of the Mandibular Condyle: A Systematic Review. J. Clin. Med., 10.","DOI":"10.3390\/jcm10020230"},{"key":"ref_79","first-page":"323","article-title":"Fiber reinforced composites orthodontic retainers","volume":"64","author":"Lucchese","year":"2015","journal-title":"Minerva Stomatol."},{"key":"ref_80","first-page":"91","article-title":"Osseointegrated dental implants supporting fixed prostheses in patients affected by Sj\u00f6gren\u2019s Sindrome: A narrative review","volume":"34","author":"Polizzi","year":"2020","journal-title":"J. Biol. Regul. Homeost. 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