{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:01:05Z","timestamp":1791414065237,"version":"4.3.3"},"reference-count":154,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T00:00:00Z","timestamp":1632787200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FONDATION ALCEA","award":["XXX"],"award-info":[{"award-number":["XXX"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Benzodiazepines have proven to be highly effective for treating insomnia and anxiety. Although considered safe when taken for a short period of time, a major risk\u2013benefit dilemma arises in the context of long-term use, relating to addiction, withdrawal symptoms, and potential side effects. For these reasons, benzodiazepines are not recommended for treating chronic sleep disorders, anxiety disorders, nor for people over the age of 65, and withdrawal among long-term users is a public health issue. Indeed, only 5% of patients manage to discontinue using these drugs on their own. Even with the help of a general practitioner, this rate does not exceed 25 to 30% of patients, of which approximately 7% manage to remain drug-free in the long term. Cognitive Behavioral Therapies (CBT) offer a crucial solution to this problem, having been shown to increase abstinence success to 70\u201380%. This article examines traditional and novel CBT techniques in this regard, such as Acceptance and Commitment Therapy, which address both the underlying condition (insomnia\/anxiety) and the substance-related disorder. The theoretical framework and evidence supporting the use of these approaches are reviewed. Finally, current research gaps are discussed, and key research perspectives are proposed.<\/jats:p>","DOI":"10.3390\/ijerph181910222","type":"journal-article","created":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T12:29:14Z","timestamp":1632832154000},"page":"10222","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Cognitive Behavioral Therapy and Acceptance and Commitment Therapy for the Discontinuation of Long-Term Benzodiazepine Use in Insomnia and Anxiety Disorders"],"prefix":"10.3390","volume":"18","author":[{"given":"M\u00e9lin\u00e9e","family":"Chapoutot","sequence":"first","affiliation":[{"name":"Association Nationale de Promotion des Connaissances sur Le Sommeil, 69001 Lyon, France"},{"name":"Lyon Neuroscience Research Centre, CNRS UMR 5292-INSERM U1028, Lyon 1 University, 69005 Bron, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9938-9639","authenticated-orcid":false,"given":"Laure","family":"Peter-Derex","sequence":"additional","affiliation":[{"name":"Association Nationale de Promotion des Connaissances sur Le Sommeil, 69001 Lyon, France"},{"name":"Lyon Neuroscience Research Centre, CNRS UMR 5292-INSERM U1028, Lyon 1 University, 69005 Bron, France"},{"name":"Sleep Medicine and Respiratory Disease Centre, Croix-Rousse Hospital, CHU of Lyon, 69004 Lyon, France"},{"name":"Faculty of Medicine Lyon Sud-Charles M\u00e9rieux, Lyon 1 University, 69622 Villeurbanne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Bastuji","sequence":"additional","affiliation":[{"name":"Lyon Neuroscience Research Centre, CNRS UMR 5292-INSERM U1028, Lyon 1 University, 69005 Bron, France"},{"name":"Sleep Medicine and Respiratory Disease Centre, Croix-Rousse Hospital, CHU of Lyon, 69004 Lyon, France"},{"name":"Faculty of Medicine Lyon Sud-Charles M\u00e9rieux, Lyon 1 University, 69622 Villeurbanne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Leslie","sequence":"additional","affiliation":[{"name":"Xceltranslate, 06000 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Schoendorff","sequence":"additional","affiliation":[{"name":"Institut de Psychologie Contextuelle, Montreal, QC H2Y 2S9, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Heinzer","sequence":"additional","affiliation":[{"name":"Centre D\u2019Investigation et de Recherche Sur le Sommeil, CHUV, 1011 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Siclari","sequence":"additional","affiliation":[{"name":"Centre D\u2019Investigation et de Recherche Sur le Sommeil, CHUV, 1011 Lausanne, 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Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9816-3267","authenticated-orcid":false,"given":"Guillaume T.","family":"Vallet","sequence":"additional","affiliation":[{"name":"LAPSCO, Universit\u00e9 Clermont Auvergne, CNRS, LAPSCO, 63000 Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Royce","family":"Anders","sequence":"additional","affiliation":[{"name":"Laboratoire EMC, Lyon 2 Universit\u00e9, 69500 Bron, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Ounnoughene","sequence":"additional","affiliation":[{"name":"Cabinet de Psychiatrie du Plateau de Haye, 54320 Max\u00e9ville, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Spencer","sequence":"additional","affiliation":[{"name":"Faculty of Psychology, Swiss Distance Learning University, 3900 Brig, 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