{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T02:05:07Z","timestamp":1771466707376,"version":"3.50.1"},"reference-count":72,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T00:00:00Z","timestamp":1634256000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>The role of leukotrienes (LTs) in the pathogenesis of systemic sclerosis (SSc) needs clarification. We analyzed the association of salivary (sa) and plasma (p) levels (pg\/mL) of cysteinyl-leukotrienes (CysLT) and LTB4 with SSc vascular manifestations and nailfold capillaroscopy (NFC) in a cross-sectional study. Patients and healthy controls were evaluated for vascular manifestations and NFC. LTs were compared between groups as follows: SSc with or SSc without vascular features and controls, and by NFC parameters. Twenty SSc patients and 16 volunteers were recruited; Raynaud\u2019s phenomenon (RP) history (SSc: saCysLT 99.4 \u00b1 21.8 vs. controls: 23.05 \u00b1 23.7, p = 0.01), RP at examination (SSc: saCysLT 129.3 \u00b1 24.6 vs. controls: 23.05 \u00b1 22.46, p = 0.01; pCysLT SSc: 87.5 \u00b1 11.2 vs. controls: 32.37 \u00b1 10.75, p = 0.002), capillary loss (saCysLT 138.6 \u00b1 26.7 vs. 23.05 \u00b1 21.6, p = 0.0007; saLTB4 3380.9 \u00b1 426.6 vs. 1216.33 \u00b1 346.1, p = 0.0005), \u201clate\u201d scleroderma pattern vs. controls (saCysLT 205.6 \u00b1 32 vs. 23 \u00b1 19.6, p = 0.0002; saLTB4 4564.9 \u00b1 503.6 vs. 1216.3 \u00b1 308.3; p &lt; 0.0001) were all significant. Late patterns had higher levels (saCysLT, p = 0.002; LTB4 p = 0.0006) compared to active and early patterns (LTB4, p = 0.0006), and giant capillaries (p = 0.01) showed higher levels of LTs. Levels of pCysLT were higher in patients with RP at examination vs. patients without RP; saCysLT and LTB4 were higher in SSc group with vs. without capillary loss. LTs could be involved in the pathophysiology of vascular abnormalities. Further research is required to determine if blocking LTs could be a therapeutic target for SSc vascular manifestations.<\/jats:p>","DOI":"10.3390\/ijerph182010841","type":"journal-article","created":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T13:35:47Z","timestamp":1634304947000},"page":"10841","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Systemic Sclerosis: Elevated Levels of Leukotrienes in Saliva and Plasma Are Associated with Vascular Manifestations and Nailfold Capillaroscopic Abnormalities"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8006-7683","authenticated-orcid":false,"given":"Ang\u00e9lica","family":"Mandujano","sequence":"first","affiliation":[{"name":"Departamento de Atenci\u00f3n a la Salud, Universidad Aut\u00f3noma Metropolitana-Xochimilco, Mexico City 04960, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio","family":"M\u00e9ndez-Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones en Matem\u00e1ticas Aplicadas y en Sistemas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City 04510, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis Humberto","family":"Silveira-Torre","sequence":"additional","affiliation":[{"name":"Departamento de Reumatolog\u00eda, Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez, Mexico City 14080, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1056\/NEJMra0806188","article-title":"Scleroderma","volume":"360","author":"Gabrielli","year":"2009","journal-title":"N. 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