{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T23:55:05Z","timestamp":1790121305550,"version":"4.0.1"},"reference-count":54,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T00:00:00Z","timestamp":1634774400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Despite the significance of early detection of breast cancer through screening, the screening uptake in China remains relatively low. Protection motivation theory (PMT) suggested by Rogers is one of the theories concerning threat appeal. This study aimed to apply the protection motivation theory (PMT) in predicting breast cancer screening intention. In this cross-sectional study, a sample of Chinese urban women was recruited using the convenient sampling method from five communities in Wuhan. Data were collected using a self-report questionnaire that included demographic variables, knowledge about breast cancer, six PMT subconstructs, and screening intention. We used the structural equation modeling (SEM) to identify the predictor factors associated with screening intention. Of the total sample (n = 412), 86.65% had intention to participate in screening. Our data fit the hypothesized SEM model well (Goodness of fit index (GFI) = 0.91, adjusted GFI (AGFI) = 0.89, comparative fit index (CFI) = 0.91, root mean square error of approximation (RMSEA) = 0.05, standardized root mean residual (SRMR) = 0.06, and Chi-square\/df = 2.01). Three PMT subconstructs (perceived severity, response cost, and self-efficacy) were significantly associated with screening intention. Knowledge, social status, and medical history had significantly indirect associations with screening intention through the mediating effect of PMT subconstructs. Considering the utility of PMT, intervention programs might be more effective based on the subconstructs of PMT, especially to improve self-efficacy, perceived severity, and knowledge, reduce response cost, as well as targeting specific demographic groups.<\/jats:p>","DOI":"10.3390\/ijerph182111093","type":"journal-article","created":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T00:22:02Z","timestamp":1634862122000},"page":"11093","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Determinants of Intention to Participate in Breast Cancer Screening among Urban Chinese Women: An Application of the Protection Motivation Theory"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8200-1933","authenticated-orcid":false,"given":"Miao","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Epidemiology, School of Health Sciences, Wuhan University, Wuhan 430071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenshuang","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Health Sciences, Wuhan University, Wuhan 430071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinmei","family":"Li","sequence":"additional","affiliation":[{"name":"Wuhan Center for Disease Control and Prevention, Wuhan 430015, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8263-643X","authenticated-orcid":false,"given":"Xinguang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Florida, Gainesville, FL 32610, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Cancer Prevention and Control, Wuhan 430079, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Zuo","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Health Sciences, Wuhan University, Wuhan 430071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2028-973X","authenticated-orcid":false,"given":"Qing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Health Sciences, Wuhan University, Wuhan 430071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,21]]},"reference":[{"key":"ref_1","unstructured":"International Agency for Research on Cancer (2021, January 15). Latest Global Cancer Data: Cancer Burden Rises to 19.3 Million New Cases and 10.0 Million Cancer Deaths in 2020. Available online: https:\/\/www.iarc.who.int\/faq\/latest-global-cancer-data-2020-qa."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s10549-008-0303-z","article-title":"Breast cancer in a transitional society over 18 years: Trends and present status in Shanghai, China","volume":"117","author":"Fan","year":"2009","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1002\/ijc.30794","article-title":"Benefits and harms of breast cancer screening with mammography in women aged 40\u201349 years: A systematic review","volume":"141","author":"Vroling","year":"2017","journal-title":"Int. J. Cancer"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1001\/jama.2014.1398","article-title":"A systematic assessment of benefits and risks to guide breast cancer screening decisions","volume":"311","author":"Pace","year":"2014","journal-title":"JAMA"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"R9","DOI":"10.1186\/bcr3090","article-title":"Balancing harms and benefits of service mammography screening programs: A cohort study","volume":"14","author":"Puliti","year":"2012","journal-title":"Breast Cancer Res."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Dibden, A., Offman, J., Duffy, S.W., and Gabe, R. (2020). Worldwide review and meta-analysis of cohort studies measuring the effect of mammography screening programmes on incidence-based breast cancer mortality. Cancers, 12.","DOI":"10.3390\/cancers12040976"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e279","DOI":"10.1016\/S1470-2045(13)70567-9","article-title":"Breast cancer in China","volume":"15","author":"Fan","year":"2014","journal-title":"Lancet. Oncol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e183","DOI":"10.5888\/pcd10.130136","article-title":"Breast cancer screening among adult women in China, 2010","volume":"10","author":"Wang","year":"2013","journal-title":"Prev. Chronic. Dis."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"286","DOI":"10.3389\/fonc.2019.00286","article-title":"Ultrasound for breast cancer screening in high-risk women: Results from a population-based cancer screening program in China","volume":"9","author":"Wang","year":"2019","journal-title":"Front. Oncol."},{"key":"ref_10","first-page":"236","article-title":"Accuracy and direct medical cost of different screening modalities for breast cancer among Chinese women","volume":"36","author":"Kang","year":"2014","journal-title":"Zhonghua Zhong Liu Za Zhi"},{"key":"ref_11","first-page":"208","article-title":"Study on the coverage of cervical and breast cancer screening among women aged 35\u201369 years and related impact of socioeconomic factors in China, 2013","volume":"39","author":"Bao","year":"2018","journal-title":"Zhonghua Liu Xing Bing Xue Za Zhi"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.ypmed.2004.11.016","article-title":"Who has regular mammograms? Effects of knowledge, beliefs, socioeconomic status, and health-related factors","volume":"41","author":"Achat","year":"2005","journal-title":"Prev. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1089\/jwh.2007.0603","article-title":"Factors associated with mammography utilization: A systematic quantitative review of the literature","volume":"17","author":"Schueler","year":"2008","journal-title":"J. Womens Health"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Liu, L.Y., Wang, F., Yu, L.X., Ma, Z.B., Zhang, Q., Gao, D.Z., Li, Y.Y., Li, L., Zhao, Z.T., and Yu, Z.G. (2014). Breast cancer awareness among women in Eastern China: A cross-sectional study. BMC Public Health, 14.","DOI":"10.1186\/1471-2458-14-1004"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.3332\/ecancer.2020.1146","article-title":"A review of barriers and facilitators to mammography in Asian women","volume":"14","author":"Momenimovahed","year":"2020","journal-title":"Ecancermedicalscience"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e028705","DOI":"10.1136\/bmjopen-2018-028705","article-title":"Factors associated with breast cancer screening participation among women in mainland China: A systematic review","volume":"9","author":"Wu","year":"2019","journal-title":"BMJ Open"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"921607","DOI":"10.1155\/2012\/921607","article-title":"Improving breast cancer outcomes among women in China: Practices, knowledge, and attitudes related to breast cancer screening","volume":"2012","author":"Wu","year":"2012","journal-title":"Int. J. Breast Cancer"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.cdp.2005.06.013","article-title":"Health beliefs and practices related to breast cancer screening in Filipino, Chinese and Asian-Indian women","volume":"30","author":"Wu","year":"2006","journal-title":"Cancer Detect. Prev."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1002\/cncr.20507","article-title":"Promoting cancer screening: Learning from experience","volume":"101","author":"Meissner","year":"2004","journal-title":"Cancer"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.healthpol.2011.02.001","article-title":"The importance of socio-economic variables in cancer screening participation: A comparison between population-based and opportunistic screening in the EU-15","volume":"101","author":"Walsh","year":"2011","journal-title":"Health Policy"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1146\/annurev.publhealth.29.020907.143420","article-title":"A critical review of theory in breast cancer screening promotion across cultures","volume":"29","author":"Pasick","year":"2008","journal-title":"Annu. Rev. Public Health"},{"key":"ref_22","first-page":"2031","article-title":"Effects of model-based interventions on breast cancer screening behavior of women: A systematic review","volume":"19","author":"Saei","year":"2018","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/109019818401100101","article-title":"The Health belief model: A decade later","volume":"11","author":"Janz","year":"1984","journal-title":"Health Educ. Q."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Noman, S., Shahar, H.K., Abdul, R.H., Ismail, S., Abdulwahid, A.-J.M., and Azzani, M. (2020). The effectiveness of educational interventions on breast cancer screening uptake, knowledge, and beliefs among women: A systematic review. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph18010263"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1097\/00002820-200605000-00012","article-title":"Psychosocial factors related to repeat mammography screening over 5 years in African American women","volume":"29","author":"Russell","year":"2006","journal-title":"Cancer Nurs."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/0091-7435(91)90034-2","article-title":"Screening mammography rates and barriers to use: A Los Angeles county survey","volume":"20","author":"Bastani","year":"1991","journal-title":"Prev. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1080\/00223980.1975.9915803","article-title":"A protection motivation theory of fear appeals and attitude change1","volume":"91","author":"Rogers","year":"1975","journal-title":"J. Psychol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Xiao, H., Li, S., Chen, X., Yu, B., Gao, M., Yan, H., and Okafor, C.N. (2014). Protection motivation theory in predicting intention to engage in protective behaviors against schistosomiasis among middle school students in rural China. PLoS Negl. Trop. Dis., 8.","DOI":"10.1371\/journal.pntd.0003246"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1080\/21645515.2015.1123358","article-title":"Analysis of hepatitis B vaccination behavior and vaccination willingness among migrant workers from rural China based on protection motivation theory","volume":"12","author":"Liu","year":"2016","journal-title":"Hum. Vaccin. Immunother."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1002\/pon.4510","article-title":"Protection motivation theory in predicting intention to receive cervical cancer screening in rural Chinese women","volume":"27","author":"Bai","year":"2018","journal-title":"Psychooncology"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/0277-9536(95)00443-2","article-title":"Cognition and affect after cervical screening: The role of previous test outcome and personal obligation in future uptake expectations","volume":"43","author":"Orbell","year":"1996","journal-title":"Soc. Sci. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1002\/pon.5307","article-title":"Protection motivation theory in predicting cervical cancer screening participation: A longitudinal study in rural Chinese women","volume":"29","author":"Li","year":"2020","journal-title":"Psychooncology"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1111\/nhs.12533","article-title":"Breast cancer screening behaviors among Chinese women in Mainland China","volume":"20","author":"Bao","year":"2018","journal-title":"Nurs. Health Sci."},{"key":"ref_34","first-page":"203","article-title":"Knowledge, attitudes, and behaviour regarding breast cancer screening among women from different socio-economic regions in southwest China: A cross-sectional study","volume":"12","author":"Huang","year":"2011","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"90","DOI":"10.5152\/ejbh.2019.4537","article-title":"An application of the protection motivation theory to predict breast self-examination behavior among female healthcare workers","volume":"15","author":"Bashirian","year":"2019","journal-title":"Eur. J. Breast Health"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5812\/ijcm.100535","article-title":"Determinants of breast cancer screening: Application of protection motivation theory","volume":"13","author":"Ghofranipour","year":"2020","journal-title":"Int. J. Cancer Manag."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"224","DOI":"10.3961\/jpmph.18.277","article-title":"Factors affecting breast self-examination behavior among female healthcare workers in Iran: The role of social support theory","volume":"52","author":"Bashirian","year":"2019","journal-title":"J. Prev. Med. Public Health"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"568","DOI":"10.2471\/BLT.18.207944","article-title":"Cost-effectiveness of risk-based breast cancer screening programme, China","volume":"96","author":"Sun","year":"2018","journal-title":"Bull. World Health Organ."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"China Anti-Cancer Association, National Clinical Research Center for Cancer (2019). Breast cancer screening guideline for Chinese women. Cancer Biol. Med., 16, 822\u2013824.","DOI":"10.20892\/j.issn.2095-3941.2019.0321"},{"key":"ref_40","first-page":"303","article-title":"Development of breast cancer screening protection motivation scale for Chinese women and its reliability and validity test","volume":"37","author":"Zhang","year":"2021","journal-title":"Chin. J. Health Educ."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.1559-1816.2000.tb02308.x","article-title":"Prediction and intervention in health-related behavior: A meta-analytic review of protection motivation theory","volume":"30","author":"Milne","year":"2000","journal-title":"J. Appl. Soc. Psychol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/j.1559-1816.2000.tb02323.x","article-title":"A meta-analysis of research on protection motivation theory","volume":"2","author":"Floyd","year":"2000","journal-title":"J. Appl. Soc. Psychol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1080\/0887044021000019358","article-title":"Planning and self-efficacy in the adoption and maintenance of breast self-examination: A longitudinal study on self-regulatory cognitions","volume":"18","author":"Luszczynska","year":"2003","journal-title":"Psychol. Health"},{"key":"ref_44","first-page":"347","article-title":"From \u2018I Wish\u2019 to \u2018I Will\u2019: Social-cognitive predictors of behavioral intentions","volume":"8","author":"Garcia","year":"2003","journal-title":"J. Health Psychol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1023\/A:1011233007132","article-title":"Attitudes to screening for cervical cancer: A population-based study in Sweden","volume":"12","author":"Eaker","year":"2001","journal-title":"Cancer Causes Control"},{"key":"ref_46","first-page":"755","article-title":"Effect of an educational intervention based on protection motivation theory on preventing cervical cancer among marginalized women in West Iran","volume":"19","author":"Malmir","year":"2018","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"85","DOI":"10.15171\/hpp.2016.15","article-title":"Response costs of mammography adherence: Iranian women's perceptions","volume":"6","author":"Khodayarian","year":"2016","journal-title":"Health Promot. Perspect."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"e018523","DOI":"10.1136\/bmjopen-2017-018523","article-title":"Factors associated with insufficient awareness of breast cancer among women in Northern and Eastern China: A case-control study","volume":"8","author":"Liu","year":"2018","journal-title":"BMJ Open"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"4191","DOI":"10.7314\/APJCP.2012.13.8.4191","article-title":"Identifying women's knowledge about risk factors of breast cancer and reasons for having mammography","volume":"13","author":"Guvenc","year":"2012","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1073274819863777","DOI":"10.1177\/1073274819863777","article-title":"Knowledge, attitude, and practice regarding breast cancer early detection among women in a mountainous area in Northern Vietnam","volume":"26","author":"Toan","year":"2019","journal-title":"Cancer Control"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1097\/NCC.0000000000000195","article-title":"Social cultural influences on breast cancer views and breast health practices among Chinese women in the United Kingdom","volume":"38","author":"Shang","year":"2015","journal-title":"Cancer Nurs."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Molaei-Zardanjani, M., Savabi-Esfahani, M., and Taleghani, F. (2019). Fatalism in breast cancer and performing mammography on women with or without a family history of breast cancer. BMC Womens Health, 19.","DOI":"10.1186\/s12905-019-0810-6"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1158\/1055-9965.EPI-06-0608","article-title":"Fatalistic beliefs about cancer prevention and three prevention behaviors","volume":"16","author":"Niederdeppe","year":"2007","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s13187-013-0496-7","article-title":"Fatalistic cancer beliefs and information sources among rural and urban adults in the USA","volume":"28","author":"Befort","year":"2013","journal-title":"J. Cancer Educ."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/18\/21\/11093\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:20:34Z","timestamp":1760167234000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/18\/21\/11093"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,21]]},"references-count":54,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2021,11]]}},"alternative-id":["ijerph182111093"],"URL":"https:\/\/doi.org\/10.3390\/ijerph182111093","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,21]]}}}