{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:36:03Z","timestamp":1782779763962,"version":"3.54.5"},"reference-count":39,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T00:00:00Z","timestamp":1635379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61701482"],"award-info":[{"award-number":["61701482"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Natural Science Foundation of Anhui Province, China","award":["1808085MF191"],"award-info":[{"award-number":["1808085MF191"]}]},{"name":"the Major science and technology projects in Anhui Province","award":["202103a07020004"],"award-info":[{"award-number":["202103a07020004"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Objective: To evaluate the bone response to an 8 month aerobic gymnastics training program in young opioid-addicted women. Design: Randomized controlled trial (parallel design). Setting: Women\u2019s Specific Drug Rehabilitation Center in China. Patients: One hundred and two young women with low bone quality and previous opioid addiction were divided into two groups: (a) the low bone quality intervention experimental group (n = 55; age: 30.3 \u00b1 6.1) and (b) the low bone quality observed control group (observation group; n = 47; age: 29.0 \u00b1 5.3). Interventions: The intervention group took aerobic gymnastics regularly for 80 min\/d and 5 d\/wk for 8 months and completed follow-up testing. Main Outcome Measures: Substance use history and other life habits affecting bone quality were assessed by questionnaire-based interviews. Bone quality (stiffness-index, T-score, Z-score) was examined with quantitative ultrasound. Anthropometric characteristics (body weight, fat-free mass, fat mass) were obtained by bioelectrical impedance analysis. Results: After the 8 month intervention, the stiffness index of bone quality increased significantly (before: 82 \u00b1 6, after: 108 \u00b1 14, p &lt; 0.05) in the experimental group. However, the bone quality did not change significantly in the controls (before: 79 \u00b1 10, after: 77 \u00b1 13, p &gt; 0.05). The bone change in the difference group was significant (experimental group: 31.7% vs observation group: -0.03%). Fat mass decreased in the experimental group (experimental group: before: 19.6 \u00b1 3.7 kg, after: 18.8 \u00b1 4.0 kg, p &lt; 0.05). Meanwhile, the change in fat-free mass was the determination of the change in bone quality in the experimental group. Conclusions: Our results suggested that aerobic gymnastics intervention can be an effective strategy for the prevention and treatment of drug-induced osteoporosis in detoxification addicts.<\/jats:p>","DOI":"10.3390\/ijerph182111336","type":"journal-article","created":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T23:50:28Z","timestamp":1635465028000},"page":"11336","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effect of Eight-Month Exercise Intervention on Bone Outcomes of Young Opioid-Dependent Women"],"prefix":"10.3390","volume":"18","author":[{"given":"Zenghui","family":"Ding","sequence":"first","affiliation":[{"name":"Center for Information Technology of Sports and Health, Institute of Intelligent Machines, Hefei Institutes of Physical Science, Chinese Academy of Sciences , Hefei 230031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuchang","family":"Ma","sequence":"additional","affiliation":[{"name":"Center for Information Technology of Sports and Health, Institute of Intelligent Machines, Hefei Institutes of Physical Science, Chinese Academy of Sciences , Hefei 230031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianjun","family":"Yang","sequence":"additional","affiliation":[{"name":"Center for Information Technology of Sports and Health, Institute of Intelligent Machines, Hefei Institutes of Physical Science, Chinese Academy of Sciences , Hefei 230031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yining","family":"Sun","sequence":"additional","affiliation":[{"name":"Center for Information Technology of Sports and Health, Institute of Intelligent Machines, Hefei Institutes of Physical Science, Chinese Academy of Sciences , Hefei 230031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.drugalcdep.2017.02.010","article-title":"A comparison of bone quality and its determinants in young opioid-dependent women with healthy control group","volume":"175","author":"Ding","year":"2017","journal-title":"Drug Alcohol Depend."},{"key":"ref_2","first-page":"1","article-title":"Bone mineral density and its determinants in men with opioid dependence","volume":"35","author":"Gotthardt","year":"2016","journal-title":"J. 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