{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:53:08Z","timestamp":1791899588041,"version":"4.3.4"},"reference-count":99,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2021,10,30]],"date-time":"2021-10-30T00:00:00Z","timestamp":1635552000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["K01MH118073"],"award-info":[{"award-number":["K01MH118073"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Men who have sex with men and transgender women in the United States are at increased risk for HIV and may benefit from pre-exposure prophylaxis (PrEP), a once-a-day pill to prevent HIV. Due to stigma and discrimination, sexual and gender minority (SGM) populations are also at risk for depression and anxiety. This scoping review sought to identify literature addressing relationships between the PrEP care continuum, depression, and anxiety among SGM individuals and others at high risk for HIV. We conducted a systematic review of four databases (i.e., PubMed, PsycInfo, Web of Science, Google Scholar) and identified 692 unique articles that were screened for inclusion criteria, with 51 articles meeting the final inclusion criteria. Data were extracted for key study criteria (e.g., geographic location, participant demographics, study design, main findings). Results suggest that while depression and anxiety are not associated with PrEP awareness or willingness to use, they can be barriers to seeking care and to PrEP adherence. However, empirical studies show that taking PrEP is associated with reductions in anxiety. Findings suggest the need to implement mental health screenings in PrEP clinical care. In addition, addressing systemic and structural issues that contribute to mental health disorders, as well as PrEP-related barriers, is critical.<\/jats:p>","DOI":"10.3390\/ijerph182111431","type":"journal-article","created":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T22:21:34Z","timestamp":1635805294000},"page":"11431","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["A Scoping Review Investigating Relationships between Depression, Anxiety, and the PrEP Care Continuum in the United States"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3581-7531","authenticated-orcid":false,"given":"Sarah J.","family":"Miller","sequence":"first","affiliation":[{"name":"Department of Psychology, College of Arts and Sciences, University of South Carolina, Columbia, SC 29208, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayward E.","family":"Harrison","sequence":"additional","affiliation":[{"name":"Department of Psychology, College of Arts and Sciences, University of South Carolina, Columbia, SC 29208, USA"},{"name":"South Carolina Smart State Center for Healthcare Quality, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamla","family":"Sanasi-Bhola","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, School of Medicine, University of South Carolina, Columbia, SC 29203, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,30]]},"reference":[{"key":"ref_1","unstructured":"(2021, July 27). CDC HIV Basic Statistics, Available online: https:\/\/www.cdc.gov\/hiv\/basics\/statistics.html."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1001\/jama.2019.1343","article-title":"Ending the HIV epidemic: A plan for the United States","volume":"321","author":"Fauci","year":"2019","journal-title":"JAMA"},{"key":"ref_3","unstructured":"(2021, September 07). CDC HIV Special Focus Profiles, Available online: https:\/\/www.cdc.gov\/hiv\/library\/reports\/hiv-surveillance\/vol-32\/content\/special-focus-profiles.html."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2774","DOI":"10.1007\/s10461-016-1656-7","article-title":"Diagnosed HIV infection in transgender adults and adolescents: Results from the national HIV surveillance system, 2009\u20132014","volume":"21","author":"Clark","year":"2017","journal-title":"AIDS Behav."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.2105\/AJPH.2018.304727","article-title":"Estimating the prevalence of HIV and sexual behaviors among the US transgender population: A systematic review and meta-analysis, 2006\u20132017","volume":"109","author":"Becasen","year":"2019","journal-title":"Am. J. Public Health"},{"key":"ref_6","unstructured":"(2021, September 09). HIV.gov Pre-Exposure Prophylaxis, Available online: https:\/\/www.hiv.gov\/hiv-basics\/hiv-prevention\/using-hiv-medication-to-reduce-risk\/pre-exposure-prophylaxis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1016\/S0140-6736(13)61127-7","article-title":"Antiretroviral prophylaxis for HIV infection in injecting drug users in Bangkok, Thailand (the Bangkok Tenofovir study): A randomised, double-blind, placebo-controlled phase 3 trial","volume":"381","author":"Choopanya","year":"2013","journal-title":"Lancet"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1097\/QAD.0000000000000613","article-title":"The impact of adherence to preexposure prophylaxis on the risk of HIV infection among people who inject drugs","volume":"29","author":"Martin","year":"2015","journal-title":"AIDS"},{"key":"ref_9","unstructured":"(2021, September 09). FDA Truvada for PrEP Fact Sheet, Available online: https:\/\/www.fda.gov\/media\/83586\/download."},{"key":"ref_10","unstructured":"(2021, September 13). HIV.gov Long-Acting HIV Prevention Tools, Available online: https:\/\/www.hiv.gov\/hiv-basics\/hiv-prevention\/potential-future-options\/long-acting-prep."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1056\/NEJMoa2101016","article-title":"Cabotegravir for HIV prevention in cisgender men and transgender women","volume":"385","author":"Landovitz","year":"2021","journal-title":"New Engl. J. Med."},{"key":"ref_12","unstructured":"(2021, September 09). Center for Disease Control and Prevention Preexposure Prophylaxis for the Prevention of HIV Infection in the United States\u20142017 Update: A Clinical Practice Guideline 2017, Available online: https:\/\/www.cdc.gov\/hiv\/pdf\/risk\/prep\/cdc-hiv-prep-guidelines-2017.pdf."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1097\/QAD.0000000000001385","article-title":"Defining the HIV pre-exposure prophylaxis care continuum","volume":"31","author":"Nunn","year":"2017","journal-title":"AIDS"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1097\/QAI.0000000000001251","article-title":"Uptake of HIV Pre-Exposure Prophylaxis (PrEP) in a national cohort of gay and bisexual men in the United States: The motivational PrEP cascade","volume":"74","author":"Parsons","year":"2017","journal-title":"J. Acquir. Immune Defic. Syndr."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1097\/QAI.0000000000002345","article-title":"Growth in proportion and disparities of HIV PrEP use among key populations identified in the United States national goals: Systematic review and meta-analysis of published surveys","volume":"84","author":"Kamitani","year":"2020","journal-title":"J. Acquir. Immune Defic. Syndr."},{"key":"ref_16","first-page":"16","article-title":"Racial characteristics of FTC\/TDF for Pre-Exposure Prophylaxis (PrEP) users in the US","volume":"16","author":"Bush","year":"2016","journal-title":"ASM Microbe\/ICAAC"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1089\/apc.2012.0419","article-title":"From efficacy to effectiveness: Facilitators and barriers to PrEP acceptability and motivations for adherence among MSM and transgender women in New York City","volume":"27","author":"Golub","year":"2013","journal-title":"AIDS Patient Care STDS"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1521\/aeap.2017.29.4.302","article-title":"Attitudes, beliefs, and barriers to PrEP among trans men","volume":"29","author":"Rowniak","year":"2017","journal-title":"AIDS Educ. Prev."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"520","DOI":"10.2174\/1570162X12666140129100411","article-title":"PrEP awareness and perceived barriers among single young men who have sex with men in the United States","volume":"11","author":"Bauermeister","year":"2013","journal-title":"Curr. HIV Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1037\/0033-2909.129.5.674","article-title":"Prejudice, social stress, and mental health in lesbian, gay, and bisexual populations: Conceptual issues and research evidence","volume":"129","author":"Meyer","year":"2003","journal-title":"Psychol. Bull."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1001\/jamapsychiatry.2017.4602","article-title":"Epidemiology of adult DSM-5 major depressive disorder and its specifiers in the United States","volume":"75","author":"Hasin","year":"2018","journal-title":"JAMA Psychiatry"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.2105\/AJPH.2006.096826","article-title":"Lifetime prevalence of mental disorders and suicide attempts in diverse lesbian, gay, and bisexual populations","volume":"98","author":"Meyer","year":"2008","journal-title":"Am. J. Public Health"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1037\/a0031774","article-title":"Anxiety and depression in transgender individuals: The roles of transition status, loss, social support, and coping","volume":"81","author":"Budge","year":"2013","journal-title":"J. Consult. Clin. Psychol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/mpr.1359","article-title":"Twelve-month and lifetime prevalence and lifetime morbid risk of anxiety and mood disorders in the United States","volume":"21","author":"Kessler","year":"2012","journal-title":"Int. J. Methods Psychiatr. Res."},{"key":"ref_25","unstructured":"World Health Organization (2016). Consolidated Guidelines on the Use of Antiretroviral Drugs for Treating and Preventing HIV Infection 2016 Recommendations for a Public Health Approach, World Health Organization."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1097\/QAD.0000000000002227","article-title":"Mental health and HIV\/AIDS: The need for an integrated response","volume":"33","author":"Remien","year":"2019","journal-title":"AIDS"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e25748","DOI":"10.1002\/jia2.25748","article-title":"Integrating mental health into HIV prevention and care: A call to action","volume":"24","author":"Remien","year":"2021","journal-title":"J. Int. AIDS Soc."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1080\/1364557032000119616","article-title":"Scoping studies: Towards a methodological framework","volume":"8","author":"Arksey","year":"2005","journal-title":"Int. J. Soc. Res. Methodol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/1748-5908-5-69","article-title":"Scoping studies: Advancing the methodology","volume":"5","author":"Levac","year":"2010","journal-title":"Implement. Sci."},{"key":"ref_30","first-page":"141","article-title":"Guidance for conducting systematic scoping reviews","volume":"13","author":"Peters","year":"2015","journal-title":"JBI Evid. Implement."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Haddaway, N.R., Collins, A.M., Coughlin, D., and Kirk, S. (2015). The role of Google Scholar in evidence reviews and its applicability to grey literature searching. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0138237"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: An updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s11121-017-0756-6","article-title":"A multi-US city assessment of awareness and uptake of Pre-Exposure Prophylaxis (PrEP) for HIV prevention among black men and transgender women who have sex with men","volume":"18","author":"Eaton","year":"2017","journal-title":"Prev. Sci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2694","DOI":"10.1007\/s10461-019-02446-3","article-title":"Prevalence and correlates of PrEP awareness and use among black men who have sex with men and women (MSMW) in the United States","volume":"23","author":"Friedman","year":"2019","journal-title":"AIDS Behav."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Krakower, D.S., Mimiaga, M.J., Rosenberger, J.G., Novak, D.S., Mitty, J.A., White, J.M., and Mayer, K.H. (2012). Limited awareness and low immediate uptake of pre-exposure prophylaxis among men who have sex with men using an internet social networking site. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0033119"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Liu, Y., Brown, L., Przybyla, S., Bleasdale, J., Mitchell, J., and Zhang, C. (2021). Characterizing racial differences of mental health burdens, psychosocial determinants, and impacts on HIV prevention outcomes among young men who have sex with men: A community-based study in two, U.S. Cities. J. Racial Ethn. Health Disparities, 1\u201311.","DOI":"10.1007\/s40615-021-01052-1"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s12529-020-09925-1","article-title":"Intersecting barriers to PrEP awareness and uptake in black men who have sex with men in Atlanta, GA: A syndemic perspective","volume":"28","author":"Sullivan","year":"2020","journal-title":"Int. J. Behav. Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"108477","DOI":"10.1016\/j.drugalcdep.2020.108477","article-title":"Willingness to initiate Pre-Exposure Prophylaxis (PrEP) and its use among opioid-dependent individuals in drug treatment","volume":"219","author":"Ni","year":"2021","journal-title":"Drug Alcohol Depend."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1089\/apc.2018.0182","article-title":"Awareness and interest in HIV pre-exposure prophylaxis among street-based female sex workers: Results from a US context","volume":"33","author":"Tomko","year":"2019","journal-title":"AIDS Patient care STDs"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1007\/s10461-020-02979-y","article-title":"A pilot study to evaluate a novel pre-exposure prophylaxis peer outreach and navigation intervention for women at high risk for HIV infection","volume":"25","author":"Blackstock","year":"2021","journal-title":"AIDS Behav."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.30845\/aijcr.v10n1p1","article-title":"Evaluating HIV risk factors and willingness to use prep among African American collegiate women","volume":"10","author":"Bologna","year":"2020","journal-title":"Am. Int. J. Contemp. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s10508-019-01470-7","article-title":"Syndemics and the PrEP cascade: Results from a sample of young latino men who have sex with men","volume":"49","author":"Blashill","year":"2020","journal-title":"Arch. Sex. Behav."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.drugalcdep.2016.02.044","article-title":"Willingness to Use HIV pre-exposure prophylaxis among community-recruited, older people who inject drugs in Washington, DC","volume":"164","author":"Kuo","year":"2016","journal-title":"Drug Alcohol Depend."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"3576","DOI":"10.1007\/s10461-018-2067-8","article-title":"Facilitators and barriers to Pre-Exposure Prophylaxis (PrEP) use among black individuals in the United States: Results from the National Survey on HIV in the Black Community (NSHBC)","volume":"22","author":"Ojikutu","year":"2018","journal-title":"AIDS Behav."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"108058","DOI":"10.1016\/j.jsat.2020.108058","article-title":"Awareness about and willingness to use Long-Acting Injectable Pre-Exposure Prophylaxis (LAI-PrEP) among people who use drugs","volume":"117","author":"Shrestha","year":"2020","journal-title":"J. Subst. Abuse Treat."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.drugalcdep.2016.12.023","article-title":"Correlates of willingness to initiate pre-exposure prophylaxis and anticipation of practicing safer drug- and sex-related behaviors among high-risk drug users on methadone treatment","volume":"173","author":"Shrestha","year":"2017","journal-title":"Drug Alcohol Depend."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1080\/09540121.2020.1762067","article-title":"Racial and ethnic differences in women\u2019s HIV risk and attitudes towards pre-exposure prophylaxis (prep) in the context of the substance use, violence, and depression syndemic","volume":"33","author":"Willie","year":"2021","journal-title":"AIDS Care"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1007\/s10461-021-03159-2","article-title":"Multilevel barriers to HIV prep uptake and adherence among black and hispanic\/latinx transgender women in Southern California","volume":"25","author":"Ogunbajo","year":"2021","journal-title":"AIDS Behav."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1521\/aeap.2020.32.6.472","article-title":"Barriers and facilitators to PrEP initiation and adherence among transgender and gender non-binary individuals in Southern California","volume":"32","author":"Watson","year":"2020","journal-title":"AIDS Educ. Prev."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1007\/s10461-020-02807-3","article-title":"Understanding prep persistence: Provider and patient perspectives","volume":"24","author":"Laborde","year":"2020","journal-title":"AIDS Behav."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1080\/09540121.2018.1447079","article-title":"HIV risk perception and eligibility for pre-exposure prophylaxis in women involved in the criminal justice system","volume":"30","author":"Rutledge","year":"2018","journal-title":"AIDS Care"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1097\/QAI.0000000000002668","article-title":"Referral linkage to preexposure prophylaxis care and persistence on preexposure prophylaxis in an integrated health care system","volume":"87","author":"Bruxvoort","year":"2021","journal-title":"JAIDS J. Acquir. Immune Defic. Syndr."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e25399","DOI":"10.1002\/jia2.25399","article-title":"Lack of health insurance is associated with delays in PrEP initiation among young black men who have sex with men in Atlanta, US: A longitudinal cohort study","volume":"22","author":"Serota","year":"2019","journal-title":"J. Int. AIDS Soc."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1093\/cid\/ciz894","article-title":"Pre-exposure prophylaxis uptake and discontinuation among young black men who have sex with men in Atlanta, Georgia: A prospective cohort study","volume":"71","author":"Serota","year":"2020","journal-title":"Clin. Infect. Dis"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"e25223","DOI":"10.1002\/jia2.25223","article-title":"Pre-exposure prophylaxis initiation and adherence among black men who have sex with men (MSM) in three US cities: Results from the HPTN 073 study","volume":"22","author":"Wheeler","year":"2019","journal-title":"J. Int. AIDS Soc."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1097\/QAI.0000000000002407","article-title":"Brief report: Associations between self-reported substance use behaviors and PrEP acceptance and adherence among black MSM in the HPTN 073 study","volume":"85","author":"Okafor","year":"2020","journal-title":"J. Acquir. Immune Defic. Syndr."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1097\/QAI.0000000000002332","article-title":"Nondaily use of HIV preexposure prophylaxis in a large online survey of primarily men who have sex with men in the United States","volume":"84","author":"Sewell","year":"2020","journal-title":"J. Acquir. Immune Defic. Syndr."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1007\/s10461-020-03004-y","article-title":"Mental health, social influences, and HIV pre-exposure prophylaxis (prep) utilization among men and transgender individuals screening for HIV prevention trials","volume":"25","author":"Wood","year":"2020","journal-title":"AIDS Behav."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1007\/s10508-020-01791-y","article-title":"Factors associated with being PrEP-na\u00efve among a US National cohort of former-PrEP and PrEP-na\u00efve participants meeting objective criteria for PrEP care","volume":"50","author":"Carneiro","year":"2021","journal-title":"Arch. Sex. Behav."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1080\/09540121.2019.1659921","article-title":"Understanding the impact of a syndemic on the use of pre-exposure prophylaxis in a community-based sample of behaviorally PrEP-eligible BMSM in the United States","volume":"32","author":"Chandler","year":"2020","journal-title":"AIDS Care"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1097\/QAI.0000000000001822","article-title":"Elevated HIV prevalence and correlates of PrEP use among a community sample of black men who have sex with men","volume":"79","author":"Eaton","year":"2018","journal-title":"J. Acquir. immune Defic. Syndr."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1080\/19359705.2019.1688216","article-title":"Use of prep, sexual behaviors and mental health correlates in a sample of gay, bisexual and other men who have sex with men","volume":"24","author":"Moeller","year":"2020","journal-title":"J. Gay Lesbian Ment. Health"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1177\/0956462420911559","article-title":"Correlation of pre-exposure prophylaxis adherence to a mental health diagnosis or experience of childhood trauma in high-risk youth","volume":"31","author":"Young","year":"2020","journal-title":"Int. J. STD AIDS"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1097\/QAD.0000000000001615","article-title":"Hair levels of preexposure prophylaxis drugs measure adherence and are associated with renal decline among men\/transwomen","volume":"31","author":"Gandhi","year":"2017","journal-title":"Aids"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1001\/jamainternmed.2015.4683","article-title":"Preexposure prophylaxis for HIV infection integrated with municipal-and community-based sexual health services","volume":"176","author":"Liu","year":"2016","journal-title":"JAMA Intern. Med."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.3201\/eid2412.180400","article-title":"Substance use and adherence to HIV preexposure prophylaxis for men who have sex with men","volume":"24","author":"Hoenigl","year":"2018","journal-title":"Emerg. Infect. Dis."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1097\/QAI.0000000000001965","article-title":"Factors associated with sex-related pre-exposure prophylaxis adherence among men who have sex with men in New York City in HPTN 067","volume":"80","author":"Mannheimer","year":"2019","journal-title":"J. Acquir. immune Defic. Syndr."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"3436","DOI":"10.1007\/s10461-020-02901-6","article-title":"Adherence to pre-exposure prophylaxis in black men who have sex with men and transgender women in a community setting in Harlem, NY","volume":"24","author":"Colson","year":"2020","journal-title":"AIDS Behav."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1093\/infdis\/jiy368","article-title":"Trajectories and predictors of longitudinal preexposure prophylaxis adherence among men who have sex with men","volume":"218","author":"Pasipanodya","year":"2018","journal-title":"J. Infect. Dis."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"e25472","DOI":"10.1002\/jia2.25472","article-title":"Missed opportunities to prevent HIV infections among pre-exposure prophylaxis users: A population-based mixed methods study, San Francisco, United States","volume":"23","author":"Spinelli","year":"2020","journal-title":"J. Int. AIDS Soc."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"e25250","DOI":"10.1002\/jia2.25250","article-title":"Patterns and clinical consequences of discontinuing HIV preexposure prophylaxis during primary care","volume":"22","author":"Krakower","year":"2019","journal-title":"J. Int. AIDS Soc."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1097\/QAD.0000000000002347","article-title":"Racial\/ethnic and HIV risk category disparities in preexposure prophylaxis discontinuation among patients in publicly funded primary care clinics","volume":"33","author":"Scott","year":"2019","journal-title":"Aids"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"E104","DOI":"10.1097\/QAI.0000000000002054","article-title":"Predictors of disengagement in care for individuals receiving Pre-Exposure Prophylaxis (PrEP)","volume":"81","author":"Zucker","year":"2019","journal-title":"JAIDS-J. Acquir. Immune Defic. Syndr."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1007\/s10461-017-1871-x","article-title":"Lessons for patient education around long-acting injectable PrEP: Findings from a mixed-method study of phase II trial participants","volume":"22","author":"Meyers","year":"2017","journal-title":"AIDS Behav."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1007\/s10461-015-1055-5","article-title":"Sexual behavior, risk compensation, and HIV prevention strategies among participants in the San Francisco PrEP demonstration project: A qualitative analysis of counseling notes","volume":"20","author":"Hojilla","year":"2016","journal-title":"AIDS Behav."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Zapata, J.P., Petroll, A., de St. Aubin, E., and Quinn, K. (2020). Perspectives on social support and stigma in prep-related care among gay and bisexual men: A qualitative investigation. J. Homosex., 1\u201323.","DOI":"10.1080\/00918369.2020.1819709"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1080\/09540121.2019.1695734","article-title":"PrEP and sexual well-being: A qualitative study on PrEP, sexuality of MSM, and patient-provider relationships","volume":"32","author":"Devarajan","year":"2020","journal-title":"AIDS Care"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1089\/apc.2015.0002","article-title":"Getting prepared for HIV prevention navigation: Young black gay men talk about HIV prevention in the biomedical era","volume":"29","author":"Mutchler","year":"2015","journal-title":"AIDS Patient Care STDs"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1007\/s10508-019-1417-6","article-title":"Making meaning of the impact of Pre-Exposure Prophylaxis (PrEP) on public health and sexual culture: Narratives of three generations of gay and bisexual men","volume":"48","author":"Hammack","year":"2019","journal-title":"Arch. Sex. Behav."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1007\/s10461-019-02747-7","article-title":"The unanticipated benefits of PrEP for young black gay, bisexual, and other men who have sex with men","volume":"24","author":"Quinn","year":"2020","journal-title":"AIDS Behav."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1007\/s11121-017-0799-8","article-title":"Risk perception, sexual behaviors, and PrEP adherence among substance-using men who have sex with men: A qualitative study","volume":"18","author":"Storholm","year":"2017","journal-title":"Prev. Sci."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1080\/09540121.2019.1622639","article-title":"Beyond HIV prevention: A qualitative study of patient-reported outcomes of PrEP among MSM patients in two public STD clinics in Baltimore","volume":"32","author":"Yang","year":"2020","journal-title":"AIDS Care"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1080\/09540121.2016.1168911","article-title":"HIV-negative male couples\u2019 attitudes about Pre-Exposure Prophylaxis (PrEP) and using PrEP with a sexual agreement","volume":"28","author":"Mitchell","year":"2016","journal-title":"AIDS Care"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1089\/apc.2011.0283","article-title":"Sexual risk behaviors and acceptability of HIV pre-exposure prophylaxis among HIV-negative gay and bisexual men in serodiscordant relationships: A mixed methods study","volume":"26","author":"Brooks","year":"2012","journal-title":"AIDS Patient Care STDs"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1080\/00224499.2019.1572064","article-title":"The impact of Pre-Exposure Prophylaxis (PrEP) use on sexual anxiety, satisfaction, and esteem among gay and bisexual men","volume":"56","author":"Whitfield","year":"2019","journal-title":"J. Sex. Res."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1089\/lgbt.2019.0025","article-title":"Psychosocial syndemic risks surrounding physical health conditions among sexual and gender minority individuals","volume":"6","author":"Scheer","year":"2019","journal-title":"LGBT Health"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/BF02879919","article-title":"Psychosocial health problems increase risk for HIV among urban young men who have sex with men: Preliminary evidence of a syndemic in need of attention","volume":"34","author":"Mustanski","year":"2007","journal-title":"Ann. Behav. Med."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1016\/j.socscimed.2006.05.012","article-title":"Syndemics, sex and the city: Understanding sexually transmitted diseases in social and cultural context","volume":"63","author":"Singer","year":"2006","journal-title":"Soc. Sci. Med."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1007\/s10461-016-1415-9","article-title":"The Effect of depressive symptoms on adherence to daily oral PrEP in men who have sex with men and transgender women: A marginal structural model analysis of the IPrEx OLE study","volume":"20","author":"Mehrotra","year":"2016","journal-title":"AIDS Behav."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"e25351","DOI":"10.1002\/jia2.25351","article-title":"Give PrEP a chance: Moving on from the \u201cRisk Compensation\u201d concept","volume":"22","author":"Delabre","year":"2019","journal-title":"J. Int. AIDS Soc."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1177\/014662167700100306","article-title":"The CES-D scale: A self-report depression scale for research in the general population","volume":"1","author":"Radloff","year":"1977","journal-title":"Appl. Psychol. Meas."},{"key":"ref_92","unstructured":"(2021, September 16). Center for Disease Control & Prevention HIV in the Southern United States 2019, Available online: https:\/\/www.cdc.gov\/hiv\/pdf\/policies\/cdc-hiv-in-the-south-issue-brief.pdf."},{"key":"ref_93","unstructured":"(2021, September 27). Center for Disease Control and Prevention HIV in the United States by Region, Available online: https:\/\/www.cdc.gov\/hiv\/statistics\/overview\/geographicdistribution.html."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1007\/s10900-017-0325-8","article-title":"State of HIV in the US deep south","volume":"42","author":"Reif","year":"2017","journal-title":"J. Community Health"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"e41","DOI":"10.1097\/MCG.0000000000000151","article-title":"Adherence during antiviral treatment regimens for chronic Hepatitis C: A qualitative study of patient-reported facilitators and barriers","volume":"49","author":"Evon","year":"2015","journal-title":"J. Clin. Gastroenterol"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1080\/19359705.2015.1105765","article-title":"Self-administered screening for syndemic mental health problems should be routinely implemented among MSM PrEP users","volume":"20","author":"Tan","year":"2016","journal-title":"J. Gay Lesbian Ment. Health"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.cbpra.2016.02.004","article-title":"\u201cLife-Steps\u201d for PrEP adherence: Demonstration of a CBT-based intervention to increase adherence to Preexposure Prophylaxis (PrEP) medication among sexual-minority men at high risk for HIV acquisition","volume":"24","author":"Taylor","year":"2017","journal-title":"Cogn. Behav. Pract."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1097\/COH.0000000000000220","article-title":"Current concepts for PrEP adherence","volume":"11","author":"Haberer","year":"2016","journal-title":"Curr. Opin. HIV AIDS"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1089\/apc.2017.0255","article-title":"A mobile health strategy to support adherence to antiretroviral preexposure prophylaxis","volume":"32","author":"Fuchs","year":"2018","journal-title":"AIDS Patient Care STDs"}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/18\/21\/11431\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:23:23Z","timestamp":1760167403000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/18\/21\/11431"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,30]]},"references-count":99,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2021,11]]}},"alternative-id":["ijerph182111431"],"URL":"https:\/\/doi.org\/10.3390\/ijerph182111431","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,30]]}}}