{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:29:02Z","timestamp":1790015342487,"version":"4.0.1"},"reference-count":199,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2021,10,30]],"date-time":"2021-10-30T00:00:00Z","timestamp":1635552000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>The illegal trade of wildlife in SE Asia has been identified as the likely cause of the COVID-19 pandemic. We reviewed 198 papers on the current COVID pandemic in Cambodia, diseases such as avian influenza and Nipah virus, most likely to develop into a new pandemic in Cambodia, and common features of disease that require mitigation. Artisanal goldmining uses pure mercury in the areas where wildlife is smuggled to China. Moreover, 30\u201340% of Cambodians are zinc deficient. High levels of arsenic in irrigation water (&gt;1000 \u00b5g\/L) are associated with very low levels of zinc in rice (5 \u00b5g\/g) and rice is the primary staple food for the region. Brown rice from nine of 15 paddy fields in the arsenic zone of Cambodia had double the new guidelines of 100 \u00b5g\/kg inorganic arsenic for children\u2019s food in the EU and USA. The combination of deficiencies of essential micronutrients like zinc and pervasive presence of arsenic and mercury has the potential to compromise the immunity of many Cambodians. Innovative solutions are suggested to improve micronutrient nutrition. Toxins that suppress the immune system must be better managed to reduce the virulence of pathogens. Cambodia was not likely the source of the COVID-19 but does have problems that could result in a new pandemic.<\/jats:p>","DOI":"10.3390\/ijerph182111446","type":"journal-article","created":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T22:21:34Z","timestamp":1635805294000},"page":"11446","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Role of Micronutrients and Toxic Metals in the Management of Epidemics in Cambodia"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5427-1290","authenticated-orcid":false,"given":"Thomas","family":"Murphy","sequence":"first","affiliation":[{"name":"Faculty of Science and Technology, International University, Phnom Penh 12000, Cambodia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2965-8415","authenticated-orcid":false,"given":"Kongkea","family":"Phan","sequence":"additional","affiliation":[{"name":"Faculty of Science and Technology, International University, Phnom Penh 12000, Cambodia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim Neil","family":"Irvine","sequence":"additional","affiliation":[{"name":"Faculty of Architecture & Planning, Rangsit Campus, Thammasat University, Khlong Nueng 12121, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Lean","sequence":"additional","affiliation":[{"name":"Lean Environmental, Apsley, ON K0L1A0, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,30]]},"reference":[{"key":"ref_1","unstructured":"Global Witness (2015). The Cost of Luxury: Cambodia\u2019s Illegal Trade in Precious Wood with China, Global Witness."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"127","DOI":"10.2166\/wqrj.2003.008","article-title":"New Microcystin Concerns in the Lower Great Lakes","volume":"38","author":"Murphy","year":"2003","journal-title":"Water Qual. Res. J. Can."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e01886","DOI":"10.1002\/eap.1886","article-title":"Changing landscapes of Southeast Asia and rodent-borne diseases: Decreased diversity but increased transmission risks","volume":"29","author":"Morand","year":"2019","journal-title":"Ecol. Appl."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s11684-020-0814-5","article-title":"Avian influenza A (H7N9) virus: From low pathogenic to highly pathogenic","volume":"15","author":"Liu","year":"2021","journal-title":"Front. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1080\/17441730.2018.1513111","article-title":"Migration and left-behind parents and children of migrants in Cambodia: A look at household composition and the economic situation","volume":"14","author":"Zimmer","year":"2018","journal-title":"Asian Popul. Stud."},{"key":"ref_6","unstructured":"World Food Programme (2021, October 29). Vulnerability and Migration in Cambodia. World Food Programme Cambodia Country Office. Available online: https:\/\/docs.wfp.org\/api\/documents\/WFP-0000105976\/download\/."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Horiuchi, Y., Kusama, K., Kanha, S., Yoshiike, N., and FIDR Research Team (2019). Urban-rural differences in nutritional status and dietary intakes of school-aged children in Cambodia. Nutrients, 11.","DOI":"10.3390\/nu11010014"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Greffeuille, V., Sophonneary, P., Laillou, A., Gauthier, L., Hong, R., Poirot, E., Dijkhuizen, M., Wieringa, F., and Berger, J. (2016). Persistent inequalities in child undernutrition in Cambodia from 2000 until today. Nutrients, 8.","DOI":"10.3390\/nu8050297"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Wieringa, F.T., Dahl, M., Chamnan, C., Poirot, E., Kuong, K., Sophonneary, P., Sinuon, M., Greuffeille, V., Hong, R., and Berger, J. (2016). The high prevalence of anemia in Cambodian children and women cannot be satisfactorily explained by nutritional deficiencies or hemoglobin disorders. Nutrients, 8.","DOI":"10.3390\/nu8060348"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jrurstud.2016.02.002","article-title":"Negotiating rural-urban transformation and life course fluidity: Rural young people and urban sojourn in contemporary Cambodia","volume":"44","author":"Peou","year":"2016","journal-title":"J. Rural Stud."},{"key":"ref_11","first-page":"16","article-title":"Land Grabbing in Laos and Cambodia: Understanding Why It is Happening","volume":"31","author":"Baird","year":"2017","journal-title":"Geogr. Rev."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5696\/2156-9614-9.22.190603","article-title":"Correlation between Arsenic and Zinc Levels in Rice from an Arsenic-Rich Zone in Cambodia: Environmental and Health Implications","volume":"9","author":"Murphy","year":"2019","journal-title":"J. Health Pollut."},{"key":"ref_13","unstructured":"(2021, October 29). Worldometer. Available online: https:\/\/www.worldometers.info\/coronavirus\/."},{"key":"ref_14","unstructured":"(2021, October 29). Khmer Times, Escape from Sokha Hotel: The Expos\u00e9 to the Possible Cause of Feb 20 Incident. Available online: https:\/\/www.khmertimeskh.com\/50823790\/escape-from-sokha-hotel-the-expose-to-the-possible-cause-of-feb-20-incident\/."},{"key":"ref_15","unstructured":"Khmer Times (2021, October 29). Hopes for Early Tourism Resumption Dashed. Available online: https:\/\/www.khmertimeskh.com\/734635\/hopes-for-early-tourism-resumption-dashed\/."},{"key":"ref_16","unstructured":"Khmer Times (2021, October 29). Tourism Sector Revenues Fell to $1 Billion Last Year. Available online: https:\/\/www.khmertimeskh.com\/50841611\/tourism-sector-revenues-fell-to-1-billion-last-year\/."},{"key":"ref_17","unstructured":"(2021, October 29). Our World in Data. Available online: https:\/\/ourworldindata.org\/COVID-vaccinations."},{"key":"ref_18","unstructured":"(2021, May 12). WHO-Covax. Available online: https:\/\/www.who.int\/initiatives\/act-accelerator\/covax."},{"key":"ref_19","unstructured":"Khmer Times (2021, October 29). Cambodia Ranks Second in ASEAN as the Country That Vaccinated More People against COVID-19. Available online: https:\/\/www.khmertimeskh.com\/50846882\/cambodia-ranks-second-in-asean-as-the-country-that-vaccinated-more-people-against-COVID-19\/."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1126\/science.abf8003","article-title":"Timing the SARS-CoV-2 index case in Hubei province","volume":"372","author":"Pekar","year":"2021","journal-title":"Science"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1007\/s42399-020-00363-4","article-title":"Comorbidity and its Impact on Patients with COVID-19","volume":"2","author":"Sanyaolu","year":"2020","journal-title":"SN Compr. Clin. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"108651","DOI":"10.1016\/j.clim.2020.108651","article-title":"Interrelations between COVID-19 and other disorders","volume":"224","author":"Gasmi","year":"2021","journal-title":"J. Clin. Immunol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"580057","DOI":"10.3389\/fpubh.2020.580057","article-title":"The Effects of Air Pollution on COVID-19 Infection and Mortality-A Review on Recent Evidence","volume":"8","author":"Ali","year":"2020","journal-title":"Front. Public Health"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Pegoraro, V., Heiman, F., Levante, A., Urbinati, D., and Peduto, I. (2021). An Italian individual-level data study investigating on the association between air pollution exposure and COVID-19 severity in primary-care setting. BMC Public Health, 21.","DOI":"10.1186\/s12889-021-10949-9"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"111809","DOI":"10.1016\/j.fct.2020.111809","article-title":"Toxic metal exposure as a possible risk factor for COVID-19 and other respiratory infectious diseases","volume":"146","author":"Skalny","year":"2020","journal-title":"Food Chem. Toxicol."},{"key":"ref_26","unstructured":"University of North Carolina, Gillings School of Global Public Health (2021, October 29). Researchers Receive $900K+ in Grants to Investigate Links between Arsenic Exposure, COVID-19 Risk. Available online: https:\/\/sph.unc.edu\/sph-news\/researchers-receive-900k-in-grants-to-investigate-links-between-arsenic-exposure-COVID-19-risk\/."},{"key":"ref_27","unstructured":"Graziano, J. (2010). One in Five Deaths in Bangladesh Linked to Arsenic [Internet], Columbia University. Available online: https:\/\/www.mailman.columbia.edu\/public-health-now\/news\/one-five-deaths-bangladesh-linked-arsenic."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"200612","DOI":"10.5696\/2156-9614-10.26.200612","article-title":"Interactions of Dimethylarsinic Acid, Total Arsenic and Zinc Affecting Rice Crop Management and Human Health in Cambodia","volume":"10","author":"Murphy","year":"2020","journal-title":"J. Health Pollut."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1007\/s10653-015-9759-z","article-title":"Current status of arsenic exposure and social implication in the Mekong River basin of Cambodia","volume":"38","author":"Phan","year":"2016","journal-title":"Environ. Geochem. Health"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1071\/EN14006","article-title":"Improved groundwater geogenic arsenic hazard map for Cambodia","volume":"11","author":"Sovann","year":"2014","journal-title":"Environ. Chem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/ngeo2589","article-title":"Arsenic release metabolically limited to permanently water-saturated soil in Mekong Delta","volume":"9","author":"Stuckey","year":"2016","journal-title":"Nature Geosci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"251","DOI":"10.2147\/RMHP.S153188","article-title":"Arsenic contamination in groundwater in Bangladesh: Implications and challenges for healthcare policy","volume":"11","author":"Ahmad","year":"2018","journal-title":"Risk Manag. Healthc. Policy"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.1038\/s41598-021-81579-9","article-title":"Arsenic exposure in Indo Gangetic plains of Bihar causing increased cancer risk","volume":"11","author":"Kumar","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1007\/s11356-017-9631-z","article-title":"Remarks on the current quality of groundwater in Vietnam","volume":"26","author":"Le","year":"2019","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"142062","DOI":"10.1016\/j.scitotenv.2020.142062","article-title":"Arsenic in waters, soils, sediments, and biota from Mexico: An environmental review","volume":"752","author":"Armienta","year":"2021","journal-title":"Sci. Total Environ."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.cotox.2018.01.003","article-title":"Arsenic and the immune system","volume":"10","author":"Bellamri","year":"2018","journal-title":"Curr. Opin. Toxicol."},{"key":"ref_37","unstructured":"EFSA Panel (2018). Scientific Opinion on the risk for public health related to the presence of mercury and methylmercury in food. EFSA Panel on Contaminants in the Food Chain (CONTAM). EFSA J., 10, 2985."},{"key":"ref_38","unstructured":"(2021, October 29). Minamata Convention on Mercury, UN Environment Programme. Available online: http:\/\/www.mercuryconvention.org\/."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"113","DOI":"10.5645\/ghp2013.01.016","article-title":"Emerging Problems with Mercury in Cambodia","volume":"1","author":"Murphy","year":"2013","journal-title":"Glob. Health Perspect."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Lee, T.X. (2020). Mercury as a factor in COVID-19 mortality: Hypothesis and evidence. Qeios.","DOI":"10.32388\/OF0L6S.5"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Moghaddam, A., Heller, R.A., Sun, Q., Seelig, J., Cherkezov, A., Seibert, L., Hackler, J., Seemann, P., Diegmann, J., and Pilz, M. (2020). Selenium Deficiency Is Associated with Mortality Risk from COVID-19. Nutrients, 12.","DOI":"10.20944\/preprints202007.0113.v1"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1080\/15563650.2017.1400555","article-title":"Rethinking mercury: The role of selenium in the pathophysiology of mercury toxicity","volume":"56","author":"Spiller","year":"2018","journal-title":"Clin. Toxicol. Phila Pa."},{"key":"ref_43","first-page":"2","article-title":"Selenium\u2019s Utility in Mercury Toxicity: A Mini-Review Roswell","volume":"12","author":"Timmerman","year":"2021","journal-title":"Food Sci. Nutr."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Sethuram, R., Bai, D., and Abu-Soud, H.M. (2021). Potential Role of Zinc in the COVID-19 Disease Process and its Probable Impact on Reproduction. Reprod. Sci.","DOI":"10.1007\/s43032-020-00400-6"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1016\/j.csbj.2021.02.015","article-title":"COVID-19 pandemic: Can zinc supplementation provide an additional shield against the infection?","volume":"19","author":"Razzaque","year":"2021","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"527","DOI":"10.2147\/JIR.S295377","article-title":"The Implications of Zinc Therapy in Combating the COVID-19 Global Pandemic","volume":"14","author":"Samad","year":"2021","journal-title":"J. Inflamm. Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.3389\/fimmu.2020.01736","article-title":"A Hypothesis for the Possible Role of Zinc in the Immunological Pathways Related to COVID-19 Infection","volume":"11","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.3389\/fimmu.2020.01712","article-title":"The potential impact of zinc supplementation on COVID-19 pathogenesis","volume":"11","author":"Wessels","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_49","first-page":"802","article-title":"Should we supplement zinc in COVID-19 patients? Evidence from meta-analysis","volume":"131","author":"Szarpak","year":"2021","journal-title":"Pol. Arch. Intern. Med."},{"key":"ref_50","unstructured":"Johnston, R., and Conkle, J. (2021, October 29). Micronutrient Deficiencies and Interventions in Cambodia: Information for Improved Programming [Internet], Available online: https:\/\/www.spring-nutrition.org\/publications\/projects\/a2z\/micronutrient-deficiencies-and-interventions-cambodia-information-improved."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.aninu.2017.03.002","article-title":"Strategies and challenges to increase the precision in feeding zinc to monogastric livestock","volume":"3","author":"Brugger","year":"2017","journal-title":"Anim. Nutr."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1002\/jpln.201700412","article-title":"Irrigation and Zn fertilizer management improves Zn phyto-availability in various rice production systems","volume":"181","author":"Rehman","year":"2018","journal-title":"J. Plant Nutr. Soil Sci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s12892-019-0333-0","article-title":"Assessment of Soil Zn Availability for Khao Dok Mali 105 Rice: A Case study in Thailand","volume":"23","author":"Sukyankij","year":"2020","journal-title":"J. Crop Sci. Biotechnol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"e12896","DOI":"10.1111\/mcn.12896","article-title":"Effectiveness of a locally produced ready-to-use supplementary food in preventing growth faltering for children under 2 years in Cambodia: A cluster randomized controlled trial","volume":"16","author":"Borg","year":"2020","journal-title":"Matern. Child Nutr."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"362","DOI":"10.3945\/jn.112.166058","article-title":"Extruded rice grains fortified with zinc, iron, and vitamin A increase zinc status of Thai school children when incorporated into a school lunch program","volume":"143","author":"Pinkaew","year":"2013","journal-title":"J. Nutr."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"010424","DOI":"10.7189\/jogh.10.010424","article-title":"Effects of therapeutic zinc supplementation for diarrhea and two preventive zinc supplementation regimens on the incidence and duration of diarrhea and acute respiratory tract infections in rural Laotian children: A randomized controlled trial","volume":"10","author":"Barffour","year":"2020","journal-title":"J. Glob. Health"},{"key":"ref_57","unstructured":"Institut de Recherche en Sciences de la Sante, Burkina Faso (2021, October 29). Assessment of a Combined Strategy of Seasonal Malaria Chemoprevention + Supplementation with PlumpyDoz and Vitamin A-Zinc to Prevent Malaria and Malnutrition in Burkina Faso. National Library of Medicine, Available online: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04238845?draw=3."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"108379","DOI":"10.1016\/j.biocon.2019.108379","article-title":"Plight of the commons: 17 years of wildlife trafficking in Cambodia","volume":"241","author":"Heinrich","year":"2020","journal-title":"Biolog. Conserv."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Hul, V., Delaune, D., Karlsson, E.A., Hassanin, A., Tey, P.O., Baidaliuk, A., G\u00e1mbaro, F., Tu, V.T., Keatts, L., and Mazet, J. (2021). A novel SARS-CoV-2 related coronavirus in bats from Cambodia. bioRxiv.","DOI":"10.1101\/2021.01.26.428212"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1080\/22221751.2019.1644539","article-title":"Mapping histoplasmosis in South East Asia\u2014Implications for diagnosis in AIDS","volume":"8","author":"Baker","year":"2019","journal-title":"Emerg. Microbes Infect."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1007\/s00253-021-11143-y","article-title":"The microbiome of bat guano: For what is this knowledge important?","volume":"105","author":"Fira","year":"2021","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Fagre, A.C., and Kading, R.C. (2019). Can Bats Serve as Reservoirs for Arboviruses?. Viruses, 11.","DOI":"10.3390\/v11030215"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"539","DOI":"10.2471\/BLT.20.254227","article-title":"Nipah virus circulation at human-bat interfaces, Cambodia","volume":"98","author":"Cappelle","year":"2020","journal-title":"Bull World Health Organ."},{"key":"ref_64","unstructured":"Ashwell, D., and Walston, N. (2008). An Overview of the Use of Plants and Animals in Traditional Medicine Systems in Cambodia, TRAFFIC Southeast Asia. Available online: http:\/\/www.trafficj.org\/publication\/08_medical_plants_Cambodia.pdf."},{"key":"ref_65","first-page":"249","article-title":"Bats as materia medica: An ethnomedical review and implications for conservation","volume":"16","author":"Riccucci","year":"2013","journal-title":"Vespertilio"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.ijid.2020.11.019","article-title":"Circulation of Nipah virus at the human\u2013Flying fox interface in Cambodia","volume":"101","author":"Duong","year":"2020","journal-title":"Int. J. Infect. Dis."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.3201\/eid1212.060732","article-title":"Foodborne transmission of Nipah virus, Bangladesh","volume":"12","author":"Luby","year":"2006","journal-title":"Emerg. Infect. Dis."},{"key":"ref_68","unstructured":"Murphy, T.P., Sampson, M., Guo, J., Parr, T., Gilbert, M., and Irvine, K. (2021, October 29). Mercury contamination along the Mekong River, Cambodia report to the Blacksmith Institute. 40 p. Available online: https:\/\/www.researchgate.net\/publication\/269696979_Mercury_Contamination_Along_the_Mekong_River_Cambodia_2006."},{"key":"ref_69","unstructured":"Hruby, D. (2021, October 29). Taking Count of Cambodia\u2019s Flying Fox Bats. Available online: https:\/\/english.cambodiadaily.com\/news\/taking-count-of-cambodias-flying-fox-bats-45421\/."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/S0965-2299(03)00055-4","article-title":"Use of animal products in traditional Chinese medicine: Environmental impact and health hazards","volume":"11","author":"Still","year":"2003","journal-title":"Complement. Ther. Med."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jtemb.2017.05.006","article-title":"Bioaccessibility and health risk assessment of mercury in cinnabar containing Traditional Chinese Medicines","volume":"44","author":"Lu","year":"2017","journal-title":"J. Trace Elem. Med. Biol."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Huong, N.Q., Nga, N.T.T., Long, N.V., Luu, B.D., Latinne, A., Pruvot, M., Phuong, N.T., Quang, L., Hung, V.V., and Lan, N.T. (2020). Coronavirus testing indicates transmission risk increases along wildlife supply chains for human consumption in Viet Nam, 2013\u20132014. PLoS ONE, 15.","DOI":"10.1101\/2020.06.05.098590"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1126\/science.abg6302","article-title":"Emerging H5N8 Avian influenza viruses","volume":"372","author":"Shi","year":"2021","journal-title":"Science"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.cimid.2008.01.003","article-title":"Highly pathogenic H5N1 avian influenza virus: Cause of the next pandemic?","volume":"32","author":"Pappaioanou","year":"2009","journal-title":"Comp. Immunol. Microbiol. Infect. Dis."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/1743-422X-6-207","article-title":"From where did the 2009 \u2018swine-origin\u2019 influenza A virus (H1N1) emerge?","volume":"6","author":"Gibbs","year":"2009","journal-title":"Virol. J."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"328","DOI":"10.9734\/BJECC\/2014\/13098","article-title":"Climate change resilience and public education in response to hydrologic extremes in Singapore","volume":"4","author":"Chang","year":"2014","journal-title":"Brit. J. Environ. Clim. Chang."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-12-394276-0.00001-9","article-title":"How Much Nutritional Iron Deficiency in Humans Globally Is due to an Underlying Zinc Deficiency?","volume":"115","author":"Graham","year":"2012","journal-title":"Adv. Agron."},{"key":"ref_78","unstructured":"WHO (2020). Frequently Asked Questions about Alcohol and COVID-19, World Health Organization. Available online: https:\/\/www.euro.who.int\/__data\/assets\/pdf_file\/0007\/442690\/FAQ-COVID-19-alcohol.pdf."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Suzuki, T., Imura, N., and Clarkson, T.W. (1991). Effect of Inorganic Mercury on the Immune System. Advances in Mercury Toxicology, Springer.","DOI":"10.1007\/978-1-4757-9071-9"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1351\/PAC-REP-08-04-02","article-title":"Immunological effect of mercury","volume":"81","author":"Schwenk","year":"2009","journal-title":"Pure Appl. Chem."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Batista-Duharte, A., T\u00e9llez-Mart\u00ednez, D., Jellmayer, J.A., Fuentes, D.L.P., Polesi, M.C., Baviera, A.M., and Carlos, I.Z. (2018). Repeated Exposition to Mercury (II) Chloride Enhances Susceptibility to S. schenckii sensu stricto Infection in Mice. J. Fungi, 4.","DOI":"10.3390\/jof4020064"},{"key":"ref_82","unstructured":"(2021, October 29). Artisanal Gold Council. Available online: https:\/\/www.artisanalgold.org\/."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1006\/enrs.2002.4358","article-title":"Assessment of Mercury Exposure and Malaria in a Brazilian Amazon Riverine Community","volume":"90","author":"Crompton","year":"2002","journal-title":"Environ. Res. A"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.envres.2014.03.024","article-title":"Novel biomarkers of mercury-induced autoimmune dysfunction: A cross-sectional study in Amazonian Brazil","volume":"132","author":"Motts","year":"2014","journal-title":"Environ. Res."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.chemosphere.2007.01.003","article-title":"Mercury in hair and blood from residents of Phnom Penh (Cambodia) and possible effect on serum hormone levels","volume":"68","author":"Agusa","year":"2007","journal-title":"Chemosphere"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"33","DOI":"10.5696\/2156-9614-5-9.33","article-title":"Mercury Contamination of Skin Whitening Creams, Phnom Penh","volume":"5","author":"Murphy","year":"2015","journal-title":"J. Health Pollut."},{"key":"ref_87","first-page":"1569","article-title":"Prevalence of vitamin D deficiency in nurses had the Royal irrigation hospital","volume":"95","author":"Hattapornsawan","year":"2012","journal-title":"J. Med. Assoc. Thai."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Smith, G., Wimalawansa, S.J., Laillou, A., Sophonneary, P., Un, S., Hong, R., Poirot, E., Kuong, K., Chamnan, C., and De Los Reyes, F.N. (2016). High prevalence of vitamin D deficiency in Cambodian women: A common deficiency in a sunny country. Nutrients, 8.","DOI":"10.3390\/nu8050290"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/S0045-6535(98)00006-X","article-title":"Mercury and organochlorine exposure from fish consumption in Hong Kong","volume":"37","author":"Dickman","year":"1998","journal-title":"Chemosphere"},{"key":"ref_90","unstructured":"Murphy, T., Phan, K., Lean, D., Hintelmann, H., Hul, S., and Park, H. (2021, October 29). Protocol: Pilot-Scale Fish Consumption Guideline for Tonle Sap Lake. Ethical Review, Ministry of Health, Cambodia. Available online: https:\/\/www.researchgate.net\/publication\/342392421_Protocol_Pilot-Scale_Fish_Consumption_Guideline_for_Tonle_Sap_Lake."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Avery, J.C., and Hoffmann, P.R. (2018). Selenium, Selenoproteins, and Immunity. Nutrients, 10.","DOI":"10.3390\/nu10091203"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s12011-019-01691-w","article-title":"The Role of Selenium in Arsenic and Cadmium Toxicity: An Updated Review of Scientific Literature","volume":"193","author":"Zwolak","year":"2020","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.3390\/ijerph7041342","article-title":"The essential toxin: Impact of zinc on human health","volume":"7","author":"Plum","year":"2010","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Camara, A.Y., Wan, Y., Yu, Y., Wang, Q., Wang, K., and Li, H. (2019). Effect of Endogenous Selenium on Arsenic Uptake and Antioxidative Enzymes in As-Exposed Rice Seedlings. Int. J. Environ. Res., 16.","DOI":"10.3390\/ijerph16183350"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"19876","DOI":"10.1021\/acsomega.1c02741","article-title":"Rice Cd Levels in Cambodia Ranged 3 Orders of Magnitude due to Season and Soil Cd Levels","volume":"6","author":"Hu","year":"2021","journal-title":"ACS Omega"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"180911","DOI":"10.5696\/2156-9614-8.19.180911","article-title":"Groundwater Irrigation and Arsenic Speciation in Rice in Cambodia","volume":"8","author":"Murphy","year":"2018","journal-title":"J. Health Pollut."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/1476-069X-12-73","article-title":"Arsenic immunotoxicity: A review","volume":"12","author":"Dangelben","year":"2013","journal-title":"Environ. Health"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1","DOI":"10.9734\/JGEESI\/2016\/23526","article-title":"Assessment of Population Exposed to Groundwater Arsenic in As-affected Areas of Cambodia","volume":"5","author":"Eliyan","year":"2016","journal-title":"J. Geog. Environ. Earth Sci. Int."},{"key":"ref_99","unstructured":"WHO (1998). World Health Organization, Guidelines for Drinking-Water Quality, World Health Organization. [2nd ed.]."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1016\/j.apgeochem.2008.06.022","article-title":"Arsenicosis in Cambodia: Case studies and policy response","volume":"23","author":"Sampson","year":"2008","journal-title":"J. Appl. Geochem."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"3088","DOI":"10.1016\/j.apgeochem.2008.06.027","article-title":"Linking organic matter deposition and iron mineral transformations to groundwater arsenic levels in the Mekong delta, Cambodia","volume":"23","author":"Quicksall","year":"2008","journal-title":"J. Appl. Geochem."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.scitotenv.2006.09.010","article-title":"Magnitude of arsenic pollution in the Mekong and Red River Deltas-Cambodia and Vietnam","volume":"372","author":"Berg","year":"2007","journal-title":"Sci. Tot. Environ."},{"key":"ref_103","unstructured":"Irvine, K., Murphy, T., Vermette, S., and Vanchan, V. (2010). Arsenic Bioaccumulation in an Arsenic Rich area of Cambodia. Water Resources and Development in Southeast Asia, Pearson Custom Publishing. Available online: https:\/\/www.researchgate.net\/publicatioR;n\/259892742_Arsenic_Bioaccumulation_in_an_Arsenic_Rich_area_of_Cambodia."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.jhazmat.2012.07.005","article-title":"Arsenic contamination in the food chain and its risk assessment of populations residing in the Mekong River basin of Cambodia","volume":"262","author":"Phan","year":"2013","journal-title":"J. Hazard. Mater."},{"key":"ref_105","unstructured":"Bhattacharya, P., Polya, D.A., and Jovanovic, D. (2017). Groundwater sampling, arsenic analysis and risk communication: Cambodia case study. Chapter A14. Best Practice Guide on the Control of Arsenic in Drinking Water, IWA Publishing. Available online: https:\/\/core.ac.uk\/download\/pdf\/84587547.pdf."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/nature07093","article-title":"Near-surface wetland sediments as a source of arsenic release to ground water in Asia","volume":"454","author":"Polizzotto","year":"2008","journal-title":"Nature"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.envres.2014.12.001","article-title":"Neurobehavioral effects of arsenic exposure among secondary school children in the Kandal Province, Cambodia","volume":"137","author":"Vibol","year":"2015","journal-title":"Environ. Res."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"469","DOI":"10.2478\/abm-2010-0058","article-title":"Arsenic and amputations in Cambodia","volume":"4","author":"Gollogly","year":"2010","journal-title":"Asian Biomed."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"180910","DOI":"10.5696\/2156-9614-8.19.180910","article-title":"Effects of Arsenic, Iron and Fertilizers in Soil on Rice in Cambodia","volume":"8","author":"Murphy","year":"2018","journal-title":"J. Health Pollut."},{"key":"ref_110","unstructured":"Murphy, T., Phan, K., Chan, L., Poulain, A., Irvine, K.N., and Lean, D.R.S. (2021, October 29). Appendix 2 Effect of Irrigation Water on Arsenic Content of Rice. Available online: https:\/\/www.researchgate.net\/publication\/322896929_Appendix_2_Effect_of_Irrigation_Water_on_Arsenic_Content_of_Rice."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Carey, M., Donaldson, E., Signes-Pastor, A.J., and Meharg, A.A. (2018). Dilution of rice with other gluten free grains to lower inorganic arsenic in foods for young children in response to European Union regulations provides impetus to setting stricter standards. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0194700"},{"key":"ref_112","unstructured":"FDA (2021, October 29). FDA in Brief: FDA Takes Action to Limit Inorganic Arsenic Levels in Infant Rice Cereal, Available online: https:\/\/www.fda.gov\/news-events\/fda-newsroom\/fda-brief-fda-takes-action-limit-inorganic-arsenic-levels-infant-rice-cereal."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jhydrol.2016.01.072","article-title":"Closing the irrigation deficit in Cambodia: Implications for transboundary impacts on groundwater and Mekong River flow","volume":"535","author":"Erban","year":"2016","journal-title":"J. Hydrol."},{"key":"ref_114","unstructured":"UNESCO (2021, October 29). Groundwater Resources in the Greater Mekong Subregion: Collaborative Management to Increase Climate Change Resilience. Available online: https:\/\/www.adaptation-fund.org\/project\/groundwater-resources-greater-mekong-subregion-collaborative-management-increase-resilience-cambodia-lao-peoples-democratic-republic-myanmar-thailand-vietnam-2\/."},{"key":"ref_115","unstructured":"National Health and Medical Research Council (2021, October 29). Australian Drinking Water Guidelines 6, Natural Resource Management Ministerial Council, Australian Government, Available online: https:\/\/www.nhmrc.gov.au\/sites\/default\/files\/documents\/reports\/aust-drinking-water-guidelines.pdf."},{"key":"ref_116","unstructured":"(2021, October 29). Canadian Water Quality Guidelines for the Protection of Agricultural Water Uses. Available online: https:\/\/ccme.ca\/en\/res\/arsenic-canadian-water-quality-guidelines-for-the-protection-of-agricultural-water-uses-en.pdf."},{"key":"ref_117","unstructured":"(1992). Wastewater Quality Guidelines for Agricultural Use. Pescod MB. Wastewater Treatment and Use in Agriculture [Internet], Food and Agricultural Organization of the United Nations. Available online: http:\/\/www.fao.org\/3\/T0551E\/t0551e00.htm."},{"key":"ref_118","unstructured":"Matsuno, Y. (2010). Monitoring and Management of Irrigation Water Quality in Japan, Food and Fertilizer Technology Center. Available online: http:\/\/www.fftc.agnet.org\/library.php?func=view&id=20110726150303&type_id=4."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.desal.2006.07.015","article-title":"Wastewater recycling and reuse in Eureau countries: Trends and challenges","volume":"218","author":"Angelakis","year":"2008","journal-title":"Desalination"},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Jeong, H., Kim, H., and Jang, T. (2016). Irrigation water quality standards for indirect wastewater reuse in agriculture: A contribution towards sustainable wastewater reuse in South Korea. Water, 8.","DOI":"10.3390\/w8040169"},{"key":"ref_121","unstructured":"Lin, H.T., Chen, S.W., Shen, C.J., and Chu, C. (2008, January 16\u201323). Arsenic species in groundwater in paddy fields with high soil arsenic. Proceedings of the 14th International Conference on Heavy Metals in the Environment, Taipei, Taiwan. Available online: http:\/\/public.tactri.gov.tw\/pdf\/2008\/arsenic%20species%20in%20groundwater.pdf."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1002\/csc2.20381","article-title":"Zinc nutrition to enhance rice productivity, zinc use efficiency, and grain biofortification under different production systems","volume":"61","author":"Zulfiqar","year":"2020","journal-title":"Crop Sci."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1039\/c3em00105a","article-title":"Biovolatilisation: A poorly studied pathway of the arsenic biogeochemical cycle","volume":"15","author":"Mestrot","year":"2013","journal-title":"Environ. Sci. Process Impacts"},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Alexander, J., Tinkov, A., Strand, T.A., Alehagen, U., Skalny, A., and Aaseth, J. (2020). Early Nutritional Interventions with Zinc, Selenium and Vitamin D for Raising Anti-Viral Resistance against Progressive COVID-19. Nutrients, 12.","DOI":"10.3390\/nu12082358"},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Calder, P.C., Carr, A.C., Gombart, A.F., and Eggersdorfer, M. (2020). Optimal Nutritional Status for a Well-Functioning Immune System Is an Important Factor to Protect against Viral Infections. Nutrients, 12.","DOI":"10.3390\/nu12041181"},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Pecora, F., Persico, F., Argentiero, A., Neglia, C., and Esposito, S. (2020). The Role of Micronutrients in Support of the Immune Response against Viral Infections. Nutrients, 12.","DOI":"10.3390\/nu12103198"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"7016","DOI":"10.1038\/s41598-017-07484-2","article-title":"Harvesting more grain zinc of wheat for human health","volume":"7","author":"Chen","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/S0140-6736(21)00394-9","article-title":"Revisiting maternal and child undernutrition in low-income and middle-income countries: Variable progress towards an unfinished agenda","volume":"397","author":"Victora","year":"2021","journal-title":"Lancet"},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Gammoh, N.Z., and Rink, L. (2017). Zinc in infection and inflammation. Nutrients, 9.","DOI":"10.20944\/preprints201705.0176.v1"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1177\/15648265090301S103","article-title":"Preventive zinc supplementation among infants, preschoolers, and older pre-pubertal children","volume":"30","author":"Brown","year":"2009","journal-title":"Food. Nutr. Bull."},{"key":"ref_131","first-page":"CD009384","article-title":"Zinc supplementation for preventing mortality, morbidity, and growth failure in children aged 6 months to 12 years of age","volume":"5","author":"Junior","year":"2014","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Liu, E., Pimpin, L., Shulkin, M., Kranz, S., Duggan, C.P., Mozaffarian, D., and Fawzi, W.W. (2018). Effect of zinc supplementation on growth outcomes in children under 5 years of age. Nutrients, 10.","DOI":"10.3390\/nu10030377"},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Vogel-Gonz\u00e1lez, M., Tall\u00f3-Parra, M., Herrera-Fern\u00e1ndez, V., P\u00e9rez-Vilar\u00f3, G., Chill\u00f3n, M., Nogu\u00e9s, X., G\u00f3mez-Zorrilla, S., L\u00f3pez-Montesinos, I., Arnau-Barr\u00e9s, I., and Sorli-Red\u00f3, M.L. (2020). Low zinc levels at clinical admission associates with poor outcomes in COVID-19. MedRxiv, Available online: https:\/\/www.medrxiv.org\/content\/10.1101\/2020.10.07.20208645v1.full.pdf.","DOI":"10.1101\/2020.10.07.20208645"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.ijid.2020.09.014","article-title":"COVID-19: Poor outcomes in patients with zinc deficiency","volume":"100","author":"Jothimani","year":"2020","journal-title":"Int. J. Infect. Dis."},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Yakoob, M.Y., Theodoratou, E., Jabeen, A., Imdad, A., Eisele, T.P., Ferguson, J., Jhass, A., Rudan, I., Campbell, H., and Black, R.E. (2011). Preventive zinc supplementation in developing countries: Impact on mortality and morbidity due to diarrhea, pneumonia and malaria. BMC Public Health, 11.","DOI":"10.1186\/1471-2458-11-S3-S23"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1475-2891-7-7","article-title":"Major Reduction of Malaria Morbidity with Combined Vitamin A and Zinc Supplementation in Young Children in Burkina Faso: A Randomized Double Blind Trial","volume":"7","author":"Augustin","year":"2008","journal-title":"Nutr. J."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1159\/000348263","article-title":"Zinc Supplementation in Public Health","volume":"62","author":"Penny","year":"2013","journal-title":"Ann. Nutr. Metab."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"7954","DOI":"10.4081\/pr.2019.7954","article-title":"A randomized controlled trial of zinc supplementation in the treatment of acute respiratory tract infection in Thai children","volume":"11","author":"Rerksuppaphol","year":"2019","journal-title":"Pediatr. Rep."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"415","DOI":"10.4269\/ajtmh.19-0584","article-title":"Impact of Daily Preventive Zinc or Therapeutic Zinc Supplementation for Diarrhea on Plasma Biomarkers of Environmental Enteric Dysfunction among Rural Laotian Children: A Randomized Controlled Trial","volume":"102","author":"Wessells","year":"2020","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Whitfield, K.C., Smith, G., Chamnan, C., Karakochuk, C.D., Sophonneary, P., Kuong, K., Dijkhuizen, M.A., Hong, R., Berger, J., and Green, T.J. (2017). High prevalence of thiamine (vitamin B1) deficiency in early childhood among a nationally representative sample of Cambodian women of childbearing age and their children. PLoS Negl. Trop. Dis., 11.","DOI":"10.1371\/journal.pntd.0005814"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1097\/MCO.0000000000000603","article-title":"Micronutrient deficiencies and their public health implications for South-East Asia","volume":"22","author":"Wieringa","year":"2019","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care."},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Gombart, A.F., Pierre, A., and Maggini, S. (2020). A Review of Micronutrients and the Immune System-Working in Harmony to Reduce the Risk of Infection. Nutrients, 12.","DOI":"10.3390\/nu12010236"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/j.foodchem.2007.01.038","article-title":"Iron content in common Cambodian fish species: Perspectives for dietary iron intake in poor, rural households","volume":"104","author":"Roos","year":"2007","journal-title":"Food Chem."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/sj.ejcn.1601567","article-title":"Food consumption, energy and nutrient intake and nutritional status in rural Bangladesh: Changes from 1981\u20131982 to 1995\u20131996","volume":"57","author":"Hels","year":"2003","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Irizarry, L., Prost, M.A., and Murillo, D. (2017). Standards and specifications for fortified rice [Internet]. Scaling Up Rice Fortification in Latin America and the Caribbean, Sight and Life.","DOI":"10.52439\/SZTR4103"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/sj.ejcn.1602361","article-title":"Risk of zinc, iodine and other micronutrient deficiencies among schoolchildren in North East Thailand","volume":"60","author":"Thurlow","year":"2006","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_147","first-page":"1","article-title":"Zinc-enriched fertilizers as a potential public health intervention in Africa","volume":"389","author":"Joy","year":"2015","journal-title":"Plant Sci."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"e20016","DOI":"10.1002\/agg2.20016","article-title":"Effect of low-use-rate zinc fertilization on rice growth and grain yield","volume":"3","author":"Coffin","year":"2020","journal-title":"Agrosyst. Geosci. Environ."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.geoderma.2018.09.032","article-title":"Toward understanding the binding of Zn in soils by two-dimensional correlation spectroscopy and synchrotron-radiation-based spectromicroscopies","volume":"337","author":"Sun","year":"2019","journal-title":"Geoderma"},{"key":"ref_150","unstructured":"(2000). Dutch Target and Intervention Values. (The New Dutch List) [Internet]. Annexes, Circular on Target Values and Intervention Values for Soil Remediation, Dutch Ministry of Housing, Spatial Planning and the Environment. Available online: https:\/\/www.esdat.net\/Environmental%20Standards\/Dutch\/annexS_I2000Dutch%20Environmental%20Standards.pdf."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"8430","DOI":"10.1021\/es901825t","article-title":"Arsenic limits trace mineral nutrition (selenium, zinc, and nickel) in Bangladesh rice grain","volume":"43","author":"Williams","year":"2009","journal-title":"Environ. Sci. Technol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.agee.2018.11.009","article-title":"Impact of Alternate Wetting and Drying Irrigation on Arsenic Uptake and Speciation in Flooded Rice Systems","volume":"272","author":"Li","year":"2019","journal-title":"Agric. Ecosyst. Environ. Agric."},{"key":"ref_153","first-page":"365","article-title":"Improved yield and Zn accumulation for rice grain by Zn fertilization and optimized water management","volume":"15","author":"Wang","year":"2014","journal-title":"Univ.-Sci. B (Biovmed. Biotechnol.)"},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Boukhris, I., Smaoui, S., Ennouri, K., Morjene, N., Farhat-Khemakhem, A., Blibech, M., Alghamdi, O.A., and Chouayekh, H. (2020). Towards understanding the antagonistic activity of phytic acid against common foodborne bacterial pathogens using a general linear model. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0231397"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1007\/s13197-013-0978-y","article-title":"Reduction of phytic acid and enhancement of bioavailable micronutrients in food grains","volume":"52","author":"Gupta","year":"2015","journal-title":"J. Food Sci. Technol."},{"key":"ref_156","first-page":"68","article-title":"Optimization of optimum condition for phytic acid extraction from rice bran","volume":"5","author":"Saad","year":"2011","journal-title":"Afr. J. Plant Sci."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1136\/gut.35.9.1233","article-title":"Phytase activity in the human and rat small intestine","volume":"35","author":"Iqbal","year":"1994","journal-title":"Gut"},{"key":"ref_158","unstructured":"(2021, October 30). Betagro. Available online: https:\/\/www.facebook.com\/Betagro-Cambodia-Company-Limited-289698104551105\/."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1017\/S1751731119002337","article-title":"Dietary phytase and myo-inositol supplementation are associated with distinct plasma metabolome profile in broiler chickens","volume":"14","author":"Kenez","year":"2020","journal-title":"Animal"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"3997","DOI":"10.1016\/j.psj.2020.05.008","article-title":"Response of broiler chickens in the starter and finisher phases to 3 sources of microbial phytase","volume":"99","author":"Babatunde","year":"2020","journal-title":"Poult. Sci."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"920","DOI":"10.3382\/ps\/pex390","article-title":"Influence of phytase or myo-inositol supplements and performance and phytate degradation products in the crop, ileum and blood of broiler chickens","volume":"97","author":"Sommerfeld","year":"2018","journal-title":"Poult. Sci."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s40781-016-0124-2","article-title":"Study on minerals status of dairy cows and their supplementation through area specific mineral mixture in the state of Jharkhand","volume":"58","author":"Bhanderi","year":"2016","journal-title":"J. Anim. Sci. Technol."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"783","DOI":"10.3945\/an.112.002881","article-title":"History of zinc in agriculture","volume":"3","author":"Nielsen","year":"2012","journal-title":"Adv. Nutr."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"e9238","DOI":"10.7717\/peerj.9238","article-title":"Rapid identification of melioidosis agent by an insulated isothermal PCR on a field\u2013deployable device","volume":"8","author":"Chua","year":"2020","journal-title":"PeerJ"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"e00006-19","DOI":"10.1128\/CMR.00006-19","article-title":"Human Melioidosis","volume":"33","author":"Gassiep","year":"2020","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1016\/S0035-9203(08)70007-5","article-title":"A first report of pulmonary melioidosis in Cambodia","volume":"102","author":"Overtoom","year":"2008","journal-title":"Trans R Soc. Trop. Med. Hyg."},{"key":"ref_167","doi-asserted-by":"crossref","unstructured":"Bory, S., Daily, F., Khim, G., Letchford, J., Sok, S., Kol, H., Seang Lak, M., Tuseo, L., Vibol, C., and Oeng, S. (2017). A Report from the Cambodia Training Event for Awareness of Melioidosis (C-TEAM). Trop. Med. Infect. Dis., 3.","DOI":"10.3390\/tropicalmed3010023"},{"key":"ref_168","doi-asserted-by":"crossref","unstructured":"Suntornsut, P., Wongsuwan, N., Malasit, M., Kitphati, R., Michie, S., Peacock, S.J., and Limmathurotsakul, D. (2016). Barriers and Recommended Interventions to Prevent Melioidosis in Northeast Thailand: A Focus Group Study Using the Behaviour Change Wheel. PLoS Negl. Trop. Dis., 10.","DOI":"10.1371\/journal.pntd.0004823"},{"key":"ref_169","unstructured":"Somony, T. Personal communication."},{"key":"ref_170","unstructured":"Joffre, O.M., Pant, J., Somony, T., Chantrea, B., and Hav, V. (2019). Transforming Aquaculture in Cambodia through Introduction of Improved Tilapia, WorldFish. Available online: https:\/\/digitalarchive.worldfishcenter.org\/bitstream\/handle\/20.500.12348\/2663\/2019-03.pdf."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1080\/10807039.2020.1799187","article-title":"Health risk assessment of inorganic arsenic exposure through fish consumption in Yellowknife, Northwest Territories, Canada","volume":"27","author":"Tanamal","year":"2020","journal-title":"Hum. Ecol. Risk Assess."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.scitotenv.2007.11.020","article-title":"Probabilistic assessment of safe groundwater utilization in farmed fish ponds of blackfoot disease hyperendemic areas in terms of the regulation of arsenic concentrations","volume":"39","author":"Jang","year":"2008","journal-title":"Sci. Tot. Environ."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1021\/es504520w","article-title":"Environmental Concerns of Roxarsone in Broiler Poultry Feed and Litter in Maryland, USA","volume":"49","author":"Fisher","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1007\/s11270-020-04716-6","article-title":"Effect of Arsenic Pollution Extent on Microbial Community in Shimen Long-Term Arsenic-Contaminated Soil","volume":"231","author":"Yu","year":"2020","journal-title":"Water Air Soil. Pollut."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1126\/science.818707","article-title":"Blue green algae: Their excretion of iron selective chelators enables them to dominate other algae","volume":"192","author":"Murphy","year":"1976","journal-title":"Science"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1093\/jn\/137.5.1341","article-title":"Host-Pathogen Interactions: The Role of Iron","volume":"137","author":"Doherty","year":"2007","journal-title":"J. Nutr."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/are.13881","article-title":"Controlling of geosmin and 2-methylisoborneol induced off-flavours in recirculating aquaculture system farmed fish\u2014A review","volume":"50","author":"Vielma","year":"2019","journal-title":"Aquac. Res."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1038\/s41564-020-0697-x","article-title":"Developmentally regulated volatiles geosmin and 2-methylisoborneol attract a soil arthropod to Streptomyces bacteria promoting spore dispersal","volume":"5","author":"Becher","year":"2020","journal-title":"Nat. Microbiol."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/sj.jim.7000121","article-title":"Effects of carbon source, phosphorus concentration, and several micronutrients on biomass and geosmin production by Streptomyces halstedii","volume":"26","author":"Schrader","year":"2001","journal-title":"J. Ind. Microbiol. Biotechnol."},{"key":"ref_180","unstructured":"Byrne, J. (2021, October 30). KnipBio Says Its SCP Meal Has Benefits for RAS Production. FeedNavigator.com. Available online: https:\/\/www.feednavigator.com\/Article\/2020\/08\/27\/KnipBio-says-its-SCP-meal-has-benefits-for-RAS-production."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.3389\/fmicb.2019.02447","article-title":"Microbial Production of the Off-Flavor Geosmin in Tilapia Production in Brazilian Water Reservoirs: Importance of Bacteria in the Intestine and Other Fish-Associated Environments","volume":"10","author":"Lukassen","year":"2019","journal-title":"Front. Microbiol."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"653025","DOI":"10.3389\/fimmu.2021.653025","article-title":"Mechanisms Used by Probiotics to Confer Pathogen Resistance to Teleost Fish","volume":"12","author":"Simon","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.fsi.2017.01.017","article-title":"Dietary zinc promotes immuno-biochemical plasticity and protects fish against multiple stresses","volume":"62","author":"Kumar","year":"2017","journal-title":"Fish Shellfish Immunol."},{"key":"ref_184","doi-asserted-by":"crossref","unstructured":"Hu, Y., Li, J., Lou, B., Wu, R., Wang, G., Lu, C., Wang, H., Pi, J., and Xu, Y. (2020). The Role of Reactive Oxygen Species in Arsenic Toxicity. Biomolecules, 10.","DOI":"10.3390\/biom10020240"},{"key":"ref_185","doi-asserted-by":"crossref","unstructured":"Beaver, L.M., Truong, L., Barton, C.L., Chase, T.T., Gonnerman, G.D., Wong, C.P., Tanguay, R.L., and Ho, E. (2017). Combinatorial effects of zinc deficiency and arsenic exposure on zebrafish (Danio rerio) development. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0183831"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.aquaculture.2013.04.026","article-title":"Comparison of chelated zinc and zinc sulfate as zinc sources for growth and immune response of shrimp (Litopenaeus vannamei)","volume":"406\u2013407","author":"Lin","year":"2013","journal-title":"Aquaculture"},{"key":"ref_187","unstructured":"Turner, W. (2021, October 30). Namsai Farms. Available online: http:\/\/tilapiathai.com\/."},{"key":"ref_188","unstructured":"Daniels, W. Personal communication."},{"key":"ref_189","unstructured":"CAST (2021, October 30). Kansas State Research and Extension News. Available online: https:\/\/www.ksre.k-state.edu\/news\/stories\/2019\/02\/SIIL-CAST.html."},{"key":"ref_190","unstructured":"(2021, October 30). Consumer Reports. Arsenic in Your Food, Our Findings Show a Real Need for Federal Standards for This Toxin. Available online: https:\/\/www.consumerreports.org\/cro\/magazine\/2012\/11\/arsenic-in-your-food\/index.htm."},{"key":"ref_191","unstructured":"British Nutrition Foundation (2021, October 30). Arsenic in Rice\u2014Is It a Cause for Concern?. Available online: https:\/\/www.nutrition.org.uk\/nutritioninthenews\/headlines\/arsenicinrice.html#:~:text=Why%20is%20rice%20is%20a,how%20it%20has%20been%20cooked."},{"key":"ref_192","unstructured":"Codex Alimenatarius Commission (2021, October 30). Joint FAO\/WHO Food Standards Programme. Codex General Standard for Contaminants and Toxins in Food and Feed, Codex Stan 193\u20131995. Available online: http:\/\/www.fao.org\/fao-who-codexalimentarius\/sh-proxy\/en\/?lnk=1&url=https%253A%252F%252Fworkspace.fao.org%252Fsites%252Fcodex%252FStandards%252FCODEX%2BSTAN%2B193-1995%252FCXS_193e.pdf."},{"key":"#cr-split#-ref_193.1","unstructured":"The European Commission (2015). Amending Regulation"},{"key":"#cr-split#-ref_193.2","unstructured":"(EC) No 1881\/2006 as Regards Maximum Levels of Inorganic Arsenic in Foodstuffs, The European Commission."},{"key":"ref_194","unstructured":"Codex Alimentarius Commission (1987). Codex Standard for Follow-Up Formula, Codex Alimentarius Commission. Available online: http:\/\/www.fao.org\/fao-who-codexalimentarius\/sh-proxy\/en\/?lnk=1&url=https%253A%252F%252Fworkspace.fao.org%252Fsites%252Fcodex%252FStandards%252FCODEX%2BSTAN%2B156-1987%252FCXS_156e.pdf."},{"key":"ref_195","unstructured":"(2021, October 30). USEPA\u2019s Mercury Study Report to Congress. Oral RFD, Table 1, Available online: https:\/\/www3.epa.gov\/airtoxics\/112nmerc\/volume5.pdf."},{"key":"ref_196","unstructured":"USEPA\u2019s Integrated Risk Information System (IRIS) (2021, October 30). Methylmercury (MeHg), CASRN 22967-92-6|DTXSID9024198, Available online: https:\/\/cfpub.epa.gov\/ncea\/iris2\/chemicalLanding.cfm?substance_nmbr=73."},{"key":"ref_197","unstructured":"(2021, October 30). ASEAN Guidelines for Cosmetic Good Manufacturing Practice. ASEAN Cosmetic Documents, Available online: http:\/\/elib.fda.moph.go.th\/fulltext2\/word\/14697\/1.pdf."},{"key":"ref_198","doi-asserted-by":"crossref","unstructured":"Kuong, K., Tor, P., Perignon, M., Fiorentino, M., Chamnan, C., Berger, J., Burja, K., Dijkhuizen, M.A., Parker, M., and Roos, N. (2019). Multi-Micronutrient Fortified Rice Improved Serum Zinc and Folate Concentrations of Cambodian School Children. A Double-Blinded Cluster-Randomized Controlled Trial. Nutrients, 12.","DOI":"10.3390\/nu11122843"}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/18\/21\/11446\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:23:38Z","timestamp":1760167418000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/18\/21\/11446"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,30]]},"references-count":199,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2021,11]]}},"alternative-id":["ijerph182111446"],"URL":"https:\/\/doi.org\/10.3390\/ijerph182111446","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,30]]}}}