{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T07:17:52Z","timestamp":1792135072963,"version":"4.4.0"},"reference-count":100,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2021,10,31]],"date-time":"2021-10-31T00:00:00Z","timestamp":1635638400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Hypothermia in pediatrics is mainly about small body size. The key thermal factor here is the large surface-to-volume ratio. Although small mammals, including human infants and children, are adapted to higher heat losses through their elevated metabolic rate and thermogenic capacity, they are still at risk of hypothermia because of a small regulatory range and an impending metabolic exhaustion. However, some small mammalian species (hibernators) use reduced metabolic rates and lowered body temperatures as adaptations to impaired energy supply. Similar to nature, hypothermia has contradictory effects in clinical pediatrics as well: In neonates, it is a serious risk factor affecting respiratory adaptation in term and developmental outcome in preterm infants. On the other hand, it is an important self-protective response to neonatal hypoxia and an evidence-based treatment option for asphyxiated babies. In children, hypothermia first enabled the surgical repair of congenital heart defects and promotes favorable outcome after ice water drowning. Yet, it is also a major threat in various prehospital and clinical settings and has no proven therapeutic benefit in pediatric critical care. All in all, pediatric hypothermia is an ambiguous issue whose harmful or beneficial effects strongly depend on the particular circumstances.<\/jats:p>","DOI":"10.3390\/ijerph182111484","type":"journal-article","created":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T22:21:34Z","timestamp":1635805294000},"page":"11484","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Pediatric Hypothermia: An Ambiguous Issue"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7081-6123","authenticated-orcid":false,"given":"Dominique","family":"Singer","sequence":"first","affiliation":[{"name":"Division of Neonatology and Pediatric Critical Care Medicine, University Medical Center Eppendorf, 20246 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Stave, U. (1978). Heat production and temperature regulation. Perinatal Physiology, Plenum. Chapter 21.","DOI":"10.1007\/978-1-4684-2316-7"},{"key":"ref_2","unstructured":"Polin, R.A., Fox, W.W., and Abman, S.H. (2011). Fetal and Neonatal Physiology, Elesevier Saunders. [4th ed.]. Section IX."},{"key":"ref_3","unstructured":"Weyland, W., Braun, U., and Kettler, D. (1997). Thermoregulatorische Besonderheiten des p\u00e4diatrischen Patienten. Perioperative Hypothermie\u2013Probleme, Pr\u00e4vention und Therapie, Aktiv Druck & Verlag."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1159\/000495437","article-title":"What is the right temperature for a neonate","volume":"22","author":"Singer","year":"2020","journal-title":"Pediatr. Adolesc. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1055\/s-2002-33168","article-title":"Phylogenese des Stoffwechsels der S\u00e4ugetiere","volume":"37","author":"Singer","year":"2002","journal-title":"Anaesthesiol. Intensivmed. Notfallmed. Schmerzther."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1007\/s00101-007-1220-y","article-title":"Warum 37 \u00b0C? Evolution\u00e4re Grundlagen der Thermoregulation","volume":"56","author":"Singer","year":"2007","journal-title":"Anaesthesist"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/BF00692726","article-title":"Reduction of metabolism during hibernation and daily torpor in mammals and birds: Temperature effect or physiological inhibition?","volume":"158","author":"Geiser","year":"1988","journal-title":"J. Comp. Physiol. B"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.resp.2004.03.014","article-title":"Natural hypometabolism during hibernation and daily torpor in mammals","volume":"141","author":"Heldmaier","year":"2004","journal-title":"Respir. Physiol. Neurobiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/978-3-642-12422-8_13","article-title":"Mammalian hibernation: Physiology, cell signaling, and gene controls on metabolic rate depression","volume":"Volume 21","author":"Lubzens","year":"2010","journal-title":"Dormancy and Resistance to Harsh Environments (Topics in Current Genetics)"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Schmidt-Nielsen, K. (1984). Scaling: Why Is Animal Size So Important?, Cambridge University Press.","DOI":"10.1017\/CBO9781139167826"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/35001159","article-title":"Laying down the law: Every living thing obeys the rules of scaling discovered by Max Kleiber (Millenium Essay)","volume":"403","author":"Smil","year":"2000","journal-title":"Nature"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"110847","DOI":"10.1016\/j.cbpa.2020.110847","article-title":"Body size, time and dimensions of oxygen diffusion","volume":"252","author":"Lindstedt","year":"2021","journal-title":"Comp. Biochem. Physiol. Mol. Integr. Physiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1055\/s-2007-1014020","article-title":"Metabolic reduction in hypothermia: Pathophysiological problems and natural examples\u2014Part 1\/2","volume":"38","author":"Singer","year":"1990","journal-title":"Thorac. Cardiovasc. Surg."},{"key":"ref_14","unstructured":"Hochachka, P.W., Lutz, P.L., Sick, T., Rosenthal, M., and van den Thillart, G. (1993). Metabolic size allometry and the limits to beneficial metabolic reduction: Hypothesis of a uniform specific minimal metabolic rate. Surviving Hypoxia: Mechanisms of Control and Adaptation, CRC Press."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.resp.2004.02.009","article-title":"Metabolic adaptation to hypoxia: Cost and benefit of being small","volume":"141","author":"Singer","year":"2004","journal-title":"Respir. Physiol. Neurobiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0300-9629(81)90645-9","article-title":"Mammalian hibernation and the oxygen consumption of a denning black bear (Ursus americanus)","volume":"69","author":"Watts","year":"1981","journal-title":"Comp. Biochem. Physiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1126\/science.1199435","article-title":"Hibernation in black bears: Independence of metabolic suppression from body temperature","volume":"331","author":"Blake","year":"2011","journal-title":"Science"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0034-5687(99)00038-9","article-title":"How newborn mammals cope with hypoxia","volume":"116","author":"Mortola","year":"1999","journal-title":"Respir. Physiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S1095-6433(99)00057-4","article-title":"Neonatal tolerance to hypoxia. A comparative-physiological approach","volume":"123","author":"Singer","year":"1999","journal-title":"Comp. Biochem. Physiol."},{"key":"ref_20","unstructured":"Dakshinamurti, S. (2021). The human fetus and metabolic adaptations to hypoxia. Hypoxic Respiratory Failure in the Newborn: From Origins to Clinical Management, CRC Press Taylor & Francis. Chapter 2."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.3109\/14767058.2015.1077221","article-title":"Effect of persistent pulmonary hypertension on brain oxygenation in asphyxiated term newborns treated with hypothermia","volume":"29","author":"Gagnon","year":"2016","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"ref_22","unstructured":"Vijverberg, J.R.G., Lopriore, E., Te Pas, A.B., Rijken, M., van Zwet, E.W., de Bruine, F.T., and Steggerda, S.J. (2021). Persistent pulmonary hypertension in neonates with perinatal asphyxia and therapeutic hypothermia: A frequent and perilous combination. J. Matern. Fetal Neonatal Med., 1\u20137."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Okken, A., and Koch, J. (1995). Thermoregulation of Sick and Low Birth Weight Neonates, Springer.","DOI":"10.1007\/978-3-642-79934-1"},{"key":"ref_24","unstructured":"Martin, R.J., Fanaroff, A.A., and Walsh, M.C. (2015). The thermal environment of the intensive care nursery. Fanaroff & Martin\u2019s Neonatal-Perinatal Medicine: Diseases of the Fetus and Infant, Elsevier Saunders. [10th ed.]. Chapter 36."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1136\/adc.44.235.323","article-title":"Temporary loss of a metabolic response to cold stress in infants of low birthweight","volume":"44","author":"Hey","year":"1969","journal-title":"Arch. Dis. Child."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1136\/emermed-2011-200479","article-title":"Too cold for comfort: A neonate with severe hypothermia","volume":"29","author":"Sargant","year":"2012","journal-title":"Emerg. Med. J."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1159\/000239893","article-title":"Hypothermia in the treatment of asphyxia neonatorum","volume":"6","author":"Miller","year":"1964","journal-title":"Biol. Neonat."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/978-1-4684-3228-2_58","article-title":"Mechanisms of hypothermic protection against anoxia","volume":"33","author":"Miller","year":"1972","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1542\/peds.22.5.876","article-title":"The influence of the thermal environment upon the survival of newly born premature infants","volume":"22","author":"Silverman","year":"1958","journal-title":"Pediatrics"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1542\/peds.34.2.171","article-title":"Body temperature and survival of premature infants","volume":"34","author":"Day","year":"1964","journal-title":"Pediatrics"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e150277","DOI":"10.1001\/jamapediatrics.2015.0277","article-title":"(Canadian Neonatal Network): Association between admission temperature and mortality and major morbidity in preterm infants born at fewer than 33 weeks\u2019 gestation","volume":"169","author":"Lyu","year":"2015","journal-title":"JAMA Pediatr."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jpeds.2016.04.016","article-title":"(Effective Perinatal Intensive Care in Europe [EPICE] Research Group): Admission hypothermia in very preterm infants and neonatal mortality and morbidity","volume":"175","author":"Wilson","year":"2016","journal-title":"J. Pediatr."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jpeds.2017.09.021","article-title":"(NICHD Neonatal Research Network): Admission temperature and associated mortality and morbidity among moderately and extremely preterm infants","volume":"192","author":"Laptook","year":"2018","journal-title":"J. Pediatr."},{"key":"ref_34","first-page":"CD004210","article-title":"Interventions to prevent hypothermia at birth in preterm and\/or low birth weight infants","volume":"2","author":"McCall","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Boundy, E.O., Dastjerdi, R., Spiegelman, D., Fawzi, W.W., Missmer, S.A., Lieberman, E., Kajeepeta, S., Wall, S., and Chan, G.J. (2016). Kangaroo mother care and neonatal outcomes: A meta-analysis. Pediatrics, 137.","DOI":"10.1542\/peds.2015-2238"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Conde-Agudelo, A., and D\u00edaz-Rossello, J.L. (2016). Kangaroo mother care to reduce morbidity and mortality in low birthweight infants. Cochrane Database Syst. Rev., CD002771.","DOI":"10.1002\/14651858.CD002771.pub4"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/S0022-3476(97)70349-4","article-title":"Body temperatures and oxygen consumption during skin-to-skin (kangaroo) care in stable preterm infants weighing less than 1500 grams","volume":"130","author":"Bauer","year":"1997","journal-title":"J. Pediatr."},{"key":"ref_38","first-page":"220","article-title":"Thermoregulation of premature infants during and after skin-to-skin care","volume":"217","author":"Heimann","year":"2013","journal-title":"Z. Geburtshilfe Neonatol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.jpeds.2012.02.034","article-title":"Early skin-to-skin care in extremely preterm infants: Thermal balance and care environment","volume":"161","author":"Karlsson","year":"2012","journal-title":"J. Pediatr."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"WHO Immediate KMC Study Group, Arya, S., Naburi, H., Kawaza, K., Newton, S., Anyabolu, C.H., Bergman, N., Rao, S.P.N., Mittal, P., and Assenga, E. (2021). Immediate \u201cKangaroo Mother Care\u201d and survival of infants with low birth weight. N. Engl. J. Med., 384, 2028\u20132038.","DOI":"10.1056\/NEJMoa2026486"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/BF00691146","article-title":"pH-temperature interactions on protein function and hibernation: GDP binding to brown adipose tissue mitochondria","volume":"158","author":"Malan","year":"1988","journal-title":"J. Comp. Physiol. B"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1159\/000369119","article-title":"Innate hypothermia after hypoxic ischaemic delivery","volume":"107","author":"Jayasinghe","year":"2015","journal-title":"Neonatology"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1152\/jappl.1999.87.4.1346","article-title":"Influence of core temperature on autoresuscitation during repeated exposure to hypoxia in normal rat pups","volume":"87","author":"Serdarevich","year":"1999","journal-title":"J. Appl. Physiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.resp.2005.05.006","article-title":"Protective responses of the newborn to hypoxia","volume":"149","author":"Fewell","year":"2005","journal-title":"Respir. Physiol. Neurobiol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1203\/01.pdr.0000228333.11132.fa","article-title":"Preterminal gasping during hypoxic cardiac arrest increases cardiac function in immature rats","volume":"60","author":"Manole","year":"2006","journal-title":"Pediatr. Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.resp.2004.01.011","article-title":"Implications of hypoxic hypometabolism during mammalian ontogenesis","volume":"141","author":"Mortola","year":"2004","journal-title":"Respir. Physiol. Neurobiol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1111\/j.1651-2227.1995.tb13586.x","article-title":"Iatrogenic radiant heat burns in severely asphyxic newborns","volume":"84","author":"Simonsen","year":"1995","journal-title":"Acta Paediatr."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1055\/s-2000-10202","article-title":"Vorteile der wassergefilterten gegen\u00fcber herk\u00f6mmlicher Infrarot-Strahlung in der Neonatologie","volume":"204","author":"Singer","year":"2000","journal-title":"Z. Geburtsh. Neonatol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/pr.2016.198","article-title":"Therapeutic hypothermia translates from ancient history in to practice","volume":"81","author":"Gunn","year":"2017","journal-title":"Pediatr. Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/B978-0-444-64029-1.00010-2","article-title":"Neonatal encephalopathy and hypoxic-ischemic encephalopathy","volume":"162","author":"Gunn","year":"2019","journal-title":"Handb. Clin. Neurol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s11910-019-0916-0","article-title":"Therapeutic hypothermia in neonatal hypoxic-ischemic encephalopathy","volume":"19","author":"Wassink","year":"2019","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"ref_52","first-page":"CD003311","article-title":"Cooling for newborns with hypoxic ischaemic encephalopathy","volume":"2013","author":"Jacobs","year":"2013","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.clp.2018.01.010","article-title":"Therapeutic hypothermia: How can we optimize this therapy to further improve outcomes?","volume":"45","author":"Natarajan","year":"2018","journal-title":"Clin. Perinatol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1056\/NEJMoa1310519","article-title":"Targeted temperature management at 33 \u00b0C versus 36 \u00b0C after cardiac arrest","volume":"369","author":"Nielsen","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1056\/NEJMoa2100591","article-title":"Hypothermia versus normothermia after out-of-hospital cardiac arrest","volume":"384","author":"Dankiewicz","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"e1273","DOI":"10.1016\/S2214-109X(21)00264-3","article-title":"Hypothermia for moderate or severe neonatal encephalopathy in low-income and middle-income countries (HELIX): A randomised controlled trial in India, Sri Lanka, and Bangladesh","volume":"9","author":"Thayyil","year":"2021","journal-title":"Lancet Glob. Health"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Krishnan, V., Kumar, V., Shankaran, S., and Thayyil, S. (2021). Rise and fall of therapeutic hypothermia in low-resource settings: Lessons from the HELIX trial. Indian J. Pediatr.","DOI":"10.1007\/s12098-021-03861-y"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/S1474-4422(12)70058-3","article-title":"Tertiary mechanisms of brain damage: A new hope for treatment of cerebral palsy?","volume":"11","author":"Fleiss","year":"2012","journal-title":"Lancet Neurol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1002\/ana.22518","article-title":"Stem cell therapy for neonatal brain injury: Perspectives and challenges","volume":"70","author":"Titomanlio","year":"2011","journal-title":"Ann. Neurol."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Nair, J., and Kumar, V.H.S. (2018). Current and emerging therapies in the management of hypoxic ischemic encephalopathy in neonates. Children, 5.","DOI":"10.3390\/children5070099"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1097\/00000658-195011000-00001","article-title":"Hypothermia; its possible role in cardiac surgery: An investigation of factors governing survival in dogs at low body temperatures","volume":"132","author":"Bigelow","year":"1950","journal-title":"Ann. Surg."},{"key":"ref_62","first-page":"52","article-title":"Closure of atrial septal defects with the aid of hypothermia; experimental accomplishments and the report of one successful case","volume":"33","author":"Lewis","year":"1953","journal-title":"Surgery"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0033-0620(72)90027-8","article-title":"Complete correction of cardiovascular malformations in the first year of life","volume":"15","author":"Neutze","year":"1972","journal-title":"Prog. Cardiovasc. Dis."},{"key":"ref_64","unstructured":"Kirklin, J.W., and Barrat-Boyes, B.G. (1993). Hypothermia, circulatory arrest, and cardiopulmonary bypass. Cardiac Surgery, Churchill Livingstone\/Wiley Medical. [2nd ed.]."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/S0002-9149(83)80096-4","article-title":"Terminal cardiac electrical activity in pediatric patients","volume":"51","author":"Walsh","year":"1983","journal-title":"Am. J. Cardiol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1197\/j.aem.2005.12.019","article-title":"Ventricular fibrillation in pediatric cardiac arrest","volume":"13","author":"Smith","year":"2006","journal-title":"Acad. Emerg. Med."},{"key":"ref_67","unstructured":"Fleisher, G.R., Ludwig, S., and Henretig, F.M. (2006). Environmental emergencies. Textbook of Pediatric Emergency Medicine, Lippincott Williams & Wilkins. [5th ed.]."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s13049-016-0303-7","article-title":"Accidental hypothermia-an update (The content of this review is endorsed by the International Commission for Mountain Emergency Medicine, ICAR MEDCOM)","volume":"24","author":"Paal","year":"2016","journal-title":"Scand. J. Trauma Resusc. Emerg. Med."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"28","DOI":"10.2174\/1573396314666180412090930","article-title":"Special traumatized populations: Accidental hypothermia in children","volume":"14","author":"Mehrotra","year":"2018","journal-title":"Curr. Pediatr. Rev."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"e284","DOI":"10.1097\/PEC.0000000000001588","article-title":"Hypothermia as an outcome predictor tool in pediatric trauma: A propensity-matched analysis","volume":"37","author":"McCarty","year":"2021","journal-title":"Pediatr. Emerg. Care."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Nemeth, M., Miller, C., and Br\u00e4uer, A. (2021). Perioperative Hypothermia in Children. Int. J. Environ. Res. Public Health., 18.","DOI":"10.3390\/ijerph18147541"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1097\/00003246-199210000-00007","article-title":"Effect of hypothermia on the coagulation cascade","volume":"20","author":"Rohrer","year":"1992","journal-title":"Crit. Care Med."},{"key":"ref_73","first-page":"294","article-title":"Influence of perioperative hypothermia on blood clotting in children","volume":"119","author":"Trckova","year":"2018","journal-title":"Bratisl. Lek. Listy."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1055\/s-2007-989337","article-title":"Ertrinkungsunf\u00e4lle im Kindesalter","volume":"2","author":"Singer","year":"2007","journal-title":"Notfallmed. Up2date"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"e521","DOI":"10.1097\/CCM.0000000000001283","article-title":"Excellent outcome with extracorporeal membrane oxygenation after accidental profound hypothermia (13.8 \u00b0C) and drowning","volume":"43","author":"Romlin","year":"2015","journal-title":"Crit. Care Med."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Elsner, R., and Gooden, B. (1983). Diving and Asphyxia: A Comparative Study of Animals and Man, Cambridge University Press. Monographs of the Physiological Society No. 40.","DOI":"10.1017\/CBO9780511735714"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"629","DOI":"10.5694\/j.1326-5377.1992.tb137408.x","article-title":"Why some people do not drown. Hypothermia versus the diving response","volume":"157","author":"Gooden","year":"1992","journal-title":"Med. J. Aust."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.resuscitation.2010.01.037","article-title":"Prognostic factors in avalanche resuscitation: A systematic review","volume":"81","author":"Boyd","year":"2010","journal-title":"Resuscitation"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1093\/ejcts\/ezaa159","article-title":"Successful resuscitation from accidental hypothermia of 11.8 \u00b0C: Where is the lower bound for human beings?","volume":"58","author":"Mroczek","year":"2020","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.resuscitation.2014.04.029","article-title":"\u201cNobody is dead until warm and dead\u201d: Prolonged resuscitation is warranted in arrested hypothermic victims also in remote areas--a retrospective study from northern Norway","volume":"85","author":"Hilmo","year":"2014","journal-title":"Resuscitation"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.resuscitation.2021.02.015","article-title":"European Resuscitation Council Guidelines 2021: Paediatric Life Support","volume":"161","author":"Turner","year":"2021","journal-title":"Resuscitation"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1016\/S0140-6736(02)11392-4","article-title":"Management of profound hypothermia in children without the use of extracorporeal life support therapy","volume":"360","year":"2002","journal-title":"Lancet"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1016\/j.jpedsurg.2012.09.014","article-title":"Extracorporeal cardiopulmonary resuscitation (EC-CPR) for hypothermic arrest in children: Is meaningful survival a reasonable expectation?","volume":"47","author":"Skarda","year":"2012","journal-title":"J. Pediatr. Surg."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1053\/j.jvca.2019.07.152","article-title":"Prognostic factors for nonasphyxia-related cardiac arrest patients undergoing extracorporeal rewarming\u2013HELP registry study","volume":"34","author":"Darocha","year":"2020","journal-title":"J. Cardiothorac. Vasc. Anesth."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1055\/s-0043-118769","article-title":"Ertrinkungsunf\u00e4lle bei Kindern und Jugendlichen","volume":"13","author":"Olfe","year":"2018","journal-title":"Notfallmed. Up2date"},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Biermann, D., Gottschalk, U., K\u00f6hne, M., Holst, T., H\u00fcners, I., von Stumm, M., Mueller, G., Stark, V., van R\u00fcth, V., and Kozlik-Feldmann, R. (2021). Outcomes of extracorporeal membrane oxygenation and cardiopulmonary bypass in children after drowning-related resuscitation. Perfusion, 2676591211041229.","DOI":"10.1177\/02676591211041229"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1097\/PCC.0000000000000763","article-title":"(Therapeutic Hypothermia After Pediatric Cardiac Arrest Out-of-Hospital Trial Investigators). Targeted temperature management after pediatric cardiac arrest due to drowning: Outcomes and complications","volume":"17","author":"Moler","year":"2016","journal-title":"Pediatr. Crit. Care. Med."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1001\/jama.1990.03450140078038","article-title":"Some people are dead when they\u2019re cold and dead","volume":"264","author":"Auerbach","year":"1990","journal-title":"JAMA"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1097\/00006565-199704000-00004","article-title":"Failure of aggressive therapy to alter outcome in pediatric near-drowning","volume":"13","author":"Spack","year":"1997","journal-title":"Pediatr. Emerg. Care"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"h418","DOI":"10.1136\/bmj.h418","article-title":"Outcome after resuscitation beyond 30 minutes in drowned children with cardiac arrest and hypothermia: Dutch nationwide retrospective cohort study","volume":"350","author":"Kieboom","year":"2015","journal-title":"BMJ"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1056\/NEJMoa1411480","article-title":"(THAPCA Trial Investigators). Therapeutic hypothermia after out-of-hospital cardiac arrest in children","volume":"372","author":"Moler","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1056\/NEJMoa1610493","article-title":"(THAPCA Trial Investigators). Therapeutic hypothermia after in-hospital cardiac arrest in children","volume":"376","author":"Moler","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/S1474-4422(13)70077-2","article-title":"(Paediatric Traumatic Brain Injury Consortium). Comparison of hypothermia and normothermia after severe traumatic brain injury in children (Cool Kids): A phase 3, randomised controlled trial","volume":"12","author":"Adelson","year":"2013","journal-title":"Lancet Neurol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1097\/CCM.0000000000002205","article-title":"Meta-Analysis of therapeutic hypothermia for traumatic brain injury in adult and pediatric patients","volume":"45","author":"Crompton","year":"2017","journal-title":"Crit. Care Med."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1097\/MCC.0000000000000070","article-title":"Fever and therapeutic normothermia in severe brain injury: An update","volume":"20","author":"Bohman","year":"2014","journal-title":"Curr. Opin. Crit. Care."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.pediatrneurol.2018.07.004","article-title":"Targeted temperature management in pediatric neurocritical care","volume":"88","author":"Benedetti","year":"2018","journal-title":"Pediatr. Neurol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1152\/physiol.00046.2018","article-title":"Engineering human stasis for long-duration spaceflight","volume":"34","author":"Nordeen","year":"2019","journal-title":"Physiol. Bethesda"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1111\/febs.14683","article-title":"Bringing nature back: Using hibernation to reboot organ preservation","volume":"286","author":"Storey","year":"2019","journal-title":"FEBS J."},{"key":"ref_99","first-page":"139","article-title":"Human hibernation for space flight: Utopistic vision or realistic possibility?","volume":"59","author":"Singer","year":"2006","journal-title":"J. Brit. Interplanet. Soc."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1007\/s00424-018-2244-7","article-title":"Hibernating astronauts-science or fiction?","volume":"471","author":"Singer","year":"2019","journal-title":"Pfl\u00fcgers Arch."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/18\/21\/11484\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:24:01Z","timestamp":1760167441000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/18\/21\/11484"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,31]]},"references-count":100,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2021,11]]}},"alternative-id":["ijerph182111484"],"URL":"https:\/\/doi.org\/10.3390\/ijerph182111484","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,31]]}}}