{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T21:26:46Z","timestamp":1783546006440,"version":"3.55.0"},"reference-count":29,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2021,11,13]],"date-time":"2021-11-13T00:00:00Z","timestamp":1636761600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Romanian Ministry of Education and Research, CCCDI - UEFISCDI","award":["PN III-P2-2.1-PED-2019-1057"],"award-info":[{"award-number":["PN III-P2-2.1-PED-2019-1057"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>(1) Background and objective: Cardiac rehabilitation (CR) means delivering health education by structured exercises with the means of risk reduction, in a cost-effective manner. Well-conducted CR improves functional capacity, decreases re-hospitalization, and reduces mortality up to 25%. We bring to attention the protocol of a randomised control trial with the aim of validating the prototype of an assistive upper-body robotic exoskeleton system enhanced with a non-immersive virtual reality exergame (CardioVR-ReTone) in patients who undergone cardiac surgery. (2) Methods: Description of the CardioVR-ReTone system and the technical specification, followed by the group selection, randomization and evaluated variables. (3) Expected results: The primary outcome measurement is the modification of life quality at the end of the CR exercise training program. Secondary outcomes will encompass measurements of sternal stability, muscular activity, cardiac response to exercise, pain level and compliance\/adherence to CR. (4) Conclusions: Implementing these novel features of the CardioVR-ReTone system, addressability, and efficacy of CR, so problematic in certain situations and especially in cardiac surgery, will be greatly facilitated, being independent of the skills and availability of the rehabilitation therapist.<\/jats:p>","DOI":"10.3390\/ijerph182211922","type":"journal-article","created":{"date-parts":[[2021,11,14]],"date-time":"2021-11-14T20:48:36Z","timestamp":1636922916000},"page":"11922","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Cardiac Rehabilitation Early after Sternotomy Using New Assistive VR-Enhanced Robotic Exoskeleton\u2014Study Protocol for a Randomised Controlled Trial"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5906-8024","authenticated-orcid":false,"given":"Mihaela","family":"Mocan","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University of Medicine and Pharmacy Iuliu Ha\u021bieganu Cluj-Napoca, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia Irina","family":"Vlaicu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Medicine and Pharmacy Iuliu Ha\u021bieganu Cluj-Napoca, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9407-2261","authenticated-orcid":false,"given":"Anca Daniela","family":"Farca\u0219","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Medicine and Pharmacy Iuliu Ha\u021bieganu Cluj-Napoca, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4870-8249","authenticated-orcid":false,"given":"Horea","family":"Feier","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Institute of Cardiovascular Diseases Timisoara, University of Medicine and Pharmacy Victor Babes, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3892-0211","authenticated-orcid":false,"given":"Simona","family":"Dragan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Clinic of Cardiovascular Prevention and Rehabilitation, University of Medicine and Pharmacy Victor Babes, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2488-7254","authenticated-orcid":false,"given":"Bogdan","family":"Mocan","sequence":"additional","affiliation":[{"name":"Department of Industrial Engineering and Robotics, Technical University of Cluj-Napoca, 400020 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/nrcardio.2014.98","article-title":"Global availability of cardiac rehabilitation","volume":"11","author":"Sarrafzadegan","year":"2014","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1177\/2047487319854140","article-title":"Exercise-based cardiac rehabilitation in patients with reduced left ventricular ejection fraction: The Cardiac Rehabilitation Outcome Study in Heart Failure (CROS-HF): A systematic review and meta-analysis","volume":"27","author":"Nebel","year":"2020","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.rehab.2017.12.008","article-title":"Cardiorespiratory demand and rate of perceived exertion during overground walking with a robotic exoskeleton in long-term manual wheelchair users with chronic spinal cord injury: A cross-sectional study","volume":"61","author":"Escalona","year":"2018","journal-title":"Ann. Phys. Rehabil. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.neucom.2015.03.091","article-title":"Adaptive guidance system design for the assistive robotic walker","volume":"170","author":"Lu","year":"2015","journal-title":"Neurocomputing"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"33","DOI":"10.12680\/balneo.2019.236","article-title":"Cardiac rehabilitation for older patients with cardiovascular pathology using robotic systems\u2014A survey","volume":"10","author":"Mocan","year":"2019","journal-title":"Balneo Res. J."},{"key":"ref_6","first-page":"411","article-title":"Exoskeleton robotic systems used as a tool for cardiac rehabilitation","volume":"62","author":"Mocan","year":"2019","journal-title":"Acta Tech. Napoc.-Ser. Appl. Math. Mech. Eng."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"291","DOI":"10.12680\/balneo.2018.199","article-title":"Smart Homes for Older People Involved in Rehabilitation Activities-Reality or Dream, Acceptance or Rejection?","volume":"9","author":"Cramariuc","year":"2018","journal-title":"Balneo Res. J."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1177\/2047487317710803","article-title":"Clinical and cost-effectiveness of home-based cardiac rehabilitation compared to conventional, centre-based cardiac rehabilitation: Results of the FIT@Home study","volume":"24","author":"Kraal","year":"2017","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.pmr.2018.12.012","article-title":"Robotics for lower limb rehabilitation","volume":"30","author":"Esquenazi","year":"2019","journal-title":"Phys. Med. Rehabil. Clin. N. Am."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.patrec.2017.04.007","article-title":"Learning assistive strategies for exoskeleton robots from user-robot physical interaction","volume":"99","author":"Hamaya","year":"2017","journal-title":"Pattern Recognit. Lett."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12877-018-0921-1","article-title":"A wearable hip-assist robot reduces the cardiopulmonary metabolic energy expenditure during stair ascent in elderly adults: A pilot cross-sectional study","volume":"18","author":"Kim","year":"2018","journal-title":"BMC Geriatr."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.jht.2013.06.001","article-title":"Chronic stroke survivors achieve comparable outcomes following virtual task specific repetitive training guided by a wearable robotic orthosis (UL-EXO7) and actual task specific repetitive training guided by a physical therapist","volume":"26","author":"Byl","year":"2013","journal-title":"J. Hand Ther."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S1474-4422(13)70305-3","article-title":"Three-dimensional, task-specific robot therapy of the arm after stroke: A multicentre, parallel-group randomised trial","volume":"13","author":"Blanco","year":"2014","journal-title":"Lancet Neurol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1177\/1545968318820169","article-title":"Effect of specific over nonspecific VR-based rehabilitation on poststroke motor recovery: A systematic meta-analysis","volume":"33","author":"Maier","year":"2019","journal-title":"Neurorehabil. Neural Repair"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Ambrosetti, M., Abreu, A., Corr\u00e0, U., Davos, C.H., Hansen, D., Frederix, I., Iliou, M.C., Pedretti, R.F.E., Schmid, J.P., and Vigorito, C. (2020). Secondary prevention through comprehensive cardiovascular rehabilitation: From knowledge to implementation. 2020 update. A position paper from the secondary prevention and rehabilitation section of the European association of preventive cardiology. Eur. J. Prev. Cardiol., 460\u2013495.","DOI":"10.1177\/2047487320913379"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1111\/j.1526-4637.2012.01517.x","article-title":"Reliability, validity, and sensitivity measures of expanded and revised version of the short-form McGill Pain Questionnaire (SF-MPQ-2) in Iranian patients with neuropathic and non-neuropathic pain","volume":"13","author":"Adelmanesh","year":"2012","journal-title":"Pain Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1016\/j.jpain.2012.09.011","article-title":"Evaluation of the psychometric properties of the revised short-form McGill Pain Questionnaire (SF-MPQ-2)","volume":"13","author":"Lovejoy","year":"2012","journal-title":"J. Pain"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Gull, M.A., Bai, S., and Bak, T. (2020). A review on design of upper limb exoskeletons. Robotics, 9.","DOI":"10.3390\/robotics9010016"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Qassim, H.M., and Wan Hasan, W. (2018). A Review on upper limb rehabilitation robots. Appl. Sci., 10.","DOI":"10.3390\/app10196976"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"S189","DOI":"10.1016\/j.pmrj.2018.07.011","article-title":"Robotic and sensor technology for upper limb rehabilitation","volume":"10","author":"Jakob","year":"2018","journal-title":"PM R"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2","DOI":"10.4172\/2168-9695.1000177","article-title":"A brief review on robotic exoskeletons for upper extremity rehabilitation to find the gap between research porotype and commercial type","volume":"6","author":"Islam","year":"2017","journal-title":"Adv. Robot. Autom."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"H\u00f8eg, E.R., Povlsen, T.M., Bruun-Pedersen, J.R., Lange, B., Nilsson, N.C., Haugaard, K.B., Faber, S.M., Hansen, S.W., Kimby, C.K., and Serafin, S. (2021). System immersion in virtual reality-based rehabilitation of motor function in older adults: A systematic review and meta-analysis. Front. Virtual Real., 2.","DOI":"10.3389\/frvir.2021.647993"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/frvir.2020.585993","article-title":"The ultimate display for physical rehabilitation: A bridging review on immersive virtual reality","volume":"1","author":"Elor","year":"2020","journal-title":"Front. Virtual Real."},{"key":"ref_24","unstructured":"(2020). Statista Forecast Unit Shipments of Augmented (AR) and Virtual Reality (VR) Headsets from 2019 to 2023 (in Millions). Teh. Rep., Available online: https:\/\/www.statista.com\/statistics\/653390\/worldwide-virtual-and-augmented-reality-headset-shipments\/."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12984-020-00801-3","article-title":"Immersive virtual reality health games: A narrative review of game design","volume":"18","author":"Tao","year":"2021","journal-title":"J. Neuroeng. Rehabil."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1080\/09638288.2019.1631892","article-title":"Virtual reality and video games in cardiac rehabilitation programs. A systematic review","volume":"43","year":"2021","journal-title":"Disabil. Rehabil."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Calborean, A., Macavei, S., Mocan, M., Ciuce, C., Cordos, A., Bintintan, A., Chira, R., Pestean, C., Pop, O., and Barbu-Tudoran, L. (2020). Laparoscopic compatible device incorporating inductive proximity sensors for precise detection of gastric and colorectal small tumors. Surg. Oncol., 35.","DOI":"10.1016\/j.suronc.2020.10.012"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"110146","DOI":"10.1016\/j.msec.2019.110146","article-title":"New inductive proximity sensor platform for precise localization of small colorectal tumors","volume":"106","author":"Calborean","year":"2020","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_29","first-page":"533","article-title":"Automatic arterial puncture sensorial device for fast arterial blood gas sampling from radial artery during COVID-19 pandemic","volume":"Volume 88","author":"Mocan","year":"2020","journal-title":"Joint International Conference of the International Conference on Mechanisms and Mechanical Transmissions and the International Conference on Robotics"}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/18\/22\/11922\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:29:43Z","timestamp":1760167783000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/18\/22\/11922"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,13]]},"references-count":29,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2021,11]]}},"alternative-id":["ijerph182211922"],"URL":"https:\/\/doi.org\/10.3390\/ijerph182211922","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,13]]}}}