{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T09:48:29Z","timestamp":1791452909551,"version":"4.3.3"},"reference-count":68,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2021,11,14]],"date-time":"2021-11-14T00:00:00Z","timestamp":1636848000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Background: Down syndrome is the most frequent genetic cause of intellectual disability, with an estimated birth prevalence of 14 per 10,000 live births. In Brazil, statistical data on the occurrence of babies born with Down syndrome remain unclear. We aimed to estimate the occurrence of Down syndrome between 2012 and 2018, and to observe its association with maternal, gestational, paternal characteristics, and newborn vitality. Methods: A retrospective study was carried out using secondary data included in the Certificate of Live Birth in a state located in the southeastern region of Brazil. Data analysis was performed in the software Stata 14.1. Pearson\u2019s chi-square test for bivariate analysis, and logistic regression for multivariate analysis were performed, with a 95% confidence interval (CI) and a significance of 5%. Results: We observed that 157 cases of Down syndrome were reported among 386,571 live births, representing an incidence of 4 in 10,000 live births. Down syndrome was associated with maternal age \u2265 35 years, paternal age \u2265 30 years, the performance of six or more prenatal consultations, prematurity, and low birth weight (p &lt; 0.05). Conclusions: Women aged 35 and over were more likely to have children born with Down syndrome. In addition, there is an association of Down syndrome with premature birth, low birth weight, and the number of prenatal consultations (\u22656).<\/jats:p>","DOI":"10.3390\/ijerph182211954","type":"journal-article","created":{"date-parts":[[2021,11,14]],"date-time":"2021-11-14T20:48:36Z","timestamp":1636922916000},"page":"11954","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Down Syndrome in Brazil: Occurrence and Associated Factors"],"prefix":"10.3390","volume":"18","author":[{"given":"Mariana Rabello","family":"Laignier","sequence":"first","affiliation":[{"name":"Nursing Department at the Health Sciences Center, Universidade Federal do Esp\u00edrito Santo, Vit\u00f3ria 29075-910, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2424-6510","authenticated-orcid":false,"given":"Lu\u00eds Carlos","family":"Lopes-J\u00fanior","sequence":"additional","affiliation":[{"name":"Nursing Department at the Health Sciences Center, Universidade Federal do Esp\u00edrito Santo, Vit\u00f3ria 29075-910, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel Esperidon","family":"Santana","sequence":"additional","affiliation":[{"name":"Associa\u00e7\u00e3o de Pais, Amigos e Pessoas com S\u00edndrome de Down do Esp\u00edrito Santo, Vit\u00f3ria 29075-910, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franci\u00e9le Marabotti Costa","family":"Leite","sequence":"additional","affiliation":[{"name":"Nursing Department at the Health Sciences Center, Universidade Federal do Esp\u00edrito Santo, Vit\u00f3ria 29075-910, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1980-5119","authenticated-orcid":false,"given":"Carolina Laura","family":"Brancato","sequence":"additional","affiliation":[{"name":"Associa\u00e7\u00e3o de Pais, Amigos e Pessoas com S\u00edndrome de Down do Esp\u00edrito Santo, Vit\u00f3ria 29075-910, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s00439-009-0696-8","article-title":"Molecular genetic analysis of Down syndrome","volume":"126","author":"Patterson","year":"2009","journal-title":"Hum. 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