{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T18:19:34Z","timestamp":1778869174040,"version":"3.51.4"},"reference-count":19,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T00:00:00Z","timestamp":1637280000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Uterine myomas or uterine fibroids are the most common benign uterine masses affecting women. The management of large myoma during pregnancy is challenging, and surgical treatment is a possible option. We report nine cases of pregnant women affected by uterine masses larger than 10 cm, who underwent surgical treatment during the second trimester of pregnancy. In all cases, the masses were preconceptionally unknown and diagnosed during the first trimester. In eight cases, no maternal and fetal complications arose during or after surgical treatment and delivery occurred at full term of pregnancy. In one case, spontaneous abortion was recorded. In all cases, histologic diagnosis demonstrated the benign nature. Women affected by large uterine masses diagnosed for the first time in pregnancy could be taken into consideration for surgical treatment in a referral center during the second trimester.<\/jats:p>","DOI":"10.3390\/ijerph182212139","type":"journal-article","created":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T02:43:09Z","timestamp":1637289789000},"page":"12139","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Surgical Treatment of \u201cLarge Uterine Masses\u201d in Pregnancy: A Single-Center Experience"],"prefix":"10.3390","volume":"18","author":[{"given":"Anna Franca","family":"Cavaliere","sequence":"first","affiliation":[{"name":"Obstetrics and Gynaecology Unit, Santo Stefano Hospital, AUSL Toscana Centro, 59100 Prato, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annalisa","family":"Vidiri","sequence":"additional","affiliation":[{"name":"Universit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3886-3007","authenticated-orcid":false,"given":"Salvatore","family":"Gueli Alletti","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Fagotti","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Concetta","family":"La Milia","sequence":"additional","affiliation":[{"name":"Universit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Perossini","sequence":"additional","affiliation":[{"name":"Universit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7848-0329","authenticated-orcid":false,"given":"Stefano","family":"Restaino","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Gynecology, University Hospital of Udine, Azienda Sanitaria Universitaria Friuli Centrale, 33100 Udine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2424-2691","authenticated-orcid":false,"given":"Giuseppe","family":"Vizzielli","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Gynecology, University Hospital of Udine, Azienda Sanitaria Universitaria Friuli Centrale, 33100 Udine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Lanzone","sequence":"additional","affiliation":[{"name":"Universit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"},{"name":"Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Scambia","sequence":"additional","affiliation":[{"name":"Universit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"},{"name":"Division of Gynecologic Oncology, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"16043","DOI":"10.1038\/nrdp.2016.43","article-title":"Uterine fibroids","volume":"2","author":"Stewart","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"319.e1","DOI":"10.1016\/j.ajog.2013.07.017","article-title":"The impact of uterine leiomyomas: A national survey of affected women","volume":"209","author":"Borah","year":"2013","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.ijgo.2013.01.021","article-title":"Myomectomy during cesarean delivery","volume":"121","author":"Song","year":"2013","journal-title":"Int. J. Gynaecol. Obstet."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1097\/GCO.0000000000000220","article-title":"Management of uterine fibroids in pregnancy: Recent trends","volume":"27","author":"Vitale","year":"2015","journal-title":"Curr. Opin. Obstet. Gynecol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1097\/GRF.0000000000000169","article-title":"Are Women With Uterine Fibroids at Increased Risk for Adverse Pregnancy Outcome?","volume":"59","author":"Ezzedine","year":"2016","journal-title":"Clin. Obstet. Gynecol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"607","DOI":"10.2147\/IJWH.S138982","article-title":"Updated approaches for management of uterine fibroids","volume":"9","author":"Mas","year":"2017","journal-title":"Int. J. Womens Health"},{"key":"ref_7","first-page":"1789","article-title":"Myoma and myomectomy: Poor evidence concern in pregnancy","volume":"43","author":"Milazzo","year":"2017","journal-title":"J. Obstet\/Gynaecol. Res."},{"key":"ref_8","first-page":"100","article-title":"Uterine Fibroids: Diagnosis and Treatment","volume":"95","author":"Buchanan","year":"2017","journal-title":"Am. Fam. Physician"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s10397-015-0894-4","article-title":"The prevalence of occult leiomyosarcoma at surgery for presumed uterine fibroids: A meta-analysis","volume":"12","author":"Pritts","year":"2015","journal-title":"Gynecol. Surg."},{"key":"ref_10","first-page":"84","article-title":"Leiomyosarcoma: A rare malignant transformation of a uterine leiomyoma","volume":"36","author":"Patacchiola","year":"2015","journal-title":"Eur. J. Gynaecol. Oncol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.ajog.2007.12.039","article-title":"Fibroids and reproductive outcomes: A systematic literature review from conception to delivery","volume":"198","author":"Klatsky","year":"2008","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1017\/S0266462318000168","article-title":"Preoperative Magnetic Resonance Imaging Diagnostic Features of Uterine Leiomyosarcomas: A Systematic Review","volume":"34","author":"Kaganov","year":"2018","journal-title":"Int. J. Technol. Assess. Health Care"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s13304-013-0198-z","article-title":"Management of uterine leiomyomas in pregnancy: Review of literature","volume":"65","author":"Vitale","year":"2013","journal-title":"Updates Surg."},{"key":"ref_14","first-page":"16","article-title":"FDA warns against power morcellation for hysterectomy and fibroids","volume":"114","author":"Wallis","year":"2014","journal-title":"Am. J. Nurs."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"318","DOI":"10.2174\/1381612826666200204093737","article-title":"The Medical Device Applied to Uterine Fibroids Morcellation: Analysis of Critical Biological Issues and Drawbacks from A Medical-Legal Prospective","volume":"26","author":"Mynbaev","year":"2020","journal-title":"Curr. Pharm. Des."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.jmig.2019.04.031","article-title":"Medicolegal Issues in Power Morcellation: Cautionary Rules for Gynecologists to Avoid Unfavorable Outcomes","volume":"27","author":"Zaami","year":"2020","journal-title":"J. Minim. Invasive Gynecol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"(2017). Committee Opinion No. 696: Nonobstetric Surgery During Pregnancy. Obstet. Gynecol., 129, 777\u2013778.","DOI":"10.1097\/AOG.0000000000002014"},{"key":"ref_18","first-page":"4970802","article-title":"Uterine Fibroid Torsion during Pregnancy: A Case of Laparotomic Myomectomy at 18 Weeks\u2019 Gestation with Systematic Review of the Literature","volume":"2017","author":"Basso","year":"2017","journal-title":"Case Rep. Obstet. Gynecol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1002\/uog.21881","article-title":"Intraoperative ultrasound assistance during myomectomy in pregnant woman","volume":"55","author":"Moruzzi","year":"2020","journal-title":"Ultrasound Obstet. Gynecol."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/18\/22\/12139\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:32:35Z","timestamp":1760167955000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/18\/22\/12139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,19]]},"references-count":19,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2021,11]]}},"alternative-id":["ijerph182212139"],"URL":"https:\/\/doi.org\/10.3390\/ijerph182212139","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,19]]}}}