{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T03:25:43Z","timestamp":1773285943725,"version":"3.50.1"},"reference-count":124,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T00:00:00Z","timestamp":1638144000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>The evolutionarily conserved signaling pathway Notch is unequivocally essential for embryogenesis. Notch\u2019s contribution to the muscle repair process in adult tissue is complex and obscure but necessary. Notch integrates with other signals in a functional antagonist manner to direct myoblast activity and ultimately complete muscle repair. There is profound recent evidence describing plausible mechanisms of Notch in muscle repair. However, the story is not definitive as evidence is slowly emerging that negates Notch\u2019s importance in myoblast proliferation. The purpose of this review article is to examine the prominent evidence and associated mechanisms of Notch\u2019s contribution to the myogenic repair phases. In addition, we discuss the emerging roles of Notch in diseases associated with muscle atrophy. Understanding the mechanisms of Notch\u2019s orchestration is useful for developing therapeutic targets for disease.<\/jats:p>","DOI":"10.3390\/ijerph182312558","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T04:48:37Z","timestamp":1638247717000},"page":"12558","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Current Thoughts of Notch\u2019s Role in Myoblast Regulation and Muscle-Associated Disease"],"prefix":"10.3390","volume":"18","author":[{"given":"Jeffrey C.","family":"Gerrard","sequence":"first","affiliation":[{"name":"Department of Applied Physiology, Health and Clinical Sciences, University of North Carolina-Charlotte, Charlotte, NC 28223, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamison P.","family":"Hay","sequence":"additional","affiliation":[{"name":"Department of Applied Physiology, Health and Clinical Sciences, University of North Carolina-Charlotte, Charlotte, NC 28223, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan N.","family":"Adams","sequence":"additional","affiliation":[{"name":"Department of Applied Physiology, Health and Clinical Sciences, University of North Carolina-Charlotte, Charlotte, NC 28223, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"III","given":"James C.","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Applied Physiology, Health and Clinical Sciences, University of North Carolina-Charlotte, Charlotte, NC 28223, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8632-5791","authenticated-orcid":false,"given":"Joshua R.","family":"Huot","sequence":"additional","affiliation":[{"name":"Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaitlin M.","family":"Weathers","sequence":"additional","affiliation":[{"name":"Department of Applied Physiology, Health and Clinical Sciences, University of North Carolina-Charlotte, Charlotte, NC 28223, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6207-5986","authenticated-orcid":false,"given":"Joseph S.","family":"Marino","sequence":"additional","affiliation":[{"name":"Department of Applied Physiology, Health and Clinical Sciences, University of North Carolina-Charlotte, Charlotte, NC 28223, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan T.","family":"Arthur","sequence":"additional","affiliation":[{"name":"Department of Applied Physiology, Health and Clinical Sciences, University of North Carolina-Charlotte, Charlotte, NC 28223, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,29]]},"reference":[{"key":"ref_1","first-page":"2135","article-title":"Notch signaling at a glance","volume":"126","author":"Hori","year":"2013","journal-title":"J. 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