{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T05:23:39Z","timestamp":1780550619826,"version":"3.54.1"},"reference-count":46,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T00:00:00Z","timestamp":1638748800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST- 109-2314-B-037-016-MY2"],"award-info":[{"award-number":["MOST- 109-2314-B-037-016-MY2"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Kaohsiung Municipal Siaogang Hospital, Taiwan","award":["H-110-002"],"award-info":[{"award-number":["H-110-002"]}]},{"name":"Regenerative Medicine and Cell Therapy Research Center, Kaohsiung Medial University, Tai-wan","award":["KMU-TC109A02-5"],"award-info":[{"award-number":["KMU-TC109A02-5"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Ligament reconstruction is indicated in patients with an isolated posterior cruciate ligament (PCL) injury who fail conservative treatment. To eliminate the need for PCL reconstruction, an ideal rehabilitation program is important for patients with an isolated PCL injury. The purpose of this study was to investigate the improvement in functional outcome, proprioception, and muscle strength after a Both Sides Up (BOSU) ball was used in a balance combined with strength training program in patients with an isolated PCL injury. Ten patients with isolated PCL injuries were recruited to receive a 12 week training program as a study group. In the control group (post-PCL reconstruction group), ten subjects who had undergone isolated PCL reconstruction for more than 2 years were enrolled without current rehabilitation. The Lysholm score, IKDC score, proprioception (active and passive), and isokinetic muscle strength tests at 60\u00b0\/s, 120\u00b0\/s, and 240\u00b0\/s, were used before and after training on the injured and normal knees in the study group, and in the post-PCL reconstruction group. The results were analyzed with a paired t-test to compare the change between pre-training, post-training, and the normal leg in the study group, and with an independent t-test for comparisons between the study and post-PCL reconstruction groups. Both the Lysholm and IKDC scores were significantly improved (p &lt; 0.01) after training, and no difference was observed compared to the post-PCL reconstruction group. The active and passive proprioception was improved post-training compared to pre-training, with no difference to that in the post-PCL reconstruction group. Isokinetic knee quadriceps muscle strength was significantly greater post-training than pre-training in PCL injured knees at 60\u00b0\/s, 120\u00b0\/s, and 240\u00b0\/s, and in hamstring muscle strength at 60\u00b0\/s and 120\u00b0\/s. Muscle strength in the post-training injured knee group showed no significant difference compared to that in the post-training normal leg and the post-PCL reconstruction group. The post-training improvement of muscle strength was higher in the PCL injured leg compared to the normal leg and there was no difference between the dominant and non-dominant injured leg in the study group. After 12 weeks of BOSU balance with strength training in patients with an isolated PCL injury, the functional outcome, proprioception, and isokinetic muscle strength were significantly improved, and comparable to the contralateral normal leg and the post-PCL reconstruction group. We suggest that programs combining BOSU balance and strength training should be introduced in patients with a PCL injury to promote positive clinical results.<\/jats:p>","DOI":"10.3390\/ijerph182312849","type":"journal-article","created":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T02:48:13Z","timestamp":1638845293000},"page":"12849","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Twelve Weeks of a Staged Balance and Strength Training Program Improves Muscle Strength, Proprioception, and Clinical Function in Patients with Isolated Posterior Cruciate Ligament Injuries"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7194-9147","authenticated-orcid":false,"given":"Cheng-Chang","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, Kaohsiung Municipal Siaogang Hospital, Kaohsiung 812, Taiwan"},{"name":"School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan"},{"name":"Department of Orthopaedic Surgery, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan"},{"name":"Regenerative Medicine and Cell Therapy Research Center, Kaohsiung Medical University, Kaohsiung 807, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin-I","family":"Yao","sequence":"additional","affiliation":[{"name":"Kaohsiung Municipal Kaohsiung Commercial High School, Kaohsiung 800, Taiwan"},{"name":"Department of Sports Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsang-Yu","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan"},{"name":"Doctoral Degree Program in Biomedical Engineering, Kaohsiung Medical University, Kaohsiung 807, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Chuan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9916-2119","authenticated-orcid":false,"given":"Hwai-Ting","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul Pei-Hsi","family":"Chou","sequence":"additional","affiliation":[{"name":"School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan"},{"name":"Department of Orthopaedic Surgery, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan"},{"name":"Department of Sports Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1177\/0363546504270481","article-title":"Evaluation and treatment of posterior cruciate ligament injuries: Revisited","volume":"32","author":"Wind","year":"2004","journal-title":"Am. J. Sports Med."},{"key":"ref_2","first-page":"45","article-title":"Posterior cruciate ligament injuries in the athlete: Diagnosis and treatment","volume":"67","author":"Colvin","year":"2009","journal-title":"Bull. Hosp. Jt. Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"233","DOI":"10.2106\/00004623-198769020-00010","article-title":"The role of the posterolateral and cruciate ligaments in the stability of the human knee. A biomechanical study","volume":"69","author":"Gollehon","year":"1987","journal-title":"J. Bone Jt. Surg. Am."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s11420-007-9058-z","article-title":"The nonoperative treatment of acute, isolated (partial or complete) posterior cruciate ligament-deficient knees: An intermediate-term follow-up study","volume":"3","author":"Patel","year":"2007","journal-title":"HSS J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0278-5919(20)30314-8","article-title":"Combined posterior cruciate ligament injuries","volume":"13","author":"Clancy","year":"1994","journal-title":"Clin. Sports Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0749-8063(05)80424-4","article-title":"Posterior cruciate ligament injuries in trauma patients","volume":"9","author":"Fanelli","year":"1993","journal-title":"Arthroscopy"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1177\/03635465980260032301","article-title":"Evaluation and treatment of posterior cruciate ligament injuries","volume":"26","author":"Harner","year":"1998","journal-title":"Am. J. Sports Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1177\/03635465990270030201","article-title":"The natural history of acute, isolated, nonoperatively treated posterior cruciate ligament injuries. A prospective study","volume":"27","author":"Shelbourne","year":"1999","journal-title":"Am. J. Sports Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1097\/01.jsa.0000212325.23560.d2","article-title":"Isolated posterior cruciate ligament injuries of the knee","volume":"14","author":"Petrigliano","year":"2006","journal-title":"Sports Med. Arthrosc. Rev."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1097\/BOT.0b013e318270def4","article-title":"Investigation of multiligamentous knee injury patterns with associated injuries presenting at a level I trauma center","volume":"27","author":"Becker","year":"2013","journal-title":"J. Orthop. Trauma"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"277","DOI":"10.5435\/JAAOS-D-14-00326","article-title":"Management of Posterior Cruciate Ligament Injuries: An Evidence-Based Review","volume":"24","author":"Bedi","year":"2016","journal-title":"J. Am. Acad Orthop. Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1007\/s12178-018-9487-y","article-title":"Nonoperative Treatment of PCL Injuries: Goals of Rehabilitation and the Natural History of Conservative Care","volume":"11","author":"Wang","year":"2018","journal-title":"Curr. Rev. Musculoskelet. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1177\/0363546511435783","article-title":"In vivo analysis of the isolated posterior cruciate ligament-deficient knee during functional activities","volume":"40","author":"Goyal","year":"2012","journal-title":"Am. J. Sports Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1007\/s00167-003-0409-0","article-title":"Diagnostic evaluation of posterior cruciate ligament injuries","volume":"11","author":"Margheritini","year":"2003","journal-title":"Knee Surg. Sports Traumatol. Arthrosc."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1177\/0363546513486771","article-title":"Minimum 10-year follow-up of patients after an acute, isolated posterior cruciate ligament injury treated nonoperatively","volume":"41","author":"Shelbourne","year":"2013","journal-title":"Am. J. Sports Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.1007\/s00167-016-4052-y","article-title":"Incidence and long-term follow-up of isolated posterior cruciate ligament tears","volume":"25","author":"Sanders","year":"2017","journal-title":"Knee Surg. Sports Traumatol. Arthrosc."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1249\/MSS.0b013e3181981eb5","article-title":"Dual fluoroscopic analysis of the posterior cruciate ligament-deficient patellofemoral joint during lunge","volume":"41","author":"Gill","year":"2009","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1177\/0363546508325664","article-title":"Posterolateral structures of the knee in posterior cruciate ligament deficiency","volume":"37","author":"Kozanek","year":"2009","journal-title":"Am. J. Sports Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1177\/036354659602400310","article-title":"Long-term followup of the untreated isolated posterior cruciate ligament-deficient knee","volume":"24","author":"Boynton","year":"1996","journal-title":"Am. J. Sports Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"705","DOI":"10.2519\/jospt.2010.3345","article-title":"A progressive 5-week exercise therapy program leads to significant improvement in knee function early after anterior cruciate ligament injury","volume":"40","author":"Eitzen","year":"2010","journal-title":"J. Orthop. Sports Phys. Ther."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1002\/jor.20754","article-title":"Perturbation training prior to ACL reconstruction improves gait asymmetries in non-copers","volume":"27","author":"Hartigan","year":"2009","journal-title":"J. Orthop. Res."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Myer, G.D., Ford, K.R., Brent, J.L., and Hewett, T.E. (2007). Differential neuromuscular training effects on ACL injury risk factors in\u201dhigh-risk\u201d versus \u201clow-risk\u201d athletes. BMC Musculoskelet. Disord., 8.","DOI":"10.1186\/1471-2474-8-39"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1007\/s00167-012-1970-1","article-title":"Posterior cruciate ligament tears: Functional and postoperative rehabilitation","volume":"21","author":"Pierce","year":"2013","journal-title":"Knee Surg. Sports Traumatol. Arthrosc."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"126","DOI":"10.5792\/ksrr.2013.25.3.126","article-title":"Proprioception and clinical results of anterolateral single-bundle posterior cruciate ligament reconstruction with remnant preservation","volume":"25","author":"Lee","year":"2013","journal-title":"Knee Surg. Relat. Res."},{"key":"ref_25","first-page":"422","article-title":"Effects of balance training on selected skills","volume":"20","author":"Yaggie","year":"2006","journal-title":"J. Strength Cond. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1136\/bjsm.2008.046516","article-title":"Effect of proprioception training on knee joint position sense in female team handball players","volume":"42","author":"Panics","year":"2008","journal-title":"Br. J. Sports Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"305","DOI":"10.2519\/jospt.2004.34.6.305","article-title":"Neuromuscular training improves single-limb stability in young female athletes","volume":"34","author":"Paterno","year":"2004","journal-title":"J. Orthop. Sports Phys. Ther."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.knee.2008.04.003","article-title":"Alignment control exercise changes lower extremity movement during stop movements in female basketball players","volume":"15","author":"Kato","year":"2008","journal-title":"Knee"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/00003086-198509000-00007","article-title":"Rating systems in the evaluation of knee ligament injuries","volume":"198","author":"Tegner","year":"1985","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1097\/00003086-198306000-00017","article-title":"Long-term follow-up study of a distal iliotibial band transfer (DIT) for anterolateral knee instability","volume":"176","author":"Odensten","year":"1983","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1007\/BF01560215","article-title":"Evaluation of knee ligament injuries with the IKDC form","volume":"1","author":"Hefti","year":"1993","journal-title":"Knee Surg. Sports Traumatol. Arthrosc."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.csm.2008.03.004","article-title":"Neuromuscular consequences of anterior cruciate ligament injury","volume":"27","author":"Ingersoll","year":"2008","journal-title":"Clin. Sports Med."},{"key":"ref_33","first-page":"35","article-title":"The natural history of rupture of the posterior cruciate ligament","volume":"74","author":"Dejour","year":"1988","journal-title":"Rev. Chir. Orthop. Reparatrice Appar. Mot."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"6823","DOI":"10.12659\/MSM.912162","article-title":"Effects of Postoperative Physiotherapy Supervision Duration on Clinical Outcome, Speed, and Agility in Males 8 Months After Anterior Cruciate Ligament Reconstruction","volume":"24","author":"Sikorski","year":"2018","journal-title":"Med. Sci. Monit."},{"key":"ref_35","first-page":"35","article-title":"The effect of physiotherapy on knee joint extensor and flexor muscle strength after anterior cruciate ligament reconstruction using hamstring tendon","volume":"17","author":"Czamara","year":"2011","journal-title":"Med. Sci. Monit."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Czamara, A., Krzemi\u0144ska, K., Widuchowski, W., and Dragan, S.L. (2021). The Muscle Strength of the Knee Joint after ACL Reconstruction Depends on the Number and Frequency of Supervised Physiotherapy Visits. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph182010588"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1007\/s001670050169","article-title":"Proprioception in the posterior cruciate ligament deficient knee","volume":"7","author":"Safran","year":"1999","journal-title":"Knee Surg. Sports Traumatol. Arthrosc."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"276","DOI":"10.3109\/17453679108993609","article-title":"Mechanoreceptors in the posterior cruciate ligament. Histologic study on cadaver knees","volume":"62","author":"Katonis","year":"1991","journal-title":"Acta Orthop. Scand."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"243","DOI":"10.2106\/00004623-198769020-00011","article-title":"Neural anatomy of the human anterior cruciate ligament","volume":"69","author":"Schutte","year":"1987","journal-title":"J. Bone Jt. Surg. Am."},{"key":"ref_40","first-page":"35","article-title":"Analysis of proprioception in the posterior cruciate ligament-deficient knee","volume":"14","author":"Clark","year":"1986","journal-title":"Am. J. Sports Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.jsams.2007.07.007","article-title":"Posterior cruciate ligament deficiency: Biomechanical and biological consequences and the outcomes of conservative treatment. A systematic review","volume":"11","author":"Grassmayr","year":"2008","journal-title":"J. Sci. Med. Sport"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1177\/0363546507310075","article-title":"Effect of posterior cruciate ligament deficiency on in vivo translation and rotation of the knee during weightbearing flexion","volume":"36","author":"Li","year":"2008","journal-title":"Am. J. Sports Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1177\/036354658601400107","article-title":"Long-term results of nonoperative treatment of isolated posterior cruciate ligament injuries in the athlete","volume":"14","author":"Parolie","year":"1986","journal-title":"Am. J. Sports Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.arthro.2015.01.012","article-title":"Quadriceps Strength and Endurance After Posterior Cruciate Ligament Tears Versus Matched Group With Anterior Cruciate Ligament Tears","volume":"31","author":"Lee","year":"2015","journal-title":"Arthroscopy"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1177\/036354658801600303","article-title":"Functional analysis of untreated and reconstructed posterior cruciate ligament injuries","volume":"16","author":"Tibone","year":"1988","journal-title":"Am. J. Sports Med."},{"key":"ref_46","first-page":"523","article-title":"Effect of physiotherapy on the strength of tibial internal rotator muscles in males after anterior cruciate ligament reconstruction (ACLR)","volume":"17","author":"Czamara","year":"2011","journal-title":"Med. Sci. Monit."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/18\/23\/12849\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:42:05Z","timestamp":1760168525000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/18\/23\/12849"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,6]]},"references-count":46,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["ijerph182312849"],"URL":"https:\/\/doi.org\/10.3390\/ijerph182312849","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,6]]}}}