{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:06:43Z","timestamp":1793639203559,"version":"4.5.1"},"reference-count":25,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T00:00:00Z","timestamp":1639094400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32060208"],"award-info":[{"award-number":["32060208"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Background: Osteoporosis (OP) is a common orthopedic disease in the elderly, and Adiponectin (ADIPOQ) is closely related to bone metabolism. Objective: To determine the relationship between five single nucleotide polymorphism (SNP) loci in the ADIPOQ gene and osteoporosis in middle-aged and elderly Mulam subjects in Hechi, Guangxi. Methods: This case-control study included 297 middle-aged and elderly Mulam subjects with normal bone mass, 49 subjects with reduced bone mass, and 38 subjects with osteoporosis. Five loci (rs266729, rs1063539, rs2241766, rs3774261, rs710445) of the ADIPOQ in the Mulam subjects were genotyped using SNP with multiple-base extension. Results: The bone strength index (SI) of middle-aged and elderly Mulam subjects showed an overall decreasing trend when the subjects were older. Age, muscle mass, and subcutaneous fat content were the main factors influencing the SI in Mulam subjects. The GC genotype of rs266729 and the GA and GG genotypes of rs710445 were significantly correlated with risk of bone loss (p &lt; 0.05). rs2241766 and rs1063539 showed strong LD (D\u2019 &gt; 0.8, r2 &gt; 0.33). rs710445 and rs266729 loci and rs3774261 and rs2241766 loci showed complete LD (D\u2019 = 1). Conclusions: The GC genotype at rs266729 of the ADIPOQ gene, the GA and GG genotypes at rs710445, and the haplotypes CCGAA and GGTAG correlated with osteoporosis (p &lt; 0.05). The allele C of rs1063539, rs266729 and rs710445 may afford protection for osteoporosis. The allele G may be the genetic susceptibility gene for osteoporosis, increasing the risk of osteoporosis.<\/jats:p>","DOI":"10.3390\/ijerph182413034","type":"journal-article","created":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T08:17:58Z","timestamp":1639124278000},"page":"13034","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Correlation of ADIPOQ Gene Single Nucleotide Polymorphisms with Bone Strength Index in Middle-Aged and the Elderly of Guangxi Mulam Ethnic Group"],"prefix":"10.3390","volume":"18","author":[{"given":"Min","family":"Zhou","sequence":"first","affiliation":[{"name":"School of Public Health and Management, Youjiang Medical University for Nationalities, Baise 533000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Ning","sequence":"additional","affiliation":[{"name":"School of Public Health, Shantou University Medical College, Shantou 515000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueming","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning 530021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2619-1656","authenticated-orcid":false,"given":"Michael","family":"Aschner","sequence":"additional","affiliation":[{"name":"Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiufeng","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Youjiang Medical University for Nationalities, Baise 533000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyun","family":"Bin","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Youjiang Medical University for Nationalities, Baise 533000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5124-4230","authenticated-orcid":false,"given":"Jinhua","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Youjiang Medical University for Nationalities, Baise 533000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1111\/jcmm.14061","article-title":"ADIPOQ, KCNJ11 and TCF7L2 polymorphisms in type 2 diabetes in Kyrgyz population: A case-control study","volume":"23","author":"Isakova","year":"2018","journal-title":"J. Cell. Mol. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"8","DOI":"10.5772\/63218","article-title":"Elevated Adiponectin Antibody Levels in Sera of Patients with Atherosclerosis-Related Coronary Artery Disease, Cerebral Infarction and Diabetes Mellitus","volume":"5","author":"Hiwasa","year":"2016","journal-title":"J. Circ. Biomark."},{"key":"ref_3","first-page":"627","article-title":"Research progress of association between adiponectin gene polymorphism and coro-nary heart disease","volume":"28","author":"Jia","year":"2020","journal-title":"Chin. J. Arterioscler."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1172\/JCI73780","article-title":"S-nitrosoglutathione reductase-dependent PPAR\u03b3 denitrosylation participates in MSC-derived adipogenesis and osteogenesis","volume":"125","author":"Cao","year":"2015","journal-title":"J. Clin. Investig."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.bone.2004.06.008","article-title":"Adiponectin and its receptors are expressed in bone-forming cells","volume":"35","author":"Berner","year":"2004","journal-title":"Bone"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3603","DOI":"10.1210\/en.2008-1639","article-title":"In Vitro and in Vivo Effects of Adiponectin on Bone","volume":"150","author":"Williams","year":"2009","journal-title":"Endocrinology"},{"key":"ref_7","first-page":"109","article-title":"Correlation of the adiponectin gene single nu-cleotide polymorphisms with bone mineral density in females of Guangxi Zhuang nationality","volume":"43","author":"Wang","year":"2012","journal-title":"Acta Anat. Sin."},{"key":"ref_8","first-page":"746","article-title":"Progress in adiponectin inosteoporosis bone metabolic diseases","volume":"39","author":"Wang","year":"2016","journal-title":"Chin. J. Anat."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.bbrc.2005.03.210","article-title":"Adiponectin increases bone mass by suppressing osteoclast and activating osteoblast","volume":"331","author":"Oshima","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"5481","DOI":"10.2174\/092986712803833146","article-title":"Adiponectin in metabolic bone disease","volume":"19","author":"Kanazawa","year":"2012","journal-title":"Curr. Med. Chem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.1210\/jc.2011-0047","article-title":"Influence of Adipokines and Ghrelin on Bone Mineral Density and Fracture Risk: A Systematic Review and Meta-Analysis","volume":"96","author":"Biver","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_12","first-page":"465","article-title":"Relationship between serum adiponectin level and bone mineral density in elderly men","volume":"19","author":"Zhang","year":"2013","journal-title":"Chin. J. Osteoporosis."},{"key":"ref_13","first-page":"909","article-title":"Correlation between adipokines Omentin-1, adiponec-tinand bone mineal density in middle-aged women","volume":"25","author":"Chen","year":"2019","journal-title":"Chin. J. Osteoporos."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.bone.2010.08.010","article-title":"Adiponectin and bone mass density: The InCHI-ANTI study","volume":"47","author":"Napoli","year":"2010","journal-title":"Bone"},{"key":"ref_15","first-page":"43","article-title":"nvestigation on prevalence of chronic diseases among Mulam residents in Guangxi","volume":"19","author":"Shi","year":"2013","journal-title":"Appl. Prev. Med."},{"key":"ref_16","first-page":"683","article-title":"Differences of bone mineral density and change with age among female adults of minorities in Guangxi","volume":"49","author":"Chen","year":"2018","journal-title":"Acta Anat. Sin."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1007\/s11999-011-1863-5","article-title":"Defining Ethnic and Racial Differences in Osteoporosis and Fragility Fractures","volume":"469","author":"Cauley","year":"2011","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref_18","first-page":"1125","article-title":"Principles and Guidelines for Diagnosis and treatment of Primary Osteoporosis in Communities","volume":"22","author":"Xia","year":"2019","journal-title":"Chin. Gen. Pract."},{"key":"ref_19","first-page":"28","article-title":"Analysis of bone strength and influencing factors in adults","volume":"30","author":"Shi","year":"2010","journal-title":"J. Shanghai Jiaotong Univ. Med. Sci."},{"key":"ref_20","first-page":"1129","article-title":"Meta-analysis on the prevalence rate osteoporosis in the middle-aged and elderly in China","volume":"18","author":"Han","year":"2014","journal-title":"Chin. J. Tissue Eng. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1172\/JCI200419900","article-title":"PPARgamma insufficiency enhances oste-ogenesis through osteoblast formation from bone marrow progenitors","volume":"113","author":"Akune","year":"2004","journal-title":"J. Clin. Investig."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"4840531","DOI":"10.1155\/2018\/4840531","article-title":"The Effectiveness of Physical Exercise on Bone Density in Osteoporotic Patients","volume":"2018","author":"Benedetti","year":"2018","journal-title":"Biomed. Res. Int."},{"key":"ref_23","first-page":"6252","article-title":"Association between adiponectin gene single nu-cleotide poly morphisms and bone mineral density in a female population of Zhuang nationality in Guangxi Baise area","volume":"15","author":"Wang","year":"2011","journal-title":"Chin. J. Tissue Eng. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s00774-014-0570-1","article-title":"The association between genetic variants of RUNX2, ADIPOQ and vertebral fracture in Korean postmenopausal women","volume":"33","author":"Kim","year":"2014","journal-title":"J. Bone Miner. Metab."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3858\/emm.2012.44.6.045","article-title":"Association ofADIPOR1polymorphisms with bone mineral density in postmenopausal Korean women","volume":"44","author":"Kim","year":"2012","journal-title":"Exp. Mol. Med."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/18\/24\/13034\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:45:02Z","timestamp":1760168702000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/18\/24\/13034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,10]]},"references-count":25,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["ijerph182413034"],"URL":"https:\/\/doi.org\/10.3390\/ijerph182413034","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,10]]}}}