{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:56:25Z","timestamp":1791939385663,"version":"4.3.4"},"reference-count":66,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,12,28]],"date-time":"2021-12-28T00:00:00Z","timestamp":1640649600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Pan American Health Organization - Brazil","award":["SCON2021-00098"],"award-info":[{"award-number":["SCON2021-00098"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>The Global Program to Eliminate Lymphatic Filariasis (GPELF) is a program that aims to eliminate lymphatic filariasis by 2030. The GPELF strategy is based on interrupting transmission using mass drug administration (MDA) and, in parallel, managing morbidity cases. However, it has been seen that there is a shortage of research in the literature and public policies regarding this last pillar. In this study, we reviewed the literature and available information regarding the burden of filarial morbidity. In addition, we identified that in the Americas, the implementation of structured services with regard to morbidity assistance in the Americas was scarce. We formed a review that aimed to assess the pathogenesis, epidemiology, repercussions, and treatment of filarial morbidity in countries in the Americas where lymphatic filariasis is endemic. Structured searches were carried out on PubMed, LILACS, Scopus, and Web of Science databases without time and language restrictions. Three reviewers evaluated the 2150 studies and performed data extraction, and quality assessment by assigning scores to the studies found. The current literature and available information on the burden of filarial morbidity, as well as the implementation of structured services with regard to morbidity assistance in the Americas, were all found to be scarce. Now that this knowledge gap has been identified, both health services and researchers need to seek the implementation and enhancement of the maintenance of GPELF strategies that relate to the morbidity pillar.<\/jats:p>","DOI":"10.3390\/ijerph19010316","type":"journal-article","created":{"date-parts":[[2021,12,29]],"date-time":"2021-12-29T02:31:27Z","timestamp":1640745087000},"page":"316","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Lymphatic Filariasis: A Systematic Review on Morbidity and Its Repercussions in Countries in the Americas"],"prefix":"10.3390","volume":"19","author":[{"given":"Zulma M.","family":"Medeiros","sequence":"first","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz, Departamento de Parasitologia, Instituto Aggeu Magalh\u00e3es, Recife 50670-420, Brazil"},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Universidade de Pernambuco, Recife 50100-130, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda V. B.","family":"Vieira","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz, Departamento de Parasitologia, Instituto Aggeu Magalh\u00e3es, Recife 50670-420, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9775-1078","authenticated-orcid":false,"given":"Amanda T.","family":"Xavier","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz, Departamento de Parasitologia, Instituto Aggeu Magalh\u00e3es, Recife 50670-420, Brazil"},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Universidade de Pernambuco, Recife 50100-130, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilberto S. N.","family":"Bezerra","sequence":"additional","affiliation":[{"name":"Materials Research Institute, Technological University of the Shannon: Midlands Midwest, N37 HD68 Athlone, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria de F\u00e1tima C.","family":"Lopes","sequence":"additional","affiliation":[{"name":"Minist\u00e9rio da Sa\u00fade, Secretaria de Vigil\u00e2ncia em Sa\u00fade, Bras\u00edlia 70723-040, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4495-9673","authenticated-orcid":false,"given":"Cristine V.","family":"Bonfim","sequence":"additional","affiliation":[{"name":"Minist\u00e9rio da Educa\u00e7\u00e3o, Funda\u00e7\u00e3o Joaquim Nabuco, Diretoria de Pesquisas Sociais, Recife 52061-540, Brazil"},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Sa\u00fade Coletiva, Universidade Federal de Pernambuco, Recife 50670-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana M.","family":"Aguiar-Santos","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz, Departamento de Parasitologia, Instituto Aggeu Magalh\u00e3es, Recife 50670-420, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,28]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2020). 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