{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:45:39Z","timestamp":1787028339011,"version":"build-2736575974"},"reference-count":45,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,1,6]],"date-time":"2022-01-06T00:00:00Z","timestamp":1641427200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Introduction: birth size is affected by diverse maternal, environmental, social, and economic factors. Aim: analyze the relationships between birth size\u2014shown by the indicators small for gestational age (SGA) and large for gestational age (LGA)\u2014and maternal, social, and environmental factors in the Argentine province of Jujuy, located in the Andean foothills. Methods: data was obtained from 49,185 mother-newborn pairs recorded in the Jujuy Perinatal Information System (SIP) between 2009 and 2014, including the following: newborn and maternal weight, length\/height, and body mass index (BMI); gestational age and maternal age; mother\u2019s educational level, nutritional status, marital status and birth interval; planned pregnancy; geographic-linguistic origin of surnames; altitudinal place of birth; and unsatisfied basic needs (UBN). The dataset was split into two groups, SGA and LGA, and compared with adequate for gestational age (AGA). Bivariate analysis (ANOVA) and general lineal modeling (GLM) with multinomial distribution were employed. Results: for SGA newborns, risk factors were altitude (1.43 [1.12\u20131.82]), preterm birth (5.33 [4.17\u20136.82]), older maternal age (1.59 [1.24\u20132.05]), and primiparous mothers (1.88 [1.06\u20133.34]). For LGA newborns, the risk factors were female sex (2.72 [5.51\u20132.95]), overweight (1.33 [1.22\u20132.46]) and obesity (1.85 [1.66\u20132.07]). Conclusions: the distribution of birth size and the factors related to its variability in Jujuy are found to be strongly conditioned by provincial terrain and the clinal variation due to its Andean location.<\/jats:p>","DOI":"10.3390\/ijerph19020621","type":"journal-article","created":{"date-parts":[[2022,1,6]],"date-time":"2022-01-06T03:41:32Z","timestamp":1641440492000},"page":"621","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Birth Size and Maternal, Social, and Environmental Factors in the Province of Jujuy, Argentina"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9051-5451","authenticated-orcid":false,"given":"Jorge Ivan","family":"Martinez","sequence":"first","affiliation":[{"name":"Instituto de Ecorregiones Andinas (INECOA) CONICET-UNJu, San Salvador de Jujuy 4600, Argentina"},{"name":"Departamento de Gen\u00e9tica y Bioantropolog\u00eda, Instituto de Biolog\u00eda de la Altura (InBiAl), National University of Jujuy, San Salvador de Jujuy 4600, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3478-3969","authenticated-orcid":false,"given":"Marcelo Isidro","family":"Figueroa","sequence":"additional","affiliation":[{"name":"Instituto de Ecorregiones Andinas (INECOA) CONICET-UNJu, San Salvador de Jujuy 4600, Argentina"},{"name":"Departamento de Biolog\u00eda Molecular, Instituto de Estudios Celulares, Gen\u00e9ticos y Moleculares (ICeGeM), National University of Jujuy, San Salvador de Jujuy 4600, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8918-8833","authenticated-orcid":false,"given":"Jos\u00e9 Miguel","family":"Mart\u00ednez-Carri\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Applied Economics, Faculty of Economics and Business, Murcia University, 30100 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8960-7826","authenticated-orcid":false,"given":"Emma Laura","family":"Alfaro-Gomez","sequence":"additional","affiliation":[{"name":"Instituto de Ecorregiones Andinas (INECOA) CONICET-UNJu, San Salvador de Jujuy 4600, Argentina"},{"name":"Departamento de Gen\u00e9tica y Bioantropolog\u00eda, Instituto de Biolog\u00eda de la Altura (InBiAl), National University of Jujuy, San Salvador de Jujuy 4600, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1679-0727","authenticated-orcid":false,"given":"Jos\u00e9 Edgardo","family":"Dipierri","sequence":"additional","affiliation":[{"name":"Departamento de Gen\u00e9tica y Bioantropolog\u00eda, Instituto de Biolog\u00eda de la Altura (InBiAl), National University of Jujuy, San Salvador de Jujuy 4600, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1038\/s41598-019-38583-x","article-title":"Optimal birth weight and term mortality risk differ among different ethnic groups in the U.S","volume":"9","author":"Jeon","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Hajihosseini, M., Savu, A., Moore, L., Dinu, I., and Kaul, P. (2021). An updated reference for age-sex-specific birth weight percentiles stratified for ethnicity based on data from all live birth infants between 2005 and 2014 in Alberta, Canada. Can. J. Public Health, 1\u201310.","DOI":"10.17269\/s41997-021-00520-9"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/ajpa.24215","article-title":"Newborn anthropometry, maternal capital, and altitude in the highland population from the province of Jujuy, Argentina","volume":"175","author":"Figueroa","year":"2021","journal-title":"Am. J. Phys. Anthr."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Grant, I.D., Giussani, D.A., and Aiken, C.E. (2021). Fetal growth and spontaneous preterm birth in high-altitude pregnancy: A systematic review, meta-analysis, and meta-regression. Int. J. Gynecol. Obstet., 1\u20139.","DOI":"10.1002\/ijgo.13978"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ajhb.20994","article-title":"Maternal capital and the metabolic ghetto: An evolutionary perspective on the transgenerational basis of health inequalities","volume":"22","author":"Wells","year":"2010","journal-title":"Am. J. Hum. Biol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"F7","DOI":"10.1136\/adc.2006.096214","article-title":"Neonatal anthropometric charts: What they are, what they are not","volume":"92","author":"Bertino","year":"2007","journal-title":"Arch. Dis. Child.-Fetal Neonatal Ed."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/S0140-6736(14)60932-6","article-title":"International standards for newborn weight, length, and head circumference by gestational age and sex: The Newborn Cross-Sectional Study of the INTERGROWTH-21st Project","volume":"384","author":"Villar","year":"2014","journal-title":"Lancet"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0022-3476(67)80066-0","article-title":"A practical classification of newborn infants by weight and gestational age","volume":"71","author":"Battaglia","year":"1967","journal-title":"J. Pediatr."},{"key":"ref_9","first-page":"21","article-title":"Los apellidos de Salta en el Siglo XXI: Origen geo-ling\u00fc\u00edstico, diversidad y frecuencia","volume":"28","author":"Albeck","year":"2017","journal-title":"Rev. Andes"},{"key":"ref_10","first-page":"4","article-title":"Estructura genetico isonimica del Noroeste argentine","volume":"22","author":"Dipierri","year":"2011","journal-title":"J. Basic Appl. Genet."},{"key":"ref_11","first-page":"305","article-title":"GM, KM immunoglobulin allotypes and other serum genetic markers (HP, GC, PI, and TF) among South American populations living at different altitudes (Jujuy Province, Argentina): Admixture estimates","volume":"72","author":"Dipierri","year":"2000","journal-title":"Hum. Biol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1353\/hub.2016.a668391","article-title":"STR Markers Unveil Microgeographic Differentiation over the Steep Mountainous Landscape of Jujuy Province, Northwest Argentina","volume":"88","author":"Dipierri","year":"2016","journal-title":"Hum. Biol."},{"key":"ref_13","first-page":"519","article-title":"Genetic structure of Native Andean populations from Argentina inhabiting different altitudes","volume":"72","author":"Demarchi","year":"2000","journal-title":"Hum. Biol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Muzzio, M., Motti, J.M.B., Sepulveda, P.B.P., Yee, M.-C., Cooke, T., Santos, M.R., Ramallo, V., Alfaro, E., Dipierri, J.E., and Bailliet, G. (2018). Population structure in Argentina. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0196325"},{"key":"ref_15","first-page":"431","article-title":"Geographical altitude, size, mass and body surface area in children (1\u20134 years) in the Province of Jujuy (Argentina)","volume":"42","author":"Bejarano","year":"2014","journal-title":"Ann. Hum. Biol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.jped.2018.03.007","article-title":"Geographic altitude and prevalence of underweight, stunting and wasting in newborns with the INTERGROWTH-21st standard","volume":"95","author":"Martinez","year":"2019","journal-title":"J. Pediatr."},{"key":"ref_17","first-page":"55","article-title":"Effect of high altitude on birth weight and adverse perinatal outcomes in two Argentine populations","volume":"70","author":"Grandi","year":"2013","journal-title":"Rev. Fac. Cienc. Med."},{"key":"ref_18","first-page":"440","article-title":"Variaci\u00f3n altitudinal del peso al nacer en la provincia de Jujuy","volume":"100","author":"Alvarez","year":"2002","journal-title":"Arch. Arg. Pediatr."},{"key":"ref_19","unstructured":"Ministerio de Salud de la Naci\u00f3n Argentina (2011). Gu\u00eda para Investigaciones con Seres Humanos. RES. 1480\/2011."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0029-7844(95)00386-X","article-title":"A united states national reference for fetal growth","volume":"87","author":"Alexander","year":"1996","journal-title":"Obstet. Gynecol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/psp.457","article-title":"A review of name-based ethnicity classification methods and their potential in population studies","volume":"13","author":"Mateos","year":"2007","journal-title":"Popul. Space Place"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1538-4632.1995.tb00338.x","article-title":"Local Indicators of Spatial Association\u2014LISA","volume":"27","author":"Anselin","year":"1995","journal-title":"Geogr. Anal."},{"key":"ref_23","unstructured":"R Core Team (2019). R: A Language and Environment for Statistical Computing (Version 3.6. 1) [Computer Software], R Foundation for Statistical Computing."},{"key":"ref_24","unstructured":"(2015). RStudio Team RStudio: Integrated Development Environment for R, RStudio PBC."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Venables, W.N., and Ripley, B.D. (2002). Random and Mixed Effects. Modern Applied Statistics with S, Springer.","DOI":"10.1007\/978-0-387-21706-2"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Buck Louis, G.M., and Platt, R.W. (2011). Reproductive and Perinatal Epidemiology, Oxford University Press.","DOI":"10.1093\/acprof:oso\/9780195387902.001.0001"},{"key":"ref_27","first-page":"156","article-title":"Peso al nacimiento y altura en la provincia de Jujuy","volume":"3","author":"Dipierri","year":"1992","journal-title":"Cuad. FHYCS-UNJU"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/ajpa.1330560302","article-title":"Optimal birthweights in Peruvian populations at high and low altitudes","volume":"56","author":"Beall","year":"1981","journal-title":"Am. J. Phys. Anthr."},{"key":"ref_29","unstructured":"WHO (2006). Promoting Optimal Fetal Development: Report of a Technical Consultation, WHO."},{"key":"ref_30","first-page":"428","article-title":"International BMI-for-age references underestimate thinness and overestimate overweight and obesity in Bolivian adolescents","volume":"25","author":"Botti","year":"2010","journal-title":"Nutr. Hosp."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"F372","DOI":"10.1136\/adc.2006.109579","article-title":"High-altitude ancestry protects against hypoxia-associated reductions in fetal growth","volume":"92","author":"Julian","year":"2007","journal-title":"Arch. Dis. Child.-Fetal Neonatal Ed."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"j3677","DOI":"10.1136\/bmj.j3677","article-title":"Estimates of burden and consequences of infants born small for gestational age in low and middle income countries with INTERGROWTH-21st standard: Analysis of CHERG datasets","volume":"358","author":"Lee","year":"2017","journal-title":"BMJ"},{"key":"ref_33","first-page":"547","article-title":"Prevalence of low weight and small for gestational age in Argentina: Comparison between the INTERGROWTH-21st standard and an Argentine reference","volume":"115","author":"Revollo","year":"2017","journal-title":"Arch. Argent. Pediatr."},{"key":"ref_34","first-page":"CD011739","article-title":"Regimens of fetal surveillance of suspected large-for-gestational-age fetuses for improving health outcomes","volume":"4","author":"Culliney","year":"2016","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1017\/S0021932016000493","article-title":"Maternal Height and Pre-Pregnancy Weight Status are Associated with Fetal Growth Patterns and Newborn Size","volume":"49","author":"Hartmann","year":"2017","journal-title":"J. Biosoc. Sci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e23454","DOI":"10.1002\/ajhb.23454","article-title":"Proportionality indices, geographic altitude, and gestational age in newborns from Jujuy, Argentina","volume":"33","author":"Revollo","year":"2021","journal-title":"Am. J. Hum. Biol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1515\/jpm-2020-0119","article-title":"Individualized sex-specific birth weight percentiles for gestational age based on maternal height and weight","volume":"49","author":"Voigt","year":"2021","journal-title":"J. P\u00e9rinat. Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"e26","DOI":"10.1016\/S2214-109X(13)70006-8","article-title":"National and regional estimates of term and preterm babies born small for gestational age in 138 low-income and middle-income countries in 2010","volume":"1","author":"Lee","year":"2013","journal-title":"Lancet Glob. Health"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Kozuki, N., Lee, A.C., Silveira, M.F., Victora, C.G., Adair, L., Humphrey, J., Ntozini, R., Black, R.E., Katz, J., and Child Health Epidemiology Reference Group Small-for-Gestational-Age-Preterm Birth Working Group (2013). The associations of birth intervals with small-for-gestational-age, preterm, and neonatal and infant mortality: A meta-analysis. BMC Public Health, 13.","DOI":"10.1186\/1471-2458-13-S3-S3"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1097\/AOG.0000000000002358","article-title":"Within-Family Analysis of Interpregnancy Interval and Adverse Birth Outcomes","volume":"130","author":"Class","year":"2017","journal-title":"Obstet. Gynecol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"331","DOI":"10.4067\/S0717-75262009000600003","article-title":"Riesgo obst\u00e9trico y perinatal en embarazadas mayores de 35 a\u00f1os","volume":"74","author":"Chamy","year":"2009","journal-title":"Rev. Chil. Obstet. Ginecol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"037","DOI":"10.1055\/s-0039-1694775","article-title":"The Association between Advanced Maternal Age and Diagnosis of Small for Gestational Age","volume":"37","author":"Palatnik","year":"2020","journal-title":"Am. J. Perinatol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.jpeds.2015.11.043","article-title":"Born Large for Gestational Age: Bigger Is Not Always Better","volume":"170","author":"Chiavaroli","year":"2016","journal-title":"J. Pediatr."},{"key":"ref_44","first-page":"159","article-title":"Ethnicity determination by names among the Aymara of Chile and Bolivia","volume":"61","author":"Chakraborty","year":"1989","journal-title":"Hum. Biol."},{"key":"ref_45","first-page":"1001","article-title":"Paternal directional mating in two Amerindian subpopulations located at different altitudes in northwestern Argentina","volume":"70","author":"Dipierri","year":"1998","journal-title":"Hum. Biol."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/19\/2\/621\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T13:36:29Z","timestamp":1760362589000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/19\/2\/621"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,6]]},"references-count":45,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,1]]}},"alternative-id":["ijerph19020621"],"URL":"https:\/\/doi.org\/10.3390\/ijerph19020621","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,6]]}}}