{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:50:09Z","timestamp":1790117409327,"version":"4.0.1"},"reference-count":44,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T00:00:00Z","timestamp":1641513600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Exposome factors, such as sleep deprivation and diet, could affect skin barrier function. The objectives of this study are to compare skin barrier function between patients with Obstructive Sleep Apnea Syndrome (OSAS) and healthy individuals, and to evaluate the effect of other exposome factors on skin. A cross-sectional study was conducted. Patients with OSAS and healthy volunteers matched by age and sex were included. OSAS severity was assessed by the Apnea-Hypopnea Index (AHI). Validated questionnaires were used to assess diet, anxiety, depression, and psychological stress. Skin barrier function parameters including temperature, erythema, melanin, pH, transepidermal water loss (TEWL), and stratum corneum hydration (SCH) were measured on the volar forearm. A total of 86 participants were included, 56 patients with OSAS and 30 healthy volunteers. TEWL was higher in OSAS patients than in healthy individuals (8.01 vs. 8.68 g\u00b7m\u22122\u00b7h\u22121). Regarding disease severity, severe patients had higher TEWL values (9.31 vs. 8.46 vs. 7.08 g\u00b7m\u22122\u00b7h\u22121) compared to moderate and mild patients. Patients with OSAS had significantly lower sleep quality (11.89 vs. 6.47 Pittsburgh Sleep Quality Index score; p &lt; 0.001), poor adherence to the Mediterranean Diet (8.46 vs. 9.77; p = 0.005), and significantly higher anxiety and depression levels than healthy individuals. In conclusion, patients with OSAS may have skin barrier impairment, reflected in higher TEWL values. These patients also have higher levels of anxiety, depression, stress, and a lower adherence to a Mediterranean Diet, all exposome factors that might impact on skin barrier function.<\/jats:p>","DOI":"10.3390\/ijerph19020659","type":"journal-article","created":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T03:46:27Z","timestamp":1641527187000},"page":"659","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Impact of Exposome Factors on Epidermal Barrier Function in Patients with Obstructive Sleep Apnea Syndrome"],"prefix":"10.3390","volume":"19","author":[{"given":"Maria","family":"Romera-Vilchez","sequence":"first","affiliation":[{"name":"Dermatology Department, Faculty of Medicine, University of Granada, 18012 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4035-7955","authenticated-orcid":false,"given":"Trinidad","family":"Montero-Vilchez","sequence":"additional","affiliation":[{"name":"Dermatology Department, Hospital Universitario Virgen de las Nieves, 18012 Granada, Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria GRANADA, 18012 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Herrero-Fernandez","sequence":"additional","affiliation":[{"name":"Dermatology Department, Faculty of Medicine, University of Granada, 18012 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan-Angel","family":"Rodriguez-Pozo","sequence":"additional","affiliation":[{"name":"Dermatology Department, Hospital Universitario Virgen de las Nieves, 18012 Granada, Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria GRANADA, 18012 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"Jimenez-Galvez","sequence":"additional","affiliation":[{"name":"Pneumnology Department, Hospital Universitario Virgen de las Nieves, 18012 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concepcion","family":"Morales-Garcia","sequence":"additional","affiliation":[{"name":"Pneumnology Department, Hospital Universitario Virgen de las Nieves, 18012 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agustin","family":"Buendia-Eisman","sequence":"additional","affiliation":[{"name":"Dermatology Department, Faculty of Medicine, University of Granada, 18012 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4186-1435","authenticated-orcid":false,"given":"Salvador","family":"Arias-Santiago","sequence":"additional","affiliation":[{"name":"Dermatology Department, Faculty of Medicine, University of Granada, 18012 Granada, Spain"},{"name":"Dermatology Department, Hospital Universitario Virgen de las Nieves, 18012 Granada, Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria GRANADA, 18012 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ad.2014.03.008","article-title":"New experimental models of skin homeostasis and diseases","volume":"106","author":"Larcher","year":"2015","journal-title":"Actas Dermosifiliogr"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1684\/ejd.2021.4021","article-title":"Cutaneous homeostasis and epidermal barrier function in a young healthy Caucasian population","volume":"31","year":"2021","journal-title":"Eur. 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