{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T07:55:39Z","timestamp":1793087739972,"version":"4.5.0"},"reference-count":130,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T00:00:00Z","timestamp":1642636800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Agencia Espa\u00f1ola de Cooperaci\u00f3n Internacional para el Desarrollo (AECID), Ministry of Foreign Affairs and Cooperation, Madrid, Spain","award":["2017\/ACDE\/001583"],"award-info":[{"award-number":["2017\/ACDE\/001583"]}]},{"name":"the International Atomic Energy Agency (Animal Production and Health Section, Joint FAO\/IAEA)","award":["RLA5049"],"award-info":[{"award-number":["RLA5049"]}]},{"name":"Acci\u00f3n Estrat\u00e9gica en Salud (AES) y Fondos FEDER, Plan Estatal de Investigaci\u00f3n Cient\u00edfica y T\u00e9cnica y de Innovaci\u00f3n, ISCIII-MINECO, Madrid, Spain","award":["PI16\/00520"],"award-info":[{"award-number":["PI16\/00520"]}]},{"name":"Red de Investigaci\u00f3n de Centros de Enfermedades Tropicales \u2013 RICET, , ISCIII-Subdirecci\u00f3n General de Redes y Centros de Investigaci\u00f3n Cooperativa RETICS), Ministry of Health and Consumption, Madrid","award":["RD16\/0027\/0023"],"award-info":[{"award-number":["RD16\/0027\/0023"]}]},{"name":"CIBER de Enfermedades Infecciosas, ISCIII, Ministry of Science and Education, Madrid, Spain","award":["CB21\/\/13\/00056"],"award-info":[{"award-number":["CB21\/\/13\/00056"]}]},{"name":"PROMETEO Program, Programa de Ayudas para Grupos de Investigaci\u00f3n de Excelencia, Gene-ralitat Valenciana, Valencia, Spain","award":["2016\/099 and 2021\/004"],"award-info":[{"award-number":["2016\/099 and 2021\/004"]}]},{"name":"Proyectos de Cooperaci\u00f3n al Desarrollo de la Universidad de Valencia, Spain","award":["2017\/01"],"award-info":[{"award-number":["2017\/01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>The Northern Bolivian Altiplano is the fascioliasis endemic area with the reported highest human prevalence and intensities. A multidisciplinary One Health initiative was implemented to decrease infection\/reinfection rates detected by periodic monitoring between the ongoing yearly preventive chemotherapy campaigns. Within a One Health axis, the information obtained throughout 35 years of field work on transmission foci and affected rural schools and communities\/villages is analysed. Aspects linked to human infection risk are quantified, including: (1) geographical extent of the endemic area, its dynamics, municipalities affected, and its high strategic importance; (2) human population at risk, community development and mortality rates, with emphasis on problems in infancy and gender; (3) characteristics of the freshwater collections inhabited by lymnaeid snail vectors and constituting transmission foci; (4) food infection sources, including population surveys with questionnaire and reference to the most risky edible plant species; (5) water infection sources; (6) household characteristics; (7) knowledge of the inhabitants on Fasciola hepatica and the disease; (8) behavioural, traditional, social, and religious aspects; (9) livestock management. This is the widest and deepest study of this kind ever performed. Results highlight prevention and control difficulties where inhabitants follow century-old behaviours, traditions, and beliefs. Intervention priorities are proposed and discussed.<\/jats:p>","DOI":"10.3390\/ijerph19031120","type":"journal-article","created":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T22:40:20Z","timestamp":1642718420000},"page":"1120","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["One Health Action against Human Fascioliasis in the Bolivian Altiplano: Food, Water, Housing, Behavioural Traditions, Social Aspects, and Livestock Management Linked to Disease Transmission and Infection Sources"],"prefix":"10.3390","volume":"19","author":[{"given":"Ren\u00e9","family":"Angles","sequence":"first","affiliation":[{"name":"C\u00e1tedra de Parasitolog\u00eda, Facultad de Medicina, Universidad Mayor de San Andr\u00e9s (UMSA), Av. Saavedra, Miraflores, La Paz 10077, Bolivia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Buchon","sequence":"additional","affiliation":[{"name":"Unidad de Limnolog\u00eda, Instituto de Ecolog\u00eda, Universidad Mayor de San Andr\u00e9s (UMSA), Campus Calle 27, Cota Cota, La Paz 10077, Bolivia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1584-8330","authenticated-orcid":false,"given":"M. Adela","family":"Valero","sequence":"additional","affiliation":[{"name":"Departamento de Parasitologia, Facultad de Farmacia, Universidad de Valencia, Av. Vicent Andres Estelles s\/n, 46100 Burjassot, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2347-7269","authenticated-orcid":false,"given":"M. Dolores","family":"Bargues","sequence":"additional","affiliation":[{"name":"Departamento de Parasitologia, Facultad de Farmacia, Universidad de Valencia, Av. Vicent Andres Estelles s\/n, 46100 Burjassot, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1685-7004","authenticated-orcid":false,"given":"Santiago","family":"Mas-Coma","sequence":"additional","affiliation":[{"name":"Departamento de Parasitologia, Facultad de Farmacia, Universidad de Valencia, Av. Vicent Andres Estelles s\/n, 46100 Burjassot, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.ijpara.2021.02.006","article-title":"The influence of liver fluke infection on production in sheep and cattle: A meta-analysis","volume":"51","author":"Hayward","year":"2021","journal-title":"Int. J. Parasitol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/B978-0-12-800099-1.00002-8","article-title":"Neurological and ocular fascioliasis in humans","volume":"84","author":"Agramunt","year":"2014","journal-title":"Adv. Parasitol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1017\/S0031182018001464","article-title":"Numerous Fasciola plasminogen-binding proteins may underlie blood-brain barrier leakage and explain neurological disorder complexity and heterogeneity in the acute and chronic phases of human fascioliasis","volume":"146","author":"Valero","year":"2019","journal-title":"Parasitology"},{"key":"ref_4","first-page":"R1","article-title":"Progress in assessment of morbidity due to Fasciola hepatica infection: A review of recent literature","volume":"87","author":"Chen","year":"1990","journal-title":"Trop. Dis. Bull."},{"key":"ref_5","first-page":"253","article-title":"Human fascioliasis emergence risks in developed countries: From individual patients and small epidemics to climate and global change impacts","volume":"38","year":"2020","journal-title":"Enf. Emerg. Microbiol. Cl\u00edn."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.medmal.2006.07.018","article-title":"Clinical and biological abnormalities in patients after fasciolosis treatment","volume":"36","author":"Rondelaud","year":"2006","journal-title":"Med. Mal. Infect."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Bargues, M.D., Artigas, P., Khoubbane, M., Flores, R., Gl\u00f6er, P., Rojas-Garcia, R., Ashrafi, K., Falkner, G., and Mas-Coma, S. (2011). Lymnaea schirazensis, an overlooked snail distorting fascioliasis data: Genotype, phenotype, ecology, worldwide spread, susceptibility, applicability. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0024567"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1093\/trstmh\/trv110","article-title":"Higher physiopathogenicity by Fasciola gigantica than by the genetically close F. hepatica: Experimental long-term follow-up of biochemical markers","volume":"110","author":"Valero","year":"2016","journal-title":"Trans. Roy. Soc. Trop. Med. Hyg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0065-308X(09)69002-3","article-title":"Fasciola, lymnaeids and human fascioliasis, with a global overview on disease transmission, epidemiology, evolutionary genetics, molecular epidemiology and control","volume":"69","author":"Valero","year":"2009","journal-title":"Adv. Parasitol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Bargues, M.D., Valero, M.A., Trueba, G.A., Fornasini, M., Villavicencio, A.E., Guam\u00e1n, R., De Elias-Escribano, A., Perez-Crespo, I., Artigas, P., and Mas-Coma, S. (2021). Multi-marker genotyping and CIAS morphometric phenotyping of Fasciola gigantica-sized flukes from Ecuador, with an analysis of the Radix absence in the New World and the evolutionary lymnaeid snail vector filter. Animals, 11.","DOI":"10.3390\/ani11092495"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Fox, N.J., White, P.C.L., McClean, C.J., Marion, G., Evans, A., and Hutchings, M.R. (2011). Predicting impacts of climate change on Fasciola hepatica risk. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0016126"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"317","DOI":"10.4081\/gh.2014.22","article-title":"Impact of climate change and man-made irrigation systems on the transmission risk, long-term trend and seasonality of human and animal fascioliasis in Pakistan","volume":"8","author":"Afshan","year":"2014","journal-title":"Geospat. Health"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1017\/S0031182018000914","article-title":"Human fascioliasis infection sources, their diversity, incidence factors, analytical methods and prevention measures","volume":"145","author":"Bargues","year":"2018","journal-title":"Parasitology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1086\/514822","article-title":"Immune suppression in advanced chronic fascioliasis: An experimental study in a rat model","volume":"195","author":"Girones","year":"2007","journal-title":"J. Infect. Dis."},{"key":"ref_15","unstructured":"World Health Organization (2013). Sustaining the Drive to Overcome the Global Impact of Neglected Tropical Diseases, Department of Control of Neglected Tropical Diseases, World Health Organization."},{"key":"ref_16","unstructured":"World Health Organization (2020). Ending the Neglect to Attain the Sustainable Development Goals. A Road Map for Neglected Tropical Diseases 2021\u20132030, World Health Organization. Available online: https:\/\/www.who.int\/neglected_diseases\/Ending-the-neglect-to-attain-the-SDGs--NTD-Roadmap.pdf."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Zumaquero-Rios, J.L., Sarracent-Perez, J., Rojas-Garcia, R., Rojas-Rivero, L., Martinez-Tovilla, Y., Valero, M.A., and Mas-Coma, S. (2013). Fascioliasis and intestinal parasitoses affecting schoolchildren in Atlixco, Puebla State, Mexico: Epidemiology and treatment with nitazoxanide. PLoS Negl. Trop. Dis., 7.","DOI":"10.1371\/journal.pntd.0002553"},{"key":"ref_18","first-page":"621","article-title":"Fascioliasis en la poblaci\u00f3n rural de las provincias de Curico, Talca y Linares","volume":"120","author":"Apt","year":"1992","journal-title":"Rev. M\u00e9d. Chile"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.actatropica.2011.09.002","article-title":"Characterisation of fascioliasis lymnaeid intermediate hosts from Chile by DNA sequencing, with emphasis on Lymnaea viator and Galba truncatula","volume":"120","author":"Artigas","year":"2011","journal-title":"Acta Trop."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/1756-3305-4-104","article-title":"Human fascioliasis in Argentina: Retrospective overview, critical analysis and baseline for future research","volume":"4","author":"Agramunt","year":"2011","journal-title":"Parasit. Vectors"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1186\/s13071-016-1589-z","article-title":"Human fascioliasis endemic areas in Argentina: Multigene characterisation of the lymnaeid vectors and climatic-environmental assessment of the transmission pattern","volume":"9","author":"Bargues","year":"2016","journal-title":"Parasit. Vectors"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1186\/1756-3305-4-200","article-title":"A new baseline for fascioliasis in Venezuela: Lymnaeid vectors ascertained by DNA sequencing and analysis of their relationships with human and animal infection","volume":"4","author":"Bargues","year":"2011","journal-title":"Parasit. Vectors"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.actatropica.2011.07.002","article-title":"Hyperendemic human fascioliasis in Andean valleys: An altitudinal transect analysis in children of Cajamarca province, Peru","volume":"120","author":"Gonzalez","year":"2011","journal-title":"Acta Trop."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1046\/j.1365-3156.2002.00870.x","article-title":"High fascioliasis infection in children linked to a man-made irrigation zone in Peru","volume":"7","author":"Esteban","year":"2002","journal-title":"Trop. Med. Int. Health"},{"key":"ref_25","first-page":"33","article-title":"Human fascioliasis in Bolivia: Coprological surveys in different provinces of the Department of La Paz","volume":"57","author":"Angles","year":"1997","journal-title":"Res. Rev. Parasitol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0035-9203(99)90289-4","article-title":"High endemicity of human fascioliasis between Lake Titicaca and La Paz valley, Bolivia","volume":"93","author":"Esteban","year":"1999","journal-title":"Trans. Roy. Soc. Trop. Med. Hyg."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1046\/j.1365-3156.1999.00418.x","article-title":"The Northern Bolivian Altiplano: A region highly endemic for human fascioliasis","volume":"4","author":"Angles","year":"1999","journal-title":"Trop. Med. Int. Health"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"603","DOI":"10.4269\/ajtmh.1992.46.603","article-title":"Use of the Falcon Assay Screening Test\u2013Enzyme-Linked Immunosorbent Assay (FAST-ELISA) and the Enzyme-Linked Immunoelectrotransfer Blot (EITB) to determine the prevalence of human Fascioliasis in the Bolivian Altiplano","volume":"46","author":"Hillyer","year":"1992","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_29","first-page":"109","article-title":"Human fascioliasis in Bolivia: Serological surveys in Los Andes province of the Department of La Paz","volume":"57","author":"Strauss","year":"1997","journal-title":"Res. Rev. Parasitol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"417","DOI":"10.4269\/ajtmh.1998.58.417","article-title":"Immunodiagnosis of Fasciola hepatica (Fascioliasis) in a human population in the Bolivian Altiplano using purified cathepsin L cysteine proteinase","volume":"58","author":"Parkinson","year":"1998","journal-title":"Amer. J Trop. Med. Hyg."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.actatropica.2008.08.007","article-title":"Anaemia in advanced chronic fasciolosis","volume":"108","author":"Valero","year":"2008","journal-title":"Acta Trop."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1080\/00034983.1999.11813491","article-title":"Analysis of climatic data and forecast indices for human fascioliasis at very high altitude","volume":"93","author":"Fuentes","year":"1999","journal-title":"Ann. Trop. Med. Parasitol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"17","DOI":"10.14411\/fp.2000.004","article-title":"Comparative infectivity of Fasciola hepatica metacercariae from isolates of the main and secondary reservoir animal host species in the Bolivian Altiplano high human endemic region","volume":"47","author":"Valero","year":"2000","journal-title":"Folia Parasitol."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Bargues, M.D., Gayo, V., Sanchis, J., Artigas, P., Khoubbane, M., Birriel, S., and Mas-Coma, S. (2017). DNA multigene characterization of Fasciola hepatica and Lymnaea neotropica and its fascioliasis transmission capacity in Uruguay, with historical correlation, human report review and infection risk analysis. PLoS Negl. Trop. Dis., 11.","DOI":"10.1371\/journal.pntd.0005352"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"S115","DOI":"10.1017\/S0031182001008034","article-title":"Fasciola hepatica and lymnaeid snails occurring at very high altitude in South America","volume":"123","author":"Funatsu","year":"2001","journal-title":"Parasitology"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/PL00008588","article-title":"Developmental differences in the uterus of Fasciola hepatica between livestock liver fluke populations from Bolivian highland and European lowlands","volume":"87","author":"Valero","year":"2001","journal-title":"Parasitol. Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.vetpar.2011.07.003","article-title":"Correlation between egg-shedding and uterus development in Fasciola hepatica human and animal isolates: Applied implications","volume":"183","author":"Valero","year":"2011","journal-title":"Vet. Parasitol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"105518","DOI":"10.1016\/j.actatropica.2020.105518","article-title":"Impact of fascioliasis reinfection on Fasciola hepatica egg shedding: Relationship with the immune-regulatory response","volume":"209","author":"Valero","year":"2020","journal-title":"Acta Trop."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Valero, M.A., Perez-Crespo, I., Chillon-Marinas, C., Khoubbane, M., Quesada, C., Reguera-Gomez, M., Mas-Coma, S., Fresno, M., and Girones, N. (2017). Fasciola hepatica reinfection potentiates a mixed Th1\/Th2\/Th17\/Treg response and correlates with the clinical phenotypes of anemia. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0173456"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1002\/eji.201545905","article-title":"Fasciola hepatica tegumental antigens induce anergic like T cells via dendritic cells in a mannose receptor dependent manner","volume":"46","author":"Aldridge","year":"2016","journal-title":"Eur. J. Immunol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0001-706X(97)00669-4","article-title":"Presence of very high prevalence and intensity of infection with Fasciola hepatica among Aymara children from the Northern Bolivian Altiplano","volume":"66","author":"Esteban","year":"1997","journal-title":"Acta Trop."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1046\/j.1365-3156.1997.d01-356.x","article-title":"A population-based coprological study of human fascioliasis in a hyperendemic area of the Bolivian Altiplano","volume":"2","author":"Esteban","year":"1997","journal-title":"Trop. Med. Int. Health"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e1720","DOI":"10.1371\/journal.pntd.0001720","article-title":"Administration of triclabendazole is safe and effective in controlling fascioliasis in an endemic community of the Bolivian Altiplano","volume":"6","author":"Villegas","year":"2012","journal-title":"PLoS Negl. Trop. Dis."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Valero, M.A., Periago, M.V., Perez-Crespo, I., Angles, R., Villegas, F., Aguirre, C., Strauss, W., Espinoza, J.R., Herrera, P., and Terashima, A. (2012). Field evaluation of a coproantigen detection test for fascioliasis diagnosis and surveillance in human hyperendemic areas of Andean countries. PLoS Negl. Trop. Dis., 6.","DOI":"10.1371\/journal.pntd.0001812"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1093\/trstmh\/trz093","article-title":"Triclabendazole in the treatment of human fascioliasis: A review","volume":"113","author":"Gandhi","year":"2019","journal-title":"Trans. Roy. Soc. Trop. Med. Hyg."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1186\/s13071-020-04045-x","article-title":"Genetic uniformity, geographical spread and anthropogenic habitat modifications of lymnaeid vectors found in a One Health initiative in the highest human fascioliasis hyperendemic of the Bolivian Altiplano","volume":"13","author":"Bargues","year":"2020","journal-title":"Parasit Vectors"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"583204","DOI":"10.3389\/fvets.2020.583204","article-title":"Sheep and cattle reservoirs in the highest human fascioliasis hyperendemic area: Experimental transmission capacity, field epidemiology and control within a One Health initiative in Bolivia","volume":"7","author":"Buchon","year":"2020","journal-title":"Front. Vet. Sci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"100249","DOI":"10.1016\/j.onehlt.2021.100249","article-title":"Domestic pig prioritized in one health action against fascioliasis in human endemic areas: Experimental assessment of transmission capacity and epidemiological evaluation of reservoir role","volume":"13","author":"Funatsu","year":"2021","journal-title":"One Health"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"591384","DOI":"10.3389\/fvets.2020.591384","article-title":"Donkey fascioliasis within a One Health control action: Transmission capacity, field epidemiology, and reservoir role in a human hyperendemic area","volume":"7","author":"Buchon","year":"2020","journal-title":"Front. Vet. Sci."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Mas-Coma, S., Cafrune, M.M., Funatsu, I.R., Mangold, A.J., Angles, R., Buchon, P., Fantozzi, M.C., Artigas, P., Valero, M.A., and Bargues, M.D. (2021). Fascioliasis in llama, Lama glama, in Andean endemic areas: Experimental transmission capacity by the high altitude snail vector Galba truncatula and epidemiological analysis of its reservoir role. Animals, 11.","DOI":"10.3390\/ani11092693"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"e025620","DOI":"10.1590\/s1984-29612021014","article-title":"One Health initiative in the Bolivian Altiplano human fascioliasis hyperendemic area: Lymnaeid biology, population dynamics, microecology and climatic factor influences","volume":"30","author":"Bargues","year":"2021","journal-title":"Braz. J. Vet. Parasitol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1017\/S0031182014000869","article-title":"Diagnosis of human fascioliasis by stool and blood techniques: Update for the present global scenario","volume":"141","author":"Bargues","year":"2014","journal-title":"Parasitology"},{"key":"ref_53","first-page":"326","article-title":"An ether sedimentation technique for routine stool examinations","volume":"8","author":"Ritchie","year":"1948","journal-title":"Bull. U.S. Army Med. Depart."},{"key":"ref_54","first-page":"397","article-title":"A simple device for quantitative stool thick-smear technique in Schistosomiasis mansoni","volume":"14","author":"Katz","year":"1972","journal-title":"Rev. Inst. Med. Trop. Sao P\u00e3ulo"},{"key":"ref_55","unstructured":"Ash, L.R., Orihel, T.C., and Savioli, L. (1994). Bench Aids for the Diagnosis of Intestinal Parasites, World Health Organization."},{"key":"ref_56","unstructured":"Ander-Egg, E. (1995). T\u00e9cnicas de Investigaci\u00f3n Social, Editorial Lumen, Colecci\u00f3n Pol\u00edtica, Servicios y Trabajo Social. [24th ed.]."},{"key":"ref_57","unstructured":"INE (2021, August 09). Bolivia: Proyecciones de Poblaci\u00f3n, Seg\u00fan Departamento y Municipio, 2012\u20132022, Revisi\u00f3n 2020, Available online: https:\/\/www.ine.es\/dyngs\/INEbase\/es\/categoria.htm?c=Estadistica_P&cid=1254735572981."},{"key":"ref_58","first-page":"71","article-title":"Fascioliasis in cattle in the human high endemic region of the Bolivian Northern Altiplano","volume":"57","author":"Buchon","year":"1997","journal-title":"Res. Rev. Parasitol."},{"key":"ref_59","first-page":"73","article-title":"Human fascioliasis in Bolivia: A general analysis and a critical review of existing data","volume":"55","author":"Angles","year":"1995","journal-title":"Res. Rev. Parasitol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0001-706X(01)00106-1","article-title":"Validation of a mapping and predicting model for human fasciolosis transmission in Andean very high altitude endemic areas using remote sensing data","volume":"79","author":"Fuentes","year":"2001","journal-title":"Acta Trop."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"5372","DOI":"10.1128\/IAI.67.10.5372-5378.1999","article-title":"Fasciola hepatica suppresses a protective Th1 response against Bordetella Pertussis","volume":"67","author":"Brady","year":"1999","journal-title":"Infect. Immun."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.actatropica.2006.09.002","article-title":"High risk of bacterobilia in advanced experimental chronic fasciolosis","volume":"100","author":"Valero","year":"2006","journal-title":"Acta Trop."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1590\/S1726-46342010000400018","article-title":"Fasciolosis humana y animal en el Per\u00fa: Impacto en la econom\u00eda de las zonas end\u00e9micas","volume":"27","author":"Espinoza","year":"2010","journal-title":"Rev. Peru. Med. Exp. Salud P\u00fabl."},{"key":"ref_64","unstructured":"Sanjin\u00e9s Goytia, J., Bermejo, A., Revollo, M., Guti\u00e9rrez, R., and Pacheco, A. (1996). Diagnostico Ambiental del Sistema Titicaca-Desaguadero-Poopo-Salar de Coipasa (Sistema TDPS) Bolivia-Per\u00fa, Divisi\u00f3n de Aguas Continentales, Programa de las Naciones Unidas para el Medio Ambiente, Departamento de Desarrollo Regional y Medio Ambiente, Secretar\u00eda General de la Organizaci\u00f3n de los Estados Americanos. Available online: https:\/\/www.oas.org\/usde\/publications\/Unit\/oea31s\/."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Defossez, A.C., Fassin, D., and Viveros, M. (1992). El embarazo en mujeres aymaras migrantes. Un estudio en zonas urbanopopulares al oeste de La Paz. Mujeres de los Andes: Condiciones de Vida y Salud, Institut Fran\u00e7ais d\u2019\u00c9tudes Andines (IFEA), Travaux de l\u2019IFEA.","DOI":"10.4000\/books.ifea.2027"},{"key":"ref_66","unstructured":"Morales Anaya, R., Aguilar, A.M., and Pinto, G. (1984). Desarrollo y Pobreza en Bolivia: An\u00e1lisis de la Situaci\u00f3n del Ni\u00f1o y la Mujer, UNICEF."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/ajpa.1330900105","article-title":"Differences in physical growth of Aymara and Quechua children living at high altitude in Peru","volume":"90","author":"Bergman","year":"1993","journal-title":"Amer. J. Phys. Anthropol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1002\/ajpa.1330520309","article-title":"The physical growth of high altitude Bolivian Aymara children","volume":"52","author":"Stinson","year":"1980","journal-title":"Amer. J. Phys. Anthropol."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Morales, R., Aguilar, A.M., and Calzadilla, A. (2005). Undernutrition in Bolivia: Geography and Culture Matter, Latin American Research Network. Paper No. R-492.","DOI":"10.2139\/ssrn.1814747"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"326","DOI":"10.4269\/ajtmh.17-0143","article-title":"Differences in nutritional and health status in school children from the highlands and lowlands of Bolivia","volume":"98","author":"Teran","year":"2018","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/978-94-009-2141-2_9","article-title":"Disease and Disability Among the Aymara","volume":"Volume 2","author":"Schull","year":"1990","journal-title":"The Aymara. Studies in Human Biology"},{"key":"ref_72","first-page":"65","article-title":"Sobre un caso de parasitosis por fasciola hep\u00e1tica. El Hospital, La Paz","volume":"45","author":"Pinilla","year":"1978","journal-title":"Rev. M\u00e9d. Costa Rica"},{"key":"ref_73","first-page":"104","article-title":"Veinte casos de Fascioliasis humana en La Paz. Semana M\u00e9dica, Buenos Aires","volume":"14","author":"Pinilla","year":"1962","journal-title":"Prensa M\u00e9dica La Paz"},{"key":"ref_74","first-page":"104","article-title":"Distomatosis extrahep\u00e1tica","volume":"14","author":"Hartmann","year":"1962","journal-title":"Prensa M\u00e9dica La Paz"},{"key":"ref_75","first-page":"75","article-title":"Fasciolicidal activity of diamphenetide and niclofolan against Fasciola hepatica in sheep in the Altiplano Region of Bolivia","volume":"13","author":"Ueno","year":"1973","journal-title":"Nat. Inst. Anim. Health Quart."},{"key":"ref_76","first-page":"61","article-title":"Fascioliasis of livestock and snail host for Fasciola in the Altipiano region of Bolivia","volume":"15","author":"Ueno","year":"1975","journal-title":"Nat. Inst. Anim. Health Quart."},{"key":"ref_77","first-page":"14","article-title":"Fasciolasis en la ciudad de La Paz","volume":"34","year":"1988","journal-title":"Cuad. Hosp. Cl\u00ednicas La Paz"},{"key":"ref_78","first-page":"1","article-title":"High contamination with enteroparasites of vegetables expedited in the markets of the city La Paz, Bolivia","volume":"16","author":"Laura","year":"2008","journal-title":"Biofarbo Organo Of. Del Col. De Bioqu\u00edmica Y Farm. De Boliv."},{"key":"ref_79","first-page":"397","article-title":"Fascioliasis hepato-biliar en la infancia","volume":"27","year":"1988","journal-title":"Rev. Soc. Bol. Pediatr. La Paz"},{"key":"ref_80","unstructured":"Centellas Guevara, M.R. (1987). Inmunofluorescencia Indirecta en el Diagn\u00f3stico de la Distomatosis Hep\u00e1tica Humana, Tesis de Grado, Facultad de Farmacia y Bioqu\u00edmica, Universidad Mayor de San Andr\u00e9s (UMSA)."},{"key":"ref_81","first-page":"73","article-title":"Experiencias en el control de la Fascioliasis hep\u00e1tica 1988\u20131989. Informe de la organizaci\u00f3n Foster Parents Plan del Plan Altiplano La Paz a la Jefatura Nacional de Zoonosis del Ministerio de Previsi\u00f3n Social y Salud Publica, La Paz","volume":"55","author":"Villca","year":"1995","journal-title":"Res. Rev. Parasitol."},{"key":"ref_82","unstructured":"Caceres Vega, E. (1989). Fasciola hepatica\u2013\u00abEnfermedad y Pobreza Campesina\u00bb, Acci\u00f3n un Maestro M\u00e1s, Imprenta Metodista."},{"key":"ref_83","unstructured":"Justiniano, J.G., and Arce Lema, J. (1989). Resoluci\u00f3n Biministerial No. 0597 de 4 de Agosto de 1989 por la que se declara de inter\u00e9s la Vigilancia y Control de la Fascioliasis, Teniasis-Cisticercosis e Hidatidosis en las \u00e1reas epizoend\u00e9micas del territorio nacional y se crea el \u201cComit\u00e9 t\u00e9cnico de Vigilancia y Control de las Zoonosis\u201d."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.4269\/ajtmh.20-0139","article-title":"Early postnatal and preschool age infection by Fasciola spp.: Report of five cases from Vietnam and worldwide review","volume":"103","author":"De","year":"2020","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"156","DOI":"10.4269\/ajtmh.2009.81.156","article-title":"MM3-ELISA detection of Fasciola hepatica coproantigens in preserved human stool samples","volume":"81","author":"Ubeira","year":"2009","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_86","unstructured":"Cotruvo, J.A., Dufour, A., Rees, G., Bartram, J., Carr, R., Cliver, D.O., Craun, G.F., Fayer, R., and Gannon, V.P.J. (2004). Human fascioliasis. Waterborne Zoonoses: Identification, Causes and Control, IWA Publishing."},{"key":"ref_87","first-page":"35","article-title":"Lymnaeid snails in the human fascioliasis high endemic zone of the Northern Bolivian Altiplano","volume":"55","author":"Oviedo","year":"1995","journal-title":"Res. Rev. Parasitol."},{"key":"ref_88","unstructured":"Doumenge, J.P., Mott, K.E., Cheung, C., Villenave, D., Chapuis, O., Perrin, M.F., and Reaud-Thomas, G. (1987). Atlas of the Global Distribution of Schistosomiasis, Presses Universitaires de Bordeaux."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1093\/clinids\/21.5.1228","article-title":"An outbreak of acute fascioliasis among Aymara Indians in the Bolivian Altiplano","volume":"21","author":"Bjorland","year":"1995","journal-title":"Clin. Infect. Dis."},{"key":"ref_90","first-page":"19","article-title":"El clima de la provincia Aroma del departamento de La Paz, Bolivia","volume":"4","author":"Lorini","year":"1983","journal-title":"Ecol. Boliv."},{"key":"ref_91","unstructured":"Dejoux, C., and Iltis, A. (1991). Climatolog\u00eda e hidrolog\u00eda de la cuenca del Lago Titicaca. El Lago Titicaca. S\u00edntesis del Conocimiento Limnol\u00f3gico Actual, ORSTOM-HISBOL."},{"key":"ref_92","unstructured":"Dejoux, C., and Iltis, A. (1991). Caracter\u00edsticas f\u00edsico-qu\u00edmicas del agua. El Lago Titicaca. S\u00edntesis del Conocimiento Limnol\u00f3gico Actual, ORSTOM-HISBOL."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Dejoux, C., and Iltis, A. (1991). Los moluscos. El Lago Titicaca. S\u00edntesis del Conocimiento Limnol\u00f3gico Actual, ORSTOM-HISBOL.","DOI":"10.1007\/978-94-011-2406-5"},{"key":"ref_94","first-page":"486","article-title":"Biologische Abwasserreinigung mit Flechtbinsen","volume":"17","author":"Althaus","year":"1966","journal-title":"Das Gas. Wasserfach"},{"key":"ref_95","first-page":"49","article-title":"Pflanzenbiologische Methoden zur Gewaessersanierung und zur Grundwasseranreicherung","volume":"4","author":"Seidel","year":"1978","journal-title":"Schr. Der Obersten Nat. Des Saarl."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Periago, M.V., Valero, M.A., Artigas, P., Agramunt, V.H., Bargues, M.D., Curtale, F., and Mas-Coma, S. (2021). Very high fascioliasis intensities in schoolchildren of Nile Delta governorates: The Old World highest burdens found in lowlands. Pathogens, 10.","DOI":"10.3390\/pathogens10091210"},{"key":"ref_97","first-page":"5","article-title":"Clinical signs and household characteristics associated with human fascioliasis among rural population in Egypt: A case-control study","volume":"45","author":"Curtale","year":"2003","journal-title":"Parassitologia"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1051\/parasite\/1980554393","article-title":"Donn\u00e9es \u00e9pid\u00e9miologiques sur la distomatose humaine \u00e0 Fasciola hepatica L. dans la r\u00e9gion du Limousin, France. Les plantes consomm\u00e9es et les limn\u00e9es vectrices","volume":"55","author":"Rondelaud","year":"1980","journal-title":"Ann. Parasitol. Hum. Comp."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Rivera, M., Galetovic, A., Licuime, R., and G\u00f3mez-Silva, B. (2018). A microethnographic and ethnobotanical approach to Llayta consumption among Andes feeding practices. Foods, 7.","DOI":"10.20944\/preprints201810.0702.v1"},{"key":"ref_100","first-page":"15","article-title":"Estudio fisicoqu\u00edmico, microbiol\u00f3gico y toxicol\u00f3ico de los polisac\u00e1ridos del Nostoc commune y Nostoc sphaericum","volume":"17","author":"Jurado","year":"2014","journal-title":"Rev. Peru. Qu\u00edm. Ing. Qu\u00edm."},{"key":"ref_101","first-page":"158","article-title":"Hiperendemicidad de Fasciolosis humana en el Valle del Mantaro, Per\u00fa: Factores de riesgo de la infeccion por Fasciola hepatica","volume":"24","author":"Raymundo","year":"2004","journal-title":"Rev. Gastroenterol. Peru"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.meegid.2012.01.009","article-title":"Fasciola hepatica phenotypic characterisation in Andean human endemic areas: Valley versus altiplanic patterns analysed in liver flukes from sheep from Cajamarca and Mantaro, Peru","volume":"12","author":"Valero","year":"2012","journal-title":"Infect. Genet. Evol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1186\/1756-3305-5-174","article-title":"Molecular characterisation of Galba truncatula, Lymnaea neotropica and L. schirazensis from Cajamarca, Peru and their potential role in transmission of human and animal fascioliasis","volume":"5","author":"Bargues","year":"2012","journal-title":"Parasit. Vector"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"100265","DOI":"10.1016\/j.onehlt.2021.100265","article-title":"Spread of the fascioliasis endemic area assessed by seasonal follow-up of rRNA ITS-2 sequenced lymnaeid populations in Cajamarca, Peru","volume":"13","author":"Bargues","year":"2021","journal-title":"One Health"},{"key":"ref_105","first-page":"96","article-title":"Seroprevalencia de fasciolosis en escolares y en ganado vacuno en la provincia de Huancavelica, Per\u00fa","volume":"22","author":"Valencia","year":"2005","journal-title":"Rev. Peru. Med. Exp. Salud P\u00fabl."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.trstmh.2005.05.016","article-title":"Risk factors for Fasciola hepatica infection in children: A case control study","volume":"100","author":"Marcos","year":"2006","journal-title":"Trans. Roy. Soc. Trop. Med. Hyg."},{"key":"ref_107","first-page":"143","article-title":"Fasciolosis humana y compromiso gastrointestinal: Estudio de 277 pacientes en el Hospital Nacional Cayetano Heredia. 1970\u20132002","volume":"24","author":"Blancas","year":"2004","journal-title":"Rev. Gastroenterol. Per\u00fa"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1556\/1646.7.2015.3.7","article-title":"The effects of aqueous extract of alfalfa on blood glucose and lipids in alloxan-induced diabetic rats","volume":"7","author":"Amraie","year":"2015","journal-title":"Intervent. Med. Appl. Sci."},{"key":"ref_109","first-page":"153","article-title":"Gastronomy and industrialized food in the Aymara communities of the Pilcuyo District, El Collao Province-Ilave-Puno-Peru","volume":"71","author":"Alanoca","year":"2020","journal-title":"Am. Scient. Res. J. Eng. Technol. Sci."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"50","DOI":"10.4269\/ajtmh.1998.58.50","article-title":"High Cryptosporidium prevalences in healthy Aymara children from the Northern Bolivian Altiplano","volume":"58","author":"Esteban","year":"1998","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"658","DOI":"10.4269\/ajtmh.2004.70.658","article-title":"Evidence of waterborne transmission of Blastocystis hominis","volume":"70","author":"Leelayoova","year":"2004","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_112","first-page":"251","article-title":"Natural water, an additional source for human infection by Fasciola hepatica in the Northern Bolivian Altiplano","volume":"38","author":"Bargues","year":"1996","journal-title":"Parassitologia"},{"key":"ref_113","first-page":"252","article-title":"The human host, a viable definitive host for Fasciola hepatica in the Northern Bolivian Altiplano","volume":"38","author":"Bargues","year":"1996","journal-title":"Parassitologia"},{"key":"ref_114","first-page":"59","article-title":"Conocimientos, actitudes y pr\u00e1cticas sobre Fascioliasis en madres de una zona rural andina del Norte peruano","volume":"27","year":"2010","journal-title":"Rev. Peru. Med. Exp. Salud."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1093\/trstmh\/try049","article-title":"Risk factors for human fascioliasis in schoolchildren in Ba\u00f1os del Inca, Cajamarca, Peru","volume":"112","author":"Rivera","year":"2018","journal-title":"Trans. Roy. Soc. Trop. Med. Hyg."},{"key":"ref_116","first-page":"259","article-title":"Enfermedad, moda y cuerpo social en el altiplano aymara: Un \u00abboceto\u00bb de inspiraci\u00f3n colonial sobre modelos de identidad en los Andes","volume":"28","year":"1998","journal-title":"Rev. Esp. Antropol. Am."},{"key":"ref_117","first-page":"1","article-title":"Medicina tradicional Aimara-Per\u00fa","volume":"1","author":"Mamani","year":"2013","journal-title":"Comuniaccion"},{"key":"ref_118","unstructured":"Fernandez Juarez, G. (2002). Aymaras De Bolivia Entre La Tradicion Y El Cambio Cultural, Ediciones Abya-Yala. Colecci\u00f3n Hombre y Ambiente No. 67\u201368."},{"key":"ref_119","first-page":"181","article-title":"Food consumption and energy expenditure of Aymara in a herding community of the Bolivian Altiplano","volume":"20","author":"Kim","year":"1991","journal-title":"J. Human Ergol."},{"key":"ref_120","first-page":"20","article-title":"Indigenous food systems and climate change: Impacts of climatic shifts on the production and processing of native and traditional crops in the Bolivian Andes","volume":"4","author":"Humphries","year":"2016","journal-title":"Front. Public Health"},{"key":"ref_121","first-page":"219","article-title":"Los quelites: Riqueza de especies y conocimiento tradicional en la comunidad otomm\u00ed de San Pedro Arriba, Temoaya, Estado de Mexico","volume":"49","year":"2020","journal-title":"Polibotanica"},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Mateos-Maces, L., Ch\u00e1vez-Servia, J.L., Vera-Guzm\u00e1n, A.M., Aquino-Bola\u00f1os, E.N., Alba-Jim\u00e9nez, J.E., and Villag\u00f3mez-Gonz\u00e1lez, B.B. (2020). Edible leafy plants from Mexico as sources of antioxidant compounds, and their nutritional, nutraceutical and antimicrobial potential: A review. Antioxidants, 9.","DOI":"10.3390\/antiox9060541"},{"key":"ref_123","first-page":"153","article-title":"Agrobiodiversity conservation as a coping strategy: Adapting to climate change in the northern highlands of Bolivia","volume":"11","author":"Baldinelli","year":"2014","journal-title":"Cons. J. Sustain. Dev."},{"key":"ref_124","first-page":"36","article-title":"Educaci\u00f3n y alimentaci\u00f3n en las comunidades aymaras de Puno","volume":"10","author":"Apaza","year":"2019","journal-title":"Comuniaccion: Rev. De Investig. En Comun. Y Desarro."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"e189","DOI":"10.1017\/S0022149X20000693","article-title":"Equines as reservoirs of human fascioliasis: Transmission capacity, epidemiology and pathogenicity in Fasciola hepatica infected mules","volume":"94","author":"Neira","year":"2020","journal-title":"J. Helminthol."},{"key":"ref_126","first-page":"157","article-title":"Fasciola in horses in the Republic of South Africa: A single natural case of Fasciola hepatica and the failure to infest ten horses either with F. hepatica or Fasciola gigantica","volume":"55","author":"Alves","year":"1988","journal-title":"Onderstepoort J. Vet. Res."},{"key":"ref_127","first-page":"71","article-title":"La fasciolose des \u00e9quid\u00e9s, une infestation parasitaire inhabituelle","volume":"57","author":"Dorchies","year":"2010","journal-title":"Bul. Groupem. Techn. V\u00e9t."},{"key":"ref_128","first-page":"115","article-title":"Small mammals (Lagomorpha and Rodentia) and fascioliasis transmission in the Northern Bolivian Altiplano endemic zone","volume":"57","author":"Fuentes","year":"1997","journal-title":"Res. Rev. Parasitol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1007\/s11250-020-02211-y","article-title":"Economic impact of the liver condemnation of cattle infected with Fasciola hepatica in the Peruvian Andes","volume":"52","author":"Lucas","year":"2020","journal-title":"Trop. Anim. Health Prod."},{"key":"ref_130","first-page":"95","article-title":"Fascioliasis in sheep in the human high endemic region of the Northern Bolivian Altiplano","volume":"58","author":"Grock","year":"1998","journal-title":"Res. Rev. Parasitol."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/19\/3\/1120\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:04:29Z","timestamp":1760133869000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/19\/3\/1120"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,20]]},"references-count":130,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,2]]}},"alternative-id":["ijerph19031120"],"URL":"https:\/\/doi.org\/10.3390\/ijerph19031120","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,20]]}}}