{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:47:32Z","timestamp":1760150852405,"version":"build-2065373602"},"reference-count":82,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,1,21]],"date-time":"2022-01-21T00:00:00Z","timestamp":1642723200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>SARS-CoV-2 virus can not only damage the respiratory system but may also pose a threat to other organs, such as the heart or vessels. This review focuses on cardiovascular complications of COVID-19, including acute cardiac injury, arrhythmias, biomarkers, accompanying comorbidities and outcomes in patients diagnosed with SARS-CoV-2 infection. The research was conducted on the databases: PubMed, Springer, ScienceDirect, UpToDate, Oxford Academic, Wiley Online Library, ClinicalKey. Fifty-six publications from 1 November 2020 till 15 August 2021 were included in this study. The results show that cardiac injury is present in about 1 in 4 patients with COVID-19 disease, and it is an independent risk factor, which multiplies the death rate several times in comparison to infected patients without myocardial injury. New-onset cardiac injury occurs in nearly every 10th patient of the COVID-19-suffering population. Comorbidities (such as hypertension, cardiovascular disease and diabetes) severely deteriorate the outcome. Therefore, patients with SARS-CoV-2 infection should be carefully assessed in terms of cardiac medical history and possible cardiological complications.<\/jats:p>","DOI":"10.3390\/ijerph19031184","type":"journal-article","created":{"date-parts":[[2022,1,21]],"date-time":"2022-01-21T08:37:18Z","timestamp":1642754238000},"page":"1184","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Cardiovascular System during SARS-CoV-2 Infection"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6016-1891","authenticated-orcid":false,"given":"Maciej","family":"Ko\u017alik","sequence":"first","affiliation":[{"name":"Department of Cardiology and Structural Heart Disease, Medical University of Silesia, 40-635 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8026-4887","authenticated-orcid":false,"given":"Adrianna","family":"B\u0142ahuszewska","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Internal Medicine, Medical University of Bialystok, 15-276 Bialystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maciej","family":"Ka\u017amierski","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Structural Heart Disease, Medical University of Silesia, 40-635 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/S0140-6736(20)32656-8","article-title":"6-month consequences of COVID-19 in patients discharged from hospital: A cohort study","volume":"397","author":"Huang","year":"2021","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/S0140-6736(21)01755-4","article-title":"1-year outcomes in hospital survivors with COVID-19: A longitudinal cohort study","volume":"398","author":"Huang","year":"2021","journal-title":"Lancet"},{"key":"ref_3","unstructured":"COVIDSurg Collaborative (2020). Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: An international cohort study. Lancet, 396, 27\u201338."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/ane.13266","article-title":"Neurological Manifestations of COVID-19: A systematic review and current update","volume":"142","author":"Whittaker","year":"2020","journal-title":"Acta Neurol. Scand."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.neurol.2020.10.001","article-title":"Neurological manifestations associated with SARS-CoV-2 and other coronaviruses: A narrative review for clinicians","volume":"177","author":"Maury","year":"2021","journal-title":"Rev. Neurol."},{"key":"ref_6","unstructured":"Epidemiology Working Group for NCIP Epidemic Response, and Chinese Centre for Disease Control and Prevention (2020). The epidemio logical characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China. Zhonghua Liu Xing Bing Xue Za Zhi, 41, 145\u2013151."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"4432","DOI":"10.1038\/s41598-021-83822-9","article-title":"Association of coagulation dysfunction with cardiac injury among hospitalized patients with COVID-19","volume":"11","author":"Chen","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1161\/CIRCULATIONAHA.120.053311","article-title":"Multiple Biomarker Approach to Risk Stratification in COVID-19","volume":"143","author":"Smilowitz","year":"2021","journal-title":"Circulation"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.clinbiochem.2021.01.006","article-title":"Using high sensitivity cardiac troponin values in patients with SARS-CoV-2 infection (COVID-19): The Padova experience","volume":"90","author":"Babuin","year":"2021","journal-title":"Clin Biochem."},{"key":"ref_10","first-page":"1","article-title":"High sensitivity troponin and COVID-19 outcomes","volume":"8","author":"Papageorgiou","year":"2021","journal-title":"Acta Cardiol."},{"key":"ref_11","first-page":"2425","article-title":"Impact of acute myocardial injury on prognosis in patients with COVID-19","volume":"25","author":"Karahan","year":"2021","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.mayocpiqo.2021.08.005","article-title":"SARS-CoV-2 Viral Load and Cardiac Injury are Independent and Incremental Predictors of Adverse Outcome","volume":"5","author":"Chehab","year":"2021","journal-title":"Mayo Clin. Proc. Innov. Qual. Outcomes"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"4828","DOI":"10.1038\/s41598-021-84467-4","article-title":"Evaluation of myocardial injury patterns and ST changes among critical and non-critical patients with coronavirus-19 disease","volume":"11","author":"Liaqat","year":"2021","journal-title":"Sci Rep."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.amjms.2021.02.007","article-title":"Hyper-Inflammatory Response Involves in Cardiac Injury Among Patients With Coronavirus Disease 2019","volume":"361","author":"Xia","year":"2021","journal-title":"Am. J. Med. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1161\/CIRCULATIONAHA.120.050543","article-title":"Myocardial Injury in Severe COVID-19 Compared with Non-COVID-19 Acute Respiratory Distress Syndrome","volume":"143","author":"Metkus","year":"2021","journal-title":"Circulation"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.acvd.2021.01.003","article-title":"Characteristics and outcomes of patients hospitalized for COVID-19 in France: The Critical COVID-19 France (CCF) study","volume":"114","author":"Bonnet","year":"2021","journal-title":"Arch. Cardiovasc. Dis."},{"key":"ref_17","first-page":"1","article-title":"Widespread myocardial dysfunction in COVID-19 patients detected by myocardial strain imaging using 2-D speckle-tracking echocardiography","volume":"28","author":"Li","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/j.mayocp.2021.01.006","article-title":"Cardiac Abnormalities in COVID-19 and Relationship to Outcome","volume":"96","author":"Krishna","year":"2021","journal-title":"Mayo Clin. Proc."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.amjcard.2021.01.037","article-title":"Impact and Determinants of High-Sensitivity Cardiac Troponin-T Concentration in Patients with COVID-19 Admitted to Critical Care","volume":"147","author":"Demir","year":"2021","journal-title":"Am. J. Cardiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1161\/CIRCULATIONAHA.121.053982","article-title":"Cardiovascular Evaluation After COVID-19 in 137 Collegiate Athletes: Results of an Algorithm-Guided Screening","volume":"143","author":"Hendrickson","year":"2021","journal-title":"Circulation"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"632434","DOI":"10.3389\/fcvm.2020.632434","article-title":"Biventricular Longitudinal Strain Predict Mortality in COVID-19 Patients","volume":"7","author":"Xie","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1002\/iid3.484","article-title":"The Prognostic Value of Myocardial Injury in COVID-19 Patients and Associated Characteristics","volume":"9","author":"He","year":"2021","journal-title":"Immun. Inflamm. Dis."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"641088","DOI":"10.3389\/fcvm.2021.641088","article-title":"Prognostic Value of Right Ventricular Ejection Fraction Assessed by 3D Echocardiography in COVID-19 Patients","volume":"8","author":"Zhang","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e13638","DOI":"10.1111\/eci.13638","article-title":"Clinical conditions and echocardiographic parameters associated with mortality in COVID-19","volume":"51","author":"Silverio","year":"2021","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"3145","DOI":"10.1016\/j.jacc.2021.04.075","article-title":"Effect of Statin Therapy on Cognitive Decline and Incident Dementia in Older Adults","volume":"77","author":"Zhou","year":"2021","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"585220","DOI":"10.3389\/fcvm.2020.585220","article-title":"Pre-existing Health Conditions and Epicardial Adipose Tissue Volume: Potential Risk Factors for Myocardial Injury in COVID-19 Patients","volume":"7","author":"Huang","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.7150\/ijms.53641","article-title":"Cardiac Troponin I association with critical illness and death risk in 726 seriously ill COVID-19 patients: A retrospective cohort study","volume":"18","author":"Chen","year":"2021","journal-title":"Int. J. Med. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1080\/00365513.2021.1881997","article-title":"Characteristics and laboratory findings on admission to the emergency department among 2873 hospitalized patients with COVID-19: The impact of adjusted laboratory tests in multicenter studies. A multicenter study in Spain (BIOCOVID-Spain study)","volume":"81","author":"Urrechaga","year":"2021","journal-title":"Scand. J. Clin. Lab. Investig."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1093\/ehjacc\/zuaa019","article-title":"The peak levels of highly sensitive troponin I predicts in-hospital mortality in COVID-19 patients with cardiac injury: A retrospective study","volume":"10","author":"Wang","year":"2021","journal-title":"Eur. Heart J. Acute Cardiovasc. Care."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"4144","DOI":"10.1038\/s41598-021-82396-w","article-title":"Key factors leading to fatal outcomes in COVID-19 patients with cardiac injury","volume":"11","author":"He","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1080\/1354750X.2021.1874052","article-title":"Biomarkers and short-term prognosis in COVID-19","volume":"26","author":"Carrasquer","year":"2021","journal-title":"Biomarkers"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Efros, O., Barda, N., Meisel, E., Leibowitz, A., Fardman, A., Rahav, G., Klempfner, R., and Grossmanet, E. (2021). Myocardial injury in hospitalized patients with COVID-19 infection-Risk factors and outcomes. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0247800"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"e018476","DOI":"10.1161\/JAHA.120.018476","article-title":"Admission Cardiac Diagnostic Testing with Electrocardiography and Troponin Measurement Prognosticates Increased 30-Day Mortality in COVID-19","volume":"10","author":"Poterucha","year":"2021","journal-title":"J. Am. Heart Assoc."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1002\/clc.23530","article-title":"Clinical significance of coronavirus disease 2019 in hospitalized patients with myocardial injury","volume":"44","author":"Briscoe","year":"2021","journal-title":"Clin. Cardiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/ehf2.13075","article-title":"Increased mortality and worse cardiac outcome of acute myocardial infarction during the early COVID-19 pandemic","volume":"8","author":"Primessnig","year":"2021","journal-title":"ESC Heart Fail."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1536\/ihj.20-574","article-title":"Clinical Profile and 30-Day Mortality of Invasively Managed Patients with Suspected Acute Coronary Syndrome During the COVID-19 Outbreak","volume":"62","author":"Salinas","year":"2021","journal-title":"Int. Heart J."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e001497","DOI":"10.1136\/openhrt-2020-001497","article-title":"COVID-19 pandemic is associated with mechanical complications in patients with ST-elevation myocardial infarction","volume":"8","author":"Kitahara","year":"2021","journal-title":"Open Heart"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"e24552","DOI":"10.1097\/MD.0000000000024552","article-title":"Suspected myocarditis in patients with COVID-19: A multicenter case series","volume":"100","author":"Cei","year":"2021","journal-title":"Medicine"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1093\/eurheartj\/ehab075","article-title":"Patterns of myocardial injury in recovered troponin-positive COVID-19 patients assessed by cardiovascular magnetic resonance","volume":"42","author":"Kotecha","year":"2021","journal-title":"Eur. Heart J."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1001\/jamacardio.2021.0565","article-title":"Prevalence of Inflammatory Heart Disease Among Professional Athletes with Prior COVID-19 Infection Who Received Systematic Return-to-Play Cardiac Screening","volume":"6","author":"Martinez","year":"2021","journal-title":"JAMA Cardiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1161\/CIRCULATIONAHA.120.052573","article-title":"COVID-19 Myocardial Pathology Evaluation in Athletes with Cardiac Magnetic Resonance (COMPETE CMR)","volume":"143","author":"Clark","year":"2021","journal-title":"Circulation"},{"key":"ref_42","first-page":"e13788","article-title":"Cardiac arrhythmias amongst hospitalised Coronavirus 2019 (COVID-19) patients: Prevalence, characterisation, and clinical algorithm to classify arrhythmic risk","volume":"75","author":"Orlev","year":"2021","journal-title":"Int. J. Clin. Pract."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.repc.2020.11.007","article-title":"Cardiac arrhythmias in patients presenting with COVID-19 treated in Portuguese hospitals: A national registry from the Portuguese Association of Arrhythmology, Pacing and Electrophysiology","volume":"40","author":"Mesquita","year":"2021","journal-title":"Rev. Port. Cardiol."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Zylla, M.M., Merle, U., Vey, J.A., Korosoglou, G., Hofmann, E., M\u00fcller, M., Herth, F., Schmidt, W., Blessing, E., and G\u00f6ggelmann, C. (2021). Predictors and Prognostic Implications of Cardiac Arrhythmias in Patients Hospitalized for COVID-19. J. Clin. Med., 10.","DOI":"10.3390\/jcm10010133"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e12833","DOI":"10.1111\/anec.12833","article-title":"Association between electrocardiographic features and mortality in COVID-19 patients","volume":"26","author":"Beutler","year":"2021","journal-title":"Ann. Noninvasive Electrocardiol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1111\/pace.14226","article-title":"New-onset atrial arrhythmias associated with mortality in black and white patients hospitalized with COVID-19","volume":"44","author":"Dagher","year":"2021","journal-title":"Pacing Clin. Electrophysiol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Northwell COVID-19 Research Consortium, Mountantonakis, S.E., Saleh, M., Fishbein, J., Gandomi, A., Lesser, M., Chelico, J., Gabriels, J., Qiu, M., and Epstein, L.M. (2021). Atrial fibrillation is an independent predictor for in-hospital mortality in patients admitted with SARS-CoV-2 infection. Heart Rhythm, 18, 501\u2013507.","DOI":"10.1016\/j.hrthm.2021.01.018"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.amjcard.2021.01.039","article-title":"Frequency of Atrial Arrhythmia in Hospitalized Patients With COVID-19","volume":"147","author":"Yarmohammadi","year":"2021","journal-title":"Am. J. Cardiol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.medcli.2021.01.003","article-title":"Atrial fibrillation in patients with SARS-CoV-2 infection","volume":"157","author":"Veras","year":"2021","journal-title":"Med. Clin."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1111\/aas.13806","article-title":"Cardiac arrhythmias in critically ill patients with coronavirus disease 2019: A retrospective population-based cohort study","volume":"65","author":"Wetterslev","year":"2021","journal-title":"Acta Anaesthesiol. Scand."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"34","DOI":"10.5603\/CJ.a2020.0145","article-title":"New-onset atrial fibrillation during COVID-19 infection predicts poor prognosis","volume":"28","year":"2021","journal-title":"Cardiol. J."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jelectrocard.2021.01.012","article-title":"Arrhythmias in patients with coronavirus disease 2019 (COVID-19) in Wuhan, China: Incidences and implications","volume":"65","author":"Guan","year":"2021","journal-title":"J. Electrocardiol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e12815","DOI":"10.1111\/anec.12815","article-title":"The value of ECG changes in risk stratification of COVID-19 patients","volume":"26","author":"Bergamaschi","year":"2021","journal-title":"Ann. Noninvasive Electrocardiol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"8874450","DOI":"10.1155\/2021\/8874450","article-title":"Atrial Arrhythmias in Patients with Severe COVID-19","volume":"2021","author":"Han","year":"2021","journal-title":"Cardiol. Res. Pract."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.3346\/jkms.2021.36.e15","article-title":"Impact of Cardiovascular Risk Factors and Cardiovascular Diseases on Outcomes in Patients Hospitalized with COVID-19 in Daegu Metropolitan City","volume":"36","author":"Park","year":"2021","journal-title":"J. Korean Med. Sci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1097\/MCA.0000000000000934","article-title":"The relationship between coronary artery disease and clinical outcomes in COVID-19: A single-center retrospective analysis","volume":"32","author":"Peterson","year":"2021","journal-title":"Coron. Artery Dis."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jchf.2020.11.003","article-title":"Clinical Outcomes in Patients with Heart Failure Hospitalized with COVID-19","volume":"9","author":"Bhatt","year":"2021","journal-title":"JACC Heart Fail."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"642973","DOI":"10.3389\/fcvm.2021.642973","article-title":"Echocardiographic Characteristics and Outcome in Patients With COVID-19 Infection and Underlying Cardiovascular Disease","volume":"8","author":"Li","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1536\/ihj.20-180","article-title":"Cardiac Biomarker Abnormalities Are Closely Related to Prognosis in Patients with COVID-19","volume":"62","author":"Tuo","year":"2021","journal-title":"Int. Heart J."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"636073","DOI":"10.3389\/fcvm.2021.636073","article-title":"Electrocardiographic Risk Stratification in COVID-19 Patients","volume":"8","author":"Chorin","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_61","first-page":"100719","article-title":"Left ventricular global longitudinal strain in identifying subclinical myocardial dysfunction among patients hospitalized with COVID-19","volume":"32","author":"Shmueli","year":"2021","journal-title":"Int. J. Cardiol. Heart Vasc."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1111\/pace.14221","article-title":"Atrial arrhythmia related outcomes in critically ill COVID-19 patients","volume":"44","author":"Colon","year":"2021","journal-title":"Pacing Clin. Electrophysiol."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Seeherman, S., and Suzuki, Y.J. (2021). Viral Infection and Cardiovascular Disease: Implications for the Molecular Basis of COVID-19 Pathogenesis. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22041659"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"111154","DOI":"10.1016\/j.envres.2021.111154","article-title":"Impact of short-term air pollution exposure on acute coronary syndrome in two cohorts of industrial and non-industrial areas: A time series regression with 6,000,000 person-years of follow-up (ACS\u2014Air Pollution Study)","volume":"197","author":"Kralisz","year":"2021","journal-title":"Environ. Res."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1080\/AC.66.4.2126589","article-title":"Cardiac injury in patients with pandemic 2009 influenza A (H1N1) infection","volume":"66","author":"Ni","year":"2011","journal-title":"Acta Cardiol."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Ludwig, A., Lucero-Obusan, C., Schirmer, P., Winston, C., and Holodniy, M. (2015). Acute cardiac injury events \u226430 days after laboratory-confirmed influenza virus infection among U.S. veterans, 2010\u20132012. BMC Cardiovasc. Disord., 15.","DOI":"10.1186\/s12872-015-0095-0"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1136\/heartjnl-2015-307691","article-title":"Acute myocardial infarction and influenza: A meta-analysis of case-control studies","volume":"101","author":"Barnes","year":"2015","journal-title":"Heart"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.ijcard.2020.09.073","article-title":"Triggering of cardiovascular disease by infection type: The Atherosclerosis Risk in Communities study (ARIC)","volume":"325","author":"Cowan","year":"2021","journal-title":"Int. J. Cardiol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"e009683","DOI":"10.1161\/JAHA.118.009683","article-title":"Inpatient and Outpatient Infection as a Trigger of Cardiovascular Disease: The ARIC Study","volume":"7","author":"Cowan","year":"2018","journal-title":"J. Am. Heart Assoc."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.envres.2017.04.024","article-title":"Influenza as a trigger for cardiovascular disease: An investigation of serotype, subtype and geographic location","volume":"156","author":"Pearce","year":"2017","journal-title":"Environ. Res."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1200\/CCI.20.00068","article-title":"Effects of the COVID-19 Pandemic on Cancer-Related Patient Encounters","volume":"4","author":"London","year":"2020","journal-title":"JCO Clin. Cancer Inform."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1111\/j.1365-2362.2009.02153.x","article-title":"SARS-coronavirus modulation of myocardial ACE2 expression and inflammation in patients with SARS","volume":"39","author":"Oudit","year":"2009","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1007\/s00134-020-05985-9","article-title":"Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: Molecular mechanisms and potential therapeutic target","volume":"46","author":"Zhang","year":"2020","journal-title":"Intensive Care Med."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"m1313","DOI":"10.1136\/bmj.m1313","article-title":"Drugs and the renin-angiotensin system in COVID-19","volume":"369","author":"Aronson","year":"2020","journal-title":"BMJ"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1093\/cvr\/cvaa078","article-title":"The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2","volume":"116","author":"Chen","year":"2020","journal-title":"Cardiovasc. Res."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.21037\/jtd-20-3062","article-title":"Coagulation disorders and thromboembolic disease in COVID-19: Review of current evidence in search of a better approach","volume":"13","author":"Oscullo","year":"2021","journal-title":"J. Thorac. Dis."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/S2213-2600(20)30243-5","article-title":"Pulmonary and cardiac pathology in African American patients with COVID-19: An autopsy series from New Orleans","volume":"8","author":"Fox","year":"2020","journal-title":"Lancet Respir. Med."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/S0140-6736(20)30937-5","article-title":"Endothelial cell infection and endotheliitis in COVID-19","volume":"395","author":"Varga","year":"2020","journal-title":"Lancet"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1093\/cvr\/cvaa106","article-title":"COVID-19 and the cardiovascular system: Implications for risk assessment, diagnosis, and treatment options","volume":"116","author":"Guzik","year":"2020","journal-title":"Cardiovasc. Res."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/j.hrthm.2016.01.026","article-title":"The association between influenza infection, vaccination, and atrial fibrillation: A nationwide case-control study","volume":"13","author":"Chang","year":"2016","journal-title":"Heart Rhythm"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.amjmed.2012.08.005","article-title":"Pneumonia: An arrhythmogenic disease?","volume":"126","author":"Anzueto","year":"2013","journal-title":"Am. J. Med."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.ijid.2016.06.015","article-title":"Prevalence of comorbidities in the Middle East respiratory syndrome coronavirus (MERS-CoV): A systematic review and meta-analysis","volume":"49","author":"Badawi","year":"2016","journal-title":"Int. J. Infect. 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