{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T12:22:49Z","timestamp":1764937369824,"version":"build-2065373602"},"reference-count":25,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,1,29]],"date-time":"2022-01-29T00:00:00Z","timestamp":1643414400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Key Program of National Natural Science Foundation of China","award":["92043201"],"award-info":[{"award-number":["92043201"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>A cross-layer non-vertical transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) occurred in a quarantine hotel in Guangzhou, Guangdong Province, China in June 2021. To explore the cross-layer transmission path and influencing factors of viral aerosol, we set up different scenarios to carry out simulation experiments. The results showed that the air in the polluted room can enter the corridor by opening the door to take food and move out the garbage, then mix with the fresh air taken from the outside as part of the air supply of the central air conditioning system and re-enter into different rooms on the same floor leading to the same-layer transmission. In addition, flushing the toilet after defecation and urination will produce viral aerosol that pollutes rooms on different floors through the exhaust system and the vertical drainage pipe in the bathroom, resulting in cross-layer vertical transmission, also aggravating the transmission in different rooms on the same floor after mixing with the air of the room and entering the corridor to become part of the air supply, and meanwhile, continuing to increase the cross-layer transmission through the vertical drainage pipe. Therefore, the air conditioning and ventilation system of the quarantine hotel should be operated in full fresh air mode and close the return air; the exhaust volume of the bathroom should be greater than the fresh air volume. The exhaust pipe of the bathroom should be independently set and cannot be interconnected or connected in series. The riser of the sewage and drainage pipeline of the bathroom should maintain vertical to exhaust independently and cannot be arbitrarily changed to horizontal pipe assembly.<\/jats:p>","DOI":"10.3390\/ijerph19031532","type":"journal-article","created":{"date-parts":[[2022,1,29]],"date-time":"2022-01-29T23:02:06Z","timestamp":1643497326000},"page":"1532","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Simulation Studies Provide Evidence of Aerosol Transmission of SARS-CoV-2 in a Multi-Story Building via Air Supply, Exhaust and Sanitary Pipelines"],"prefix":"10.3390","volume":"19","author":[{"given":"Zhuona","family":"Zhang","sequence":"first","affiliation":[{"name":"National Institute of Environmental Health, China Center for Disease Control and Prevention, Beijing 100021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Li","sequence":"additional","affiliation":[{"name":"National Institute of Environmental Health, China Center for Disease Control and Prevention, Beijing 100021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Wang","sequence":"additional","affiliation":[{"name":"National Institute of Environmental Health, China Center for Disease Control and Prevention, Beijing 100021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoning","family":"Zhao","sequence":"additional","affiliation":[{"name":"Section of Ecological Environment & Energy Resources, Beijing Institute of Metrology, Beijing 100012, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Xu","sequence":"additional","affiliation":[{"name":"China National Center for Food Safety Risk Assessment, Beijing 100021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinqin","family":"Jiang","sequence":"additional","affiliation":[{"name":"Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sili","family":"Jiang","sequence":"additional","affiliation":[{"name":"Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayun","family":"Lyu","sequence":"additional","affiliation":[{"name":"Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiqiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Ye","sequence":"additional","affiliation":[{"name":"Guangdong Field Epidemiology Training Program, Guangzhou 511430, China"},{"name":"Heyuan Municipal Center for Disease Control and Prevention, Heyuan 517000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Yuan","sequence":"additional","affiliation":[{"name":"Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenru","family":"Feng","sequence":"additional","affiliation":[{"name":"Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiamin","family":"Xie","sequence":"additional","affiliation":[{"name":"Guangdong Field Epidemiology Training Program, Guangzhou 511430, China"},{"name":"Shunde District Center for Disease Control and Prevention, Foshan 528300, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiuling","family":"Chen","sequence":"additional","affiliation":[{"name":"Guangdong Field Epidemiology Training Program, Guangzhou 511430, China"},{"name":"Yunfu Municipal Center for Disease Control and Prevention, Yunfu 527300, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haoming","family":"Zou","sequence":"additional","affiliation":[{"name":"Guangdong Field Epidemiology Training Program, Guangzhou 511430, China"},{"name":"Zhanjiang Municipal Center for Disease Control and Prevention, Zhanjiang 524037, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongqun","family":"Xu","sequence":"additional","affiliation":[{"name":"National Institute of Environmental Health, China Center for Disease Control and Prevention, Beijing 100021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1177\/014107680309600803","article-title":"The SARS epidemic in Hong Kong: What lessons have we learned?","volume":"96","author":"Hung","year":"2003","journal-title":"J. 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