{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:18:17Z","timestamp":1791235097242,"version":"4.1.0"},"reference-count":48,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T00:00:00Z","timestamp":1643587200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Inferior alveolar nerve (IAN) block injections are commonly used in clinical practice, but they are not free from complications. The aim of the present systematic review is to assess the nerve-related adverse effects of IAN block anesthesia. A structured and systematic search was performed on the major electronic databases (PubMed, Cochrane Library, Web of Science, Scopus and CINAHL) for studies published in English until 30 September 2021. A total of 131 articles were identified through database searching using combinations of keywords. Fifteen papers were included and assessed for eligibility. Overall, nerve damage following an IAN block anesthesia injection is a rare occurrence, probably due to the direct nerve trauma of the needle, a neurotoxic effect of the used anesthetic solution and\/or a combination of them. From a medico-legal point of view, a balanced discussion prior to nerve block anesthesia should be pursued in order to avoid patients\u2019 reluctance to undergo necessary dental treatment due to the remote eventuality of nerve injury.<\/jats:p>","DOI":"10.3390\/ijerph19031627","type":"journal-article","created":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T08:20:29Z","timestamp":1643617229000},"page":"1627","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["A Systematic Review on Nerve-Related Adverse Effects following Mandibular Nerve Block Anesthesia"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1079-8565","authenticated-orcid":false,"given":"Luca","family":"Aquilanti","sequence":"first","affiliation":[{"name":"Department of Clinical Specialistic and Dental Sciences, Universit\u00e0 Politecnica delle Marche, Via Tronto 10\/A, 60126 Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Mascitti","sequence":"additional","affiliation":[{"name":"Department of Clinical Specialistic and Dental Sciences, Universit\u00e0 Politecnica delle Marche, Via Tronto 10\/A, 60126 Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucrezia","family":"Togni","sequence":"additional","affiliation":[{"name":"Department of Clinical Specialistic and Dental Sciences, Universit\u00e0 Politecnica delle Marche, Via Tronto 10\/A, 60126 Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4773-6694","authenticated-orcid":false,"given":"Maria","family":"Contaldo","sequence":"additional","affiliation":[{"name":"Multidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania \u201cLuigi Vanvitelli\u201d, Via Armanni, 5, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Rappelli","sequence":"additional","affiliation":[{"name":"Department of Clinical Specialistic and Dental Sciences, Universit\u00e0 Politecnica delle Marche, Via Tronto 10\/A, 60126 Ancona, Italy"},{"name":"Dentistry Clinic, National Institute of Health and Science of Aging, IRCCS INRCA, Via Tronto 10\/A, 60126 Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4218-3354","authenticated-orcid":false,"given":"Andrea","family":"Santarelli","sequence":"additional","affiliation":[{"name":"Department of Clinical Specialistic and Dental Sciences, Universit\u00e0 Politecnica delle Marche, Via Tronto 10\/A, 60126 Ancona, Italy"},{"name":"Dentistry Clinic, National Institute of Health and Science of Aging, IRCCS INRCA, Via Tronto 10\/A, 60126 Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1016\/j.ijom.2016.06.019","article-title":"Factors Determining Tooth Extraction Anxiety and Fear in Adult Dental Patients: A Systematic Review","volume":"45","year":"2016","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.coms.2011.04.009","article-title":"Complications of Local Anesthesia Used in Oral and Maxillofacial Surgery","volume":"23","author":"Cummings","year":"2011","journal-title":"Oral Maxillofac. Surg. Clin. N. Am."},{"key":"ref_3","first-page":"546","article-title":"An Update on Local Anesthetics in Dentistry","volume":"68","author":"Haas","year":"2002","journal-title":"J. Can. Dent. Assoc."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"701","DOI":"10.14219\/jada.archive.1979.0148","article-title":"Assessment of Allergy to Local Anesthetics","volume":"98","author":"Giovannitti","year":"1979","journal-title":"J. Am. Dent. Assoc."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/S0091-6749(96)80067-4","article-title":"Adverse Reactions to Local Anesthetics: Analysis of 197 Cases","volume":"97","author":"Gall","year":"1996","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.cden.2010.06.015","article-title":"Local Anesthetics: Pharmacology and Toxicity","volume":"54","author":"Moore","year":"2010","journal-title":"Dent. Clin. N. Am."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1124\/dmd.113.051714","article-title":"Prilocaine- and Lidocaine-Induced Methemoglobinemia Is Caused by Human Carboxylesterase-, CYP2E1-, and CYP3A4-Mediated Metabolic Activation","volume":"41","author":"Higuchi","year":"2013","journal-title":"Drug Metab. Dispos. Biol. Fate Chem."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.jds.2020.12.003","article-title":"Local Anesthesia in Oral and Maxillofacial Surgery: A Review of Current Opinion","volume":"16","author":"Wang","year":"2021","journal-title":"J. Dent. Sci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1007\/s12663-018-1092-5","article-title":"Comparison of Efficacy of Halstead, Vazirani Akinosi and Gow Gates Techniques for Mandibular Anesthesia","volume":"17","author":"Kashyap","year":"2018","journal-title":"J. Maxillofac. Oral Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.14219\/jada.archive.2006.0114","article-title":"The Significance of Needle Bevel Orientation in Achieving a Successful Inferior Alveolar Nerve Block","volume":"137","author":"Steinkruger","year":"2006","journal-title":"J. Am. Dent. Assoc."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.joen.2017.09.014","article-title":"Anesthetic Efficacy of Supine and Upright Positions for the Inferior Alveolar Nerve Block: A Prospective, Randomized Study","volume":"44","author":"Crowley","year":"2018","journal-title":"J. Endod."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"8S","DOI":"10.14219\/jada.archive.2011.0341","article-title":"Alternative Mandibular Nerve Block Techniques: A Review of the Gow-Gates and Akinosi-Vazirani Closed-Mouth Mandibular Nerve Block Techniques","volume":"142","author":"Haas","year":"2011","journal-title":"J. Am. Dent. Assoc."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/aej.12212","article-title":"Supplementary Techniques for Pain Control during Root Canal Treatment of Lower Posterior Teeth with Irreversible Pulpitis: A Systematic Review and Meta-Analysis","volume":"44","author":"Tupyota","year":"2018","journal-title":"Aust. Endod. J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1016\/j.ijom.2020.04.016","article-title":"Which Is the Most Suitable Local Anaesthetic When Inferior Nerve Blocks Are Used for Impacted Mandibular Third Molar Extraction? A Network Meta-Analysis","volume":"49","author":"Figueiredo","year":"2020","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_15","first-page":"87","article-title":"Different Anesthetics on the Efficacy of Inferior Alveolar Nerve Block in Patients with Irreversible Pulpitis: A Network Systematic Review and Meta-Analysis","volume":"151","author":"Wambier","year":"2020","journal-title":"J. Am. Dent. Assoc. 1939"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"177","DOI":"10.14219\/jada.archive.2001.0152","article-title":"Articaine Hydrochloride: A Study of the Safety of a New Amide Local Anesthetic","volume":"132","author":"Malamed","year":"2001","journal-title":"J. Am. Dent. Assoc."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2046-4053-4-1","article-title":"Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) 2015 Statement","volume":"4","author":"Moher","year":"2015","journal-title":"Syst. Rev."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Schardt, C., Adams, M.B., Owens, T., Keitz, S., and Fontelo, P. (2007). Utilization of the PICO Framework to Improve Searching PubMed for Clinical Questions. BMC Med. Inform. Decis. Mak., 7.","DOI":"10.1186\/1472-6947-7-16"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.jclinepi.2008.06.007","article-title":"AHRQ Series Paper 4: Assessing Harms When Comparing Medical Interventions: AHRQ and the Effective Health-Care Program","volume":"63","author":"Chou","year":"2010","journal-title":"J. Clin. Epidemiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"l4898","DOI":"10.1136\/bmj.l4898","article-title":"RoB 2: A Revised Tool for Assessing Risk of Bias in Randomised Trials","volume":"366","author":"Sterne","year":"2019","journal-title":"BMJ"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"i4919","DOI":"10.1136\/bmj.i4919","article-title":"ROBINS-I: A Tool for Assessing Risk of Bias in Non-Randomised Studies of Interventions","volume":"355","author":"Sterne","year":"2016","journal-title":"BMJ"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/jebm.12141","article-title":"The Methodological Quality Assessment Tools for Preclinical and Clinical Studies, Systematic Review and Meta-Analysis, and Clinical Practice Guideline: A Systematic Review","volume":"8","author":"Zeng","year":"2015","journal-title":"J. Evid. Based Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s13643-021-01626-4","article-title":"The PRISMA 2020 Statement: An Updated Guideline for Reporting Systematic Reviews","volume":"10","author":"Page","year":"2021","journal-title":"Syst. Rev."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/S1010-5182(05)80079-4","article-title":"Clinical Investigation into the Incidence of Direct Damage to the Lingual Nerve Caused by Local Anaesthesia","volume":"22","author":"Krafft","year":"1994","journal-title":"J. Cranio-Maxillofac. Surg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"901","DOI":"10.14219\/jada.archive.2000.0308","article-title":"Permanent Nerve Involvement Resulting from Inferior Alveolar Nerve Blocks","volume":"131","author":"Pogrel","year":"2000","journal-title":"J. Am. Dent. Assoc."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"519","DOI":"10.14219\/jada.archive.1990.0198","article-title":"Incidence of Lingual Nerve Trauma and Postinjection Complications in Conventional Mandibular Block Anesthesia","volume":"121","author":"Harn","year":"1990","journal-title":"J. Am. Dent. Assoc."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.14219\/jada.archive.1995.0336","article-title":"Nerve Damage Associated with Inferior Alveolar Nerve Blocks","volume":"126","author":"Pogrel","year":"1995","journal-title":"J. Am. Dent. Assoc."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.ijom.2005.10.004","article-title":"Nerve Injury Caused by Mandibular Block Analgesia","volume":"35","author":"Hillerup","year":"2006","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_29","unstructured":"Gaffen, A.S., and Haas, D.A. (2009). Retrospective Review of Voluntary Reports of Nonsurgical Paresthesia in Dentistry. J. Can. Dent. Assoc., 75."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"836","DOI":"10.14219\/jada.archive.2010.0281","article-title":"Occurrence of Paresthesia after Dental Local Anesthetic Administration in the United States","volume":"141","author":"Garisto","year":"2010","journal-title":"J. Am. Dent. Assoc."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"531","DOI":"10.14219\/jada.archive.2011.0223","article-title":"Trigeminal Nerve Injury Associated with Injection of Local Anesthetics: Needle Lesion or Neurotoxicity?","volume":"142","author":"Hillerup","year":"2011","journal-title":"J. Am. Dent. Assoc."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/j.1834-7819.2011.01317.x","article-title":"Severe Adverse Reactions to Dental Local Anaesthetics: Prolonged Mandibular and Lingual Nerve Anaesthesia","volume":"56","author":"Sambrook","year":"2011","journal-title":"Aust. Dent. J."},{"key":"ref_33","first-page":"795","article-title":"Permanent Nerve Damage from Inferior Alveolar Nerve Blocks: A Current Update","volume":"40","author":"Pogrel","year":"2012","journal-title":"J. Calif. Dent. Assoc."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/bcpt.12357","article-title":"Paraesthesia after Local Anaesthetics: An Analysis of Reports to the FDA Adverse Event Reporting System","volume":"117","author":"Piccinni","year":"2015","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1111\/j.1834-7819.2011.01358.x","article-title":"Higher Concentration Local Anaesthetics Causing Prolonged Anaesthesia. Do They? A Literature Review and Case Reports","volume":"56","author":"Kingon","year":"2011","journal-title":"Aust. Dent. J."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1080\/00016480260046463","article-title":"Taste Disturbance in Two Patients after Dental Anesthesia by Inferior Alveolar Nerve Block","volume":"122","author":"Hotta","year":"2002","journal-title":"Acta Oto-Laryngol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/j.ijom.2010.04.049","article-title":"Facial Palsy after Inferior Alveolar Nerve Block: Case Report and Review of the Literature","volume":"39","author":"Chevalier","year":"2010","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"404","DOI":"10.5005\/jp-journals-10024-1067","article-title":"An Unusual Pattern of Self-Inflicted Injury after Dental Local Anesthesia: A Report of 2 Cases","volume":"12","author":"Bendgude","year":"2011","journal-title":"J. Contemp. Dent. Pract."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Golder, S., Loke, Y.K., Wright, K., and Norman, G. (2016). Reporting of Adverse Events in Published and Unpublished Studies of Health Care Interventions: A Systematic Review. PLoS Med., 13.","DOI":"10.1371\/journal.pmed.1002127"},{"key":"ref_40","first-page":"559","article-title":"Nerve Injuries after Dental Injection: A Review of the Literature","volume":"72","author":"Smith","year":"2006","journal-title":"J. Can. Dent. Assoc."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/0030-4220(94)90315-8","article-title":"Barbed Needle and Inexplicable Paresthesias and Trismus after Dental Regional Anesthesia","volume":"77","author":"Stacy","year":"1994","journal-title":"Oral Surg. Oral Med. Oral Pathol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"344","DOI":"10.12968\/denu.1999.26.8.344","article-title":"Neurological Complications of Local Anaesthetics in Dentistry","volume":"26","author":"Crean","year":"1999","journal-title":"Dent. Update"},{"key":"ref_43","first-page":"36","article-title":"Trigeminal Nerve Injury and Repair","volume":"62","author":"Ruggiero","year":"1996","journal-title":"N. Y. State Dent. J."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1055\/s-2003-42637","article-title":"Free Radical-Induced Damage in Experimental Peripheral Nerve Injection Injury","volume":"19","author":"Saray","year":"2003","journal-title":"J. Reconstr. Microsurg."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/sj.bdj.2017.782","article-title":"Articaine and Neurotoxicity\u2014A Review","volume":"223","author":"Hopman","year":"2017","journal-title":"Br. Dent. J."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"195","DOI":"10.14219\/jada.archive.2003.0133","article-title":"Lingual Nerve Damage Due to Inferior Alveolar Nerve Blocks: A Possible Explanation","volume":"134","author":"Pogrel","year":"2003","journal-title":"J. Am. Dent. Assoc."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1111\/joor.12313","article-title":"Evidence-Based Outcomes Following Inferior Alveolar and Lingual Nerve Injury and Repair: A Systematic Review","volume":"42","author":"Kushnerev","year":"2015","journal-title":"J. Oral Rehabil."},{"key":"ref_48","first-page":"50","article-title":"Injuries to the Inferior Alveolar and Lingual Nerves","volume":"21","author":"Pogrel","year":"1993","journal-title":"J. Calif. Dent. Assoc."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/19\/3\/1627\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:11:53Z","timestamp":1760134313000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/19\/3\/1627"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,31]]},"references-count":48,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,2]]}},"alternative-id":["ijerph19031627"],"URL":"https:\/\/doi.org\/10.3390\/ijerph19031627","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,31]]}}}