{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:59:43Z","timestamp":1789174783352,"version":"build-2803163510"},"reference-count":31,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T00:00:00Z","timestamp":1644278400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Italian Workers\u2019 Compensation Authority","award":["BRiC-2018 ID3 and BRIC-2021 ID4"],"award-info":[{"award-number":["BRiC-2018 ID3 and BRIC-2021 ID4"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>(1) Background: The purpose of this review is to study the role of radiomics as a supporting tool in predicting bone disease status, differentiating benign from malignant bone lesions, and characterizing malignant bone lesions. (2) Methods: Two reviewers conducted the literature search independently. Thirteen articles on radiomics as a decision support tool for bone lesions were selected. The quality of the methodology was evaluated according to the radiomics quality score (RQS). (3) Results: All studies were published between 2018 and 2021 and were retrospective in design. Eleven (85%) studies were MRI-based, and two (15%) were CT-based. The sample size was &lt;200 patients for all studies. There is significant heterogeneity in the literature, as evidenced by the relatively low RQS value (average score = 22.6%). There is not a homogeneous protocol used for MRI sequences among the different studies, although the highest predictive ability was always obtained in T2W-FS. Six articles (46%) reported on the potential application of the model in a clinical setting with a decision curve analysis (DCA). (4) Conclusions: Despite the variability in the radiomics method application, the similarity of results and conclusions observed is encouraging. Substantial limits were found; prospective and multicentric studies are needed to affirm the role of radiomics as a supporting tool.<\/jats:p>","DOI":"10.3390\/ijerph19031880","type":"journal-article","created":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T23:37:48Z","timestamp":1644363468000},"page":"1880","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Artificial Intelligence in Bone Metastases: An MRI and CT Imaging Review"],"prefix":"10.3390","volume":"19","author":[{"given":"Eliodoro","family":"Faiella","sequence":"first","affiliation":[{"name":"Department of Radiology, University of Rome \u201cCampus Bio-Medico\u201d, Via Alvaro del Portillo, 00128 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4903-8715","authenticated-orcid":false,"given":"Domiziana","family":"Santucci","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Rome \u201cCampus Bio-Medico\u201d, Via Alvaro del Portillo, 00128 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Calabrese","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Rome \u201cSapienza\u201d, Viale del Policlinico, 00161 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Russo","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic and Trauma Surgery, University of Rome \u201cCampus Bio-Medico\u201d, Via Alvaro del Portillo, 00128 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7142-1660","authenticated-orcid":false,"given":"Gianluca","family":"Vadal\u00e0","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic and Trauma Surgery, University of Rome \u201cCampus Bio-Medico\u201d, Via Alvaro del Portillo, 00128 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9227-5535","authenticated-orcid":false,"given":"Bruno","family":"Zobel","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Rome \u201cCampus Bio-Medico\u201d, Via Alvaro del Portillo, 00128 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2621-072X","authenticated-orcid":false,"given":"Paolo","family":"Soda","sequence":"additional","affiliation":[{"name":"Unit of Computer Systems and Bioinformatics, Department of Engineering, University of Rome \u201cCampus Bio-Medico\u201d, Via Alvaro del Portillo, 00128 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3864-5800","authenticated-orcid":false,"given":"Giulio","family":"Iannello","sequence":"additional","affiliation":[{"name":"Unit of Computer Systems and Bioinformatics, Department of Engineering, University of Rome \u201cCampus Bio-Medico\u201d, Via Alvaro del Portillo, 00128 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"de Felice","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Rome \u201cSapienza\u201d, Viale del Policlinico, 00161 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Denaro","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic and Trauma Surgery, University of Rome \u201cCampus Bio-Medico\u201d, Via Alvaro del Portillo, 00128 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1053\/ctrv.2000.0210","article-title":"Metastatic Bone Disease: Clinical Features, Pathophysiology and Treatment Strategies","volume":"27","author":"Coleman","year":"2001","journal-title":"Cancer Treat. 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