{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:26:08Z","timestamp":1791476768190,"version":"4.3.4"},"reference-count":29,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T00:00:00Z","timestamp":1644451200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>This study aimed to estimate the seroprevalence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection within the staff and student populations of the University of Corsica (France) during the second wave of the epidemic. Methods: A cross-sectional survey was conducted from 23 November 2020 to 31 January 2021. The participants underwent blood sampling using a fingerstick procedure and completed an anonymized questionnaire. Sera were tested for the presence of anti-SARS-CoV-2 IgG (ELISA-S) and, if positive, with an in-house virus neutralization test (VNT). Results: A total of 418 persons were included in the study. The overall seroprevalence was 12.8% (95% confidence interval (CI), 9.8\u201316.6%). A total of 15 (31%) of the 49 individuals who had a positive ELISA-S also had a positive VNT. Seropositivity was associated with living at the city campus during the week and on weekends (OR = 3.74 [1.40\u201312.00]), using public transportation\/carpooling (OR = 2.00 [1.01\u20134.02]), and being in contact with a person who tested positive for SARS-CoV-2 (OR = 2.32 [1.20\u20134.40]). The main symptoms associated with seropositivity were \u201chaving had an acute respiratory infection\u201d (OR = 3.05 [1.43\u20136.43]) and \u201cexperiencing loss of smell\u201d (OR = 16.4 [5.87\u201350.7]). Conclusion: These results could be useful for SARS-CoV-2 prevention and control on university campuses.<\/jats:p>","DOI":"10.3390\/ijerph19041953","type":"journal-article","created":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T02:35:51Z","timestamp":1644546951000},"page":"1953","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Cross-Sectional Study of Exposure Factors Associated with Seropositivity for SARS-CoV-2 Antibodies during the Second Epidemic Wave among a Sample of the University of Corsica (France)"],"prefix":"10.3390","volume":"19","author":[{"given":"Dorine","family":"Decarreaux","sequence":"first","affiliation":[{"name":"Laboratoire de Virologie, Universit\u00e9 de Corse Pascal Paoli, UR7310 Bioscope, 20250 Corte, France"},{"name":"INSERM, Sorbonne Universit\u00e9, Institut Pierre Louis d\u2019Epid\u00e9miologie et de Sant\u00e9 Publique, IPLESP, 75012 Paris, France"},{"name":"Unit\u00e9 des Virus \u00c9mergents, Aix Marseille University, IRD 190, INSERM U1207, IHU M\u00e9diterran\u00e9e Infection, 13005 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9507-996X","authenticated-orcid":false,"given":"Julie","family":"Sevila","sequence":"additional","affiliation":[{"name":"Laboratoire de Virologie, Universit\u00e9 de Corse Pascal Paoli, UR7310 Bioscope, 20250 Corte, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3659-4512","authenticated-orcid":false,"given":"Shirley","family":"Masse","sequence":"additional","affiliation":[{"name":"Laboratoire de Virologie, Universit\u00e9 de Corse Pascal Paoli, UR7310 Bioscope, 20250 Corte, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3618-1582","authenticated-orcid":false,"given":"Lisandru","family":"Capai","sequence":"additional","affiliation":[{"name":"Laboratoire de Virologie, Universit\u00e9 de Corse Pascal Paoli, UR7310 Bioscope, 20250 Corte, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7806-4205","authenticated-orcid":false,"given":"Toscane","family":"Fouri\u00e9","sequence":"additional","affiliation":[{"name":"Unit\u00e9 des Virus \u00c9mergents, Aix Marseille University, IRD 190, INSERM U1207, IHU M\u00e9diterran\u00e9e Infection, 13005 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8695-5283","authenticated-orcid":false,"given":"Paola Mariela","family":"Saba Villarroel","sequence":"additional","affiliation":[{"name":"Unit\u00e9 des Virus \u00c9mergents, Aix Marseille University, IRD 190, INSERM U1207, IHU M\u00e9diterran\u00e9e Infection, 13005 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6052-3944","authenticated-orcid":false,"given":"Abdennour","family":"Amroun","sequence":"additional","affiliation":[{"name":"Unit\u00e9 des Virus \u00c9mergents, Aix Marseille University, IRD 190, INSERM U1207, IHU M\u00e9diterran\u00e9e Infection, 13005 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9715-8394","authenticated-orcid":false,"given":"Elif","family":"Nurtop","sequence":"additional","affiliation":[{"name":"Unit\u00e9 des Virus \u00c9mergents, Aix Marseille University, IRD 190, INSERM U1207, IHU M\u00e9diterran\u00e9e Infection, 13005 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Vareille","sequence":"additional","affiliation":[{"name":"Laboratoire de Virologie, Universit\u00e9 de Corse Pascal Paoli, UR7310 Bioscope, 20250 Corte, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Pouquet","sequence":"additional","affiliation":[{"name":"INSERM, Sorbonne Universit\u00e9, Institut Pierre Louis d\u2019Epid\u00e9miologie et de Sant\u00e9 Publique, IPLESP, 75012 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Blanchon","sequence":"additional","affiliation":[{"name":"INSERM, Sorbonne Universit\u00e9, Institut Pierre Louis d\u2019Epid\u00e9miologie et de Sant\u00e9 Publique, IPLESP, 75012 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"de Lamballerie","sequence":"additional","affiliation":[{"name":"Unit\u00e9 des Virus \u00c9mergents, Aix Marseille University, IRD 190, INSERM U1207, IHU M\u00e9diterran\u00e9e Infection, 13005 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7675-8251","authenticated-orcid":false,"given":"R\u00e9mi","family":"Charrel","sequence":"additional","affiliation":[{"name":"Unit\u00e9 des Virus \u00c9mergents, Aix Marseille University, IRD 190, INSERM U1207, IHU M\u00e9diterran\u00e9e Infection, 13005 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0799-1460","authenticated-orcid":false,"given":"Alessandra","family":"Falchi","sequence":"additional","affiliation":[{"name":"Laboratoire de Virologie, Universit\u00e9 de Corse Pascal Paoli, UR7310 Bioscope, 20250 Corte, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,10]]},"reference":[{"key":"ref_1","unstructured":"Wood, G. (2021, November 24). There\u2019s No Simple Way to Reopen Universities. Available online: https:\/\/www.theatlantic.com\/ideas\/archive\/2020\/04\/colleges-are-weighing-costs-reopening-fall\/610759\/."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1177\/1558866119840085","article-title":"Club and Intramural Sports Participation and College Student Academic Success","volume":"43","author":"Vasold","year":"2019","journal-title":"Recreat. Sports J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1001\/jama.2020.5460","article-title":"Governmental Public Health Powers during the COVID-19 Pandemic: Stay-at-Home Orders, Business Closures, and Travel Restrictions","volume":"323","author":"Gostin","year":"2020","journal-title":"JAMA"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Renault, V., Humblet, M.-F., Parisi, G., Donneau, A.-F., Bureau, F., Gillet, L., Fontaine, S., and Saegerman, C. (2021). The First Random Observational Survey of Barrier Gestures against COVID-19. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph18199972"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.jadohealth.2020.09.001","article-title":"A Cross-Sectional Study Examining the Seroprevalence of Severe Acute Respiratory Syndrome Coronavirus 2 Antibodies in a University Student Population","volume":"67","author":"Tilley","year":"2020","journal-title":"J. Adolesc. Health"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Tuells, J., Egoavil, C.M., Pena Pardo, M.A., Montagud, A.C., Montagud, E., Caballero, P., Zapater, P., Puig-Barber\u00e1, J., and Hurtado-Sanchez, J.A. (2021). Seroprevalence Study and Cross-Sectional Survey on COVID-19 for a Plan to Reopen the University of Alicante (Spain). Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph18041908"},{"key":"ref_7","first-page":"276","article-title":"Seroprevalence of SARS-CoV-2 Antibodies in Low-Income University Students","volume":"20","author":"Schimieguel","year":"2021","journal-title":"EXCLI J."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Arnold, C.R.K., Srinivasan, S., Herzog, C.M., Gontu, A., Bharti, N., Small, M., Rogers, C.J., Schade, M.M., Kuchipudi, S.V., and Kapur, V. (2021). SARS-CoV-2 Seroprevalence in a University Community: A Longitudinal Study of the Impact of Student Return to Campus on Infection Risk Among Community Members. medRxiv, 2021.02.17.21251942.","DOI":"10.1101\/2021.02.17.21251942"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Tsitsilonis, O.E., Paraskevis, D., Lianidou, E., Pierros, V., Akalestos, A., Kastritis, E., Moutsatsou, P., Scorilas, A., Sphicopoulos, T., and Terpos, E. (2020). Seroprevalence of Antibodies against SARS-CoV-2 among the Personnel and Students of the National and Kapodistrian University of Athens, Greece: A Preliminary Report. Life, 10.","DOI":"10.3390\/life10090214"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"eabf4063","DOI":"10.1126\/science.abf4063","article-title":"Immunological Memory to SARS-CoV-2 Assessed for up to 8 Months after Infection","volume":"371","author":"Dan","year":"2021","journal-title":"Science"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"104880","DOI":"10.1016\/j.antiviral.2020.104880","article-title":"Lower Prevalence of Antibodies Neutralizing SARS-CoV-2 in Group O French Blood Donors","volume":"181","author":"Gallian","year":"2020","journal-title":"Antivir. Res."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Capai, L., Ayhan, N., Masse, S., Canarelli, J., Priet, S., Simeoni, M.-H., Charrel, R., de Lamballerie, X., and Falchi, A. (2020). Seroprevalence of SARS-CoV-2 IgG Antibodies in Corsica (France), April and June 2020. J. Clin. Med., 9.","DOI":"10.3390\/jcm9113569"},{"key":"ref_13","unstructured":"Sergent, E.S.G. (2021, November 22). Calculateurs \u00c9pid\u00e9miologiques Epitools. Ausvet. Available online: https:\/\/epitools.ausvet.com.au\/."},{"key":"ref_14","unstructured":"R Core Team (2006). R: A Language and Environment for Statistical Computing, R Foundation for Statistical Computing. Available online: https:\/\/www.eea.europa.eu\/data-and-maps\/indicators\/oxygen-consuming-substances-in-rivers\/r-development-core-team-2006."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"715192","DOI":"10.3389\/fpubh.2021.715192","article-title":"Impact of the Second Epidemic Wave of SARS-CoV-2: Increased Exposure of Young People","volume":"9","author":"Capai","year":"2021","journal-title":"Front. Public Health"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.jinf.2021.04.028","article-title":"Seroprevalence of SARS-CoV-2 Antibodies in University Students: Cross-Sectional Study, December 2020, England","volume":"83","author":"Vusirikala","year":"2021","journal-title":"J. Infect."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2800","DOI":"10.1038\/s41467-020-16670-2","article-title":"Detection of Air and Surface Contamination by SARS-CoV-2 in Hospital Rooms of Infected Patients","volume":"11","author":"Chia","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Alsa\u00efdi, I., De Sousa Santos, F., Plard, B., Janvier, E., Tinland, A., Hafni, A., and Mosnier, E. (2021). Factors Associated with SARS-CoV2 Infection and Care Pathways among the Most Vulnerable Populations Living in Marseille: A Case Control Study. BMC Public Health, 21.","DOI":"10.1186\/s12889-021-11716-6"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e24320","DOI":"10.2196\/24320","article-title":"Jobs, Housing, and Mask Wearing: Cross-Sectional Study of Risk Factors for COVID-19","volume":"7","author":"Atherly","year":"2021","journal-title":"JMIR Public Health Surveill"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"100148","DOI":"10.1016\/j.lanepe.2021.100148","article-title":"Exposures Associated with SARS-CoV-2 Infection in France: A Nationwide Online Case-Control Study","volume":"7","author":"Galmiche","year":"2021","journal-title":"Lancet Reg. Health\u2013Europe"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"113610","DOI":"10.1016\/j.ijheh.2020.113610","article-title":"Impacts of Transportation and Meteorological Factors on the Transmission of COVID-19","volume":"230","author":"Wei","year":"2020","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/j.1365-3156.2008.02189.x","article-title":"Geographical Spread of SARS in Mainland China","volume":"14","author":"Fang","year":"2009","journal-title":"Trop. Med. Int. Health"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0140-6736(20)31483-5","article-title":"Prevalence of SARS-CoV-2 in Spain (ENE-COVID): A Nationwide, Population-Based Seroepidemiological Study","volume":"396","author":"Oteo","year":"2020","journal-title":"Lancet"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1056\/NEJMoa2002032","article-title":"Clinical Characteristics of Coronavirus Disease 2019 in China","volume":"382","author":"Guan","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.anl.2020.05.020","article-title":"The Diagnostic Value of Detecting Sudden Smell Loss among Asymptomatic COVID-19 Patients in Early Stage: The Possible Early Sign of COVID-19","volume":"47","author":"Kang","year":"2020","journal-title":"Auris Nasus Larynx"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/s41586-020-2456-9","article-title":"Convergent Antibody Responses to SARS-CoV-2 in Convalescent Individuals","volume":"584","author":"Robbiani","year":"2020","journal-title":"Nature"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/s41591-020-0869-5","article-title":"Temporal Dynamics in Viral Shedding and Transmissibility of COVID-19","volume":"26","author":"He","year":"2020","journal-title":"Nat. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e19994","DOI":"10.2196\/19994","article-title":"Epidemiological Parameters of COVID-19: Case Series Study","volume":"22","author":"Ma","year":"2020","journal-title":"J. Med. Internet Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1080\/22221751.2020.1837015","article-title":"A Multi-Family Cluster of COVID-19 Associated with Asymptomatic and Pre-Symptomatic Transmission in Jixi City, Heilongjiang, China, 2020","volume":"9","author":"Zhang","year":"2020","journal-title":"Emerg. Microbes Infect."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/19\/4\/1953\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:17:35Z","timestamp":1760134655000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/19\/4\/1953"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,10]]},"references-count":29,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,2]]}},"alternative-id":["ijerph19041953"],"URL":"https:\/\/doi.org\/10.3390\/ijerph19041953","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,10]]}}}