{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T18:38:17Z","timestamp":1783017497655,"version":"3.54.6"},"reference-count":62,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T00:00:00Z","timestamp":1645056000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo de Chile (ANID)","award":["ANID PIA CIE 160007"],"award-info":[{"award-number":["ANID PIA CIE 160007"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Substance use is a risk behavior that has been associated with adverse mental health outcomes in adolescence. The aim of this study was to determine the relation between behavioral problems, emotional problems, and substance use as well as the mediating role of contextual problems and sensation seeking in this relation. A cross-sectional study of 2277 adolescents from Northern Chile was conducted. The System for the Evaluation of Children and Adolescents (SENA) was used to assess substance use, contextual problems, sensation seeking, and emotional and behavioral problems. Through a mediational model, it was observed that substance use has a positive indirect effect on emotional and behavioral problems when both contextual problems and sensation seeking act as mediating variables. An indirect effect of substance use on contextual problems with sensation seeking as a mediator was also observed. The results suggests that context and sensation seeking are a relevant source of information in understanding adolescents and their propensity to use drugs. Interventions based on addressing contextual problems (problems with school, peers, and family) and enhancing personal resources should be implemented in order to reduce substance use in adolescents as well as the consequences it can generate in the short, medium, and long term.<\/jats:p>","DOI":"10.3390\/ijerph19042262","type":"journal-article","created":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T20:25:45Z","timestamp":1645129545000},"page":"2262","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Mediating Role of Contextual Problems and Sensation Seeking in the Association between Substance Use and Mental Health in Adolescents from Northern Chile"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4614-8380","authenticated-orcid":false,"given":"Alejandra","family":"Caqueo-Ur\u00edzar","sequence":"first","affiliation":[{"name":"Instituto de Alta Investigaci\u00f3n, Universidad de Tarapac\u00e1, Arica 1000000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8220-0230","authenticated-orcid":false,"given":"Diego","family":"Atencio-Quevedo","sequence":"additional","affiliation":[{"name":"Escuela de Psicolog\u00eda y Filosof\u00eda, Universidad de Tarapac\u00e1, Arica 1000000, Chile"},{"name":"Centro de Justicia Educacional (CJE), Pontificia Universidad Cat\u00f3lica de Chile, Santiago 7820436, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0882-2194","authenticated-orcid":false,"given":"Alfonso","family":"Urz\u00faa","sequence":"additional","affiliation":[{"name":"Escuela de Psicolog\u00eda, Universidad Cat\u00f3lica del Norte, Antofagasta 1270709, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome","family":"Flores","sequence":"additional","affiliation":[{"name":"Escuela de Psicolog\u00eda y Filosof\u00eda, Universidad de Tarapac\u00e1, Arica 1000000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mat\u00edas","family":"Irarr\u00e1zaval","sequence":"additional","affiliation":[{"name":"Departamento de Psiquiatr\u00eda, Facultad de Medicina, Hospital Cl\u00ednico, Universidad de Chile, Santiago 8380453, Chile"},{"name":"Institute for Depression and Personality Research MIDAP, Santiago 8380453, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Degenhardt, L., Chiu, W.-T., Sampson, N., Kessler, R.C., Anthony, J.C., Angermeyer, M., Bruffaerts, R., de Girolamo, G., Gureje, O., and Huang, Y. 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