{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T08:38:47Z","timestamp":1792226327730,"version":"4.4.0"},"reference-count":60,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T00:00:00Z","timestamp":1645056000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Adenomyosis is a common benign gynecological condition, defined as an extension of endometrial tissue into the myometrium. Some studies suggest that adenomyosis could be a favorable prediction factor associated with survival outcomes in endometrial cancer. The aim of our systematic review was to investigate the current knowledge regarding adenomyosis and a possible molecular mechanism of carcinogenesis in adenomyotic lesions. In addition, the long-term prognosis for patients with endometrial cancer and coexisting adenomyosis (and endometriosis) was a key point of the research. The current literature was reviewed by searching PubMed, using the following phrases: \u201cadenomyosis and endometrial cancer\u201d and \u201cmalignant transformation of adenomyosis\u201d. According to the literature, genetic mutations, epigenetic changes, and inactivation of specific tumor suppressor genes in adenomyosis are still poorly understood. Data regarding the influence of adenomyosis on survival outcomes in endometrial cancer seem to be contradictory and require further clinical and molecular investigation.<\/jats:p>","DOI":"10.3390\/ijerph19042294","type":"journal-article","created":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T20:25:45Z","timestamp":1645129545000},"page":"2294","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Adenomyosis as a Risk Factor for Myometrial or Endometrial Neoplasms\u2014Review"],"prefix":"10.3390","volume":"19","author":[{"given":"Maria","family":"Szubert","sequence":"first","affiliation":[{"name":"Clinic of Surgical and Oncologic Gynecology, 1st Department of Gynecology and Obstetrics, Medical University of Lodz, M. Pirogow\u2019s Teaching Hospital, Wilenska 37 St., 94-029 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1290-1223","authenticated-orcid":false,"given":"Edward","family":"Kozirog","sequence":"additional","affiliation":[{"name":"Clinic of Surgical and Oncologic Gynecology, 1st Department of Gynecology and Obstetrics, Medical University of Lodz, M. Pirogow\u2019s Teaching Hospital, Wilenska 37 St., 94-029 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2072-6533","authenticated-orcid":false,"given":"Jacek","family":"Wilczynski","sequence":"additional","affiliation":[{"name":"Clinic of Surgical and Oncologic Gynecology, 1st Department of Gynecology and Obstetrics, Medical University of Lodz, M. Pirogow\u2019s Teaching Hospital, Wilenska 37 St., 94-029 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,17]]},"reference":[{"key":"ref_1","first-page":"1146","article-title":"Diagnostic findings in adenomyosis: A pictorial review on the major concerns","volume":"19","author":"Graziano","year":"2015","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Szubert, M., Kozir\u00f3g, E., Olszak, O., Krygier-Kurz, K., Kazmierczak, J., and Wilczynski, J. (2021). Adenomyosis and Infertility-Review of Medical and Surgical Approaches. Int. J. Environ. Res. 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