{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:55:07Z","timestamp":1785776107140,"version":"3.56.0"},"reference-count":44,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T00:00:00Z","timestamp":1645488000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 108-2320-B-040-023 and MOST 110-2320-B-040-013"],"award-info":[{"award-number":["MOST 108-2320-B-040-023 and MOST 110-2320-B-040-013"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>The purpose of this study was to investigate the nutritional status of dementia patients and examine the correlation with sarcopenia, frailty, depression, and quality of life. We enrolled patients aged 60 years and over with Mini Mental State Examination (MMSE) scores \u2264 26 (Taiwan), and dementia diagnosed by a neurologist or psychiatrist. Nutritional status was assessed with the Mini Nutritional Assessment (MNA). Muscle mass was measured by dual-energy X-ray absorptiometry. Muscle strength and endurance were evaluated by handgrip, leg-back strength, dumbbell curls, sit to stand test, and gait speed. Quality of life, frailty, and depression status were measured by questionnaires. Patients with moderate dementia (MMSE \u2264 20) had a significantly lower MNA score, muscle function, and quality of life than patients with mild dementia (p &lt; 0.01). A lower MNA score was significantly associated with the risk of frailty (odds ratio: 4.76, p &lt; 0.01), depression (odds ratio: 3.17, p = 0.03), and poor quality of life (odds ratio: 2.73, p &lt; 0.05), and sarcopenia (odds ratio: 3.97, p = 0.03) after adjusting for potential confounders. In conclusion, patients with dementia were at risk of malnutrition, and nutritional status was associated to the risk of sarcopenia, frailty, depression, and quality of life.<\/jats:p>","DOI":"10.3390\/ijerph19052492","type":"journal-article","created":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T22:34:30Z","timestamp":1645569270000},"page":"2492","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Sarcopenic Obesity Tendency and Nutritional Status Is Related to the Risk of Sarcopenia, Frailty, Depression and Quality of Life in Patients with Dementia"],"prefix":"10.3390","volume":"19","author":[{"given":"Hsi-Hsien","family":"Chou","sequence":"first","affiliation":[{"name":"School of Medicine, Chung Shan Medical University, Taichung 402367, Taiwan"},{"name":"Department of Neurology, Chung Shan Medical University Hospital, Taichung 402367, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Te-Jen","family":"Lai","sequence":"additional","affiliation":[{"name":"Institute of Medicine, Chung Shan Medical University, Taichung 402367, Taiwan"},{"name":"Department of Psychiatry, Chung Shan Medical University Hospital, Taichung 402367, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Hua","family":"Yen","sequence":"additional","affiliation":[{"name":"School of Medicine, Chung Shan Medical University, Taichung 402367, Taiwan"},{"name":"Department of Family and Community Medicine, Chung Shan Medical University Hospital, Taichung 402367, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-Sheng","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Chung Shan Medical University, Taichung 402367, Taiwan"},{"name":"Graduate Program in Nutrition, Department of Nutrition, Chung Shan Medical University, Taichung 402367, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Cyun","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Chung Shan Medical University, Taichung 402367, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4271-3928","authenticated-orcid":false,"given":"Ping-Ting","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Chung Shan Medical University, Taichung 402367, Taiwan"},{"name":"Department of Nutrition, Chung Shan Medical University Hospital, Taichung 402367, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,22]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2021, August 12). 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