{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:45:41Z","timestamp":1787028341402,"version":"build-2736575974"},"reference-count":36,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T00:00:00Z","timestamp":1646006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>We investigated the association between short-term exposure to air pollution and the risk of acute exacerbation of chronic obstructive pulmonary disease (AE-COPD) in seven metropolitan cities in Korea. We used national health insurance claims data to identify AE-COPD cases in 2015. We estimated short-term exposure to particulate matter (PM) with a diameter of \u22642.5 \u03bcm (PM2.5), PM with diameters of \u226410 \u03bcm (PM10), sulfur dioxide (SO2), nitrogen dioxide (NO2), carbon monoxide (CO), and ozone (O3) obtained from the Ministry of Environment. We conducted a time-stratified, case-crossover study to evaluate the effect of short-term exposure to air pollution on hospital visits for AE-COPD, using a conditional logistic regression model. The risk of hospital visits for AE-COPD was significantly associated with interquartile range increases in PM10 in a cumulative lag model (lag 0\u20132, 0.35%, 95% confidence interval (CI) 0.06\u20130.65%; lag 0\u20133, 0.39%, 95% CI 0.01\u20130.77%). The associations were higher among patients who were men, aged 40\u201364 years, with low household income, and with a history of asthma. However, other air pollutants were not significantly associated with the risk of hospital visits for AE-COPD. Short-term exposure to air pollution, especially PM10, increases the risk of hospital visits for AE-COPD.<\/jats:p>","DOI":"10.3390\/ijerph19052823","type":"journal-article","created":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T20:09:57Z","timestamp":1646078997000},"page":"2823","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Short-Term Air Pollution Exposure and Risk of Acute Exacerbation of Chronic Obstructive Pulmonary Disease in Korea: A National Time-Stratified Case-Crossover Study"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8887-0881","authenticated-orcid":false,"given":"Yun Jung","family":"Jung","sequence":"first","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Ajou University School of Medicine, Suwon 16499, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Ajou University School of Medicine, Suwon 16499, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6548-1939","authenticated-orcid":false,"given":"Jung Yeon","family":"Heo","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Ajou University School of Medicine, Suwon 16499, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Hwa","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Ajou University School of Medicine, Suwon 16499, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1025-2044","authenticated-orcid":false,"given":"Dae Jung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon 16499, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3408-7568","authenticated-orcid":false,"given":"Kyoung Hwa","family":"Ha","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon 16499, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1164\/rccm.201701-0218PP","article-title":"Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2017 Report. GOLD Executive Summary","volume":"195","author":"Vogelmeier","year":"2017","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_2","unstructured":"World Health Organization (2022, January 10). The Top 10 Causes of Death, Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/the-top-10-causes-of-death."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"398S","DOI":"10.1378\/chest.117.5_suppl_2.398S","article-title":"Toward a consensus definition for COPD exacerbations","volume":"117","year":"2000","journal-title":"Chest"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1136\/thorax.57.10.847","article-title":"Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease","volume":"57","author":"Donaldson","year":"2002","journal-title":"Thorax"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1136\/thoraxjnl-2011-201518","article-title":"Long-term natural history of chronic obstructive pulmonary disease: Severe exacerbations and mortality","volume":"67","author":"Suissa","year":"2012","journal-title":"Thorax"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2147\/COPD.S54417","article-title":"COPD management costs according to the frequency of COPD exacerbations in UK primary care","volume":"9","author":"Punekar","year":"2014","journal-title":"Int. J. Chron. Obs. Pulmon. Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1136\/thorax.58.1.73","article-title":"Chronic obstructive pulmonary disease * 6: The aetiology of exacerbations of chronic obstructive pulmonary disease","volume":"58","author":"White","year":"2003","journal-title":"Thorax"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/S0140-6736(07)61382-8","article-title":"COPD exacerbations: Defining their cause and prevention","volume":"370","author":"Wedzicha","year":"2007","journal-title":"Lancet"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1056\/NEJMra0800353","article-title":"Infection in the pathogenesis and course of chronic obstructive pulmonary disease","volume":"359","author":"Sethi","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/j.1440-1843.2011.02112.x","article-title":"Air pollution and chronic obstructive pulmonary disease","volume":"17","author":"Ko","year":"2012","journal-title":"Respirology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1183\/09031936.97.10051064","article-title":"Air pollution and daily admissions for chronic obstructive pulmonary disease in 6 European cities: Results from the APHEA project","volume":"10","author":"Anderson","year":"1997","journal-title":"Eur. Respir. J."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.envres.2016.03.008","article-title":"Short-term exposure to air pollution and morbidity of COPD and asthma in East Asian area: A systematic review and meta-analysis","volume":"148","author":"Zhang","year":"2016","journal-title":"Environ. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.2147\/COPD.S156617","article-title":"Harmful impact of air pollution on severe acute exacerbation of chronic obstructive pulmonary disease: Particulate matter is hazardous","volume":"13","author":"Choi","year":"2018","journal-title":"Int. J. Chron. Obstruct. Pulmon. Dis."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"299","DOI":"10.2147\/COPD.S149469","article-title":"Epidemiological study of PM2.5 and risk of COPD-related hospital visits in association with particle constituents in Chuncheon, Korea","volume":"13","author":"Jo","year":"2018","journal-title":"Int. J. Chron. Obstruct. Pulmon. Dis."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1007\/s40201-021-00709-7","article-title":"Short-term effects of exposure to particulate matter and air pollution on hospital admissions for asthma and chronic obstructive pulmonary disease in Gyeonggi-do, South Korea, 2007\u20132018","volume":"19","author":"Han","year":"2021","journal-title":"J. Environ. Health Sci. Eng."},{"key":"ref_16","first-page":"e15","article-title":"Cohort profile: The national health insurance service\u2013national sample cohort (NHIS-NSC), South Korea","volume":"46","author":"Lee","year":"2017","journal-title":"Int. J. Epidemiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1056\/NEJMoa0909883","article-title":"Susceptibility to exacerbation in chronic obstructive pulmonary disease","volume":"363","author":"Hurst","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"6679","DOI":"10.1038\/s41598-019-43167-w","article-title":"Factors associated with chronic obstructive pulmonary disease exacerbation, based on big data analysis","volume":"9","author":"Lee","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12931-019-1029-7","article-title":"Change in inhaled corticosteroid treatment and COPD exacerbations: An analysis of real-world data from the KOLD\/KOCOSS cohorts","volume":"20","author":"Lee","year":"2019","journal-title":"Respir. Res."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Kim, J., Lee, J.H., Kim, Y., Kim, K., Oh, Y.M., Yoo, K.H., Rhee, C.K., Yoon, H.K., Kim, Y.S., and Park, Y.B. (2013). Association between chronic obstructive pulmonary disease and gastroesophageal reflux disease: A national cross-sectional cohort study. BMC Pulm. Med., 13.","DOI":"10.1186\/1471-2466-13-51"},{"key":"ref_21","first-page":"561","article-title":"The health care burden of high grade chronic obstructive pulmonary disease in Korea: Analysis of the Korean Health Insurance Review and Assessment Service data","volume":"8","author":"Kim","year":"2013","journal-title":"Int. J. Chron. Obs. Pulmon. Dis."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.rmed.2013.08.003","article-title":"The association between inhaled long-acting bronchodilators and less in-hospital care in newly-diagnosed COPD patients","volume":"108","author":"Kim","year":"2014","journal-title":"Respir. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"163","DOI":"10.3109\/15412555.2013.831061","article-title":"Medical utilization and cost in patients with overlap syndrome of chronic obstructive pulmonary disease and asthma","volume":"11","author":"Rhee","year":"2014","journal-title":"COPD"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1093\/oxfordjournals.aje.a115853","article-title":"The case-crossover design: A method for studying transient effects on the risk of acute events","volume":"133","author":"Maclure","year":"1991","journal-title":"Am. J. Epidemiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"178","DOI":"10.2307\/1911894","article-title":"The distributed lag between capital appropriations and expenditures","volume":"33","author":"Almon","year":"1965","journal-title":"Econometrica"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1136\/thoraxjnl-2013-204352","article-title":"Cross-sectional associations between air pollution and chronic bronchitis: An ESCAPE meta-analysis across five cohorts","volume":"69","author":"Cai","year":"2014","journal-title":"Thorax"},{"key":"ref_27","first-page":"23","article-title":"Mechanistic impact of outdoor air pollution on asthma and allergic diseases","volume":"7","author":"Huang","year":"2015","journal-title":"J. Thorac. Dis."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e270","DOI":"10.1016\/S2542-5196(19)30085-3","article-title":"Associations between daily air quality and hospitalisations for acute exacerbation of chronic obstructive pulmonary disease in Beijing, 2013\u20132017: An ecological analysis","volume":"3","author":"Liang","year":"2019","journal-title":"Lancet Planet. Health"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"3079","DOI":"10.2147\/COPD.S122282","article-title":"Major air pollutants and risk of COPD exacerbations: A systematic review and meta-analysis","volume":"11","author":"Li","year":"2016","journal-title":"Int. J. Chron. Obstruct. Pulmon. Dis."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"111590","DOI":"10.1016\/j.ecoenv.2020.111590","article-title":"Association of change in air quality with hospital admission for acute exacerbation of chronic obstructive pulmonary disease in Guangdong, China: A province-wide ecological study","volume":"208","author":"Wang","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1093\/aje\/kwu248","article-title":"Ambient carbon monoxide and the risk of hospitalization due to chronic obstructive pulmonary disease","volume":"180","author":"Tian","year":"2014","journal-title":"Am. J. Epidemiol"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/1465-9921-13-95","article-title":"How air pollution influences clinical management of respiratory diseases. A case-crossover study in Milan","volume":"13","author":"Santus","year":"2012","journal-title":"Respir. Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1111\/j.1365-2222.2011.03776.x","article-title":"Air pollution and airway disease","volume":"41","author":"Kelly","year":"2011","journal-title":"Clin. Exp. Allergy"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.abb.2003.12.018","article-title":"An in vitro and in vivo investigation of the effects of diesel exhaust on human airway lining fluid antioxidants","volume":"423","author":"Mudway","year":"2004","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/1465-9921-12-127","article-title":"The clinical features of the overlap between COPD and asthma","volume":"12","author":"Hardin","year":"2011","journal-title":"Respir. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1164\/rccm.201204-0596PP","article-title":"Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary","volume":"187","author":"Vestbo","year":"2013","journal-title":"Am. J. Respir. Crit. Care Med."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/19\/5\/2823\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:29:19Z","timestamp":1760135359000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/19\/5\/2823"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,28]]},"references-count":36,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,3]]}},"alternative-id":["ijerph19052823"],"URL":"https:\/\/doi.org\/10.3390\/ijerph19052823","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,28]]}}}