{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T02:11:35Z","timestamp":1793067095402,"version":"4.5.0"},"reference-count":76,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T00:00:00Z","timestamp":1646265600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Individuals with Down syndrome (DS) have numerous comorbidities due to trisomy 21. However, virtual reality-based therapy (VRT) has been used nowadays as a learning and visual motor tool in order to facilitate the development and learning process of this group. The aim of this article was to carry out an integrative review of the literature on the use of virtual and computational technologies in the stimulation of children with DS. A search was carried out according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) through single key words or their combinations using AND or OR operators: \u201cDown syndrome\u201d AND (\u201cdevelopment\u201d OR \u201ccognition\u201d OR \u201cvisomotor\u201d OR \u201cdigital game\u201d OR \u201cvirtual reality\u201d). Eventually, 18 articles were included in our review. The games used in the research were able to stimulate, through the visual field, global motor skills, balance, body scheme and spatial organization, in addition to the learning of mathematical concepts, in order to directly influence the autonomous life activities, language skills, social skills and educational aspects of people with DS. Electronic games contribute to the teaching-learning relationship and stimulate neuropsychomotor and cognitive functions and development in children with DS.<\/jats:p>","DOI":"10.3390\/ijerph19052955","type":"journal-article","created":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T09:24:53Z","timestamp":1646299493000},"page":"2955","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["The Use of Virtual and Computational Technologies in the Psychomotor and Cognitive Development of Children with Down Syndrome: A Systematic Literature Review"],"prefix":"10.3390","volume":"19","author":[{"given":"Elvio","family":"Boato","sequence":"first","affiliation":[{"name":"Department of Physical Education, Catholic University of Bras\u00edlia, Brasilia 71966-700, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7800-2212","authenticated-orcid":false,"given":"Geiziane","family":"Melo","sequence":"additional","affiliation":[{"name":"Department of Physical Education, Catholic University of Bras\u00edlia, Brasilia 71966-700, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3563-0590","authenticated-orcid":false,"given":"M\u00e1rio","family":"Filho","sequence":"additional","affiliation":[{"name":"Center for Science and Technology-CogniAction Lab, Catholic University of Brasilia, Brasilia 71966-700, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Moresi","sequence":"additional","affiliation":[{"name":"Center for Science and Technology-CogniAction Lab, Catholic University of Brasilia, Brasilia 71966-700, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Louren\u00e7o","sequence":"additional","affiliation":[{"name":"Department of Sport of Science, Universidade da Beira Interior, 3510-774 Covilhan, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1751-8506","authenticated-orcid":false,"given":"Rosana","family":"Trist\u00e3o","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University Hospital of University of Brasilia, Brasilia 70297-400, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.forsciint.2019.02.018","article-title":"Trisomy 21 in forensic autopsies: Review of a 20-year period","volume":"297","author":"Holz","year":"2019","journal-title":"Forensic Sci. 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