{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T18:04:53Z","timestamp":1789236293043,"version":"build-2803163510"},"reference-count":175,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T00:00:00Z","timestamp":1646265600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Human milk is the best food for infants. Breastfeeding has been associated with a reduced risk of viral and bacterial infections. Breast milk contains the perfect amount of nutrients needed to promote infant growth, except for vitamin D. Vitamin D is crucial for calcium metabolism and bone health, and it also has extra-skeletal actions, involving innate and adaptive immunity. As exclusive breastfeeding is a risk factor for vitamin D deficiency, infants should be supplemented with vitamin D at least during the first year. The promotion of breastfeeding and vitamin D supplementation represents an important objective of public health.<\/jats:p>","DOI":"10.3390\/ijerph19052973","type":"journal-article","created":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T09:24:53Z","timestamp":1646299493000},"page":"2973","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Exclusive Breastfeeding and Vitamin D Supplementation: A Positive Synergistic Effect on Prevention of Childhood Infections?"],"prefix":"10.3390","volume":"19","author":[{"given":"Raffaele","family":"Domenici","sequence":"first","affiliation":[{"name":"Pediatric Unit, Saint Luca Hospital, 55100 Lucca, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2192-518X","authenticated-orcid":false,"given":"Francesco","family":"Vierucci","sequence":"additional","affiliation":[{"name":"Pediatric Unit, Saint Luca Hospital, 55100 Lucca, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,3]]},"reference":[{"key":"ref_1","unstructured":"Horta, B.L., and Victora, C.G. (2013). Long-Term Effects of Breastfeeding: A Systematic Review, World Health Organization. Available online: https:\/\/apps.who.int\/iris\/handle\/10665\/79198."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0140-6736(15)01044-2","article-title":"Why invest, and what it will take to improve breastfeeding practices?","volume":"387","author":"Rollins","year":"2016","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0140-6736(03)13811-1","article-title":"How many child deaths can we prevent this year?","volume":"362","author":"Jones","year":"2003","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S0140-6736(15)01024-7","article-title":"Breastfeeding in the 21st century: Epidemiology, mechanisms, and lifelong effect","volume":"387","author":"Victora","year":"2016","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1089\/bfm.2018.0108","article-title":"Effect of lactation on maternal hypertension: A systematic review","volume":"13","author":"Bonifacino","year":"2018","journal-title":"Breastfeed. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1093\/heapol\/czz050","article-title":"The cost of not breastfeeding: Global results from a new tool","volume":"34","author":"Walters","year":"2019","journal-title":"Health Policy Plan."},{"key":"ref_7","first-page":"24","article-title":"Breastfeeding between health and economic advantage","volume":"7","author":"Domenici","year":"2020","journal-title":"Rivista Italiana di Pediatria Ospedaliera"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s11684-020-0748-y","article-title":"Factors influencing peak bone mass gain","volume":"15","author":"Zhu","year":"2021","journal-title":"Front. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s00431-015-2524-6","article-title":"Vitamin D in childhood and adolescence: An expert position statement","volume":"174","author":"Saggese","year":"2015","journal-title":"Eur. J. Pediatr."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1210\/er.2018-00126","article-title":"Skeletal and extraskeletal actions of vitamin D: Current evidence and outstanding questions","volume":"40","author":"Bouillon","year":"2019","journal-title":"Endocr. Rev."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.aimed.2020.07.011","article-title":"The effects of vitamin D on acute viral respiratory infections: A rapid review","volume":"7","author":"Bradley","year":"2020","journal-title":"Adv. Integr. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1111\/pedi.12673","article-title":"Vitamin D status, enterovirus infection, and type 1 diabetes in Italian children\/adolescents","volume":"19","author":"Federico","year":"2018","journal-title":"Pediatr. Diabetes"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/j.clnu.2014.01.001","article-title":"Administering 25-hydroxyvitamin D3 in vitamin D-deficient young type 1A diabetic patients reduces reactivity against islet autoantigens","volume":"33","author":"Federico","year":"2014","journal-title":"Clin. Nutr."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"744104","DOI":"10.3389\/fped.2021.744104","article-title":"Breastfeeding contributes to physiological immune programming in the newborn","volume":"9","author":"Caba","year":"2021","journal-title":"Front. Pediatr."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.pcl.2012.10.002","article-title":"Human milk composition: Nutrients and bioactive factors","volume":"60","author":"Ballard","year":"2013","journal-title":"Pediatr. Clin. N. Am."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Yi, D.Y., and Kim, S.Y. (2021). Human breast milk composition and function in human health: From nutritional components to microbiome and microRNAs. Nutrients, 13.","DOI":"10.3390\/nu13093094"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.3389\/fimmu.2018.01759","article-title":"Innate immunity of neonates and infants","volume":"9","author":"Yu","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"137","DOI":"10.4162\/nrp.2021.15.2.137","article-title":"Role of n-3 long-chain polyunsaturated fatty acids in human nutrition and health: Review of recent studies and recommendations","volume":"15","year":"2021","journal-title":"Nutr. Res. Pract."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"576133","DOI":"10.3389\/fnut.2020.576133","article-title":"Nutritional and non-nutritional composition of human milk is modulated by maternal, infant, and methodological factors","volume":"7","author":"Samuel","year":"2020","journal-title":"Front. Nutr."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Siziba, L.P., Lorenz, L., Stahl, B., Mank, M., Marosv\u00f6lgyi, T., Decsi, T., Rothenbacher, D., and Genuneit, J. (2020). Human milk fatty acid composition of allergic and non-allergic mothers: The Ulm SPATZ Health Study. Nutrients, 12.","DOI":"10.3390\/nu12061740"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1111\/j.1399-3038.2007.00711.x","article-title":"Content of beta-casomorphins in milk of women with a history of allergy","volume":"19","author":"Sidor","year":"2008","journal-title":"Pediatr. Allergy Immunol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1399-3038.2006.00395.x","article-title":"Cytokine levels in healthy and allergic mothers and their children during the first year of life","volume":"17","author":"Zizka","year":"2006","journal-title":"Pediatr. Allergy Immunol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"411","DOI":"10.18388\/abp.2009_2474","article-title":"TGF-beta(1), IL-10 and IL-4 in colostrum of allergic and nonallergic mothers","volume":"56","author":"Marek","year":"2009","journal-title":"Acta Biochim. Pol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1111\/j.1365-2222.2006.02483.x","article-title":"Transforming growth factor-beta and interleukin-10 in breast milk and development of atopic diseases in infants","volume":"36","author":"Rigotti","year":"2006","journal-title":"Clin. Exp. Allergy"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1203\/01.PDR.0000055778.58807.C8","article-title":"Breast milk fatty acids, eicosanoids, and cytokines in mothers with and without allergic disease","volume":"53","author":"Laiho","year":"2003","journal-title":"Pediatr. Res."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Hettinga, K.A., Reina, F.M., Boeren, S., Zhang, L., Koppelman, G.H., Postma, D.S., Vervoort, J.J., and Wijga, A.H. (2015). Difference in the breast milk proteome between allergic and non-allergic mothers. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0122234"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1111\/j.1365-2222.2006.02613.x","article-title":"Cytokines and soluble CD14 in breast milk in relation with atopic manifestations in mother and infant (KOALA Study)","volume":"36","author":"Snijders","year":"2006","journal-title":"Clin. Exp. Allergy"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1093\/ajcn\/84.1.190","article-title":"Fatty acid composition of human milk in atopic Danish mothers","volume":"84","author":"Lauritzen","year":"2006","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1111\/j.1365-2222.2010.03678.x","article-title":"Low breast milk levels of long-chain n-3 fatty acids in allergic women, despite frequent fish intake","volume":"41","author":"Johansson","year":"2011","journal-title":"Clin. Exp. Allergy"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Munblit, D., Treneva, M., Peroni, D.G., Colicino, S., Chow, L., Dissanayeke, S., Abrol, P., Sheth, S., Pampura, A., and Boner, A.L. (2016). Colostrum and mature human milk of women from London, Moscow, and Verona: Determinants of immune composition. Nutrients, 8.","DOI":"10.3390\/nu8110695"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1007\/s10096-012-1555-4","article-title":"Prolonged exclusive breastfeeding, autumn birth and increased gestational age are associated with lower risk of fever in children with hand, foot, and mouth disease","volume":"31","author":"Zhu","year":"2012","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1089\/bfm.2016.0007","article-title":"Breastfeeding is associated with decreased hospitalization for neonatal fever","volume":"11","author":"Rubin","year":"2016","journal-title":"Breastfeed. Med."},{"key":"ref_33","first-page":"399","article-title":"Breastfeeding can prevent hospitalization for pneumonia among children under 1 year old","volume":"87","author":"Boccolini","year":"2011","journal-title":"J. Pediatr. (Rio J.)"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.jped.2020.10.018","article-title":"Protective effect of exclusive breastfeeding and effectiveness of maternal vaccination in reducing pertussis-like illness","volume":"97","author":"Nascimento","year":"2021","journal-title":"J. Pediatr. (Rio J.)"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3345\/kjp.2019.00402","article-title":"Positive association of breastfeeding on respiratory syncytial virus infection in hospitalized infants: A multicenter retrospective study","volume":"63","author":"Jang","year":"2020","journal-title":"Clin. Exp. Pediatr."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s13006-021-00422-z","article-title":"Feeding in the first six months of life is associated with the probability of having bronchiolitis: A cohort study in Spain","volume":"16","author":"Sotos","year":"2021","journal-title":"Int. Breastfeed. J."},{"key":"ref_37","first-page":"E401","article-title":"Mothers\u2019 knowledge of breastfeeding and infant feeding types affect acute respiratory infections","volume":"61","author":"Jansen","year":"2020","journal-title":"J. Prev. Med. Hyg."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"00143","DOI":"10.1183\/23120541.00143-2016","article-title":"Breastfeeding and respiratory tract infections during the first 2 years of life","volume":"3","author":"Wang","year":"2017","journal-title":"ERJ Open Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"152","DOI":"10.3389\/fped.2019.00152","article-title":"Breastfeeding and respiratory infections in the first 6 months of life: A case control study","volume":"7","author":"Pandolfi","year":"2019","journal-title":"Front. Pediatr."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1097\/INF.0000000000000364","article-title":"Association between breast-feeding and severity of acute viral respiratory tract infection","volume":"33","author":"Vereen","year":"2014","journal-title":"Pediatr. Infect. Dis. J."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Tromp, I., Kiefte-de Jong, J., Raat, H., Jaddoe, V., Franco, O., Hofman, A., de Jongste, J., and Moll, H. (2017). Breastfeeding and the risk of respiratory tract infections after infancy: The Generation R study. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0172763"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1007\/s10995-018-2446-9","article-title":"Implementation of steps 1\u20139 to successful breastfeeding reduces the frequency of mild and severe episodes of diarrhea and respiratory tract infection among 0\u20136 month infants in Democratic Republic of Congo","volume":"22","author":"Zivich","year":"2018","journal-title":"Matern. Child Health J."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Guo, C., Zhou, Q., Li, M., Zhou, L., Xu, L., Zhang, Y., Li, D., Wang, Y., Dai, W., and Li, S. (2020). Breastfeeding restored the gut microbiota in caesarean section infants and lowered the infection risk in early life. BMC Pediatr., 20.","DOI":"10.1186\/s12887-020-02433-x"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1007\/s10995-015-1703-4","article-title":"Long-term effects of breastfeeding on children\u2019s hospitalization for respiratory tract infections and diarrhea in early childhood in Japan","volume":"19","author":"Yamakawa","year":"2015","journal-title":"Matern. Child Health J."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/jpc.13480","article-title":"Protective effects of breastfeeding against acute respiratory tract infections and diarrhoea: Findings of a cohort study","volume":"53","author":"Raheem","year":"2017","journal-title":"J. Paediatr. Child Health"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1097\/EDE.0b013e3181f55803","article-title":"Breast-feeding and childhood hospitalizations for infections","volume":"21","author":"Tarrant","year":"2010","journal-title":"Epidemiology"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Frank, N.M., Lynch, K.F., Uusitalo, U., Yang, J., L\u00f6nnrot, M., Virtanen, S.M., Hy\u00f6ty, H., Norris, J.M., and TEDDY Study Group (2019). The relationship between breastfeeding and reported respiratory and gastrointestinal infection rates in young children. BMC Pediatr., 19.","DOI":"10.1186\/s12887-019-1693-2"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1089\/bfm.2020.0064","article-title":"Exclusively breastfeeding modifies the adverse association of late preterm birth and gastrointestinal infection: A nationwide birth cohort study","volume":"15","author":"Nakamura","year":"2020","journal-title":"Breastfeed. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1111\/j.1365-2222.2012.03969.x","article-title":"Effects of prolonged breastfeeding and colostrum fatty acids on allergic manifestations and infections in infancy","volume":"42","author":"Morales","year":"2012","journal-title":"Clin. Exp. Allergy"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1038\/ejcn.2016.135","article-title":"Exclusive breastfeeding duration and infant infection","volume":"70","author":"Quigley","year":"2016","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1097\/MPG.0000000000001539","article-title":"Breast-feeding and infant hospitalization for infections: Large cohort and sibling analysis","volume":"65","author":"Lundeby","year":"2017","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"e12935","DOI":"10.1111\/mcn.12935","article-title":"Breastfeeding initiation or duration and longitudinal patterns of infections up to 2 years and skin rash and respiratory symptoms up to 8 years in the EDEN mother-child cohort","volume":"16","author":"Forhan","year":"2020","journal-title":"Matern. Child Nutr."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Davisse-Paturet, C., Adel-Patient, K., Divaret-Chauveau, A., Pierson, J., Lioret, S., Cheminat, M., Dufourg, M.N., Charles, M.A., and de Lauzon-Guillain, B. (2019). Breastfeeding status and duration and infections, hospitalizations for infections, and antibiotic use in the first two years of life in the ELFE cohort. Nutrients, 11.","DOI":"10.3390\/nu11071607"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"e20191892","DOI":"10.1542\/peds.2019-1892","article-title":"Breastfeeding and infections in early childhood: A cohort study","volume":"146","author":"Christensen","year":"2020","journal-title":"Pediatrics"},{"key":"ref_55","first-page":"126","article-title":"Effect of breastfeeding on common pediatric infections: A 5-year prospective cohort study","volume":"116","author":"Yavuz","year":"2018","journal-title":"Arch. Argent. Pediatr."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1542\/peds.2014-0646D","article-title":"Breastfeeding and risk of infections at 6 years","volume":"134","author":"Li","year":"2014","journal-title":"Pediatrics"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1186\/s13052-021-01115-3","article-title":"Exclusive breastfeeding lowers the odds of childhood diarrhea and other medical conditions: Evidence from the 2016 Ethiopian demographic and health survey","volume":"47","author":"Mulatu","year":"2021","journal-title":"Ital. J. Pediatr."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1136\/adc.2009.169912","article-title":"Protective effect of exclusive breastfeeding against infections during infancy: A prospective study","volume":"95","author":"Ladomenou","year":"2010","journal-title":"Arch. Dis. Child."},{"key":"ref_59","unstructured":"World Health Organization (2022, February 25). Breastfeeding. Available online: https:\/\/www.who.int\/health-topics\/breastfeeding#tab=tab_2."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Debes, A.K., Kohli, A., Walker, N., Edmond, K., and Mullany, L.C. (2013). Time to initiation of breastfeeding and neonatal mortality and morbidity: A systematic review. BMC Public. Health., 13.","DOI":"10.1186\/1471-2458-13-S3-S19"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/apa.13147","article-title":"Optimal breastfeeding practices and infant and child mortality: A systematic review and meta-analysis","volume":"104","author":"Sankar","year":"2015","journal-title":"Acta Paediatr."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Rodr\u00edguez-Gallego, I., Leon-Larios, F., Corrales-Gutierrez, I., and Gonz\u00e1lez-Sanz, J.D. (2021). Impact and effectiveness of group strategies for supporting breastfeeding after birth: A systematic review. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph18052550"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s13006-020-00340-6","article-title":"Interventions to promote exclusive breastfeeding among young mothers: A systematic review and meta-analysis","volume":"15","author":"Buckland","year":"2020","journal-title":"Int. Breastfeed. J."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Camacho, E.M., and Hussain, H. (2020). Cost-effectiveness evidence for strategies to promote or support breastfeeding: A systematic search and narrative literature review. BMC Pregnancy Childbirth, 20.","DOI":"10.1186\/s12884-020-03460-3"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s13006-018-0152-2","article-title":"The annual cost of not breastfeeding in Indonesia: The economic burden of treating diarrhea and respiratory disease among children (<24mo) due to not breastfeeding according to recommendation","volume":"13","author":"Siregar","year":"2018","journal-title":"Int. Breastfeed. J."},{"key":"ref_66","first-page":"125","article-title":"Pacifier use and its association with breastfeeding and acute respiratory infection (ARI) in children below 2 years old","volume":"68","author":"Siti","year":"2013","journal-title":"Med. J. Malays."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Lee, M.K., and Binns, C. (2019). Breastfeeding and the risk of infant illness in Asia: A review. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17010186"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"S18","DOI":"10.1186\/1471-2458-13-S3-S18","article-title":"Breastfeeding for reducing the risk of pneumonia morbidity and mortality in children under two: A systematic literature review and meta-analysis","volume":"13","author":"Lamberti","year":"2013","journal-title":"BMC Public Health"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/apa.13151","article-title":"Breastfeeding and childhood acute otitis media: A systematic review and meta-analysis","volume":"104","author":"Bowatte","year":"2015","journal-title":"Acta Paediatr."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"105027","DOI":"10.1016\/j.jcv.2021.105027","article-title":"Acute bronchiolitis and respiratory syncytial virus seasonal transmission during the COVID-19 pandemic in Spain: A national perspective from the pediatric Spanish Society (AEP)","volume":"145","author":"Casellas","year":"2021","journal-title":"J. Clin. Virol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/apa.16075","article-title":"Social distancing during the COVID-19 pandemic resulted in a marked decrease in hospitalisations for bronchiolitis","volume":"111","author":"Risso","year":"2022","journal-title":"Acta Paediatr."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1007\/s00431-021-03968-6","article-title":"Bronchiolitis in COVID-19 times: A nearly absent disease?","volume":"180","author":"Poschet","year":"2021","journal-title":"Eur. J. Pediatr."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"e51","DOI":"10.1136\/archdischild-2021-322835","article-title":"RSV bronchiolitis season 2021 has arrived, so be prepared!","volume":"106","author":"Hussain","year":"2021","journal-title":"Arch. Dis. Child."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1002\/ppul.25802","article-title":"The return of RSV","volume":"57","author":"Ferrero","year":"2022","journal-title":"Pediatr. Pulmonol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"3669","DOI":"10.1002\/ppul.25644","article-title":"Impact of COVID-19 social distancing on viral infection in France: A delayed outbreak of RSV","volume":"56","author":"Delestrain","year":"2021","journal-title":"Pediatr. Pulmonol."},{"key":"ref_76","unstructured":"Center for Disease Control and Prevention (2022, February 05). Protect against Flu: Caregivers of Infants and Young Children. Page Last Reviewed: 26 August 2021, Available online: https:\/\/www.cdc.gov\/flu\/highrisk\/infantcare.htm."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1186\/1471-2458-11-S3-S15","article-title":"Breastfeeding and the risk for diarrhea morbidity and mortality","volume":"11","author":"Lamberti","year":"2011","journal-title":"BMC Public Health"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1007\/s12098-015-1854-8","article-title":"Effect of exclusive breastfeeding on rotavirus infection among children","volume":"83","author":"Krawczyk","year":"2016","journal-title":"Indian J. Pediatr."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1089\/bfm.2020.0158","article-title":"Breastfeeding by women with HIV infection","volume":"15","author":"Anderson","year":"2020","journal-title":"Breastfeed. Med."},{"key":"ref_80","unstructured":"World Health Organization (2010). Antiretroviral Drugs for Treating Pregnant Women and Preventing HIV Infection in Infants: Recommendations for a Public Health Approach, World Health Organization. Available online: https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/75236\/9789241599818_eng.pdf?sequence=1&isAllowed=y."},{"key":"ref_81","unstructured":"World Health Organization (2016). Consolidated Guidelines on the Use of Antiretroviral Drugs for Treating and Preventing HIV Infection: Recommendations for a Public Health Approach, World Health Organization. [2nd ed.]. Available online: https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/208825\/9789241549684_eng.pdf?sequence=1&isAllowed=y."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Committee on Pediatric Aids (2013). Infant feeding and transmission of human immunodeficiency virus in the United States. Pediatrics, 131, 391\u2013396.","DOI":"10.1542\/peds.2012-3543"},{"key":"ref_83","unstructured":"Centers for Disease Control and Prevention (2022, February 20). HIV and Pregnant Women, Infants, and Children, Available online: https:\/\/www.cdc.gov\/hiv\/group\/gender\/pregnantwomen\/index.html."},{"key":"ref_84","unstructured":"World Health Organization (2022, February 20). Guideline: Updates on HIV and Infant Feeding: The Duration of Breastfeeding, and Support from Health Services to Improve Feeding Practices among Mothers Living with HIV, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK379872\/pdf\/Bookshelf_NBK379872.pdf."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"e25224","DOI":"10.1002\/jia2.25224","article-title":"\u201cIn the United States, we say, \u2018No breastfeeding,\u2019 but that is no longer realistic\u201d: Provider perspectives towards infant feeding among women living with HIV in the United States","volume":"22","author":"Tuthill","year":"2019","journal-title":"J. Int. AIDS Soc."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1089\/apc.2020.0223","article-title":"Not recommended, but done: Breastfeeding with HIV in Germany","volume":"35","author":"Haberl","year":"2021","journal-title":"AIDS Patient Care STDS"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1089\/bfm.2021.0107","article-title":"Breastfeeding outcomes and associated risks in HIV-infected and HIV-exposed infants: A systematic review","volume":"17","author":"Eccles","year":"2022","journal-title":"Breastfeed. Med."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"e13244","DOI":"10.1111\/mcn.13244","article-title":"Human immunodeficiency virus-positive women\u2019s perspectives on breastfeeding with antiretrovirals: A qualitative evidence synthesis","volume":"17","author":"Li","year":"2021","journal-title":"Matern. Child. Nutr."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1089\/bfm.2021.0238","article-title":"The impact of COVID-19 on breastfeeding rates in a low-income population","volume":"17","author":"Koleilat","year":"2022","journal-title":"Breastfeed. Med."},{"key":"ref_90","unstructured":"IFE-Core Group, UNICEF, WHO, and COVID-19 Infant Feeding Working Group (2021). Frequently Asked Questions: COVID-19 Vaccines and Breastfeeding Based on WHO Interim Recommendations (August 2021), World Health Organization. Available online: https:\/\/www.who.int\/publications\/i\/item\/WHO-2019-nCoV-FAQ-Breast_feeding-Vaccines-2021.1."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"597699","DOI":"10.3389\/fped.2020.597699","article-title":"Detection of SARS-CoV-2 in milk from COVID-19 positive mothers and follow-up of their infants","volume":"8","author":"Bertino","year":"2020","journal-title":"Front. Pediatr."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1007\/s00431-020-03866-3","article-title":"Perinatal COVID-19: Review of current evidence and practical approach towards prevention and management","volume":"180","author":"Vardhelli","year":"2021","journal-title":"Eur. J. Pediatr."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"738263","DOI":"10.3389\/fped.2021.738263","article-title":"Maternal transmission of SARS-CoV-2: Safety of breastfeeding in infants born to infected mothers","volume":"9","author":"Atanu","year":"2021","journal-title":"Front. Pediatr."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Citu, C., Neamtu, R., Sorop, V.B., Horhat, D.I., Gorun, F., Tudorache, E., Gorun, O.M., Boarta, A., Tuta-Sas, I., and Citu, I.M. (2021). Assessing SARS-CoV-2 vertical transmission and neonatal complications. J. Clin. Med., 10.","DOI":"10.3390\/jcm10225253"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jnn.2021.08.003","article-title":"Breastfeeding in the context of the COVID-19 pandemic: A discussion paper","volume":"28","author":"Walker","year":"2022","journal-title":"J. Neonatal. Nurs."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"P\u00e9rez-Bermejo, M., Peris-Ochando, B., and Murillo-Llorente, M.T. (2021). COVID-19: Relationship and impact on breastfeeding-a systematic review. Nutrients, 13.","DOI":"10.3390\/nu13092972"},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Kollikonda, S., Chavan, M., Cao, C., Yao, M., Hackett, L., and Karnati, S. (2021). Transmission of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) through infant feeding and early care practices: A systematic review. J. Neonatal. Perinatal. Med., 1\u201319.","DOI":"10.3233\/NPM-210775"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1159\/000518060","article-title":"Perinatal transmission and outcome of neonates born to SARS-CoV-2-positive mothers: The experience of 2 highly endemic Italian regions","volume":"118","author":"Capozza","year":"2021","journal-title":"Neonatology"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s13006-021-00430-z","article-title":"Does breastfeeding protect children from COVID-19? An observational study from pediatric services in Majorca, Spain","volume":"16","author":"Verd","year":"2021","journal-title":"Int. Breastfeed. J."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s13052-021-00998-6","article-title":"Breastfeeding and COVID-19 vaccination: Position statement of the Italian scientific societies","volume":"47","author":"Davanzo","year":"2021","journal-title":"Ital. J. Pediatr."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"770985","DOI":"10.3389\/fpubh.2021.770985","article-title":"COVID-19 vaccine hesitancy in the United States: A systematic review","volume":"9","author":"Yasmin","year":"2021","journal-title":"Front. Public Health"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"685","DOI":"10.3390\/idr13030064","article-title":"COVID-19 vaccine in pregnant and lactating women: A review of existing evidence and practice guidelines","volume":"13","author":"Garg","year":"2021","journal-title":"Infect. Dis. Rep."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"801797","DOI":"10.3389\/fimmu.2021.801797","article-title":"Milk from women diagnosed with COVID-19 does not contain SARS-CoV-2 RNA but has persistent levels of SARS-CoV-2-specific IgA antibodies","volume":"12","author":"Pace","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"783975","DOI":"10.3389\/fimmu.2021.783975","article-title":"Neutralizing activity and SARS-CoV-2 vaccine mRNA persistence in serum and breastmilk after BNT162b2 vaccination in lactating women","volume":"12","author":"Yeo","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1097\/AOG.0000000000004661","article-title":"Neutralizing antibodies and cytokines in breast milk after coronavirus disease 2019 (COVID-19) mRNA vaccination","volume":"139","author":"Narayanaswamy","year":"2022","journal-title":"Obstet. Gynecol."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Scrimin, F., Campisciano, G., Comar, M., Ragazzon, C., Davanzo, R., Quadrifoglio, M., Giangreco, M., Stabile, G., and Ricci, G. (2022). IgG and IgA antibodies post SARS-CoV-2 vaccine in the breast milk and sera of breastfeeding women. Vaccines, 10.","DOI":"10.3390\/vaccines10010125"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"e2021054260","DOI":"10.1542\/peds.2021-054260","article-title":"Human milk SARS-CoV-2 antibodies up to 6 months after vaccination","volume":"149","author":"Perez","year":"2022","journal-title":"Pediatrics"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1001\/jamapediatrics.2021.4897","article-title":"Association of human milk antibody induction, persistence, and neutralizing capacity with SARS-CoV-2 infection vs mRNA vaccination","volume":"176","author":"Young","year":"2022","journal-title":"JAMA Pediatr."},{"key":"ref_109","first-page":"118","article-title":"Vitamin D: The \u201csunshine\u201d vitamin","volume":"3","author":"Nair","year":"2012","journal-title":"J. Pharmacol. Pharmacother."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.mayocp.2013.05.011","article-title":"Vitamin D for health: A global perspective","volume":"88","author":"Holick","year":"2013","journal-title":"Mayo Clin. Proc."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/s41574-021-00593-z","article-title":"The health effects of vitamin D supplementation: Evidence from human studies","volume":"18","author":"Bouillon","year":"2022","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3945\/ajcn.115.115105","article-title":"Vitamin D content in human breast milk: A 9-mo follow-up study","volume":"103","author":"Heickendorff","year":"2016","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.cca.2021.11.022","article-title":"Gestational vitamin D3 supplementation and sun exposure significantly influence cord blood vitamin D status and 3-epi-25-hydroxyvitamin D3 levels in term newborns","volume":"524","author":"Vierucci","year":"2022","journal-title":"Clin. Chim. Acta"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1210\/jc.2015-2175","article-title":"Global consensus recommendations on prevention and management of nutritional rickets","volume":"101","author":"Munns","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s13052-018-0488-7","article-title":"Vitamin D in pediatric age: Consensus of the Italian Pediatric Society and the Italian Society of Preventive and Social Pediatrics, jointly with the Italian Federation of Pediatricians","volume":"44","author":"Saggese","year":"2018","journal-title":"Ital. J. Pediatr."},{"key":"ref_116","first-page":"CD013046","article-title":"Vitamin D supplementation for term breastfed infants to prevent vitamin D deficiency and improve bone health","volume":"12","author":"Tan","year":"2020","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1093\/advances\/nmz098","article-title":"Vitamin D in breastfed infants: Systematic review of alternatives to daily supplementation","volume":"11","author":"Taghivand","year":"2020","journal-title":"Adv. Nutr."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Jullien, S. (2021). Vitamin D prophylaxis in infancy. BMC Pediatr., 21.","DOI":"10.1186\/s12887-021-02776-z"},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Siddiqui, M., Manansala, J.S., Abdulrahman, H.A., Nasrallah, G.K., Smatti, M.K., Younes, N., Althani, A.A., and Yassine, H.M. (2020). Immune modulatory effects of vitamin D on viral infections. Nutrients, 12.","DOI":"10.3390\/nu12092879"},{"key":"ref_120","unstructured":"Ismailova, A., and White, J.H. (2021). Vitamin D, infections and immunity. Rev. Endocr. Metab. Disord., 1\u201313."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1093\/cid\/cit289","article-title":"Low serum 25-hydroxyvitamin D level and risk of upper respiratory tract infection in children and adolescents","volume":"57","author":"Science","year":"2013","journal-title":"Clin. Infect. Dis."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1007\/s00405-013-2455-7","article-title":"Serum vitamin D levels in children with recurrent otitis media","volume":"271","author":"Cayir","year":"2014","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Golan-Tripto, I., Loewenthal, N., Tal, A., Dizitzer, Y., Baumfeld, Y., and Goldbart, A. (2021). Vitamin D deficiency in children with acute bronchiolitis: A prospective cross-sectional case-control study. BMC Pediatr., 21.","DOI":"10.1186\/s12887-021-02666-4"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1093\/tropej\/50.6.364","article-title":"The frequency of nutritional rickets among hospitalized infants and its relation to respiratory diseases","volume":"50","author":"Najada","year":"2004","journal-title":"J. Trop. Pediatr."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1002\/ppul.21121","article-title":"Nutritional rickets and vitamin D deficiency--association with the outcomes of childhood very severe pneumonia: A prospective cohort study","volume":"44","author":"Banajeh","year":"2009","journal-title":"Pediatr. Pulmonol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"bcr2015212639","DOI":"10.1136\/bcr-2015-212639","article-title":"Vitamin D-dependent rickets: A resurgence of the rachitic lung in the 21st century","volume":"2015","author":"Fernandes","year":"2015","journal-title":"BMJ Case Rep."},{"key":"ref_127","first-page":"134","article-title":"Vitamin D and urinary tract infection: A systematic review and meta-analysis","volume":"49","author":"Deng","year":"2019","journal-title":"Ann. Clin. Lab. Sci."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"e4739","DOI":"10.1097\/MD.0000000000004739","article-title":"Association between vitamin D and development of otitis media: A PRISMA-compliant meta-analysis and systematic review","volume":"95","author":"Li","year":"2016","journal-title":"Medicine (Baltimore)"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1097\/INF.0b013e3182868989","article-title":"Vitamin D deficiency associated with increased incidence of gastrointestinal and ear infections in school-age children","volume":"32","author":"Thornton","year":"2013","journal-title":"Pediatr. Infect. Dis. J."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1111\/ped.12809","article-title":"Is there a relationship between low vitamin D and rotaviral diarrhea?","volume":"58","author":"Bucak","year":"2016","journal-title":"Pediatr. Int."},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Cusick, S.E., Opoka, R.O., Lund, T.C., John, C.C., and Polgreen, L.E. (2014). Vitamin D insufficiency is common in Ugandan children and is associated with severe malaria. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0113185"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/tmi.12407","article-title":"Clinical aspects of paediatric visceral leishmaniasis in North-west Ethiopia","volume":"20","author":"Diro","year":"2015","journal-title":"Trop. Med. Int. Health"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.3748\/wjg.v21.i4.1284","article-title":"Vitamin D status and viral response to therapy in hepatitis C infected children","volume":"21","author":"Eltayeb","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1016\/j.clnu.2019.08.010","article-title":"Association between vitamin D status and sepsis in children: A meta-analysis of observational studies","volume":"39","author":"Xiao","year":"2020","journal-title":"Clin. Nutr."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"e13908","DOI":"10.1111\/ijcp.13908","article-title":"Vitamin D deficiency relation to sepsis, paediatric risk of mortality III score, need for ventilation support, length of hospital stay, and duration of mechanical ventilation in critically ill children: A meta-analysis","volume":"75","author":"He","year":"2021","journal-title":"Int. J. Clin. Pract."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.2147\/RMHP.S282495","article-title":"Effect of pandemic-related confinement on vitamin D status among children aged 0\u20136 years in Guangzhou, China: A cross-sectional study","volume":"13","author":"Yu","year":"2020","journal-title":"Risk Manag. Healthc. Policy"},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Zeng, J., Wu, G., Yang, W., Gu, X., Liang, W., Yao, Y., and Song, Y. (2015). A serum vitamin D level <25 nmol\/L pose high tuberculosis risk: A meta-analysis. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0126014"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.nut.2015.05.003","article-title":"Vitamin D deficiencies among tuberculosis patients in Africa: A systematic review","volume":"31","author":"Keflie","year":"2015","journal-title":"Nutrition"},{"key":"ref_139","first-page":"3127","article-title":"Impact of vitamin D supplementation on the outcome of tuberculosis treatment: A systematic review and meta-analysis of randomized controlled trials","volume":"127","author":"Xia","year":"2014","journal-title":"Chin. Med. J. (Engl.)"},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Aibana, O., Huang, C.C., Aboud, S., Arnedo-Pena, A., Becerra, M.C., Bellido-Blasco, J.B., Bhosale, R., Calderon, R., Chiang, S., and Contreras, C. (2019). Vitamin D status and risk of incident tuberculosis disease: A nested case-control study, systematic review, and individual-participant data meta-analysis. PLoS Med., 16.","DOI":"10.1371\/journal.pmed.1002907"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"637529","DOI":"10.3389\/fpubh.2021.637529","article-title":"Serum vitamin D level and the risk of urinary tract infection in children: A systematic review and meta-analysis","volume":"9","author":"Li","year":"2021","journal-title":"Front. Public Health"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"e23827","DOI":"10.1097\/MD.0000000000023827","article-title":"Vitamin D status was associated with sepsis in critically ill children: A PRISMA compliant systematic review and meta-analysis","volume":"100","author":"Yu","year":"2021","journal-title":"Medicine (Baltimore)"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"e027666","DOI":"10.1136\/bmjopen-2018-027666","article-title":"Importance of vitamin D in acute and critically ill children with subgroup analyses of sepsis and respiratory tract infections: A systematic review and meta-analysis","volume":"9","author":"Cariolou","year":"2019","journal-title":"BMJ Open"},{"key":"ref_144","first-page":"CD008824","article-title":"Vitamin D supplementation for preventing infections in children under five years of age","volume":"11","author":"Yakoob","year":"2016","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1177\/0049475516644141","article-title":"Vitamin D deficiency and lower respiratory tract infections in children: A systematic review and meta-analysis of observational studies","volume":"47","author":"Jat","year":"2017","journal-title":"Trop. Doct."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"e17252","DOI":"10.1097\/MD.0000000000017252","article-title":"The association between vitamin D deficiency and community-acquired pneumonia: A meta-analysis of observational studies","volume":"98","author":"Zhou","year":"2019","journal-title":"Medicine (Baltimore)"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"300","DOI":"10.4103\/0976-500X.103685","article-title":"Vitamin D for prevention of respiratory tract infections: A systematic review and meta-analysis","volume":"3","author":"Charan","year":"2012","journal-title":"J. Pharmacol. Pharmacother."},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Bergman, P., Lindh, A.U., Bj\u00f6rkhem-Bergman, L., and Lindh, J.D. (2013). Vitamin D and respiratory tract infections: A systematic review and meta-analysis of randomized controlled trials. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0065835"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"696","DOI":"10.3109\/00365548.2013.803293","article-title":"Vitamin D supplementation and risk of respiratory tract infections: A meta-analysis of randomized controlled trials","volume":"45","author":"Mao","year":"2013","journal-title":"Scand. J. Infect. Dis."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1017\/S000711451500207X","article-title":"Vitamin D supplementation for the prevention of childhood acute respiratory infections: A systematic review of randomised controlled trials","volume":"114","author":"Xiao","year":"2015","journal-title":"Br. J. Nutr."},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Vuichard Gysin, D., Dao, D., Gysin, C.M., Lytvyn, L., and Loeb, M. (2016). Effect of vitamin D3 supplementation on respiratory tract infections in healthy individuals: A systematic review and meta-analysis of randomized controlled trials. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0162996"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"i6583","DOI":"10.1136\/bmj.i6583","article-title":"Vitamin D supplementation to prevent acute respiratory tract infections: Systematic review and meta-analysis of individual participant data","volume":"356","author":"Martineau","year":"2017","journal-title":"BMJ"},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Vlieg-Boerstra, B., de Jong, N., Meyer, R., Agostoni, C., De Cosmi, V., Grimshaw, K., Milani, G.P., Muraro, A., Oude Elberink, H., and Pali-Sch\u00f6ll, I. (2021). Nutrient supplementation for prevention of viral respiratory tract infections in healthy subjects: A systematic review and meta-analysis. Allergy.","DOI":"10.1111\/all.15136"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/S2213-8587(21)00051-6","article-title":"Vitamin D supplementation to prevent acute respiratory infections: A systematic review and meta-analysis of aggregate data from randomised controlled trials","volume":"9","author":"Jolliffe","year":"2021","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_155","first-page":"CD011597","article-title":"Vitamin D as an adjunct to antibiotics for the treatment of acute childhood pneumonia","volume":"7","author":"Das","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1002\/ncp.10585","article-title":"Efficacy of high-dose vitamin D supplementation as an adjuvant treatment on pneumonia: Systematic review and a meta-analysis of randomized controlled studies","volume":"36","author":"Yang","year":"2021","journal-title":"Nutr. Clin. Pract."},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Maretzke, F., Bechthold, A., Egert, S., Ernst, J.B., Melo van Lent, D., Pilz, S., Reichrath, J., Stangl, G.I., Stehle, P., and Volkert, D. (2020). Role of vitamin D in preventing and treating selected extraskeletal diseases-an Umbrella review. Nutrients, 12.","DOI":"10.3390\/nu12040969"},{"key":"ref_158","doi-asserted-by":"crossref","unstructured":"Esposito, S., Jones, M.H., Feleszko, W., Martell, J.A.O., Falup-Pecurariu, O., Geppe, N., Martin\u00f3n-Torres, F., Shen, K.L., Roth, M., and Principi, N. (2020). Prevention of new respiratory episodes in children with recurrent respiratory infections: An expert consensus statement. Microorganisms, 8.","DOI":"10.3390\/microorganisms8111810"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1186\/s13052-021-01150-0","article-title":"Prevention of recurrent respiratory infections: Inter-society consensus","volume":"47","author":"Chiappini","year":"2021","journal-title":"Ital. J. Pediatr."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/joim.13399","article-title":"Vitamin D, respiratory infections, and chronic disease: Review of meta-analyses and randomized clinical trials","volume":"291","author":"Ganmaa","year":"2022","journal-title":"J. Intern. Med."},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Mohan, M., Cherian, J.J., and Sharma, A. (2020). Exploring links between vitamin D deficiency and COVID-19. PLoS Pathog., 16.","DOI":"10.1371\/journal.ppat.1008874"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1002\/jmv.26569","article-title":"Vitamin D status may indeed be a prognosticator for morbidity and mortality in patients with COVID-19","volume":"93","author":"Mandal","year":"2021","journal-title":"J. Med. Virol."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1093\/nutrit\/nuaa092","article-title":"The implications of vitamin D deficiency on COVID-19 for at-risk populations","volume":"79","author":"DeLuccia","year":"2021","journal-title":"Nutr. Rev."},{"key":"ref_164","doi-asserted-by":"crossref","unstructured":"Rustecka, A., Maret, J., Drab, A., Leszczy\u0144ska, M., Tomaszewska, A., Lipi\u0144ska-Opa\u0142ka, A., B\u0119dzichowska, A., Kalicki, B., and Kubiak, J.Z. (2021). The impact of COVID-19 pandemic during 2020\u20132021 on the vitamin D serum levels in the paediatric population in Warsaw, Poland. Nutrients, 13.","DOI":"10.3390\/nu13061990"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"831","DOI":"10.17269\/s41997-021-00549-w","article-title":"Public health preventive measures and child health behaviours during COVID-19: A cohort study","volume":"112","author":"Li","year":"2021","journal-title":"Can. J. Public Health"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"e21","DOI":"10.3346\/jkms.2021.36.e21","article-title":"The impact of the coronavirus disease-2019 pandemic on childhood obesity and vitamin D status","volume":"36","author":"Kang","year":"2021","journal-title":"J. Korean Med. Sci."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"e180","DOI":"10.1017\/S0950268821001825","article-title":"Vitamin D levels in children with COVID-19: A report from Turkey","volume":"149","author":"Alpcan","year":"2021","journal-title":"Epidemiol. Infect."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.clnesp.2021.04.022","article-title":"Evaluation of nutritional status in pediatric patients diagnosed with COVID-19 infection","volume":"44","author":"Bayhan","year":"2021","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.1007\/s00431-021-04030-1","article-title":"The association between vitamin D levels and the clinical severity and inflammation markers in pediatric COVID-19 patients: Single-center experience from a pandemic hospital","volume":"180","author":"Yurdakul","year":"2021","journal-title":"Eur. J. Pediatr."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"648546","DOI":"10.3389\/fimmu.2021.648546","article-title":"Vitamin D in corona virus disease 2019 (COVID-19) related multisystem inflammatory syndrome in children (MIS-C)","volume":"12","author":"Feketea","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_171","doi-asserted-by":"crossref","unstructured":"Darren, A., Osman, M., Masilamani, K., Habib Ali, S., Kanthimathinathan, H.K., Chikermane, A., Al-Abadi, E., Welch, S.B., Hackett, S., and Scholefield, B.R. (2021). Vitamin D status of children with paediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus 2 (PIMS-TS). Br. J. Nutr., 1\u201326.","DOI":"10.1136\/archdischild-2021-rcpch.657"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1093\/qjmed\/hcab202","article-title":"Low vitamin D levels and prognosis in a COVID-19 pediatric population: A systematic review","volume":"114","author":"Shah","year":"2021","journal-title":"QJM"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1089\/bfm.2021.0170","article-title":"Influence of vitamin D3 levels and T cell-related cytokines in human milk on coronavirus disease 2019 infection in lactating women","volume":"16","author":"Lavangnananda","year":"2021","journal-title":"Breastfeed. Med."},{"key":"ref_174","unstructured":"National Institute for Health and Care Excellence (2022, February 05). COVID-19 Rapid Guideline: Vitamin D. Available online: www.nice.org.uk\/guidance\/ng187."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1055\/s-0043-109699","article-title":"The spectrum of vitamin D deficiency: Description of a family","volume":"125","author":"Vierucci","year":"2017","journal-title":"Exp. Clin. Endocrinol. 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