{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T18:37:55Z","timestamp":1794335875478,"version":"4.9.0"},"reference-count":156,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T00:00:00Z","timestamp":1646784000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation","doi-asserted-by":"publisher","award":["2013\/07467-1"],"award-info":[{"award-number":["2013\/07467-1"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["305414\/2019-4"],"award-info":[{"award-number":["305414\/2019-4"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfeicoamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["Finance code - 001"],"award-info":[{"award-number":["Finance code - 001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Every year, Brazil intensifies its activity in agriculture and, as a result, it has become one of the biggest consumers of pesticides in the world. The high rate of these substances raises environmental and human health concerns. Therefore, we collected papers from PubMed, Scopus, Scielo, and Web of Science databases, from 2015 to 2021. After a blind selection using the software Rayyan QCRI by two authors, 51 studies were included. Researchers from the South and the Southeast Brazilian regions contributed to most publications, from areas that concentrate agricultural commodity complexes. Among the pesticides described in the studies, insecticides, herbicides, and fungicides were the most frequent. The articles reported multiple toxic effects, particularly in rural workers. The results obtained can be used to direct policies to reduce the use of pesticides, and to protect the health of the population.<\/jats:p>","DOI":"10.3390\/ijerph19063198","type":"journal-article","created":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T01:53:54Z","timestamp":1646790834000},"page":"3198","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":87,"title":["Impact of Pesticides on Human Health in the Last Six Years in Brazil"],"prefix":"10.3390","volume":"19","author":[{"given":"Monica","family":"Lopes-Ferreira","sequence":"first","affiliation":[{"name":"Immunoregulation Unit of the Laboratory of Applied Toxinology (CeTICs\/FAPESP), Butantan Institute, Vital Brazil Avenue, 1500, Butantan, S\u00e3o Paulo 05503-009, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4430-0905","authenticated-orcid":false,"given":"Adolfo Luis Almeida","family":"Maleski","sequence":"additional","affiliation":[{"name":"Immunoregulation Unit of the Laboratory of Applied Toxinology (CeTICs\/FAPESP), Butantan Institute, Vital Brazil Avenue, 1500, Butantan, S\u00e3o Paulo 05503-009, Brazil"},{"name":"Post-Graduation Program of Toxinology, Butantan Institute, S\u00e3o Paulo 05503-009, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia","family":"Balan-Lima","sequence":"additional","affiliation":[{"name":"Immunoregulation Unit of the Laboratory of Applied Toxinology (CeTICs\/FAPESP), Butantan Institute, Vital Brazil Avenue, 1500, Butantan, S\u00e3o Paulo 05503-009, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jefferson Thiago Gon\u00e7alves","family":"Bernardo","sequence":"additional","affiliation":[{"name":"Immunoregulation Unit of the Laboratory of Applied Toxinology (CeTICs\/FAPESP), Butantan Institute, Vital Brazil Avenue, 1500, Butantan, S\u00e3o Paulo 05503-009, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas Marques","family":"Hipolito","sequence":"additional","affiliation":[{"name":"Immunoregulation Unit of the Laboratory of Applied Toxinology (CeTICs\/FAPESP), Butantan Institute, Vital Brazil Avenue, 1500, Butantan, S\u00e3o Paulo 05503-009, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7422-7449","authenticated-orcid":false,"given":"Ana Carolina","family":"Seni-Silva","sequence":"additional","affiliation":[{"name":"Immunoregulation Unit of the Laboratory of Applied Toxinology (CeTICs\/FAPESP), Butantan Institute, Vital Brazil Avenue, 1500, Butantan, S\u00e3o Paulo 05503-009, Brazil"},{"name":"Post-Graduation Program of Toxinology, Butantan Institute, S\u00e3o Paulo 05503-009, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8214-614X","authenticated-orcid":false,"given":"Joao","family":"Batista-Filho","sequence":"additional","affiliation":[{"name":"Immunoregulation Unit of the Laboratory of Applied Toxinology (CeTICs\/FAPESP), Butantan Institute, Vital Brazil Avenue, 1500, Butantan, S\u00e3o Paulo 05503-009, Brazil"},{"name":"Post-Graduation Program of Toxinology, Butantan Institute, S\u00e3o Paulo 05503-009, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Alice Pimentel","family":"Falcao","sequence":"additional","affiliation":[{"name":"Immunoregulation Unit of the Laboratory of Applied Toxinology (CeTICs\/FAPESP), Butantan Institute, Vital Brazil Avenue, 1500, Butantan, S\u00e3o Paulo 05503-009, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8161-966X","authenticated-orcid":false,"given":"Carla","family":"Lima","sequence":"additional","affiliation":[{"name":"Immunoregulation Unit of the Laboratory of Applied Toxinology (CeTICs\/FAPESP), Butantan Institute, Vital Brazil Avenue, 1500, Butantan, S\u00e3o Paulo 05503-009, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1007\/s00181-019-01711-7","article-title":"Assessing the economy\u2013climate relationships for Brazilian agriculture","volume":"59","author":"Castro","year":"2020","journal-title":"Empir. 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