{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T17:09:06Z","timestamp":1783098546447,"version":"3.54.6"},"reference-count":57,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T00:00:00Z","timestamp":1646870400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015632","name":"Louise and Alan Edwards Foundation","doi-asserted-by":"publisher","award":["-"],"award-info":[{"award-number":["-"]}],"id":[{"id":"10.13039\/501100015632","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Background: Significant alterations were recently identified in the composition and putative function of the gut microbiome in women with fibromyalgia. As diet can influence the composition of the gut microbiome, differences in nutritional intake could, in theory, account for some of these specific fibromyalgia microbiome alterations. The current study aims to compare the diet of women with fibromyalgia to that of controls in order to explore possible associations between the intake of certain nutrients, symptom severity and gut microbiome composition. Methods: The study population was comprised of 56 women with fibromyalgia and 68 controls. Dietary intake was assessed using the NIH Automated Self-Administered 24 h recall, following dietitian\u2019s instructions and the completion of a three-day dietary recall. The gut microbiome was assessed by 16S ribosomal RNA gene sequencing of stool samples. Results: Most demographic and anthropometric characteristics were comparable between groups. The average energy and macronutrient intake (total and relative) and overall diet quality score were not different between patients and controls, nor were the main vitamins, minerals, fatty acids, alcohol, caffeine, sugar or fiber intakes. The daily intake of micronutrients and normalized macronutrients in women with fibromyalgia was largely not correlated with disease-specific measures, including pain intensity, fatigue, cognitive symptoms and quality of sleep, or with the relative quantity of almost any of the gut microbiome bacterial taxa differentially abundant in fibromyalgia. Conclusion: These data demonstrate that dietary intakes, as evaluated by self-reported questionnaires, probably cannot explain the syndrome-specific differences in gut microbiome or the clinical phenotype of fibromyalgia.<\/jats:p>","DOI":"10.3390\/ijerph19063254","type":"journal-article","created":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T11:46:47Z","timestamp":1646912807000},"page":"3254","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Dietary Intake Is Unlikely to Explain Symptom Severity and Syndrome-Specific Microbiome Alterations in a Cohort of Women with Fibromyalgia"],"prefix":"10.3390","volume":"19","author":[{"given":"Amir","family":"Minerbi","sequence":"first","affiliation":[{"name":"Institute for Pain Medicine, Rambam Health Campus, Haifa 3109601, Israel"},{"name":"Ruth and Bruce Rapaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 3525433, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2434-3249","authenticated-orcid":false,"given":"Nicholas J. B.","family":"Brereton","sequence":"additional","affiliation":[{"name":"Institut de Recherche en Biologie V\u00e9g\u00e9tale, University of Montreal, Montreal, QC H1X 2B2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abraham","family":"Anjarkouchian","sequence":"additional","affiliation":[{"name":"School of Human Nutrition, McGill University, 21111 Lakeshore Rd, Montreal, QC H9X 3V9, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7156-3386","authenticated-orcid":false,"given":"Audrey","family":"Moyen","sequence":"additional","affiliation":[{"name":"School of Human Nutrition, McGill University, 21111 Lakeshore Rd, Montreal, QC H9X 3V9, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Canadian Centre for Computational Genomics, McGill University and Genome Quebec Innovation Centre, 740 Docteur Penfield Ave, Montreal, QC H3A 0G1, Canada"},{"name":"Microbiome Research Platform, McGill Interdisciplinary Initiative in Infection and Immunity, Genome Center, McGill University, 740 Docteur Penfield Ave, Montreal, QC H3A 0G1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary-Ann","family":"Fitzcharles","sequence":"additional","affiliation":[{"name":"Alan Edwards Pain Management Unit, McGill University Health Centre, 1650 Cedar Ave, Montreal, QC H3G 1A4, Canada"},{"name":"Division of Rheumatology, McGill University Health Centre, 1650 Cedar Ave, Montreal, QC H3G 1A4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoram","family":"Shir","sequence":"additional","affiliation":[{"name":"Alan Edwards Pain Management Unit, McGill University Health Centre, 1650 Cedar Ave, Montreal, QC H3G 1A4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Chevalier","sequence":"additional","affiliation":[{"name":"School of Human Nutrition, McGill University, 21111 Lakeshore Rd, Montreal, QC H9X 3V9, Canada"},{"name":"Research Institute of the McGill University Health Centre, 1001 D\u00e9carie Blvd, Montreal, QC H4A 3J1, Canada"},{"name":"Department of Medicine, McGill University, 845 Sherbrooke St. W, Montreal, QC H3A 0G4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"15022","DOI":"10.1038\/nrdp.2015.22","article-title":"Fibromyalgia","volume":"1","author":"Ablin","year":"2015","journal-title":"Nat. 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