{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:45:43Z","timestamp":1787028343564,"version":"build-2736575974"},"reference-count":36,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T00:00:00Z","timestamp":1646870400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003654","name":"Korea Environmental Industry and Technology Institute","doi-asserted-by":"publisher","award":["2017001360005"],"award-info":[{"award-number":["2017001360005"]}],"id":[{"id":"10.13039\/501100003654","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Particulate matter with a diameter of \u226410 \u00b5m (PM10) and nitrogen dioxide (NO2) affect the DNA methylation in the fetus, but epigenetic studies regarding prenatal exposure to air pollution in Asia are lacking. Therefore, this study aimed to assess whether there is any association between the ambient concentrations of PM10 and NO2 and CpG methylation in the cord blood DNA by using a Korean birth cohort. The concentrations of the air pollutants were incorporated into the final LUR model by using the maternal address data. The methylation level was determined using HumanMethylationEPIC BeadChip and a linear regression analysis model. A multipollutant model including both PM10 and NO2 and models with single pollutants were used for each trimester exposure. The number of differentially methylated positions was the largest for midpregnancy exposure in both the single pollutant models and the multipollutant regression analysis. Additionally, gene-set analysis regarding midpregnancy exposure revealed four gene ontology terms (cellular response to staurosporine, positive regulation of cytoskeleton organization, neurotransmitter transport, and execution phase of apoptosis). In conclusion, these findings show an association between prenatal PM10 and NO2 exposure and DNA methylation in several CpG sites in cord blood cells, especially for midpregnancy exposure.<\/jats:p>","DOI":"10.3390\/ijerph19063292","type":"journal-article","created":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T11:46:47Z","timestamp":1646912807000},"page":"3292","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Prenatal Exposure to Traffic-Related Air Pollution and the DNA Methylation in Cord Blood Cells: MOCEH Study"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2900-8340","authenticated-orcid":false,"given":"Jaehyun","family":"Park","sequence":"first","affiliation":[{"name":"Interdisciplinary Program in Bioinformatics, College of Natural Sciences, Seoul National University, Seoul 08826, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2927-370X","authenticated-orcid":false,"given":"Woo Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Environmental Health Center, Kangwon National University, Chuncheon 24341, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeeyoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Environmental Health Center, Kangwon National University, Chuncheon 24341, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan-Yeong","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Environmental Health Center, Kangwon National University, Chuncheon 24341, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9359-6522","authenticated-orcid":false,"given":"Hyesook","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, College of Medicine, Ewha Womans University, Seoul 07804, Korea"},{"name":"Graduate Program in System Health Science and Engineering (BK21 Plus Program), Ewha Womans University, Seoul 07804, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Chul","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, College of Medicine, Seoul National University, Seoul 03080, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1011-9446","authenticated-orcid":false,"given":"Mina","family":"Ha","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, College of Medicine, Dankook University, Cheonan 31114, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6462-0829","authenticated-orcid":false,"given":"Yangho","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan 44033, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5751-5089","authenticated-orcid":false,"given":"Sungho","family":"Won","sequence":"additional","affiliation":[{"name":"Interdisciplinary Program in Bioinformatics, College of Natural Sciences, Seoul National University, Seoul 08826, Korea"},{"name":"Department of Public Health Sciences, Seoul National University, Seoul 08826, Korea"},{"name":"Institute of Health and Environment, Seoul National University, Seoul 08826, Korea"},{"name":"RexSoft Inc., Seoul 08826, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunhee","family":"Ha","sequence":"additional","affiliation":[{"name":"Graduate Program in System Health Science and Engineering (BK21 Plus Program), Ewha Womans University, Seoul 07804, Korea"},{"name":"Department of Occupational and Environmental Medicine, College of Medicine, Ewha Womans University, Seoul 07804, Korea"},{"name":"Ewha Medical Research Institute, College of Medicine, Ewha Womans University, Seoul 07804, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1164\/rccm.201902-0286OC","article-title":"Prenatal, Early-Life, and Childhood Exposure to Air Pollution and Lung Function: The ALSPAC Cohort","volume":"202","author":"Cai","year":"2020","journal-title":"Am. 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