{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:57:57Z","timestamp":1760151477904,"version":"build-2065373602"},"reference-count":31,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T00:00:00Z","timestamp":1646956800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>This prospective study examined a population of 520 urban and rural children aged 5 to 9 years. Every 2\u20134 weeks, the clinical symptoms accompanying primary tooth replacement such as a cough, a runny nose, pain, and body temperature were assessed in each child\u2019s medical records. The authors were able to show in a statistically significant manner that the frequency, time, and type of cough were strongly related to the type of erupting teeth (p &lt; 0.001 for each relationship). A cough dependent on the type of erupting teeth was observed in 86% to 92% of the examined children, with a morning bronchial cough being connected with an eruption of the lower teeth, and an eruption of the upper teeth producing an all-day pharyngeal cough caused by mucus secretions dripping down the back of the throat. A statistically significant relationship was also confirmed between the type of erupting teeth and the incidence of a runny nose (p &lt; 0.001), the frequency of a runny nose (p &lt; 0.001), and the time when runny nose symptoms occurred (p &lt; 0.001). This study shows that the period when primary dentition is replaced with permanent teeth in children is characterized by a physiological cough and a runny nose.<\/jats:p>","DOI":"10.3390\/ijerph19063301","type":"journal-article","created":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T12:58:36Z","timestamp":1647003516000},"page":"3301","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Symptoms of the Eruption of Permanent Teeth"],"prefix":"10.3390","volume":"19","author":[{"given":"\u0141ucja","family":"Sobkowska","sequence":"first","affiliation":[{"name":"Department of Anatomy, Pozna\u0144 University of Medical Sciences, 61-712 Poznan, Poland"},{"name":"General Medical Practice \u201cBONUS 2001\u201d, 60-185 Skorzewo, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Sobkowska","sequence":"additional","affiliation":[{"name":"General Medical Practice \u201cBONUS 2001\u201d, 60-185 Skorzewo, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damian","family":"Dudek","sequence":"additional","affiliation":[{"name":"Artmedical Oral Surgery, Szosa Chelimnska 166, 87-100 Torun, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1633-7145","authenticated-orcid":false,"given":"Beniamin Oskar","family":"Grabarek","sequence":"additional","affiliation":[{"name":"Department of Histology, Cytophysiology and Embryology, Faculty of Medicine in Zabrze, The University of Technology in Katowice, Academy of Silesia, 41-800 Zabrze, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agata","family":"Czajka-Jakubowska","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Pozna\u0144 University of Medical Sciences, 61-712 Poznan, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnieszka","family":"Przysta\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Pozna\u0144 University of Medical Sciences, 61-712 Poznan, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.ajodo.2013.03.015","article-title":"Establishing the diagnostic criteria for eruption disorders based on genetic and clinical data","volume":"144","author":"Rhoads","year":"2013","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"275","DOI":"10.2319\/062717-430.1","article-title":"Primary failure of eruption: Clinical and genetic findings in the mixed dentition","volume":"88","author":"Grippaudo","year":"2018","journal-title":"Angle Orthod."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.anai.2019.12.026","article-title":"Chronic cough in children and adults","volume":"125","author":"Weinberger","year":"2020","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1016\/j.jaip.2019.01.049","article-title":"Methods of cough assessment","volume":"7","author":"Cho","year":"2019","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1016\/j.jaip.2019.04.009","article-title":"Otolaryngology Aspects of Chronic Cough","volume":"7","author":"Altman","year":"2019","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1016\/j.jaip.2019.03.030","article-title":"An Update on Speech Pathology Management of Chronic Refractory Cough","volume":"7","author":"Vertigan","year":"2019","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1016\/j.jaip.2019.04.012","article-title":"What Is Chronic Cough? Terminology","volume":"7","author":"McGarvey","year":"2019","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref_8","first-page":"24","article-title":"Systemic and local teething disturbances: Prevalence in a clinic for infants","volume":"71","author":"Cunha","year":"2004","journal-title":"J. Dent. Child."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"201","DOI":"10.17796\/jcpd.34.3.h318882h52616225","article-title":"Teething Symptoms in the First Year of Life and Associated Factors: A Cohort Study","volume":"34","author":"Feldens","year":"2010","journal-title":"J. Clin. Pediatr. Dent."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1136\/adc.67.2.233","article-title":"Fever associated with teething","volume":"67","author":"Jaber","year":"1992","journal-title":"Arch. Dis. Child."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1590\/S1806-83242012000200011","article-title":"Prenatal beliefs about children\u2019s teething in Undaipur, India: A preliminary study","volume":"26","author":"Kakatkar","year":"2012","journal-title":"Braz. Oral Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1542\/peds.105.4.747","article-title":"Symptoms Associated with Infant Teething: A Prospective Study","volume":"105","author":"Macknin","year":"2000","journal-title":"Pediatrics"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Memarpour, M., Soltanimehr, E., and Eskandarian, T. (2015). Signs and symptoms associated with primary tooth eruption: A clinical trial of nonpharmacological remedies. BMC Oral Health, 15.","DOI":"10.1186\/s12903-015-0070-2"},{"key":"ref_14","first-page":"170","article-title":"Systemic manifestations during eruption of primary teeth in infants","volume":"70","author":"Peretz","year":"2003","journal-title":"J. Dent. Child."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1542\/peds.106.6.1374","article-title":"Teething and Tooth Eruption in Infants: A Cohort Study","volume":"106","author":"Wake","year":"2000","journal-title":"Pediatrics"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1136\/adc.2006.110114","article-title":"Does a teething child need serious illness excluding?","volume":"92","author":"Tighe","year":"2007","journal-title":"Arch. Dis. Child."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"277","DOI":"10.2209\/tdcpublication.2018-0009","article-title":"Difference in Bilateral Timing of Eruption of Permanent Teeth","volume":"59","author":"Makino","year":"2018","journal-title":"Bull. Tokyo Dent. Coll."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Wong, H.M., Peng, S.-M., and McGrath, C.P.J. (2019). Association of infant growth with emergence of permanent dentition among 12 year-aged southern Chinese school children. BMC Oral Health, 19.","DOI":"10.1186\/s12903-019-0737-1"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1073\/pnas.1819412116","article-title":"Shedding new light on the mysteries of tootheruption","volume":"116","author":"Richman","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_20","first-page":"1155","article-title":"Mechanism of human tooth eruption. Review article including a new Theory for future studies on the eruption process","volume":"10","author":"Kjaer","year":"2014","journal-title":"Scientifica"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1601-6343.2009.01439.x","article-title":"Cellular et molecular basis of tooth eruption","volume":"12","author":"Wise","year":"2009","journal-title":"Orthod. Craniofacial Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1073\/pnas.1810200115","article-title":"Autocrine regulation of mesenchymal progenitor cell fates orchestrates tooth eruption","volume":"116","author":"Takahashi","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1177\/0022034519882692","article-title":"Mesenchymal Progenitor Regulation of Tooth Eruption: A View from PTHrP","volume":"99","author":"Nagata","year":"2020","journal-title":"J. Dent. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1111\/odi.13249","article-title":"A three-dimensional analysis of primary failure of eruption in humans and mice","volume":"26","author":"Tokavanich","year":"2020","journal-title":"Oral Dis."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1590\/2177-6709.24.2.020-031.oin","article-title":"Explanation for the signs and symptoms of tooth eruption: Mast cells","volume":"24","author":"Franzolin","year":"2019","journal-title":"Dent. Press J. Orthod."},{"key":"ref_26","first-page":"441","article-title":"Cytokine levels in gingival cervicular fluid of erupting primary teeth correlated with systemic disturbances accompanying teething","volume":"25","author":"Shapira","year":"2003","journal-title":"Pediatr. Dent."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e20153501","DOI":"10.1542\/peds.2015-3501","article-title":"Signs and Symptoms of Primary Tooth Eruption: A Meta-analysis","volume":"137","author":"Massignan","year":"2016","journal-title":"Pediatrics"},{"key":"ref_28","first-page":"25","article-title":"Localised disturbances associated with primary teeth eruption","volume":"12","author":"Chakraborty","year":"1994","journal-title":"J. Indian Soc. Pedod. Prev. Dent."},{"key":"ref_29","first-page":"415","article-title":"Eruption of the primary dentition in human infants: A prospective descriptive study","volume":"22","author":"Hulland","year":"2000","journal-title":"Pediatr. Dent."},{"key":"ref_30","first-page":"249","article-title":"Antybiotykooporno\u015b\u0107: Przyczyny i konsekwencje","volume":"59","author":"Hryniewicz","year":"2020","journal-title":"Adv. Microbiol."},{"key":"ref_31","unstructured":"Mazi\u0144ska, B. (2022, March 02). Europejski Dzie\u0144 Wiedzy o Antybiotykach i \u015awiatowy Tydzie\u0144 Wiedzy o Antybiotykach\u20192021\u2013Wa\u017cne Inicjatywy Edukacyjne w Dobie Narastaj\u0105cej Oporno\u015bci na Antybiotyki. Available online: http:\/\/antybiotyki.edu.pl\/wp-content\/uploads\/2022\/02\/Biuletyn-Informacyjny-2_2021.pdf."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/19\/6\/3301\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:34:46Z","timestamp":1760135686000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/19\/6\/3301"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,11]]},"references-count":31,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,3]]}},"alternative-id":["ijerph19063301"],"URL":"https:\/\/doi.org\/10.3390\/ijerph19063301","relation":{},"ISSN":["1660-4601"],"issn-type":[{"type":"electronic","value":"1660-4601"}],"subject":[],"published":{"date-parts":[[2022,3,11]]}}}